Scn1a missense mutation impairs GABAA receptor-mediated synaptic transmission in the rat hippocampus

Biochemical and Biophysical Research Communications

Volumn 400, Issue 1, 2010, Pages 117-122

  Ohno, Yukihiro ^a   Sofue, Nobumasa ^a   Ishihara, Shizuka ^a   Mashimo, Tomoji ^b   Sasa, Masashi ^c   Serikawa, Tadao ^b  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c Nagisa Hospital   (Japan)

Author keywords

Febrile seizure; GABAA receptor; Hippocampus; Nav1.1 channels; Scn1a mutation

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; PENTETRAZOLE; CONVULSANT AGENT; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE 1; NERVE PROTEIN; SCN1A PROTEIN, HUMAN; SCN1A PROTEIN, RAT; SODIUM CHANNEL; SODIUM CHANNEL NAV1.1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EPILEPTOGENESIS; FEBRILE CONVULSION; GABAERGIC SYSTEM; GENE; HIPPOCAMPUS; MALE; MISSENSE MUTATION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SCN1A GENE; SEIZURE SUSCEPTIBILITY; SYNAPTIC TRANSMISSION; ANIMAL; CHEMICALLY INDUCED; DRUG EFFECTS; FISCHER 344 RAT; GENETICS; METABOLISM; MUTANT RAT STRAIN; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; CONVULSANTS; GLUTAMATE DECARBOXYLASE; HIPPOCAMPUS; MUTATION, MISSENSE; NERVE TISSUE PROTEINS; PENTYLENETETRAZOLE; RATS; RATS, INBRED F344; RATS, MUTANT STRAINS; RECEPTORS, GABA-A; SEIZURES, FEBRILE; SODIUM CHANNELS; SYNAPTIC TRANSMISSION; NAV1.1 VOLTAGE-GATED SODIUM CHANNEL;

RATTUS;

EID: 80255134433     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.08.021     Document Type: Article

References (30)

