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Volumn 2, Issue 5, 2011, Pages

A novel mechanism of high-level, broad-spectrum antibiotic resistance caused by a single base pair change in Neisseria gonorrhoeae

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; AZITHROMYCIN;

EID: 80455132320     PISSN: None     EISSN: 21507511     Source Type: Journal    
DOI: 10.1128/mBio.00187-11     Document Type: Article
Times cited : (73)

References (45)
  • 1
    • 0028906903 scopus 로고
    • Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system
    • Hagman KE, et al. 1995. Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system. Microbiology 141:611-622.
    • (1995) Microbiology , vol.141 , pp. 611-622
    • Hagman, K.E.1
  • 2
    • 0032782869 scopus 로고    scopus 로고
    • The farAB-encoded efflux pump mediates resistance of gonococci to long-chained antibacterial fatty acids
    • Lee EH, Shafer WM. 1999. The farAB-encoded efflux pump mediates resistance of gonococci to long-chained antibacterial fatty acids. Mol. Mi-crobiol. 33:839-845.
    • (1999) Mol. Mi-crobiol , vol.33 , pp. 839-845
    • Lee, E.H.1    Shafer, W.M.2
  • 3
    • 0028364451 scopus 로고
    • Regulation of the permeability of the gonococcal cell envelope by the mtr system
    • Pan W, Spratt BG. 1994. Regulation of the permeability of the gonococcal cell envelope by the mtr system. Mol. Microbiol. 11:769-775.
    • (1994) Mol. Microbiol , vol.11 , pp. 769-775
    • Pan, W.1    Spratt, B.G.2
  • 5
    • 0037309093 scopus 로고    scopus 로고
    • The NorM efflux pump of Neisseria gonorrhoeae and Neisseria meningitidis recognizes antimicrobial cationic compounds
    • Rouquette-Loughlin C, Dunham SA, Kuhn M, Balthazar JT, Shafer WM. 2003. The NorM efflux pump of Neisseria gonorrhoeae and Neisseria meningitidis recognizes antimicrobial cationic compounds. J. Bacteriol. 185:1101-1106.
    • (2003) J. Bacteriol , vol.185 , pp. 1101-1106
    • Rouquette-Loughlin, C.1    Dunham, S.A.2    Kuhn, M.3    Balthazar, J.T.4    Shafer, W.M.5
  • 6
    • 0032539553 scopus 로고    scopus 로고
    • Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family
    • Shafer WM, Qu X-D, Waring AJ, Lehrer RI. 1998. Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family. Proc. Natl. Acad. Sci. U. S. A. 95:1829-1833.
    • (1998) Proc. Natl. Acad. Sci. U. S. A , vol.95 , pp. 1829-1833
    • Shafer, W.M.1    Qu, X.-D.2    Waring, A.J.3    Lehrer, R.I.4
  • 7
    • 0029078189 scopus 로고
    • Transcriptional control of the mtr efflux system of Neisseria gonorrhoeae
    • Hagman KE, Shafer WM. 1995. Transcriptional control of the mtr efflux system of Neisseria gonorrhoeae. J. Bacteriol. 177:4162-4165.
    • (1995) J. Bacteriol , vol.177 , pp. 4162-4165
    • Hagman, K.E.1    Shafer, W.M.2
  • 8
    • 0032767010 scopus 로고    scopus 로고
    • Induction of the mtrCDE-encoded efflux pump system of Neisseria gonorrhoeae requires MtrA, an AraC-like protein
    • Rouquette C, Harmon JB, Shafer WM. 1999. Induction of the mtrCDE-encoded efflux pump system of Neisseria gonorrhoeae requires MtrA, an AraC-like protein. Mol. Microbiol. 33:651-658.
