Telomere dysfunction and chromosome structure modulate the contribution of individual chromosomes in abnormal nuclear morphologies

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 683, Issue 1-2, 2010, Pages 16-22

  Pampalona, J ^a   Soler, D ^a   Genesca A ^a   Tusell, L ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Anaphase bridges; Chromosome instability; HMEC; Nuclear buds; Telomeres

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A;

ANAPHASE; ARTICLE; CELL DIVISION; CELL FUSION; CELL NUCLEUS; CELL PROLIFERATION; CELL STRUCTURE; CENTROMERE; CHROMOSOMAL INSTABILITY; CHROMOSOME STRUCTURE; CONTROLLED STUDY; EPITHELIUM CELL; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; MICRONUCLEUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TELOMERE;

CELL NUCLEUS; CHROMOSOMAL INSTABILITY; CHROMOSOME PAINTING; CHROMOSOME SEGREGATION; CHROMOSOME STRUCTURES; CHROMOSOMES, HUMAN; CYTOKINESIS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MAMMARY GLANDS, HUMAN; MICRONUCLEI, CHROMOSOME-DEFECTIVE; TELOMERE;

EID: 71549118520     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2009.10.001     Document Type: Article

References (32)

1. Kyrtopoulos S., Sarrif A., Elliott B., Schoket B., and Demopoulos N. Biomarkers and molecular epidemiology-present state and future trends: concluding remarks. Mutat. Res. 600 (2006) 77-78
2. Bonassi S., Ugolini D., Kirsch-Volders M., Strömberg U., Vermeulen R., and Tucker J. Human population studies with cytogenetic biomarkers: review of the literature and future prospectives. Environ. Mol. Mutagen. 45 (2005) 258-270
3. Hoffelder D., Luo L., Burke N., Watkins S., Gollin S., and Saunders W. Resolution of anaphase bridges in cancer cells. Chromosoma 112 (2004) 389-397
4. Shimizu N., Itoh N., Utiyama H., and Wahl G. Selective entrapment of extrachromosomally amplified DNA by nuclear budding and micronucleation during S phase. J. Cell Biol. 140 (1998) 1307-1320
5. Gisselsson D., Björk J., Höglund M., Mertens F., Dal Cin P., Akerman M., and Mandahl N. Abnormal nuclear shape in solid tumors reflects mitotic instability. Am. J. Pathol. 158 (2001) 199-206
6. McClintock B. The stability of broken ends of chromosomes in Zea mays. Genetics 26 (1941) 234-282
7. Hande M., Samper E., Lansdorp P., and Blasco M. Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. J. Cell Biol. 144 (1999) 589-601
8. de Lange T. Protection of mammalian telomeres. Oncogene 21 (2002) 532-540
9. DePinho R. The age of cancer. Nature 408 (2000) 248-254
10. Artandi S., Chang S., Lee S., Alson S., Gottlieb G., Chin L., and DePinho R. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 406 (2000) 641-645
11. Gisselsson D., Jonson T., Petersén A., Strömbeck B., Dal Cin P., Höglund M., Mitelman F., Mertens F., and Mandahl N. Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 12683-12688
12. Fouladi B., Sabatier L., Miller D., Pottier G., and Murnane J. The relationship between spontaneous telomere loss and chromosome instability in a human tumor cell line. Neoplasia 2 (2000) 540-554
13. Gisselsson D. Chromosome instability in cancer: how, when, and why?. Adv. Cancer Res. 87 (2003) 1-29
14. Montgomery E., Wilentz R., Argani P., Fisher C., Hruban R., Kern S., and Lengauer C. Analysis of anaphase figures in routine histologic sections distinguishes chromosomally unstable from chromosomally stable malignancies. Cancer Biol. Ther. 2 (2003) 248-252
15. Rudolph K., Millard M., Bosenberg M., and DePinho R. Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat. Genet. 28 (2001) 155-159
16. Chin K., de Solorzano C., Knowles D., Jones A., Chou W., Rodriguez E., Kuo W., Ljung B., Chew K., Myambo K., Miranda M., Krig S., Garbe J., Stampfer M., Yaswen P., Gray J., and Lockett S. In situ analyses of genome instability in breast cancer. Nat. Genet. 36 (2004) 984-988
17. Brenner A., Stampfer M., and Aldaz C. Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation. Oncogene 17 (1998) 199-205
18. Romanov S., Kozakiewicz B., Holst C., Stampfer M., Haupt L., and Tlsty T. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes. Nature 409 (2001) 633-637
19. Soler D., Genescà A., Arnedo G., Egozcue J., and Tusell L. Telomere dysfunction drives chromosomal instability in human mammary epithelial cells. Genes Chromosomes Cancer 44 (2005) 339-350
20. Tusell L., Soler D., Agostini M., Pampalona J., and Genescà A. The number of dysfunctional telomeres in a cell: one amplifies: more than one translocate. Cytogenet. Genome Res. 122 (2008) 315-325
21. Ponsa I., Barquinero J., Miró R., Egozcue J., and Genescà A. Non-disjunction and chromosome loss in gamma-irradiated human lymphocytes: a fluorescence in situ hybridization analysis using centromere-specific probes. Radiat. Res. 155 (2001) 424-431
22. Martín M., Genescà A., Latre L., Ribas M., Miró R., Egozcue J., and Tusell L. Radiation-induced chromosome breaks in ataxia-telangiectasia cells remain open. Int. J. Radiat. Biol. 79 (2003) 203-210
23. Fenech M. The in vitro micronucleus technique. Mutat. Res. 455 (2000) 81-95
24. Thomas P., Umegaki K., and Fenech M. Nucleoplasmic bridges are a sensitive measure of chromosome rearrangement in the cytokinesis-block micronucleus assay. Mutagenesis 18 (2003) 187-194
25. Hemann M., Strong M., Hao L., and Greider C. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 107 (2001) 67-77
26. Espejel S., Franco S., Rodríguez-Perales S., Bouffler S., Cigudosa J., and Blasco M. Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres. EMBO J. 21 (2002) 2207-2219
27. Deng W., Tsao S., Guan X., Lucas J., Si H., Leung C., Mak P., Wang L., and Cheung A. Distinct profiles of critically short telomeres are a key determinant of different chromosome aberrations in immortalized human cells: whole-genome evidence from multiple cell lines. Oncogene 23 (2004) 9090-9101
28. Fenech M. Chromosomal biomarkers of genomic instability relevant to cancer. Drug Discov. Today 7 (2002) 1128-1137
29. Shimizu N., Shingaki K., Kaneko-Sasaguri Y., Hashizume T., and Kanda T. When, where and how the bridge breaks: anaphase bridge breakage plays a crucial role in gene amplification and HSR generation. Exp. Cell Res. 302 (2005) 233-243
30. Titen S., and Golic K. Telomere loss provokes multiple pathways to apoptosis and produces genomic instability in Drosophila melanogaster. Genetics 180 (2008) 1821-1832
31. Rao X., Zhang Y., Yi Q., Hou H., Xu B., Chu L., Huang Y., Zhang W., Fenech M., and Shi Q. Multiple origins of spontaneously arising micronuclei in HeLa cells: direct evidence from long-term live cell imaging. Mutat. Res. 646 (2008) 41-49
32. Stewénius Y., Gorunova L., Jonson T., Larsson N., Höglund M., Mandahl N., Mertens F., Mitelman F., and Gisselsson D. Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 5541-5546