In vivo antimalarial activity of aqueous extracts from Kenyan medicinal plants and their interactions with chloroquine

Journal of Traditional Medicines

Volumn 23, Issue 4, 2006, Pages 141-146

  Muregi, Francis W ^a,b   Ishih, Akira ^a   Miyase, Toshio ^c   Suzuki, Tohru ^a   Kino, Hideto ^a   Amano, Teruaki ^b   Mkoji, Gerald M ^b   Terada, Mamoru ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^c UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

Antimalarial; Chloroquine combination; Medicinal plants; Plasmodium berghei NK65; Synergism

Indexed keywords

EID: 79958139704     PISSN: 18801447     EISSN: 18813747     Source Type: Journal    
DOI: 10.11339/jtm.23.141     Document Type: Article

References (28)

1. Teklehaimanot, A., Bosman, A.: Opportunities, problems and perspectives for malaria control in sub-Saharan Africa. Parassitologia, 41, 335-338, 1999.
2. Bloland, P.B.: Drug Resistance in Malaria. Malaria epidemiology branch, centers for disease control and prevention, World Health Organization, pp. 1-23, 2001.
3. Basco, L.K., Mitaku, S., Skaltsounis, A.L., Ravelomanaintsoa, N., Tillequin, F., Koch, M., Le Bras, J.: In vitro activities of Acridone Alkaloids against Plasmodium falciparum. Antimicrob Agents and Chemother., 5, 1169-1171, 1994.
4. Omar, S.A., Adagu, I.S., Gump, D.W., Ndaru, N.P., Warhust, D.C.: Plasmodium falciparum in Kenya: high prevalence of drug-resistance-associated polymorphisms in hospital admissions with severe malaria in an epidemic area. Ann Trop Med Parasitol., 95, 661-669, 2001.
5. Nchinda, T.C.: Malaria: A Reemerging Disease in Africa. Emerg Infect Dis., 4, 399-403, 1998.
6. WHO (World Health Organization): Severe falciparum malaria. Trans Royal Soc Trop Med Hyg., 94, 36-37, 2000.
7. Winstanley, P.A.: Chemotherapy for falciparum malaria: The armoury, the problems and the prospects. Parasitol Today., 16, 146-153, 2000.
8. Oduola, A.M., Sowumi, A., Milhow W.K., Brewer T.G., Kyle, D.E., Gerena, L., Salako, L.K., Schuster, B.G.: The Effect of Combining Promathazine with Chloroquine against Plasmodium falciparum in vitro. Am J Trop Med Hyg., 58, 625-629, 1998.
9. Rasoanaivo, P., Rafatro, H., Ramanitrahasimbola, D., Ratsimamanga-Urverg, S.: Alkaloids from Madagascan plants as Biochemical tools in drug resistant malaria. Proceedings of the 7th NAPRECA Symposium on Natural Products, (1997), Dar es Salaam Tanzania 10, 95-97, 1998.
10. Phillipson, J.D., Wright, C.W.: Antiprotozoal Agents from Plant Sources. Planta Med., 57 (1), 53-59, 1991.
11. Farnsworth, N.R., Akerere, O., Bilngel, A.S., Soejarto D.D., Guo Z.: Medicinal Plants in Therapy. Bull World Health Organ., 63, 965-981, 1985.
12. WHO (World Health Organization): World Health Organization fact sheet no. 271. World Health Organization, Geneva, 2002.
13. Tagboto, S., Townson, S.: Antiparasitic properties of medicinal plants and other naturally occurring products. Adv Parasitol., 50, 199-295, 2001.
14. WHO (World Health Organization) Centre for Health Development: Traditional Medicine: Planning for cost-effective traditional health services in the new century-a discussion paper. http:/www.who.or.jp/tm/research/, 2002.
15. Zirihi, G.N., Mambu, L., Guede-Guina F., Bodo, B., Grellier, P.: In vitro antiplasmodial activity and cytotoxicity of 33 West African plants used for treatment of malaria. J Ethnopharmacol., 98, 281-285, 2005.
16. Gessler, M.C., Tanner, M., Chollet, J., Nkunya, M.H.H., Heinrick, M.: Tanzanian Medicinal plants used traditionally for the treatment of malaria: In vivo antimalarial and in vitro cytotoxic activities. Phytother Res., 9, 504-508, 1995.
17. Ajaiyeoba, E.O., Abalogu, U.I., Krebs, H.C., Oduola, A.M.J.: In vivo antimalarial activities of Quassia amara and Quassia undulata plant extracts in mice. J Ethnopharmacol., 67, 321-171, 1999.
18. Peters, W., Portus, J.H., Robinson, B.L.: The four-day suppressive in vivo antimalarial test. Ann Trop Med Parasitol., 69, 155-171, 1975.
19. Ishih, A., Suzuki, T., Hasegawa, T., Kachi, S., Wang, H-H., Terada, M.: In vivo evaluation of combination effects of chloroquine with cepharanthin® or minocycline hydrochloride against blood-induced choloquine-resistant Plasmodium berghei NK65 infections. Tropical Medicine and Health, 32, 15-19, 2004.
20. Ishih, A., Suzuki, T., Muregi, F.W., Matsui, K., Terada, M.: Chloroquine efficacy in Plasmodium berghei NK65-infected ICR mice, with reference to the influence of initial parasite load and starting day of drug administration on the outcome of treatment. Southeast Asian J Trop Med Public Health., 37 (1), 13-17, 2006.
21. Tona, L., Ngimbi, N.P., Tsakala, M., Mesia, K., Cimanga, K., Apers, S., De Bruyne, T., Pieters, L., Totte, J., Vlietinck, A.J.: Antimalarial activity of 20 crude extracts from nine African medicinal plants used in Kinshasha, Congo. J Ethnopharmacol., 68, 193-203, 1999.
22. Chawira, A.N., Warhurst, D.C.: The effect of artemisinin combined with standard antimalarials against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum in vitro. J Trop Med Hyg., 90, 1-8, 1987.
23. Chawira, A.N., Warhurst, D.C., