Generation of micronuclei during interphase by coupling between cytoplasmic membrane blebbing and nuclear budding

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Utani, Koh ichi ^a,b   Okamoto, Atsushi ^a   Shimizu, Noriaki ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN; LAMIN B; VIRUS PROTEIN; LAMIN B1;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL BUDDING; CELL CYCLE S PHASE; CELL MEMBRANE; CHROMATIN; CHROMOSOME; CONTROLLED STUDY; HELA CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; INTERPHASE; MICRONUCLEUS; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; CELL LINE; CELL NUCLEUS; CYTOPLASM; METABOLISM; ULTRASTRUCTURE;

CELL LINE; CELL MEMBRANE; CELL NUCLEUS; CHROMATIN; CYTOPLASM; HUMANS; INTERPHASE; LAMIN TYPE B; S PHASE;

EID: 80355146294     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027233     Document Type: Article

References (47)

1. Fenech M, Kirsch-Volders M, Natarajan AT, Surralles J, Crott JW, et al. (2011) Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells. Mutagenesis 26: 125-132.
2. Cimini D, Fioravanti D, Salmon ED, Degrassi F, (2002) Merotelic kinetochore orientation versus chromosome mono-orientation in the origin of lagging chromosomes in human primary cells. J Cell Sci 115: 507-515.
3. Utani K, Kohno Y, Okamoto A, Shimizu N, (2010) Emergence of Micronuclei and Their Effects on the Fate of Cells under Replication Stress. PlosONE 5: e10089.
4. Pampalona J, Soler D, Genesca A, Tusell L, (2010) Telomere dysfunction and chromosome structure modulate the contribution of individual chromosomes in abnormal nuclear morphologies. Mutat Res 683: 16-22.
5. Hoffelder DR, Luo L, Burke NA, Watkins SC, Gollin SM, et al. (2004) Resolution of anaphase bridges in cancer cells. Chromosoma 112: 389-397.
6. Shimizu N, Shingaki K, Kaneko-Sasaguri Y, Hashizume T, Kanda T, (2005) When, where and how the bridge breaks: anaphase bridge breakage plays a crucial role in gene amplification and HSR generation. Exp Cell Res 302: 233-243.
7. Harada S, Sekiguchi N, Shimizu N, (2011) Amplification of a plasmid bearing a mammalian replication initiation region in chromosomal and extrachromosomal contexts. Nuc Acids Res 39: 958-969.
8. Von Hoff DD, McGill JR, Forseth BJ, Davidson KK, Bradley TP, et al. (1992) Elimination of extrachromosomally amplified MYC genes from human tumor cells reduces their tumorigenicity. Proc Natl Acad Sci U S A 89: 8165-8169.
9. Shimizu N, Nakamura H, Kadota T, Kitajima K, Oda T, et al. (1994) Loss of amplified c-myc genes in the spontaneously differentiated HL-60 cells. Cancer Res 54: 3561-3567.
10. Eckhardt SG, Dai A, Davidson KK, Forseth BJ, Wahl GM, et al. (1994) Induction of differentiation in HL60 cells by the reduction of extrachromosomally amplified c-myc. Proc Natl Acad Sci U S A 91: 6674-6678.
11. Shimizu N, Kanda T, Wahl GM, (1996) Selective capture of acentric fragments by micronuclei provides a rapid method for purifying extrachromosomally amplified DNA. Nat Genet 12: 65-71.
12. Shimizu N, (2009) Extrachromosomal double minutes and chromosomal homogeneously staining regions as probes for chromosome research. Cytogenet Genome Res 124: 312-326.
13. Shimizu N, (2011) Molecular mechanisms of the origin of micronuclei from extrachromosomal elements. Mutagenesis 26: 119-123.
14. Levan A, Levan G, (1978) Have double minutes functioning centromeres? Hereditas 88: 81-92.
15. Kanda T, Wahl GM, (2000) The dynamics of acentric chromosomes in cancer cells revealed by GFP- based chromosome labeling strategies. J Cell Biochem 79: 107-114.
16. Tanaka T, Shimizu N, (2000) Induced detachment of acentric chromatin from mitotic chromosomes leads to their cytoplasmic localization at G1 and the micronucleation by lamin reorganization at S phase. J Cell Sci 113: 697-707.
17. Itoh N, Shimizu N, (1998) DNA replication-dependent intranuclear relocation of double minute chromatin. J Cell Sci 111: 3275-3285.
18. Shimizu N, Ochi T, Itonaga K, (2001) Replication timing of amplified genetic regions relates to intranuclear localization but not to genetic activity or G/R band. Exp Cell Res 268: 201-210.
19. Shimizu N, Misaka N, Utani K, (2007) Nonselective DNA damage induced by a replication inhibitor results in the selective elimination of extrachromosomal double minutes from human cancer cells. Genes Chromosomes Cancer 46: 865-874.
20. Willingale-Theune J, Schweiger M, Hirsch-Kauffmann M, Meek AE, Paulin-Levasseur M, et al. (1989) Ultrastructure of Fanconi anemia fibroblasts. J Cell Sci 93: 651-665.
