Discovery of N-Aryl-2-acylindole human glucagon receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 23, 2011, Pages 7124-7130

  Sinz, Christopher ^a   Bittner, Amy ^a   Brady, Ed ^a   Candelore, Mari ^a   Dallas Yang, Qing ^a   Ding, Victor ^a   Jiang, Guoqiang ^a   Lin, Zhen ^a   Qureshi, Sajjad ^a   Salituro, Gino ^a   Saperstein, Richard ^a   Shang, Jackie ^a   Szalkowski, Deborah ^a   Tota, Laurie ^a   Vincent, Stella ^a   Wright, Michael ^a   Xu, Shiyao ^a   Yang, Xiaodong ^a   Zhang, Bei ^a   Tata, James ^a   Kim, Ronald ^a   Parmee, Emma R ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antagonist; Diabetes; Glucagon; Glucose; Indole

Indexed keywords

GLUCAGON RECEPTOR; GLUCAGON RECEPTOR ANTAGONIST; GLUCOSE; HORMONE RECEPTOR BLOCKING AGENT; INDOLE DERIVATIVE; N ARYL 2 ACYLINDOLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG SAFETY; DRUG SYNTHESIS; DRUG TOLERABILITY; GLUCOSE BLOOD LEVEL; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DOGS; DRUG DISCOVERY; HUMANS; HYPOGLYCEMIC AGENTS; INDOLES; MICE; MICE, TRANSGENIC; MOLECULAR STRUCTURE; RECEPTORS, GLUCAGON; STRUCTURE-ACTIVITY RELATIONSHIP;

MURINAE; RODENTIA;

EID: 80255129377     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.09.105     Document Type: Article

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