    • (1999) Mol. Microbiol , vol.33 , pp. 651-658
    • Rouquette, C.1    Harmon, J.B.2    Shafer, W.M.3
  • 9
    • 77956579731 scopus 로고    scopus 로고
    • Molecular mechanisms of antibiotic resistance expressed by the pathogenic Neisseria
    • In Genco C, Wetzler L (ed.), Caister Academic Press, Norfolk, United Kingdom
    • Shafer WM, Folster JP, Nicholas RA. 2010. Molecular mechanisms of antibiotic resistance expressed by the pathogenic Neisseria. In Genco C, Wetzler L (ed.), Neisseria: molecular mechanisms ofpathogenesis. Caister Academic Press, Norfolk, United Kingdom.
    • (2010) Neisseria: Molecular Mechanisms Ofpathogenesis
    • Shafer, W.M.1    Folster, J.P.2    Nicholas, R.A.3
  • 10
    • 21844452398 scopus 로고    scopus 로고
    • Characterization of the multiple transferable resistance repressor, MtrR, from Neisseria gonorrhoeae
    • Hoffmann KM, Williams D, Shafer WM, Brennan RG. 2005. Characterization of the multiple transferable resistance repressor, MtrR, from Neisseria gonorrhoeae. J. Bacteriol. 187:5008-5012.
    • (2005) J. Bacteriol , vol.187 , pp. 5008-5012
    • Hoffmann, K.M.1    Williams, D.2    Shafer, W.M.3    Brennan, R.G.4
  • 11
    • 0028997376 scopus 로고
    • Missense mutations that alter the DNA-binding domain of the MtrR protein occur frequently in rectal isolates of Neisseria gonorrhoeae that are resistant to faecal lipids
    • Shafer WM, Balthazar JT, Hagman KE, Morse SA. 1995. Missense mutations that alter the DNA-binding domain of the MtrR protein occur frequently in rectal isolates of Neisseria gonorrhoeae that are resistant to faecal lipids. Microbiology 141:907-911.
    • (1995) Microbiology , vol.141 , pp. 907-911
    • Shafer, W.M.1    Balthazar, J.T.2    Hagman, K.E.3    Morse, S.A.4
  • 12
    • 52649131941 scopus 로고    scopus 로고
    • Clinically relevant mutations that cause derepression of the Neisseria gonorrhoeae MtrC-MtrD-MtrE efflux pump system confer different levels of antimicrobial resistance and in vivo fitness
    • Warner DM, Shafer WM, Jerse AE. 2008. Clinically relevant mutations that cause derepression of the Neisseria gonorrhoeae MtrC-MtrD-MtrE efflux pump system confer different levels of antimicrobial resistance and in vivo fitness. Mol. Microbiol. 70:462-478.
    • (2008) Mol. Microbiol , vol.70 , pp. 462-478
    • Warner, D.M.1    Shafer, W.M.2    Jerse, A.E.3
  • 13
    • 0015589995 scopus 로고
    • Studies on gonococcus infection IV. Pili: Their role in attachment of gonococci to tissue culture cells
    • Swanson J. 1973. Studies on gonococcus infection IV. Pili: their role in attachment of gonococci to tissue culture cells. J. Exp. Med. 137:571-589.
    • (1973) J. Exp. Med , vol.137 , pp. 571-589
    • Swanson, J.1
  • 14
    • 1842591130 scopus 로고    scopus 로고
    • The regulation of bacterial transcription initiation
    • Browning DF, Busby SJW. 2004. The regulation of bacterial transcription initiation. Nat. Rev. Microbiol. 2:57-65.
    • (2004) Nat. Rev. Microbiol , vol.2 , pp. 57-65
    • Browning, D.F.1    Busby, S.J.W.2
  • 15
    • 65749101194 scopus 로고    scopus 로고
    • Phenotypic and genetic characterization of the 2008 WHO Neisseria gonorrhoeae reference strain panel intended for global quality assurance and quality control of gonococcal antimicrobial resistance surveillance for public health purposes
    • Unemo M, Fasth O, Fredlund H, Limnios A, Tapsall J. 2009. Phenotypic and genetic characterization of the 2008 WHO Neisseria gonorrhoeae reference strain panel intended for global quality assurance and quality control of gonococcal antimicrobial resistance surveillance for public health purposes. J. Antimicrob. Chemother. 63:1142-1151.