21. Paulin LM, Blake DL, Julien M, Rouleau L, (1996) The MAN antigens are non-lamin constituents of the nuclear lamina in vertebrate cells. Chromosoma 104: 367-379.
22. Utani K, Kawamoto JK, Shimizu N, (2007) Micronuclei bearing acentric extrachromosomal chromatin are transcriptionally competent and may perturb the cancer cell phenotype. Mol Cancer Res 5: 695-704.
23. Fenech M, (2007) Cytokinesis-block micronucleus cytome assay. Nat Protoc 2: 1084-1104.
24. Shimizu N, Itoh N, Utiyama H, Wahl G, (1998) Selective Entrapment of Extrachromosomally Amplified DNA by Nuclear Budding and Micronucleation during S-phase. J Cell Biol 140: 1307-1320.
25. de Noronha CM, Sherman MP, Lin HW, Cavrois MV, Moir RD, et al. (2001) Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr. Science 294: 1105-1108.
26. Hoyt CC, Bouchard RJ, Tyler KL, (2004) Novel nuclear herniations induced by nuclear localization of a viral protein. J Virol 78: 6360-6369.
27. Fenech M, (2009) A lifetime passion for micronucleus cytome assays-reflections from Down Under. Mutat Res 681: 111-117.
28. Dixon SJ, Aubin JE, (1987) Serum and alpha 2-macroglobulin induce transient hyperpolarizations in the membrane potential of an osteoblastlike clone. J Cell Physiol 132: 215-225.
29. Dixon SJ, Pitaru S, Bhargava U, Aubin JE, (1987) Membrane blebbing is associated with Ca2+-activated hyperpolarizations induced by serum and alpha 2-macroglobulin. J Cell Physiol 132: 473-482.
30. Sullivan T, Escalante-Alcalde D, Bhatt H, Anver M, Bhat N, et al. (1999) Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy. J Cell Biol 147: 913-920.
31. Muchir A, van Engelen BG, Lammens M, Mislow JM, McNally E, et al. (2003) Nuclear envelope alterations in fibroblasts from LGMD1B patients carrying nonsense Y259X heterozygous or homozygous mutation in lamin A/C gene. Exp Cell Res 291: 352-362.
32. Shimi T, Pfleghaar K, Kojima S, Pack CG, Solovei I, et al. (2008) The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription. Genes Dev 22: 3409-3421.
33. Charras GT, Yarrow JC, Horton MA, Mahadevan L, Mitchison TJ, (2005) Non-equilibration of hydrostatic pressure in blebbing cells. Nature 435: 365-369.
34. Maugis B, Brugues J, Nassoy P, Guillen N, Sens P, et al. (2010) Dynamic instability of the intracellular pressure drives bleb-based motility. J Cell Sci 123: 3884-3892.
35. Foisy S, Bibor HV, (1988) Synthesis of nuclear lamins in BHK-21 cells synchronized with aphidicolin. Biochem Biophys Res Commun 156: 205-210.
36. Miano JM, Long X, Fujiwara K, (2007) Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus. Am J Physiol Cell Physiol 292: C70-81.
37. Charras GT, Hu CK, Coughlin M, Mitchison TJ, (2006) Reassembly of contractile actin cortex in cell blebs. J Cell Biol 175: 477-490.
38. Charras GT, Coughlin M, Mitchison TJ, Mahadevan L, (2008) Life and times of a cellular bleb. Biophys J 94: 1836-1853.
39. Machesky LM, Tang HR, (2009) Actin-based protrusions: promoters or inhibitors of cancer invasion? Cancer Cell 16: 5-7.
40. Hagmann J, Burger MM, Dagan D, (1999) Regulation of plasma membrane blebbing by the cytoskeleton. J Cell Biochem 73: 488-499.
41. Haaf T, Raderschall E, Reddy G, Ward DC, Radding CM, et al. (1999) Sequestration of mammalian Rad51-recombination protein into micronuclei. J Cell Biol 144: 11-20.
42. Lindberg HK, Wang X, Jarventaus H, Falck GC, Norppa H, et al. (2007) Origin of nuclear buds and micronuclei in normal and folate-deprived human lymphocytes. Mutat Res 617: 33-45.
43. Shimizu N, Kamezaki F, Shigematsu S, (2005) Tracking of microinjected DNA in live cells reveals the intracellular behavior and elimination of extrachromosomal genetic material. Nuc Acids Res 33: 6296-6307.
44. Shimizu N, Hanada N, Utani K, Sekiguchi N, (2007) Interconversion of intra- and extra-chromosomal sites of gene amplification by modulation of gene expression and DNA methylation. J Cell Biochem 102: 515-529.
45. Shimizu N, Ohta M, Fujiwara C, Sagara J, Mochizuki N, et al. (1991) Expression of a novel immediate early gene during 12-O-tetradecanoylphorbol-13-acetate-induced macrophagic differentiation of HL-60 cells. J Biol Chem 266: 12157-12161.
46. Moir RD, Yoon M, Khuon S, Goldman RD, (2000) Nuclear lamins A and B1: different pathways of assembly during nuclear envelope formation in living cells. J Cell Biol 151: 1155-1168.
47. Shimizu N, Miura Y, Sakamoto Y, Tsutsui K, (2001) Plasmids with a mammalian replication origin and a matrix attachment region initiate the event similar to gene amplification. Cancer Res 61: 6987-6990.