1. v1.1) confers susceptibility to febrile seizures in rats. J. Neurosci. 2010, 30:5744-5753.
2. Shinnar S. Febrile seizures and mesial temporal sclerosis. Epilepsy Cur. 2003, 3:115-118.
3. Baulac S., Gourfinkel-An I., Nabbout R., Huberfeld G., Serratosa J., Leguern E., Baulac M. Fever genes and epilepsy. Lancet Neurol. 2004, 3:421-430.
4. Fetveit A. Assessment of febrile seizures in children. Eur. J. Pediatr. 2008, 167:17-27.
5. Scantlebury M.H., Heida J.G. Febrile seizures and temporal lobe epileptogenesis. Epilepsy Res. 2010, 89:27-33.
6. Meisler M.H., Kearney J.A. Sodium channel mutations in epilepsy and other neurological disorders. J. Clin. Invest. 2005, 115:2010-2017.
7. v1.1 sodium channels cause epilepsy?. Brain Res. Rev. 2008, 58:149-159.
8. v1.1 channels and epilepsy. J. Physiol. 2010, 588(Pt11):1849-1859.
9. Yu F.H., Mantegazza M., Westenbroek R.E., Robbins C.A., Kalume F., Burton K.A., Spain W.J., McKnight G.S., Scheuer T., Catterall W.A. Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy. Nat. Neurosci. 2006, 9:1142-1149.
10. Oakley J.C., Kalume F., Yu F.H., Scheuer T., Catterall W.A. Temperature- and age-dependent seizures in a mouse model of severe myoclonic epilepsy in infancy. Proc. Natl. Acad. Sci. USA 2009, 106:3994-3999.
11. Martin M.S., Dutt K., Papale L.A., Dube C.M., Dutton S.B., de Haan G., Shankar A., Tufik S., Meisler M.H., Baram T.Z., Goldin A.L., Escayg A. Altered function of the SCN1A voltage-gated sodium channel leads to gamma-aminobutyric acid-ergic (GABAergic) interneuron abnormalities. J. Biol. Chem. 2010, 285:9823-9834.
12. Akaike A., Ohno Y., Sasa M., Takaori S. Excitatory and inhibitory effects of dopamine on neuronal activity of the caudate nucleus neurons in vitro. Brain Res. 1987, 418:262-272.
13. Ohno Y., Warnick J.E. Effects of thyrotropin-releasing hormone on phencyclidine- and ketamine-induced spinal depression in neonatal rats. Neuropharmacology 1988, 27:1013-1018.
14. Ohno Y., Warnick J.E. Selective depression of the segmental polysynaptic reflex by phencyclidine and its analogs in the rat in vitro: interaction with N-Methyl-d-Aspartate receptors. J. Pharmacol. Exp. Ther. 1990, 252:246-252.
15. G. Paxinos, C. Watson, The Rat Brain in Stereotaxic Coordinates, 6th ed., Elsevier, Massachussets, 2007.
16. + channels amplify EPSPs in hippocampal CA1 pyramidal cells. J. Neurophysiol. 1996, 76:2181-2191.
17. Ohno Y., Ishihara S., Terada R., Kikuta M., Sofue N., Kawai Y., Serikawa T., Sasa M. Preferential increase in the hippocampal synaptic vesicle protein 2A (SV2A) by pentylenetetrazole kindling. Biochem. Biophys. Res. Commun. 2009, 390:415-420.
18. A receptor. J. Neurosci. 2002, 22:5572-5580.
19. Proctor W.R., Diao L., Freund R.K., Browning M.D., Wu P.H. Synaptic GABAergic and glutamatergic mechanisms underlying alcohol sensitivity in mouse hippocampal neurons. J. Physiol. 2006, 575:145-159.
20. v1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation. J. Neurosci. 2007, 27:5903-5914.
21. Lossin C., Wang D.W., Rhodes T.H., Vanoye C.G., George A.L. Molecular basis of an inherited epilepsy. Neuron 2002, 34:877-884.
22. Cossette P., Loukas A., Lafrenière R.G., Rochefort D., Harvey-Girard E., Ragsdale D.S., Dunn R.J., Rouleau G.A. Functional characterization of the D188V mutation in neuronal voltage-gated sodium channel causing generalized epilepsy with febrile seizures plus (GEFS). Epilepsy Res. 2003, 53:107-117.
23. Lossin C., Rhodes T.H., Desai R.R., Vanoye C.G., Wang D., Carniciu S., Devinsky O., George A.L. Epilepsy-associated dysfunction in the voltage-gated neuronal sodium channel SCN1A. J. Neurosci. 2003, 23:11289-11295.
24. Rhodes T.H., Lossin C., Vanoye C.G., Wang D.W., George A.L. Noninactivating voltage-gated sodium channels in severe myoclonic epilepsy of infancy. Proc. Natl. Acad. Sci. USA 2004, 101:11147-11152.
25. Spampanato J., Kearney J.A., de Haan G., McEwen D.P., Escayg A., Aradi I., MacDonald B.T., Levin S.I., Soltesz I., Benna P., Montalenti E., Isom L.L., Goldin A.L., Meisler M.H. A novel epilepsy mutation in the sodium channel SCN1A identifies a cytoplasmic domain for beta subunit interaction. J. Neurosci. 2004, 24:10022-10034.
26. Wu J., Javedan S.P., Ellsworth K., Smith K., Fisher R.S. Gamma oscillation underlies hyperthermia-induced epileptiform-like spikes in immature rat hippocampal slices. BMC Neurosci. 2001, 2:18.
27. A receptor gamma2 subunit mutations associated with idiopathic generalized epilepsies have temperature-dependent trafficking deficiencies. J. Neurosci. 2006, 26:2590-2597.
28. Qu L., Liu X., Wu C., Leung L.S. Hyperthermia decreases GABAergic synaptic transmission in hippocampal neurons of immature rats. Neurobiol. Dis. 2007, 27:320-327.
29. Qu L., Leung L.S. Mechanisms of hyperthermia-induced depression of GABAergic synaptic transmission in the immature rat hippocampus. J. Neurochem. 2008, 106:2158-2169.
30. Qu L., Leung L.S. Effects of temperature elevation on neuronal inhibition in hippocampal neurons of immature and mature rats. J. Neurosci. Res. 2009, 87:2773-2785.