Multiple molecular forms of circulating cardiac troponin: Analytical and clinical significance

Annals of Clinical Biochemistry

Volumn 45, Issue 4, 2008, Pages 349-355

  Gaze, David C ^a   Collinson, Paul O ^a  

^a ST GEORGE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; TROPONIN I; TROPONIN T;

ACUTE CORONARY SYNDROME; ANTICOAGULATION; ASSAY; BIOCHEMISTRY; CELL DAMAGE; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; GENE MUTATION; HEART MUSCLE CELL; KIDNEY FAILURE; KINETICS; ONTOGENY; OXIDATION; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN STRUCTURE; REVIEW;

ANIMALS; BLOOD CIRCULATION; HUMANS; MUTATION; MYOCARDIUM; PROTEIN PROCESSING, POST-TRANSLATIONAL; TROPONIN;

EID: 47749153759     PISSN: 00045632     EISSN: 00045632     Source Type: Journal    
DOI: 10.1258/acb.2007.007229     Document Type: Review

References (79)

1. Thygesen K, Alpert JS, Harvey D, et al. Universal definition of myocardial infarction: On behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Eur Heart J 2007;20:2525-38
2. Braunwald E, Antman EM, Beasley JW, et al. ACC/AHA guidelines for the management of patients with unstable angina and non-ST segment elevation myocardial infarction: executive summary and recommendations. A report of the American College of Cardiology/ American Heart Association task force on practice guidelines (Committee on the management of patients with unstable angina). J Am Coll Cardiol 2000;36:970-1062
3. McDonough JL, Van Eyk JE. Developing the next generation of cardiac markers: disease-induced modifications of troponin I. Prog Cardiovasc Dis 2004;47:207-16
4. Tobacman LS. Thin filament-mediated regulation of cardiac contraction. Annu Rev Physiol 1996;58:447-1
5. Chalovich JM. Actin mediated regulation of muscle contraction. Pharmacol Ther 1992;55:95-148
6. 2+-saturated form. Nature 2003;424:35-41
7. Dean KJ. Biochemistry and molecular biology of troponin I and T. In: Cardiac Markers. Wu AHB, ed. Totowa, NJ: Humana Press, 1998:193-204
8. Collinson PO, Boa FG, Gaze DC. Measurement of cardiac troponins. Ann Clin Biochem 2001;38:423-49
9. Mar JH, Lannello RC, Ordahl CP. Cardiac troponin T gene expression in muscle. Symp Soc Exp Biol 1992;46:237-49
10. Sutherland CJ, Esser LA, Elsom VL, et al. Identification of a program of contractile gene expression initiated upon skeletal muscle differentiation. Dev Dyn 1993;196:25-36
11. Anderson PAW, Greig A, Mark TM, et al. Troponin isoform expression in humans: a comparison among normal and failing adult heart, fetal heart and adult and fetal skeletal muscle. Circ Res 1991;69:1226-33
12. Briggs MM, Maready M, Schmidt JM, et al. Identification of a fetal exon in the human fast troponin T gene. FEBS Lett 1994;350:37-40
13. Anderson PAW, Greig A, Mark TM, et al. Molecular basis of human cardiac troponin T isoforms expressed in the developing, adult and failing heart. Circ Res 1995;76:681-6
14. Mesnard L, Logeart D, Taviaux S, et al. Human cardiac troponin T: cloning and expression of new isoforms in the normal and failing heart. Circ Res 1995;76:687-92
15. Cooper TA, Ordahl CP. A single troponin T gene regulated by different programs in cardiac and skeletal muscle development. Science 1984;226:979-82
16. Humphreys JE, Cummins P. Regulatory proteins of the myocardium. Atrial and ventricular tropomyosin and Tn-I in the developing and adult bovine and human hearts. J Mol Cell Cardiol 1984;16:643-57
17. Sasse S, Brand NJ, Kyprianu P, et al. Troponin I gene expression during human cardiac development and in end-stage heart failure. Circ Res 1993;72:932-8
18. Gaze DC, Collinson PO. Cardiac troponin I should be interpreted with caution in paediatric neonatal patients. [letter] Biol Neonate 2004;87:19
19. Gaze DC, Collinson PO. Interpretation of cardiac troponin measurements in neonates - the devil is in the details. Biol Neonate 2005;89:194-6
20. Szymankiewicz M, Matuszczak-Wleklak M, Hodgman JE, et al. Usefulness of cardiac troponin T and echocardiography in the diagnosis of hypoxic myocardial injury of full-term neonates. Biol Neonate 2005;88:19-23
21. Clark SJ, Newland P, Yoxall CW, et al. Concentrations of cardiac troponin T in neonates with and without respiratory distress. Arch Dis Child Fetal Neonatal Ed 2004;89:F348-52
22. Araújo K, da Silva J, Sanudo A, et al. Plasma concentrations of cardiac troponin I in newborn infants. Clin Chem 2004;50:1717-8
23. Trevisanuto D, Pitton M, Altinier S, et al. Cardiac troponin I, cardiac troponin T and creatine kinase MB concentrations in umbilical cord blood of healthy term neonates. Acta Paediatr 2003;192:1463-7