    • (2009) J. Antimicrob. Chemother , vol.63 , pp. 1142-1151
    • Unemo, M.1    Fasth, O.2    Fredlund, H.3    Limnios, A.4    Tapsall, J.5
  • 16
    • 0028828941 scopus 로고
    • Construction of a translational lacZ fusion system to study gene regulation in Neisseria gonorrhoeae
    • Silver LE, Clark VL. 1995. Construction of a translational lacZ fusion system to study gene regulation in Neisseria gonorrhoeae. Gene 166: 101-104.
    • (1995) Gene , vol.166 , pp. 101-104
    • Silver, L.E.1    Clark, V.L.2
  • 17
    • 0030798952 scopus 로고    scopus 로고
    • The MtrR repressor binds the DNA sequence between the mtrR and mtrC genes of Neisseria gonorrhoeae
    • Lucas CE, Balthazar JT, Hagman KE, Shafer WM. 1997. The MtrR repressor binds the DNA sequence between the mtrR and mtrC genes of Neisseria gonorrhoeae. J. Bacteriol. 179:4123- 4128.
    • (1997) J. Bacteriol. 179:4123- , pp. 4128
    • Lucas, C.E.1    Balthazar, J.T.2    Hagman, K.E.3    Shafer, W.M.4
  • 18
    • 0016610995 scopus 로고
    • Determinant of cistron specificity in bacterial ribosomes
    • Shine J, Dalgarno L. 1975. Determinant of cistron specificity in bacterial ribosomes. Nature 254:34-38.
    • (1975) Nature , vol.254 , pp. 34-38
    • Shine, J.1    Dalgarno, L.2
  • 19
    • 58149520026 scopus 로고    scopus 로고
    • MtrR modulates rpoH expression and levels of antimicrobial resistance in Neisseria gonorrhoeae
    • Folster JP, et al. 2009. MtrR modulates rpoH expression and levels of antimicrobial resistance in Neisseria gonorrhoeae. J. Bacteriol. 191: 287-297.
    • (2009) J. Bacteriol , vol.191 , pp. 287-297
    • Folster, J.P.1
  • 20
    • 39149112789 scopus 로고    scopus 로고
    • Regulation of the MtrC-MtrD-MtrE efflux-pump system modulates the in vivo fitness of Neisseria gonorrhoeae
    • Warner DM, Folster JP, Shafer WM, Jerse AE. 2007. Regulation of the MtrC-MtrD-MtrE efflux-pump system modulates the in vivo fitness of Neisseria gonorrhoeae. J. Infect. Dis. 196:1804-1812.
    • (2007) J. Infect. Dis , vol.196 , pp. 1804-1812
    • Warner, D.M.1    Folster, J.P.2    Shafer, W.M.3    Jerse, A.E.4
  • 21
    • 0017811307 scopus 로고
    • Mutations to increased antibiotic sensitivity in naturally-occurring gonococci
    • Eisenstein BI, Sparling PF. 1978. Mutations to increased antibiotic sensitivity in naturally-occurring gonococci. Nature 271:242-244.
    • (1978) Nature , vol.271 , pp. 242-244
    • Eisenstein, B.I.1    Sparling, P.F.2
  • 22
    • 0033022756 scopus 로고    scopus 로고
    • Characterization of the recD gene of Neisseria gonorrhoeae MS11 and the effect of recD inactivation on pilin variation and DNA transformation
    • Chaussee MS, Wilson J, Hill SA. 1999. Characterization of the recD gene of Neisseria gonorrhoeae MS11 and the effect of recD inactivation on pilin variation and DNA transformation. Microbiology 145:389-400.
    • (1999) Microbiology , vol.145 , pp. 389-400
    • Chaussee, M.S.1    Wilson, J.2    Hill, S.A.3
  • 23
    • 0022462167 scopus 로고
    • The repertoire of silent pilus genes in Neisseria gonorrhoeae: Evidence for gene conversion
    • Haas R, Meyer TF. 1986. The repertoire of silent pilus genes in Neisseria gonorrhoeae: evidence for gene conversion. Cell 44:107-115.
