Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 23, 2011, Pages 7180-7184

  Roth, Joshua ^a   Minond, Dmitriy ^b,c   Darout, Etzer ^a   Liu, Qin ^a   Lauer, Janelle ^a,d   Hodder, Peter ^b   Fields, Gregg B ^c,d   Roush, William R ^a  

^a Scripps Florida ^*  (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Exosite inhibitor; Metalloproteinase 13 inhibitor; MMP inhibitor

Indexed keywords

COLLAGENASE 3; COLLAGENASE 3 INHIBITOR; COLLAGENASE INHIBITOR; GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE 14; NEUTROPHIL COLLAGENASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG SYNTHESIS; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; HYDROLYSIS; STRUCTURE ACTIVITY RELATION;

BINDING SITES; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MATRIX METALLOPROTEINASE 13; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; URACIL;

EID: 80255136352     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.09.077     Document Type: Article

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