Memory complaints with and without memory impairment: The impact of leukoaraiosis on cognition

Journal of the International Neuropsychological Society

Volumn 17, Issue 6, 2011, Pages 1104-1112

  Lamar, Melissa ^a   Dannhauser, Thomas M ^b,c   Walker, Zuzana ^b,c   Rodda, Joanne E ^b,c   Cutinha, Darren J ^b,c   Shergill, Sukhwinder S ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c North Essex Partnership NHS Foundation Trust ^*  (United Kingdom)

Author keywords

Dementia; Learning and memory; Leukoaraiosis; MCI; Subjective cognitive impairment; White matter

Indexed keywords

EID: 80455149720     PISSN: 13556177     EISSN: 14697661     Source Type: Journal    
DOI: 10.1017/S1355617711001123     Document Type: Article

References (54)

1. Alexopoulos, G.S., Abrams, R.C., Young, R.C., & Shamoian, C.A. (1988). Use of the Cornell scale in nondemented patients. Journal of the American Geriatric Society, 36(3), 230-236.
2. Apostolova, L.G., Mosconi, L., Thompson, P.M., Green, A.E., Hwang, K.S., Ramirez, A.,de Leon, M.J. (2010). Subregional hippocampal atrophy predicts Alzheimer's dementia in the cognitively normal. Neurobiology of Aging, 31(7), 1077-1088.
3. Archer, H.A., Macfarlane, F., Price, S., Moore, E.K., Pepple, T., Cutler, D.,Rossor, M.N. (2006). Do symptoms of memory impairment correspond to cognitive impairment: A cross sectional study of a clinical cohort. International Journal of Geriatric Psychiatry, 21(12), 1206-1212.
4. Bombois, S., Debette, S., Delbeuck, X., Bruandet, A., Lepoittevin, S., Delmaire, C.,Pasquier, F. (2007). Prevalence of subcortical vascular lesions and association with executive function in mild cognitive impairment subtypes. Stroke, 38(9), 2595-2597.
5. Breteler, M.M. (2000). Vascular risk factors for Alzheimer's disease: An epidemiologic perspective. Neurobiology of Aging, 21(2), 153-160.
6. Burns, J.M., Church, J.A., Johnson, D.K., Xiong, C., Marcus, D., Fotenos, A.F.,Buckner, R.L. (2005). White matter lesions are prevalent but differentially related with cognition in aging and early Alzheimer disease. Archives of Neurology, 62(12), 1870-1876.
7. Chang, Y.L., Bondi, M.W., Fennema-Notestine, C., McEvoy, L.K., Hagler, D.J., Jr., Jacobson, M.W., & Dale, A.M. (2010). Brain substrates of learning and retention in mild cognitive impairment diagnosis and progression to Alzheimer's disease. Neuropsychologia, 48(5), 1237-1247.
8. Copenhaver, B.R., Rabin, L.A., Saykin,A.J., Roth, R.M., Wishart,H.A., Flashman, L.A.,Mamourian, A.C. (2006). The fornix and mammillary bodies in older adults with Alzheimer's disease, mild cognitive impairment, and cognitive complaints: A volumetric MRI study. Psychiatry Research, 147(2-3), 93-103.
9. Dannhauser, T.M., Shergill, S.S., Stevens, T., Lee, L., Seal, M., Walker, R.W., & Walker, Z. (2008). An fMRI study of verbal episodic memory encoding in amnestic mild cognitive impairment. Cortex, 44(7), 869-880.
10. de Groot, J.C., de Leeuw, F.E., Oudkerk, M., Hofman, A., Jolles, J., & Breteler, M.M. (2001). Cerebral white matter lesions and subjective cognitive dysfunction: The Rotterdam Scan Study. Neurology, 56(11), 1539-1545.
11. DeCarli, C., Mungas, D., Harvey, D., Reed, B., Weiner, M., Chui, H., & Jagust, W. (2004). Memory impairment, but not cerebrovascular disease, predicts progression of MCI to dementia. Neurology, 63(2), 220-227.
12. Delano-Wood, L., Bondi, M.W., Jak, A.J., Horne, N.R., Schweinsburg, B.C., Frank, L.R.,Salmon, D.P. (2008). Stroke risk modifies regional white matter differences in mild cognitive impairment. Neurobiology of Aging, 31, 1721-1731.
13. Delano-Wood, L., Bondi, M.W., Sacco, J., Abeles, N., Jak, A.J., Libon, D.J., & Bozoki, A. (2009). Heterogeneity in mild cognitive impairment: Differences in neuropsychological profile and associated white matter lesion pathology. Journal of the International Neuropsychological Society, 15(6), 906-914.
14. Dufouil, C., Fuhrer, R., & Alperovitch, A. (2005). Subjective cognitive complaints and cognitive decline: Consequence or predictor? The epidemiology of vascular aging study. Journal of the American Geriatric Society, 53(4), 616-621.
15. Folstein, M.R., Folstein, S.E., & McHugh, P.R. (1975). Mini-mental state: A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189-198.