24. Schiaffino S, Reggiani C. Molecular diversity of myofibrillar proteins: gene regulation and functional significance. Physiol Rev 1996;76:371-423
25. 2+ binding associated with troponin T isoforms switching in developing rabbit heart. Circ Res 1990;66:1204-16
26. Nassar R, Malouf NN, Kelly MB, et al. Force-pCa relation and troponin T isoforms of rabbit myocardium. Circ Res 1991;69:1470-5
27. Tobacman L, Lee R. Isolation and functional comparison of bovine cardiac troponin T isoforms. J Biol Chem 1987;262:4059-64
28. Roberts R, Molecular genetics. Therapy or Terror? [letter] Circulation 1994;89:499-502
29. Gomes AV, Potter JD. Cellular and molecular aspects of familial hypertrophic cardiomyopathy caused by mutations in the cardiac troponin I gene. Mol Cell Biochem 2004;263:99-114
30. Watkins H, McKenna WJ, Thierfelder L, et al. Mutations in the genes for cardiac troponin T and a-tropomyosin in hypertrophic cardiomyopathy. NEJM 1995;332:1058-64
31. Redwood CS, Moolman-Smook JC, Watkins H. Properties of mutant contractile proteins that cause hypertrophic cardiomyopathy. Cardiovasc Res 1999;44:20-36
32. Kimura A, Harada H, Park JE, et al. Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy. Nat Genet 1997;16:379-82
33. Gomes AV, Barnes JA, Harada K, et al. Role of troponin T in disease. Mol Cell Biochem 2004;263:115-29
34. Harada K, Morimoto S. Inherited cardiomyopathies as a troponin disease. Jpn J Physiol 2004;54:307-18
35. Kamisago M, Sharma SD, DePalma SR, et al. Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy. NEJM 2000;343:1688-96
36. 2+ sensitization and potentiation of the maximum level of myofibrillar ATPase activity caused by mutations of troponin T found in familial hypertrophic cardiomyopathy. J Biol Chem 1999;274:8806-12
37. Harada K, Takahashi-Yanaga F, Minakami R, et al. Functional consequences of the deletion mutation deltaGlu160 in human cardiac troponin T. J Biochem (Tokyo) 2000;127:263-8
38. 2+ desensitizing effect of a deletion mutation DK210 in cardiac troponin T that causes familial dilated cardiomyopathy. Proc Natl Acad Sci USA 2002;99:913-8
39. Swiderek K, Jaquet K, Meyer HF, et al. Sites phosphorylated in bovine cardiac troponin T and I. Characterization by P-NMR spectroscopy and phosphorylation by protein kinases. Eur J Biochem 1990;190:575-82
40. 2+ dependent actomyosin MgATPase activity and troponin T binding to tropomyosin F actin complex. Biochem J 1992;288:123-9
41. Venema RC, Kuo JF. Protein kinase C mediated phosphorylation of troponin I and C-reactive protein in isolated myocardial cells is associated with inhibition of myofibrillar actinomyosin MgATPase. J Biol Chem 1993;268:2705-11
42. Katrukha A, Severina M, Bereznikova A, et al. Phosphorylation of human cardiac troponin I by protein kinase A affects its immunological activity. In: Proceedings, International Congress of Clinical Enzymology. Cambridge, UK, 13-16 July 1996:24
43. 2+ affinity of cardiac troponin C. J Biol Chem 1995;270:30773-80
44. Sumandea MP, Burkart ME, Kobayashi T, et al. Molecular and integrated biology of thin filament protein phosphorylation in heart muscle. Ann N Y Acad Sci 2004;1015:39-52
45. Cole HA, Perry SV. The phosphorylation of troponin I from cardiac muscle. Biochem J 1975;149:525-33
46. Malhotra A, Nakouzi A, Bowman J, et al. Expression and regulation of mutant forms of cardiac Tnl in reconstituted actomyosin system: role of kinase dependent phosphorylation. Mol Cell Biochem 1997;170:99-107
47. Hunlich M, Begin KJ, Gorga JA, Fishbaugher DE, LeWinter MM, VanBuren P. Protiein kinase A mediated modulation of acto-myosin kinetics. J Mol Cell Cardiol 2005;38:119-25
48. Zkakhary DR, Moravec CS, Bond M. Regulation of PKA binding to PKAPx in the heart: alterations in human heart failure. Circulation 2000;101:1459-64
49. Wu AHB, Feng Y-J, Moore R, et al. for the American Association of Clinical Chemistry Subcommittee on cTnI Standardization. Characterization of cardiac troponin subunit release into serum after acute myocardial infarction and comparison of assays for troponin T and I. Clin Chem 1998;44:1198-208
50. VanBuren P, Okada Y. Thin filament remodelling in failing myocardium. Heart Fail Rev 2005;10:199-209
51. Katrukha AG, Berznikova AV, Esakova TV, et al. Troponin I is released into the bloodstream of patients with myocardial infarction not in free form but as complex. Clin Chem 1997;43:1379-85