    • (1986) Cell , vol.44 , pp. 107-115
    • Haas, R.1    Meyer, T.F.2
  • 24
    • 0026526855 scopus 로고
    • Silent pilin genes of Neisseria gonor-rhoeaeMS11 and the occurrence of related hypervariant sequences among other gonococcal isolates
    • Haas R, Veit S, Meyer TF. 1992. Silent pilin genes of Neisseria gonor-rhoeaeMS11 and the occurrence of related hypervariant sequences among other gonococcal isolates. Mol. Microbiol. 6:197-208.
    • (1992) Mol. Microbiol , vol.6 , pp. 197-208
    • Haas, R.1    Veit, S.2    Meyer, T.F.3
  • 25
    • 0025727324 scopus 로고
    • L-pilin variants of Neisseria gonorrhoeae MS11
    • Manning PA, et al. 1991. L-pilin variants of Neisseria gonorrhoeae MS11. Mol. Microbiol. 5:917-926.
    • (1991) Mol. Microbiol , vol.5 , pp. 917-926
    • Manning, P.A.1
  • 26
    • 0025768658 scopus 로고
    • The opacity proteins of Neisseria gonorrhoeae strain MS11 are encoded by a family of 11 complete genes
    • Bhat KS, et al. 1991. The opacity proteins of Neisseria gonorrhoeae strain MS11 are encoded by a family of 11 complete genes. Mol. Microbiol. 5:1889-1901.
    • (1991) Mol. Microbiol , vol.5 , pp. 1889-1901
    • Bhat, K.S.1
  • 27
    • 0032483026 scopus 로고    scopus 로고
    • CD66 receptor specificity exhibited by neisserial Opa variants is controlled by protein determinants in CD66 N-domains
    • Bos MP, Kuroki M, Krop-Watorek A, Hogan D, Belland RJ. 1998. CD66 receptor specificity exhibited by neisserial Opa variants is controlled by protein determinants in CD66 N-domains. Proc. Natl. Acad. Sci. U. S. A. 95:9584-9589.
    • (1998) Proc. Natl. Acad. Sci. U. S. A , vol.95 , pp. 9584-9589
    • Bos, M.P.1    Kuroki, M.2    Krop-Watorek, A.3    Hogan, D.4    Belland, R.J.5
  • 28
    • 54049127365 scopus 로고    scopus 로고
    • Neisseria gonorrhoeae suppresses the oxidative burst of human polymorphonuclear leukocytes
    • Criss AK, Seifert HS. 2008. Neisseria gonorrhoeae suppresses the oxidative burst of human polymorphonuclear leukocytes. Cell. Microbiol. 10: 2257-2270.
    • (2008) Cell. Microbiol , vol.10 , pp. 2257-2270
    • Criss, A.K.1    Seifert, H.S.2
  • 29
    • 21344432145 scopus 로고    scopus 로고
    • Neisseria gonorrhoeae downregulates expression of the human antimicrobial peptide LL-37
    • Bergman P, et al. 2005. Neisseria gonorrhoeae downregulates expression of the human antimicrobial peptide LL-37. Cell. Microbiol. 7:1009-1017.
    • (2005) Cell. Microbiol , vol.7 , pp. 1009-1017
    • Bergman, P.1
  • 30
    • 0025324683 scopus 로고
    • Construction of isogenic gonococci with variable porin structure: Effects on susceptibility to human serum and antibiotics
    • Carbonetti N, Simnad V, Elkins C, Sparling PF. 1990. Construction of isogenic gonococci with variable porin structure: effects on susceptibility to human serum and antibiotics. Mol. Microbiol. 4:1009-1018.
    • (1990) Mol. Microbiol , vol.4 , pp. 1009-1018
    • Carbonetti, N.1    Simnad, V.2    Elkins, C.3    Sparling, P.F.4
  • 31
    • 0025841780 scopus 로고
    • Expression of paraglobiside-like lipooligosac-charides may be a necessary component of gonococcal pathogenesis in men
    • Schneider H, et al. 1991. Expression of paraglobiside-like lipooligosac-charides may be a necessary component of gonococcal pathogenesis in men. J. Exp. Med. 174:1601-1605.