16. Geerlings, M.I., Jonker, C., Bouter, L.M., Ader, H.J., & Schmand, B. (1999). Association between memory complaints and incident Alzheimer's disease in elderly people with normal baseline cognition. American Journal of Psychiatry, 156(4), 531-537.
17. Hachinski, V.C., Iliff, L.D., Zilhka, E., Du Boulay, G.H., McAllister, V.L., Marshall, J.,Symon, L. (1975). Cerebral blood flow in dementia. Archives of Neurology, 32(9), 632-637.
18. Huppert, F.A., Brayne, C., Gill, C., Paykel, E.S., & Beardsall, L. (1995). CAMCOG-A concise neuropsychological test to assist dementia diagnosis: Socio-demographic determinants in an elderly population sample. British Journal of Clinical Psychology, 34(Pt 4), 529-541.
19. Jak, A.J., Bangen, K.J., Wierenga, C.E., Delano-Wood, L., Corey-Bloom, J., & Bondi, M.W. (2009). Contributions of neuropsychology and neuroimaging to understanding clinical subtypes of mild cognitive impairment. International Review of Neurobiology, 84, 81-103.
20. Jessen, F., Wiese, B., Bachmann, C., Eifflaender-Gorfer, S., Haller, F., Kolsch, H.,Bickel, H. (2010). Prediction of dementia by subjective memory impairment: Effects of severity and temporal association with cognitive impairment. Archives of General Psychiatry, 67(4), 414-422.
21. Jones, D.K., Catani, M., Pierpaoli, C., Reeves, S.J., Shergill, S.S., O'Sullivan, M.,Howard, R.J. (2006). Age effects on diffusion tensor magnetic resonance imaging tractography measures of frontal cortex connections in schizophrenia. Human Brain Mapping, 27(3), 230-238.
22. Junque, C., Pujol, J., Vendrell, P., Bruna, O., Jodar, M., Ribas, J., Marti-Vilalta, J.L. (1990). Leuko-araiosis on magnetic resonance imaging and speed of mental processing. Archives of Neurology, 47(2), 151-156.
23. Lamar, M., Charlton, R.A., Morris, R.G., & Markus, H.S. (2010). The impact of subcortical white matter disease on mood in euthymic older adults: A diffusion tensor imaging study. American Journal of Geriatric Psychiatry, 18(7), 634-642.
24. Lamar, M., Resnick, S.M., & Zonderman, A.B. (2003). Longitudinal changes in verbal memory in older adults: Distinguishing the effects of age from repeat testing. Neurology, 60(1), 82-86.
25. Libon, D.J., Xie, S.X., Eppig, J., Wicas, G., Lamar, M., Lippa, C.,Wambach, D.M. (2010). The heterogeneity of mild cognitive impairment: A neuropsychological analysis. Journal of the International Neuropsychological Society, 16(1), 84-93.
26. Lopez, O.L., Jagust, W.J., Dulberg, C., Becker, J.T., DeKosky, S.T., Fitzpatrick, A.,Kuller, L.H. (2003). Risk factors for mild cognitive impairment in the Cardiovascular Health Study Cognition Study: Part 2. Archives of Neurology, 60(10), 1394-1399.
27. Lyketsos, C.G., Toone, L., Tschanz, J., Rabins, P.V., Steinberg, M., Onyike, C.U.,Williams, M. (2005). Population-based study of medical comorbidity in early dementia and "cognitive impairment, no dementia (CIND)": Association with functional and cognitive impairment: The Cache County Study. American Journal of Geriatric Psychiatry, 13(8), 656-664.
28. McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E.M. (1984). Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology, 34(7), 939-944.
29. Minett, T.S., Dean, J.L., Firbank, M., English, P., & O'Brien, J.T. (2005). Subjective memory complaints, white-matter lesions, depressive symptoms, and cognition in elderly patients. American Journal of Geriatric Psychiatry, 13(8), 665-671.
30. Miranda, B., Madureira, S., Verdelho, A., Ferro, J., Pantoni, L., Salvadori, E.,Inzitarion, D. (2008). Self-perceived memory impairment and cognitive performance in an elderly independent population with age-related white matter changes. Journal of Neurology, Neurosurgery, and Psychiatry, 79(8), 869-873.
31. Morris, J.C. (1993). The Clinical Dementia Rating (CDR): Current version and scoring rules. Neurology, 43(11), 2412-2414.
32. Mosconi, L., De Santi, S., Li, J., Tsui, W.H., Li, Y., Boppana, M., yde Leon, M.J. (2008). Hippocampal hypometabolism predicts cognitive decline from normal aging. Neurobiology of Aging, 29(5), 676-692.
33. O'Sullivan, M., Jones, D.K., Summers, P.E., Morris, R.G., Williams, S.C., & Markus, H.S. (2001). Evidence for cortical "disconnection" as a mechanism of age-related cognitive decline. Neurology, 57(4), 632-638.