52. Giuliani I, Bertinchant JP, Greanier C, et al. Determination of cardiac troponin I forms in the blood of patients with acute myocardial infarction and patients receiving crystalloid or cold blood cardioplegia. Clin Chem 1999;45:213-22
53. Hein S, Scheffold T, Schaper J. Ischemia induces early changes to cytoskeletal and contractile proteins in diseased myocardium. J Thorac Cardiovasc Surg 1995;110:89-98
54. Wu AHB, Ford L. Release of cardiac troponin in acute coronary syndromes: ischemia or necrosis? Clin Chim Acta 1999;284:161-74
55. Labugger R, Organ L, Collier C, et al. Extensive troponin I and T modification detected in serum from patients with acute myocardial infarction. Circulation 2000;102:1221-6
56. McDonough JL, Labugger R,Pickett W, et al. Cardiac troponinIismodified in the myocardium of bypass patients. Circulation 2001;103:58-64
57. McDonough JL, Arrell DK, Van Eyk JE. Troponin I degradation and covalent complex formation accompanies myocardial ischemia/ reperfusion. Circ Res 1999;84:9-20
58. Apple FS. Standardization of cardiac markers. Scand J Clin Lab Invest Suppl 2005;240:107-11
59. Christenson RH, Duh SH, Apple FS, et al. Standardization of cardiac troponin I assays: round robin performance of ten candidate reference materials. Clin Chem 2001;47:431-7
60. Bunk DM, Welch MJ. Characterization of a new certified reference material for human cardiac troponin I. Clin Chem 2006;52:212-9
61. Christenson RH, Duh SH, Apple DS, et al. Towards standardization of cardiac troponin I measurement Part II: assessing commutability of candidate reference materials and harmonization of cardiac troponin I assays. Clin Chem 2006;52:1685-92
62. Bhayana V, Gougouilas T, Chooe S, et al. Discordance between results from serum troponin T and troponin I in renal disease. Clin Chem 1995;41:312-17
63. Katus HA, Looser S, Hallerrmayer K, et al. Development and in vitro characterization of a new immunoassay of cardiac troponin T. Clin Chem 1992;38:386-93
64. Lamb EJ, Webb MC, Abbas NA. The significance of serum troponin T in patients with kidney disease: a review of the literature. Ann Clin Biochem 2004;41:1-9
65. Khan NA, Hemmelgarn BR, Tonelli M, et al. Prognostic value of troponin T and I among asymptomatic patients with end-stage renal disease. A meta-analysis. Circulation 2005;112:3088-96
66. Diris JHC, Hackeng CM, Kooman JP, et al. Impaired renal clearance explains elevated cTnT fragments in hemodialysis patients. Circulation 2004;109:23-5
67. Giannitsis E, Katus HA. Troponin T release in hemodialysis patients. Circulation 2004;110:e25-6
68. Fahie-Wilson M, Carmichael D, Delaney MP, et al. Cardiac troponin T circulates in the free, intact form in patients with kidney failure. Clin Chem 2006;52:414-20
69. al-Hillawi E, Chilton D, Trayer IP, et al. Phosphorylation- specific antibodies for human cardiac troponin-I. Eur J Biochem 1998;256:535-40
70. Katrukha A, Bereznikova A, Filatov V, et al. Biochemical factors influencing measurement of cardiac troponin I in serum. Clin Chem Lab Med 1999;37:1091-5
71. Panteghini M, Gerhardt W, Apple FS, et al. Quality specifications for cardiac troponin assays. Clin Chem Lab Med 2001;47:587-8
72. Septh M, Seibold K, Katz N. Interaction between heparin and cardiac troponin T and troponin I from patients after coronary bypass surgery. Clin Biochem 2002;35:355-62
73. Stiegler H, Fischer Y, Vazquez-Jimenez JF, et al. Lower cardiac troponin T and I results in heparin-plasma than in serum. Clin Chem 2000;46:1338-44
74. Katrukha AG, Bereznikova AV, Filatov VL, et al. Degradation of cardiac troponin I: implication for reliable immunodetection. Clin Chem 1998;44:2433-40
75. Gerhardt W, Nordin G, Jerbert AK, et al. Troponin T and I assays show decreased concentrations in heparin plasma compared with serum: lower recoveries in early than in late phase of myocardial infarction. Clin Chem 2000;46:817-21
76. Dominici R, Infusino I, Valente C, et al. Plasma or serum samples: measurements of cardiac troponin T and of other analytes compared. Clin Chem Lab Med 2004;42:945-51
77. Wang YS, Feng CF, Er TZ, et al. Comparison of cardiac troponin I levels in serum and sodium-citrate plasma using the ACCESS 2 immunoassay. Ann Clin Lab Sci 2005;35:453-4
78. Department of Health. Coronary Heart Disease National Service Framework. London: TSO, 2002
79. Guidance on the Use of Glycoprotein Iib/Iiia Inhibitors in the Treatment of Acute Coronary Syndromes. Technology Appraisal Guidance No 12. London: National Institute for Clinical Excellence, 2000