Why endophenotype development requires families

Chinese Science Bulletin

Volumn 56, Issue 32, 2011, Pages 3382-3384

  Glahn, David C ^a,b   Blangero, John ^c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INSTITUTE OF LIVING   (United States)

^c SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

biomarker; bipolar disorder; endophenotype; family studies; schizophrenia

Indexed keywords

EID: 80355132049     PISSN: 10016538     EISSN: 18619541     Source Type: Journal    
DOI: 10.1007/s11434-011-4740-4     Document Type: Article

References (28)

1. Gottesman I I, Gould T D. The endophenotype concept in psychiatry: Etymology and strategic intentions. Am J Psychiatry, 2003, 160: 636-645.
2. Blangero J, Williams J T, Almasy L. Novel family-based approaches to genetic risk in thrombosis. J Thromb Haemost, 2003, 1: 1391-1397.
3. Lenox R H, Gould T D, Manji H K. Endophenotypes in bipolar disorder. Am J Med Genet, 2002, 114: 391-406.
4. Bearden C, Freimer N. Endophenotypes for psychiatric disorders: Ready for primetime? Trends Genet, 2006, 22: 306-313.
5. Gould T, Gottesman I. Psychiatric endophenotypes and the development of valid animal models. Genes Brain Behav, 2006, 5: 113-119.
6. Nestler E, Barrot M, DiLeone R J, et al. Neurobiology of depression. Neuron, 2002, 34: 13-25.
7. Glahn D, Almasy L, Blangero J, et al. Adjudicating neurocognitive endophenotypes for schizophrenia. Am J Med Genet B Neuropsychiatr Genet, 2007, 144B: 242-249.
8. Glahn D, Almsay L, Barguil M, et al. Neurocognitive endophenotypes for bipolar disorder identified in multiplex multigenerational families. Arch Gen Psychiatry, 2010, 67: 168-177.
9. Meyer-Lindenberg A. Neural connectivity as an intermediate pheno-type: Brain networks under genetic control. Hum Brain Mapp, 2009, 30: 1938-1946.
10. Winkler A, Kochunov P, Blangero J, et al. Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studies. Neuroimage, 2010, 53: 1135-1146.
11. Glahn D, Winkler A, Kochunov P, et al. Genetic control over the resting brain. Proc Natl Acad Sci USA, 2010, 107: 1223-1228.
12. Glahn D, Thompson P, Blangero J. Neuroimaging endophenotypes: Strategies for finding genes influencing brain structure and function. Hum Brain Mapp, 2007, 28: 488-501.
13. Harris J M, Whalley H, Yates S, et al. Abnormal cortical folding in high-risk individuals: A predictor of the development of schizophrenia? Biol Psychiatry, 2004, 56: 182-189.
14. Moffat S D, Szekely C A, Zonderman A B, et al. Longitudinal change in hippocampal volume as a function of apolipoprotein E genotype. Neurology, 2000, 55: 134-136.
15. Fleisher A, Grundman M, Jack C R, et al. Sex, apolipoprotein E epsilon 4 status, and hippocampal volume in mild cognitive impairment. Arch Neurol, 2005, 62: 953-957.
16. Hill S, De Bellis M, Keshavan M, et al. Right amygdala volume in adolescent and young adult offspring from families at high risk for developing alcoholism. Biol Psychiatry, 2001, 49: 894-905.
17. McDonald C, Bullmore E, Sham P, et al. Association of genetic risks for schizophrenia and bipolar disorder with specific and generic brain structural endophenotypes. Arch Gen Psychiatry, 2004, 61: 974-984.
18. Cannon T D, Thompson P M, van Erp T, et al. Cortex mapping reveals regionally specific patterns of genetic and disease-specific gray-matter deficits in twins discordant for schizophrenia. Proc Natl Acad Sci USA, 2002, 99: 3228-3233.
19. Greenwood P, Parasuraman R. Normal genetic variation, cognition, and aging. Behav Cogn Neurosci Rev, 2003, 2: 278-306.
20. Weiser M, Reichenberg A, Kravitz E, et al. Subtle cognitive dysfunction in nonaffected siblings of individuals affected by nonpsychotic disorders. Biol Psychiatry, 2008, 63: 602-608.
21. Greenwood T, Braff D, Light G, et al. Initial heritability analyses of endophenotypic measures for schizophrenia: The consortium on the genetics of schizophrenia. Arch Gen Psychiatry, 2007, 64: 1242-1250.
22. Freedman R, Adler L E, Leonard S. Alternative phenotypes for the complex genetics of schizophrenia. Biol Psychiatry, 1999, 45: 551-558.
23. Olincy A, Braff D, Adler L, et al. Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: Results from the consortium on genetics of schizophrenia. Schizophr Res, 2010, 119: 175-182.
24. Turetsky B I, Greenwood T, Olincy A, et al. Abnormal auditory N100 amplitude: A heritable endophenotype in first-degree relatives of schizophrenia probands. Biol Psychiatry, 2008, 64: 1051-1059.
25. Turetsky B I, Kohler C, Gur R, et al. Olfactory physiological impairment in first-degree relatives of schizophrenia patients. Schizophr Res, 2008, 102: 220-229.
26. Kurian S M, Le-Niculescu H, Patel S D, et al. Identification of blood biomarkers for psychosis using convergent functional genomics. Mol Psychiatry, 2011, 16: 37-58.
27. Gershon E, Goldin L. Clinical methods in psychiatric genetics. I. Robustness of genetic marker investigative strategies. Acta Psychiatr Scand, 1986, 74: 113-118.
28. Leboyer M, Bellivier F, Jouvent R, et al. Psychiatric genetics: Search for phenotypes. Trends Neurosci, 1998, 21: 102-105.