Quinazolinones and pyrido[3,4-d]pyrimidin-4-ones as orally active and specific matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

Journal of Medicinal Chemistry

Volumn 51, Issue 4, 2008, Pages 835-841

  Jie, Jack Li ^a,b   Nahra, Joe ^a,b   Johnson, Adam R ^a   Bunker, Amy ^a   O'Brien, Patrick ^a   Yue, Wen Song ^a   Ortwine, Daniel F ^a   Man, Chiu Fai ^a   Baragi, Vijay ^a   Kilgore, Kenneth ^a   Dyer, Richard D ^a   Han, Hyo Kyung ^a  

^a PFIZER INC   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 PYRIMIDINONE DERIVATIVE; CIPEMASTAT; COLLAGENASE 3; ILOMASTAT; MARIMASTAT; MATRIX METALLOPROTEINASE INHIBITOR; PRINOMASTAT; PYRIDO[3,4 D]PYRIMIDIN 4 ONE; QUINAZOLINONE DERIVATIVE; REBIMASTAT; TANOMASTAT; THIZOLOPYRIMIDIN DIONE; UNCLASSIFIED DRUG; ZINC ION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARTILAGE; COMPUTER AIDED DESIGN; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG METABOLISM; DRUG SAFETY; DRUG SPECIFICITY; HIGH THROUGHPUT SCREENING; MALE; NONHUMAN; OSTEOARTHRITIS; RABBIT; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; MALE; MATRIX METALLOPROTEINASE 13; OSTEOARTHRITIS; PYRIDINES; PYRIMIDINES; QUINAZOLINONES; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 39749124201     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm701274v     Document Type: Article

References (38)