Gastrodia elata prevents huntingtin aggregations through activation of the adenosine A 2A receptor and ubiquitin proteasome system

Journal of Ethnopharmacology

Volumn 138, Issue 1, 2011, Pages 162-168

  Huang, Chuen Lin ^a,b   Yang, Jung Mou ^a   Wang, Kaw Chen ^a   Lee, Yi Chao ^c   Lin, Yun Lian ^d   Yang, Ying Chen ^e   Huang, Nai Kuei ^d,f  

^a CARDINAL TIEN HOSPITAL   (Taiwan)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^d NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^e NATIONAL ILAN UNIVERSITY   (Taiwan)

^f NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Gastrodia elata; Huntington's disease; Polyglutamine; Ubiquitin proteasome system

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2A RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; GASTRODIA ELATA EXTRACT; HUNTINGTIN; NEUROPROTECTIVE AGENT; PROTEASOME; UBIQUITIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; ENZYME ACTIVATION; NEUROPROTECTION; NONHUMAN; PHEOCHROMOCYTOMA; PROTEIN AGGREGATION; RAT; SIGNAL TRANSDUCTION;

ADENOSINE A2 RECEPTOR AGONISTS; ADENOSINE A2 RECEPTOR ANTAGONISTS; ANIMALS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYSTEINE PROTEINASE INHIBITORS; DRUGS, CHINESE HERBAL; ENZYME INHIBITORS; GASTRODIA; HUNTINGTON DISEASE; LEUPEPTINS; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; NUCLEAR PROTEINS; PC12 CELLS; PHYTOTHERAPY; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; RECEPTOR, ADENOSINE A2A; SIGNAL TRANSDUCTION; TRANSFECTION; UBIQUITIN; UBIQUITINATED PROTEINS;

GASTRODIA ELATA; ORCHIDACEAE;

EID: 80255123778     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.08.075     Document Type: Article

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