Distinct effects of importin α2 and α4 on Oct3/4 localization and expression in mouse embryonic stem cells

FASEB Journal

Volumn 25, Issue 11, 2011, Pages 3958-3965

  Young, Julia C ^a   Major, Andrew T ^a   Miyamoto, Yoichi ^a   Loveland, Kate L ^a   Jans, David A ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Differentiation; Embryoid body; Importin karyopherin; Nuclear transport

Indexed keywords

BETA TUBULIN; IMPORTIN ALPHA2; IMPORTIN ALPHA4; ISOPROTEIN; KARYOPHERIN; OCTAMER TRANSCRIPTION FACTOR 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL NUCLEUS; CYTOPLASM; EMBRYO; EMBRYONIC STEM CELL; GENE; GENE OVEREXPRESSION; GENETIC TRANSFECTION; IMPALPHA3 GENE; IMPALPHA4 GENE; IMPBETA1 GENE; IPO5 GENE; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; NUCLEOTIDE SEQUENCE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ALPHA KARYOPHERINS; ANIMALS; BETA KARYOPHERINS; CELL DIFFERENTIATION; CELL LINE; EMBRYONIC STEM CELLS; KARYOPHERINS; MICE; NUCLEAR PROTEINS; OCTAMER TRANSCRIPTION FACTOR-3;

MURINAE;

EID: 80355148459     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-176941     Document Type: Article

References (30)