    • (1991) J. Exp. Med , vol.174 , pp. 1601-1605
    • Schneider, H.1
  • 32
    • 0023235875 scopus 로고
    • Gonococcal pilin variants in experimental gonorrhea
    • Swanson J, et al. 1987. Gonococcal pilin variants in experimental gonorrhea. J. Exp. Med. 165:1344-1357.
    • (1987) J. Exp. Med , vol.165 , pp. 1344-1357
    • Swanson, J.1
  • 33
    • 0029043830 scopus 로고
    • Inflammatory cytokines produced in response to experimental human gonorrhea
    • Ramsey KH, et al. 1995. Inflammatory cytokines produced in response to experimental human gonorrhea. J. Infect. Dis. 172:186-191.
    • (1995) J. Infect. Dis , vol.172 , pp. 186-191
    • Ramsey, K.H.1
  • 34
    • 0034796337 scopus 로고    scopus 로고
    • Experimental gonococcal urethritis and reinfection with homologous gonococci in male volunteers
    • Schmidt KA, et al. 2001. Experimental gonococcal urethritis and reinfection with homologous gonococci in male volunteers. Sex. Transm. Dis. 28:555-564.
    • (2001) Sex. Transm. Dis , vol.28 , pp. 555-564
    • Schmidt, K.A.1
  • 35
    • 80455174939 scopus 로고    scopus 로고
    • Experimental gonococcal infection in male volunteers: Cumulative experience with Neisseria gonorrhoeae strains FA1090 and MS11mkC
    • Hobbs MM, et al. 2011. Experimental gonococcal infection in male volunteers: cumulative experience with Neisseria gonorrhoeae strains FA1090 and MS11mkC. Front. Microbiol. 2:123.
    • (2011) Front. Microbiol , vol.2 , pp. 123
    • Hobbs, M.M.1
  • 36
    • 0021264835 scopus 로고
    • Identification of an envelope mutation (env-10) resulting inincreased antibiotic susceptibility and pyocin resistance in a clinical isolate of Neisseria gonorrhoeae
    • Shafer WM, Guymon LF, Lind I, Sparling PF. 1984. Identification of an envelope mutation (env-10) resulting inincreased antibiotic susceptibility and pyocin resistance in a clinical isolate of Neisseria gonorrhoeae. Antimi-crob. Agents Chemother. 25:767-769.
    • (1984) Antimi-crob. Agents Chemother , vol.25 , pp. 767-769
    • Shafer, W.M.1    Guymon, L.F.2    Lind, I.3    Sparling, P.F.4
  • 37
    • 0030015825 scopus 로고    scopus 로고
    • Use of a non-selective transformation tech-niquetoconstruct amultiply restriction/modification-deficient mutant of Neisseria gonorrhoeae
    • Gunn JS, Stein DC. 1996. Use of a non-selective transformation tech-niquetoconstruct amultiply restriction/modification-deficient mutant of Neisseria gonorrhoeae. Mol. Gen. Genet. 251:509-517.
    • (1996) Mol. Gen. Genet , vol.251 , pp. 509-517
    • Gunn, J.S.1    Stein, D.C.2
  • 38
    • 0014290634 scopus 로고
    • The periodicity of RNA polymerase initiations: A new regulatory feature of transcription
    • Baker RF, Yanofsky C. 1968. The periodicity of RNA polymerase initiations: a new regulatory feature of transcription. Proc. Natl. Acad. Sci. U. S. A. 60:313-320.
    • (1968) Proc. Natl. Acad. Sci. U. S. A , vol.60 , pp. 313-320
    • Baker, R.F.1    Yanofsky, C.2
  • 39
    • 0037238497 scopus 로고    scopus 로고
    • Divergence and transcrip-tional analysis of the division cell wall (dcw) gene cluster in Neisseria spp
    • Snyder LAS, Shafer WM, Saunders NJ. 2003. Divergence and transcrip-tional analysis of the division cell wall (dcw) gene cluster in Neisseria spp. Mol. Microbiol. 47:431-442.
