N-acetyl cysteine protects osteoblastic function from oxidative stress

Journal of Biomedical Materials Research - Part A

Volumn 99 A, Issue 4, 2011, Pages 523-531

  Ueno, T ^a,b   Yamada, M ^a   Igarashi, Y ^b   Ogawa, T ^a  

^a UCLA SCHOOL OF DENTISTRY   (United States)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

antioxidant; bone; glutathione; hydrogen peroxide; reactive oxygen species (ROS)

Indexed keywords

AMINO ACID DERIVATIVES; ANTI-OXIDATIVE STRESS; ANTIOXIDANT; CELL NUMBER; CULTURE MEDIA; DOSE-DEPENDENT; GENE EXPRESSION LEVELS; GLUTATHIONE; GLUTATHIONES; IN-VIVO; N-ACETYL CYSTEINE; N-ACETYL CYSTEINES; OSTEOBLASTIC CELLS; OSTEOBLASTIC FUNCTIONS; OSTEOCALCIN; OSTEOPONTIN; PROTECTIVE POTENTIALS; RAT BONE MARROW; REACTIVE OXYGEN SPECIES; REDOX BALANCES; THERAPEUTIC POTENTIALS; TYPE I COLLAGEN; VON KOSSA STAINING;

AMINO ACIDS; BONE; ENZYME ACTIVITY; GENE EXPRESSION; HYDROGEN PEROXIDE; OXIDATIVE STRESS; OXYGEN; RESTORATION; TISSUE;

CELL CULTURE;

ACETYLCYSTEINE; ALKALINE PHOSPHATASE; ANTIOXIDANT; COLLAGEN TYPE 1; GLUTATHIONE; HYDROGEN PEROXIDE; OSTEOCALCIN; OSTEOPONTIN; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; BONE MARROW; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL VIABILITY; CULTURE MEDIUM; ENZYME ACTIVITY; GENE EXPRESSION; INTRACELLULAR SPACE; MINERALIZATION; NONHUMAN; OSTEOBLAST; OXIDATIVE STRESS; RAT; RECEPTOR DOWN REGULATION;

ACETYLCYSTEINE; ALKALINE PHOSPHATASE; ANIMALS; ANTIOXIDANTS; CALCIFICATION, PHYSIOLOGIC; CELL SURVIVAL; CELLS, CULTURED; COLLAGEN TYPE I; FREE RADICAL SCAVENGERS; GENE EXPRESSION; HYDROGEN PEROXIDE; MALE; OSTEOBLASTS; OSTEOCALCIN; OSTEOPONTIN; OXIDANTS; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 80255138302     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.33211     Document Type: Article

References (37)

1. Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M,. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 2006; 160: 1-40. (Pubitemid 43227479)
2. Valko M, Morris H, Mazur M, Rapta P, Bilton RF,. Oxygen free radical generating mechanisms in the colon: Do the semiquinones of vitamin K play a role in the aetiology of colon cancer? Biochim Biophys Acta 2001; 1527: 161-166. (Pubitemid 32710142)
3. Kovacic P, Jacintho JD,. Mechanisms of carcinogenesis: Focus on oxidative stress and electron transfer. Curr Med Chem 2001; 8: 773-796. (Pubitemid 32427906)
4. Henrotin YE, Bruckner P, Pujol JP,. The role of reactive oxygen species in homeostasis and degradation of cartilage. Osteoarthritis Cartilage 2003; 11: 747-755. (Pubitemid 37184493)
5. Hecquet CM, Malik AB,. Role of H(2)O(2)-activated TRPM2 calcium channel in oxidant-induced endothelial injury. Thromb Haemost 2009; 101: 619-625.
6. Schweikl H, Spagnuolo G, Schmalz G,. Genetic and cellular toxicology of dental resin monomers. J Dent Res 2006; 85: 870-877. (Pubitemid 44578595)
7. Anup R, Aparna V, Pulimood A, Balasubramanian KA,. Surgical stress and the small intestine: Role of oxygen free radicals. Surgery 1999; 125: 560-569. (Pubitemid 29226929)
8. Bertram C, Hass R,. Cellular responses to reactive oxygen species-induced DNA damage and aging. Biol Chem 2008; 389: 211-220. (Pubitemid 351329029)
9. Eckhardt A, Gerstmayr N, Hiller KA, Bolay C, Waha C, Spagnuolo G, Camargo C, Schmalz G, Schweikl H,. TEGDMA-induced oxidative DNA damage and activation of ATM and MAP kinases. Biomaterials 2009; 30: 2006-2014.
10. Prabhu R, Anup R, Balasubramanian KA,. Surgical stress induces phospholipid degradation in the intestinal brush border membrane. J Surg Res 2000; 94: 178-184.
11. Weiss SJ, Lampert MB, Test ST,. Long-lived oxidants generated by human neutrophils: Characterization and bioactivity. Science 1983; 222: 625-628. (Pubitemid 13022413)
12. Fatokun AA, Stone TW, Smith RA,. Hydrogen peroxide-induced oxidative stress in MC3T3-E1 cells: The effects of glutamate and protection by purines. Bone 2006; 39: 542-551. (Pubitemid 44149273)
13. Lee DH, Lim BS, Lee YK, Yang HC,. Effects of hydrogen peroxide (H2O2) on alkaline phosphatase activity and matrix mineralization of odontoblast and osteoblast cell lines. Cell Biol Toxicol 2006; 22: 39-46. (Pubitemid 43207808)
14. Mody N, Parhami F, Sarafian TA, Demer LL,. Oxidative stress modulates osteoblastic differentiation of vascular and bone cells. Free Radic Biol Med 2001; 31: 509-519. (Pubitemid 32728438)
15. Arai M, Shibata Y, Pugdee K, Abiko Y, Ogata Y,. Effects of reactive oxygen species (ROS) on antioxidant system and osteoblastic differentiation in MC3T3-E1 cells. IUBMB Life 2007; 59: 27-33.
16. Ziment I,. Acetylcysteine: A drug with an interesting past and a fascinating future. Respiration 1986; 50 (Suppl 1): 26-30. (Pubitemid 17181835)
17. Meister A, Anderson ME,. Glutathione. Annu Rev Biochem 1983; 52: 711-60. (Pubitemid 13030692)
18. Maniatopoulos C, Sodek J, Melcher AH,. Bone formation in vitro by stromal cells obtained from bone marrow of young adult rats. Cell Tissue Res 1988; 254: 317-330.
19. Finkel T, Holbrook NJ,. Oxidants, oxidative stress and the biology of ageing. Nature 2000; 408: 239-247.
20. Bai XC, Lu D, Bai J, Zheng H, Ke ZY, Li XM, Luo SQ,. Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB. Biochem Biophys Res Commun 2004; 314: 197-207. (Pubitemid 38058389)
21. Okamoto H, Cujec TP, Yamanaka H, Kamatani N,. Molecular aspects of rheumatoid arthritis: Role of transcription factors. FEBS J 2008; 275: 4463-4470.
22. Hiran TS, Moulton PJ, Hancock JT,. Detection of superoxide and NADPH oxidase in porcine articular chondrocytes. Free Radic Biol Med 1997; 23: 736-743. (Pubitemid 27364867)
23. Fialkow L, Chan CK, Rotin D, Grinstein S, Downey GP,. Activation of the mitogen-activated protein kinase signaling pathway in neutrophils. Role of oxidants. J Biol Chem 1994; 269: 31234-31242.
24. Manolagas SC, Jilka RL,. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med 1995; 332: 305-311.
25. Maggio D, Barabani M, Pierandrei M, Polidori MC, Catani M, Mecocci P, Senin U, Pacifici R, Cherubini A,. Marked decrease in plasma antioxidants in aged osteoporotic women: Results of a cross-sectional study. J Clin Endocrinol Metab 2003; 88: 1523-1527. (Pubitemid 36623364)
26. Basu S, Michaelsson K, Olofsson H, Johansson S, Melhus H,. Association between oxidative stress and bone mineral density. Biochem Biophys Res Commun 2001; 288: 275-279. (Pubitemid 32999758)
27. Garrett IR, Boyce BF, Oreffo RO, Bonewald L, Poser J, Mundy GR,. Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest 1990; 85: 632-639. (Pubitemid 20087462)
28. Van de Bittner GC, Dubikovskaya EA, Bertozzi CR, Chang CJ,. In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter. Proc Natl Acad Sci USA 2010; 107: 21316-21321.
29. Smith SS, Reyes JR, Arbon KS, Harvey WA, Hunt LM, Heggland SJ,. Cadmium-induced decrease in RUNX2 mRNA expression and recovery by the antioxidant N-acetylcysteine (NAC) in the human osteoblast-like cell line, Saos-2. Toxicol In Vitro 2009; 23: 60-66.
30. Son MJ, Lee SB, Byun YJ, Lee HO, Kim HS, Kwon OJ, Jeong SW,. Sodium nitroprusside induces autophagic cell death in glutathione-depleted osteoblasts. J Biochem Mol Toxicol 2010; 24: 313-322.
31. Aita H, Tsukimura N, Yamada M, Hori N, Kubo K, Sato N, Maeda H, Kimoto K, Ogawa T,. N-acetyl cysteine prevents polymethyl methacrylate bone cement extract-induced cell death and functional suppression of rat primary osteoblasts. J Biomed Mater Res A 2010; 92: 285-296.
32. Tsukimura N, Yamada M, Aita H, Hori N, Yoshino F, Chang-Il Lee M, Kimoto K, Jewett A, Ogawa T,. N-acetyl cysteine (NAC)-mediated detoxification and functionalization of poly(methyl methacrylate) bone cement. Biomaterials 2009; 30: 3378-3389.
33. Yamada M, Ueno T, Minamikawa H, Sato N, Iwasa F, Hori N, Ogawa T,. N-acetyl cysteine alleviates cytotoxicity of bone substitute. J Dent Res 2010; 92: 89: 411-416.
34. Sato N, Ueno T, Kubo K, Suzuki T, Tsukimura N, Att W, Yamada M, Hori N, Maeda H, Ogawa T,. N-Acetyl cysteine (NAC) inhibits proliferation, collagen gene transcription, and redox stress in rat palatal mucosal cells. Dent Mater 2009; 25: 1532-1540.
35. Kim JM, Kim H, Kwon SB, Lee SY, Chung SC, Jeong DW, Min BM,. Intracellular glutathione status regulates mouse bone marrow monocyte-derived macrophage differentiation and phagocytic activity. Biochem Biophys Res Commun 2004; 325: 101-108. (Pubitemid 39441167)
36. Therond P, Abella A, Laurent D, Couturier M, Chalas J, Legrand A, Lindenbaum A,. In vitro study of the cytotoxicity of isolated oxidized lipid low-density lipoproteins fractions in human endothelial cells: Relationship with the glutathione status and cell morphology. Free Radic Biol Med 2000; 28: 585-596. (Pubitemid 30136040)
37. Jun JH, Lee SH, Kwak HB, Lee ZH, Seo SB, Woo KM, Ryoo HM, Kim GS, Baek JH,. N-acetylcysteine stimulates osteoblastic differentiation of mouse calvarial cells. J Cell Biochem 2008; 103: 1246-1255.