1. Lusk, C. P., Blobel, G., and King, M. C. (2007) Highway to the inner nuclear membrane: rules for the road. Nat. Rev. Mol. Cell. Biol. 8, 414-420 (Pubitemid 46643242)
2. Harel, A., Chan, R. C., Lachish-Zalait, A., Zimmerman, E., Elbaum, M., and Forbes, D. J. (2003) Importin beta negatively regulates nuclear membrane fusion and nuclear pore complex assembly. Mol. Biol. Cell 14, 4387-4396 (Pubitemid 37444642)
3. Geles, K. G., Johnson, J. J., Jong, S., and Adam, S. A. (2002) A role for Caenorhabditis elegans importin IMA-2 in germ line and embryonic mitosis. Mol. Biol. Cell 13, 3138-3147 (Pubitemid 35034251)
4. Harel, A., and Forbes, D. J. (2004) Importin beta: conducting a much larger cellular symphony. Mol. Cell 16, 319-330 (Pubitemid 39504787)
5. Goldfarb, D. S., Corbett, A. H., Mason, D. A., Harreman, M. T., and Adam, S. A. (2004) Importin alpha: a multipurpose nuclear-transport receptor. Trends Cell Biol. 14, 505-514 (Pubitemid 39209358)
6. Yasuhara, N., Oka, M., and Yoneda, Y. (2009) The role of the nuclear transport system in cell differentiation. Semin. Cell. Dev. Biol. 20, 590-599
7. Gorlich, D., Kostka, S., Kraft, R., Dingwall, C., Laskey, R. A., Hartmann, E., and Prehn, S. (1995) Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope. Curr. Biol. 5, 383-392
8. Gorlich, D., Vogel, F., Mills, A. D., Hartmann, E., and Laskey, R. A. (1995) Distinct functions for the two importin subunits in nuclear protein import. Nature 377, 246-248
9. Jans, D. A., Xiao, C. Y., and Lam, M. H. (2000) Nuclear targeting signal recognition: a key control point in nuclear transport? Bioessays 22, 532-544 (Pubitemid 30387974)
10. Terry, L. J., Shows, E. B., and Wente, S. R. (2007) Crossing the nuclear envelope: hierarchical regulation of nucleocytoplasmic transport. Science 318, 1412-1416 (Pubitemid 350208921)
11. Okada, N., Ishigami, Y., Suzuki, T., Kaneko, A., Yasui, K., Fukutomi, R., and Isemura, M. (2008) Importins and exportins in cellular differentiation. J. Cell Mol. Med. 12, 1863-1871
12. Hogarth, C., Itman, C., Jans, D. A., and Loveland, K. L. (2005) Regulated nucleocytoplasmic transport in spermatogenesis: a driver of cellular differentiation? Bioessays 27, 1011-1125
13. Hogarth, C. A., Calanni, S., Jans, D. A., and Loveland, K. L. (2006) Importin alpha mRNAs have distinct expression profiles during spermatogenesis. Dev. Dyn. 235, 253-262 (Pubitemid 46939722)
14. Loveland, K. L., Hogarth, C., Mendis, S., Efthymiadis, A., Ly, J., Itman, C., Meachem, S., Brown, C. W., and Jans, D. A. (2005) Drivers of germ cell maturation. Ann. N. Y. Acad. Sci. 1061, 173-182 (Pubitemid 43211596)
15. Loveland, K. L., Hogarth, C., Szczepny, A., Prabhu, S. M., and Jans, D. A. (2006) Expression of nuclear transport importins beta 1 and beta 3 is regulated during rodent spermatogenesis
16. Nakamura, T., Arai, Y., Umehara, H., Masuhara, M., Kimura, T., Taniguchi, H., Sekimoto, T., Ikawa, M., Yoneda, Y., Okabe, M., Tanaka, S., Shiota, K., and Nakano, T. (2007) PGC7/Stella protects against DNA demethylation in early embryogenesis. Nat. Cell Biol. 9, 64-71 (Pubitemid 46024198)
17. Yasuhara, N., Shibazaki, N., Tanaka, S., Nagai, M., Kamikawa, Y., Oe, S., Asally, M., Kamachi, Y., Kondoh, H., and Yoneda, Y. (2007) Triggering neural differentiation of ES cells by subtype switching of importin-alpha. Nat. Cell Biol. 9, 72-79 (Pubitemid 46024199)
18. Argentaro, A., Sim, H., Kelly, S., Preiss, S., Clayton, A., Jans, D. A., and Harley, V. R. (2003) A SOX9 defect of calmodulin-dependent nuclear import in campomelic dysplasia/autosomal sex reversal. J. Biol. Chem. 278, 33839-33847 (Pubitemid 37553218)
19. Poon, I. K., Oro, C., Dias, M. M., Zhang, J., and Jans, D. A. (2005) Apoptin nuclear accumulation is modulated by a CRM1-recognized nuclear export signal that is active in normal but not in tumor cells. Cancer Res. 65, 7059-7064 (Pubitemid 41161232)
20. Trapani, J. A., Jans, P., Smyth, M. J., Froelich, C. J., Williams, E. A., Sutton, V. R., and Jans, D. A. (1998) Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction. Cell Death Differ. 5, 488-496 (Pubitemid 28356567)
21. Roth, D. M., Moseley, G. W., Pouton, C. W., and Jans, D. A. (2011) Mechanism of microtubule-facilitated "Fast Track" nuclear import. J. Biol. Chem. 286, 14335-14351
22. Fulcher, A. J., Roth, D. M., Fatima, S., Alvisi, G., and Jans, D. A.The BRCA-1 binding protein BRAP2 is a novel, negative regulator of nuclear import of viral proteins, dependent on phosphorylation flanking the nuclear localization signal. FASEB J. 24, 1454-1466
23. Desbaillets, I., Ziegler, U., Groscurth, P., and Gassmann, M. (2000) Embryoid bodies: an in vitro model of mouse embryogenesis. Exp. Physiol. 85, 645-651
24. Koike, M., Sakaki, S., Amano, Y., and Kurosawa, H. (2007) Characterization of embryoid bodies of mouse embryonic stem cells formed under various culture conditions and estimation of differentiation status of such bodies. J. Biosci. Bioeng. 104, 294-299 (Pubitemid 350102403)
25. Niwa, H., Miyazaki, J., and Smith, A. G. (2000) Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 24, 372-376 (Pubitemid 30187435)
26. Masui, S., Nakatake, Y., Toyooka, Y., Shimosato, D., Yagi, R., Takahashi, K., Okochi, H., Okuda, A., Matoba, R., Sharov, A. A., Ko, M. S., and Niwa, H. (2007) Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells. Nat. Cell Biol. 9, 625-635 (Pubitemid 47214724)
27. Loh, Y. H., Wu, Q., Chew, J. L., Vega, V. B., Zhang, W., Chen, X., Bourque, G., George, J., Leong, B., Liu, J., Wong, K. Y., Sung, K. W., Lee, C. W., Zhao, X. D., Chiu, K. P., Lipovich, L., Kuznetsov, V. A., Robson, P., Stanton, L. W., Wei, C. L., Ruan, Y., Lim, B., and Ng, H. H. (2006) The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat. Genet. 38, 431-440
28. Feldman, N., Gerson, A., Fang, J., Li, E., Zhang, Y., Shinkai, Y., Cedar, H., and Bergman, Y. (2006) G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis. Nat. Cell Biol. 8, 188-194
29. Li, X., Sun, L., and Jin, Y. (2008) Identification of karyopherin-alpha 2 as an Oct4 associated protein. J. Genet. Genomics 35, 723-728
30. Herold, A., Truant, R., Wiegand, H., and Cullen, B. R. (1998) Determination of the functional domain organization of the importin alpha nuclear import factor. J. Cell Biol. 143, 309-318 (Pubitemid 28487852)