    • (2003) Mol. Microbiol , vol.47 , pp. 431-442
    • Snyder, L.A.S.1    Shafer, W.M.2    Saunders, N.J.3
  • 40
    • 0036791085 scopus 로고    scopus 로고
    • Molecular epidemiology of Neisseria gonorrhoeae: Sequence analysis of the porB gene confirms presence of two circulating strains
    • Unemo M, Olcén P, Berglund T, Albert J, Fredlund H. 2002. Molecular epidemiology of Neisseria gonorrhoeae: sequence analysis of the porB gene confirms presence of two circulating strains. J. Clin. Microbiol. 40: 3741-3749.
    • (2002) J. Clin. Microbiol , vol.40 , pp. 3741-3749
    • Unemo, M.1    Olcén, P.2    Berglund, T.3    Albert, J.4    Fredlund, H.5
  • 41
    • 0036168308 scopus 로고    scopus 로고
    • One year of Neisseria gonorrhoeae isolates in Sweden: The prevalence study of antibiotic susceptibility shows relation to the geographic area of exposure
    • Berglund T, Unemo M, Olcen P, Giesecke J, Fredlund H. 2002. One year of Neisseria gonorrhoeae isolates in Sweden: the prevalence study of antibiotic susceptibility shows relation to the geographic area of exposure. Int. J. STD AIDS 13:109-114.
    • (2002) Int. J. STD AIDS , vol.13 , pp. 109-114
    • Berglund, T.1    Unemo, M.2    Olcen, P.3    Giesecke, J.4    Fredlund, H.5
  • 42
    • 0034863969 scopus 로고    scopus 로고
    • Multidrug-resistant strains of Neisseria gonor-rhoeae in Greece
    • Mavroidi A, et al. 2001. Multidrug-resistant strains of Neisseria gonor-rhoeae in Greece. Antimicrob. Agents Chemother. 45:2651-2654.
    • (2001) Antimicrob. Agents Chemother , vol.45 , pp. 2651-2654
    • Mavroidi, A.1
  • 43
    • 34250186426 scopus 로고    scopus 로고
    • Neisseria gonor-rhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: Association with genetic polymorphisms inpenA,mtrR, porB1b, andponA
    • Lindberg R, Fredlund H, Nicholas R, Unemo M. 2007. Neisseria gonor-rhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms inpenA,mtrR, porB1b, andponA. Antimicrob. Agents Chemother. 51:2117-2122.
    • (2007) Antimicrob. Agents Chemother , vol.51 , pp. 2117-2122
    • Lindberg, R.1    Fredlund, H.2    Nicholas, R.3    Unemo, M.4
  • 44
    • 0030788246 scopus 로고    scopus 로고
    • Involvement of the gonococcal MtrE protein in the resistance of Neisseria gonorrhoeae to toxic hydrophobic agents
    • Delahay RM, Robertson BD, Balthazar JT, Shafer WM, Ison CA. 1997. Involvement of the gonococcal MtrE protein in the resistance of Neisseria gonorrhoeae to toxic hydrophobic agents. Microbiology 143:2127-2133.
    • (1997) Microbiology , vol.143 , pp. 2127-2133
    • Delahay, R.M.1    Robertson, B.D.2    Balthazar, J.T.3    Shafer, W.M.4    Ison, C.A.5
  • 45
    • 0016360231 scopus 로고
    • Genetic mapping of linked antibiotic resistance loci in Neisseria goneorrhoeae
    • Sarubbi FA Jr, Blackman E, Sparling PF. 1974. Genetic mapping of linked antibiotic resistance loci in Neisseria goneorrhoeae. J. Bacteriol. 120: 1284-1292.
    • (1974) J. Bacteriol , vol.120 , pp. 1284-1292
    • Sarubbi Jr., F.A.1    Blackman, E.2    Sparling, P.F.3


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