Phase i trial of hypofractionated intensity-modulated radiotherapy with temozolomide chemotherapy for patients with newly diagnosed glioblastoma multiforme

International Journal of Radiation Oncology Biology Physics

Volumn 81, Issue 4, 2011, Pages 1066-1074

  Chen, Changhu ^a   Damek, Denise ^a   Gaspar, Laurie E ^a   Waziri, Allen ^a   Lillehei, Kevin ^a   Kleinschmidt Demasters, B K ^a   Robischon, Monica ^a   Stuhr, Kelly ^a   Rusthoven, Kyle E ^a   Kavanagh, Brian D ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Chemoradiotherapy; GBM; Glioblastoma multiforme; Hypofractionation; IMRT; Intensity modulated radiotherapy

Indexed keywords

CHEMORADIOTHERAPY; GBM; GLIOBLASTOMA MULTIFORME; HYPOFRACTIONATION; IMRT; INTENSITY-MODULATED RADIOTHERAPY;

CHEMOTHERAPY; RADIOTHERAPY; SURGERY; TOXICITY; TUMORS;

PHYSICAL THERAPY;

TEMOZOLOMIDE;

ADULT; AGED; ANEMIA; ANOREXIA; ARTICLE; CANCER PATIENT; CANCER RADIOTHERAPY; CHEMORADIOTHERAPY; CLINICAL ARTICLE; CONFUSION; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DOSIMETRY; DRUG INDUCED HEADACHE; FATIGUE; FEMALE; FOCAL EPILEPSY; GLIOBLASTOMA; HISTOPATHOLOGY; HUMAN; INSOMNIA; INTENSITY MODULATED RADIATION THERAPY; KARNOFSKY PERFORMANCE STATUS; LEUKOPENIA; MALE; MAXIMUM TOLERATED DOSE; MOTOR DYSFUNCTION; NAUSEA; NEUROIMAGING; NEUTROPENIA; NUCLEAR MAGNETIC RESONANCE IMAGING; OPTIC NERVE; OVERALL SURVIVAL; PHASE 1 CLINICAL TRIAL; POSTOPERATIVE CARE; PRIORITY JOURNAL; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RADIATION INJURY; RADIATION NECROSIS; RANDOMIZED CONTROLLED TRIAL; RECURRENT CANCER; REOPERATION; THROMBOCYTOPENIA; TREATMENT DURATION; TREATMENT PLANNING; VISUAL IMPAIRMENT; VOMITING;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS, ALKYLATING; BRAIN NEOPLASMS; CHEMORADIOTHERAPY; CHEMOTHERAPY, ADJUVANT; DACARBAZINE; DOSE FRACTIONATION; DRUG ADMINISTRATION SCHEDULE; FEMALE; GLIOBLASTOMA; HUMANS; KARNOFSKY PERFORMANCE STATUS; MAGNETIC RESONANCE IMAGING; MALE; MAXIMUM TOLERATED DOSE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM, RESIDUAL; PROSPECTIVE STUDIES; RADIOTHERAPY, INTENSITY-MODULATED; TUMOR BURDEN;

EID: 80255141848     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2010.07.021     Document Type: Article

References (30)

