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Volumn 2, Issue 1, 2011, Pages 73-75

Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

CHROMAN DERIVATIVE; RHO KINASE; RHO KINASE II; RHO KINASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 79952363754     PISSN: 20402503     EISSN: 20402511     Source Type: Journal    
DOI: 10.1039/c0md00194e     Document Type: Article
Times cited : (16)

References (17)
  • 13
    • 0001597804 scopus 로고
    • Assignment of absolute stereochemistry was based on the predictive model for asymmetric induction described in ref. 10.For another example of the use of the Oppolzer auxiliary to obtain similar stereoselectivity, please refer to:
    • D. A. Evans T. C. Britton J. A. Ellman Tetrahedron Lett. 1987 28 6141
    • (1987) Tetrahedron Lett. , vol.28 , pp. 6141
    • Evans, D.A.1    Britton, T.C.2    Ellman, J.A.3
  • 15
    • 79952520519 scopus 로고    scopus 로고
    • A table of other conditions examined during efforts to optimize the asymmetric hydrogenation reaction is provided in the ESI
    • A table of other conditions examined during efforts to optimize the asymmetric hydrogenation reaction is provided in the ESI
  • 16
    • 0000360958 scopus 로고    scopus 로고
    • Second re-crystallization of the chloramphenicol base salt of chroman 7b further improved the enantiomeric purity to 99.6%. However, the re-crystallization procedure requires a large volume of acetonitrile, and 99% ee was acceptable for our purposes
    • T. Uemura X. Zhang K. Matsumura N. Sayo H. Kumobayashi T. Ohta K. Nozaki H. Takaya J. Org. Chem. 1996 61 5510
    • (1996) J. Org. Chem. , vol.61 , pp. 5510
    • Uemura, T.1    Zhang, X.2    Matsumura, K.3    Sayo, N.4    Kumobayashi, H.5    Ohta, T.6    Nozaki, K.7    Takaya, H.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.