34. Oulhaj, A., Wilcock, G.K., Smith, A.D., & de Jager, C.A. (2009). Predicting the time of conversion to MCI in the elderly: Role of verbal expression and learning. Neurology, 73(18), 1436-1442.
35. Petersen, R.C., Doody, R., Kurz, A., Mohs, R.C., Morris, J.C., Rabins, P.V.,Winblad, B. (2001). Current concepts in mild cognitive impairment. Archives of Neurology, 58(12), 1985-1992.
36. Petersen, R.C., Smith, G.E.,Waring, S.C., Ivnik, R.J., Tangalos, E.G., & Kokmen, E. (1999). Mild cognitive impairment: Clinical characterization and outcome. Archives of Neurology, 56(3), 303-308.
37. Petrovitch, H., Ross, G.W., He, Q., Uyehara-Lock, J.,Markesbery, W., Davis, D.,White, L.R. (2007). Characterization of Japanese-American men with a single neocortical AD lesion type. Neurobiology of Aging, 29, 1448-1455.
38. Price, C.C., Jefferson, A.L., Merino, J.G., Heilman, K.M., & Libon, D.J. (2005). Subcortical vascular dementia: Integrating neuropsychological and neuroradiologic data. Neurology, 65(3), 376-382.
39. Reid, L.M., & Maclullich, A.M. (2006). Subjective memory complaints and cognitive impairment in older people. Dementia and Geriatric Cognitive Disorders, 22(5-6), 471-485.
40. Reitan, R.M., & Wolfson, D. (1995). Category Test and Trail Making Test as measures of frontal lobe functions. The Clinical Neuropsychologist, 9, 50-56.
41. Rodda, J.E., Dannhauser, T.M., Cutinha, D.J., Shergill, S.S., & Walker, Z. (2009). Subjective cognitive impairment: Increased prefrontal cortex activation compared to controls during an encoding task. International Journal of Geriatric Psychiatry, 24(8), 865-874.
42. Roth, M., Tym, E., Mountjoy, C.Q., Huppert, F.A., Hendrie, H., Verma, S., & Goddard, R. (1986). CAMDEX. A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. British Journal of Psychiatry, 149, 698-709.
43. Saykin, A.J.,Wishart,H.A., Rabin, L.A., Santulli, R.B., Flashman, L.A., West, J.D.,Mamourian, A.C. (2006). Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI. Neurology, 67(5), 834-842.
44. Schofield, P.W., Marder, K., Dooneief, G., Jacobs, D.M., Sano, M., & Stern, Y. (1997). Association of subjective memory complaints with subsequent cognitive decline in community-dwelling elderly individuals with baseline cognitive impairment. American Journal of Psychiatry, 154(5), 609-615.
45. Sharpe, K., & O'Carroll, R. (1991). Estimating premorbid intellectual level in dementia using the National Adult Reading Test: A Canadian study. British Journal of Clinical Psychology, 30(Pt 4), 381-384.
46. Spreen, O., & Benton, A.L. (1969). Neurosensory Center Comprehensive Examination for Aphasia (NCCEA). Victoria, British Columbia, Canada: University of Victoria Neuropsychology Laboratory.
47. Stewart, R., Dufouil, C., Godin, O., Ritchie, K., Maillard, P., Delcroix, N.,Tzourio, C. (2008). Neuroimaging correlates of subjective memory deficits in a community population. Neurology, 70(18), 1601-1607.
48. van der Flier, W.M., van Buchem, M.A., Weverling-Rijnsburger, A.W., Mutsaers, E.R., Bollen, E.L., Admiraal-Behloul, F.,Middelkoop, H.A. (2004). Memory complaints in patients with normal cognition are associated with smaller hippocampal volumes. Journal of Neurology, 251(6), 671-675.
49. van Oijen, M., de Jong, F.J., Hofman, A., Koudstaal, P.J., & Breteler, M.M. (2007). Subjective memory complaints, education, and risk of Alzheimer's disease. Alzheimers Dementia, 3(2), 92-97.
50. van Straaten, E.C., Harvey, D., Scheltens, P., Barkhof, F., Petersen, R.C., Thal, L.J.,DeCarli, C. (2008). Periventricular white matter hyperintensities increase the likelihood of progression from amnestic mild cognitive impairment to dementia. Journal of Neurology, 255(9), 1302-1308.
51. Wechsler, D., Wycherley, R.J., Benjamin, L., Callanan, M., Lavender, T., J.R., C., & Mockler, D. (1998). Wechsler Memory Scale-III (Third ed.). London, UK: The Psychological Corporation.
52. Yip, A.G., McKee, A.C., Green, R.C., Wells, J., Young, H., Cupples, L.A., & Farrer, L.A. (2005). APOE, vascular pathology, and the AD brain. Neurology, 65(2), 259-265.
53. Yoshita, M., Fletcher, E., Harvey, D., Ortega, M., Martinez, O., Mungas, D.M., yDeCarli, C.S. (2006). Extent and distribution of white matter hyperintensities in normal aging, MCI, and AD. Neurology, 67(12), 2192-2198.
54. Zigmond, A.S., & Snaith, R.P. (1983). The hospital anxiety and depression scale. Acta Psychiatrica Scandinavica, 67(6), 361-370.