1. R. Stupp, W.P. Mason, and M.J. Van Den Bent Radiotherapy plus concomitant and adjuvant TMZ for glioblastoma N Engl J Med 352 2005 987 996 (Pubitemid 40349501)
2. R. Stupp, M.E. Hegi, and M.J. Van Den Bent Changing paradigms - An update on the multidisciplinary management of malignant glioma Oncologist 11 2006 165 180 (Pubitemid 43261763)
3. R. Stupp, M.E. Hegi, and W.P. Mason Effects of radiotherapy with concomitant and adjuvant TMZ versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-Year analysis of the EORTC-NCIC trial Lancet Oncol 10 2009 459 466
4. J.L. Chan, S.W. Lee, and B.A. Fraass Survival and failure patterns of high-grade gliomas after three-dimensional conformal radiotherapy J Clin Oncol 20 2002 1635 1642 (Pubitemid 34260545)
5. C. Tsien, J. Moughan, and J.M. Michalski Phase I three-dimensional conformal radiation dose escalation study in newly diagnosed glioblastoma: Radiation Therapy Oncology Group trial 98-03 Int J Radiat Oncol Biol Phys 73 2009 699 708
6. Common Terminology Criteria for Adverse Events v3.0 (CTCAE). Available from: www.ctep.cancer.gov/protocolDevelopment/electronic-applications/docs/ ctcaev3.pdf. Accessed January 6, 2010.
7. N.M. Bleehen, and S.P. Stenning A Medical Research Council trial of two radiotherapy doses in the treatment of grades 3 and 4 astrocytoma: The Medical Research Council Brain Tumour Working Party Br J Cancer 64 1991 769 774
8. M.D. Walker, T.A. Strike, and G.E. Sheline An analysis of dose-effect relationship in the radiotherapy of malignant gliomas Int J Radiat Oncol Biol Phys 5 1979 1725 1731 (Pubitemid 10187518)
9. C.H. Chang, J. Horton, and D. Schoenfeld Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas: A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study Cancer 52 1983 997 1007 (Pubitemid 13050763)
10. J.N. Sarkaria, M.P. Mehta, and J.S. Loeffler Radiosurgery in the initial management of malignant gliomas: Survival comparison with the RTOG recursive partitioning analysis. Radiation Therapy Oncology Group Int J Radiat Oncol Biol Phys 32 1995 931 941
11. J.S. Loeffler, E. Alexander III, and W.M. Shea Radiosurgery as part of the initial management of patients with malignant gliomas J Clin Oncol 10 1992 1379 1385 (Pubitemid 23059919)
12. L. Souhami, W. Seiferheld, and D. Brachman Randomized comparison of stereotactic radiosurgery followed by conventional radiotherapy with carmustine to conventional radiotherapy with carmustine for patients with glioblastoma multiforme: Report of Radiation Therapy Oncology Group 93-05 protocol Int J Radiat Oncol Biol Phys 60 2004 853 860 (Pubitemid 39311766)
13. E.J. Hall Radiobiology for the Radiologist 5th ed 2000 Lippincott Williams & Wilkins Philadelphia 411 415
14. W. Roa, P.M. Brasher, and G. Bauman Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: A prospective randomized clinical trial J Clin Oncol 22 2004 1583 1588 (Pubitemid 41079795)
15. C. Phillips, M. Guiney, and J. Smith A randomized trial comparing 35 Gy in 10 fractions with 60 Gy in 30 fractions of cerebral irradiation for glioblastoma multiforme and older patients with anaplastic astrocytoma Radiother Oncol 68 2003 23 26 (Pubitemid 37289332)
16. B. Gliński Postoperative hypofractionated radiotherapy versus conventionally fractionated radiotherapy in malignant gliomas: A preliminary report on a randomized trial J Neurooncol 16 1993 167 172 (Pubitemid 23304725)
17. K. Sultanem, H. Patrocinio, and C. Lambert The use of hypofractionated intensity-modulated irradiation in the treatment of glioblastoma multiforme: Preliminary results of a prospective trial Int J Radiat Oncol Biol Phys 58 2004 247 252 (Pubitemid 38010359)
18. V. Panet-Raymond, L. Souhami, and D. Roberge Accelerated hypofractionated intensity-modulated radiotherapy with concurrent and adjuvant TMZ for patients with glioblastoma multiforme: A safety and efficacy analysis Int J Radiat Oncol Biol Phys 73 2009 473 478
19. T. Iuchi, K. Hatano, and Y. Narita Hypofractionated high-dose irradiation for the treatment of malignant astrocytomas using simultaneous integrated boost technique by IMRT Int J Radiat Oncol Biol Phys 64 2006 1317 1324
20. C. Mayo, M.K. Martel, and L.B. Marks Radiation dose-volume effects of optic nerves and chiasm Int J Radiat Oncol Biol Phys 76 Suppl. 2010 S28 S35
21. N.S. Floyd, S.Y. Woo, and B.S. The Hypofractionated intensity-modulated radiotherapy for primary glioblastoma multiforme Int J Radiat Oncol Biol Phys 58 2004 721 726 (Pubitemid 38221127)
22. J.D. Cox, J. Stetz, and T.F. Pajak Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) Int J Radiat Oncol Biol Phys 31 1995 1341 1346
23. J.D. Ruben, M. Dally, and M. Bailey Cerebral radiation necrosis: Incidence, outcomes, and risk factors with emphasis on radiation parameters and chemotherapy Int J Radiat Oncol Biol Phys 65 2006 499 508
24. E. Shaw, C. Scott, and L. Souhami Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: Final report of RTOG protocol 90-05 Int J Radiat Oncol Biol Phys 47 2000 291 298 (Pubitemid 30236367)
25. K. Sultanem, H. Patrocinio, and C. Lambert The use of hypofractionated intensity-modulated irradiation in the treatment of glioblastoma multiforme: Preliminary results of a prospective trial Int J Radiat Oncol Biol Phys 58 2004 247 252 (Pubitemid 38010359)
26. I.H. Lee, M. Piert, and D. Gomez-Hassan Association of 11C-methionine PET uptake with site of failure after concurrent temozolomide and radiation for primary glioblastoma multiforme Int J Radiat Oncol Biol Phys 73 2009 479 485
27. P.H. Gutin, F.M. Iwamoto, and K. Beal Safety and efficacy of bevacizumab with hypofractionated stereotactic irradiation for recurrent malignant gliomas Int J Radiat Oncol Biol Phys 75 2009 156 163
28. J. Gonzalez, A.J. Kumar, and C.A. Conrad Effect of bevacizumab on radiation necrosis of the brain Int J Radiat Oncol Biol Phys 67 2007 323 326 (Pubitemid 46108339)
29. E.T. Wong, M. Huberman, and X.Q. Lu Bevacizumab reverses cerebral radiation necrosis J Clin Oncol 26 2008 5649 5650
30. R. Torcuator, R. Zuniga, and Y.S. Mohan Initial experience with bevacizumab treatment for biopsy confirmed cerebral radiation necrosis J Neurooncol 94 2009 63 68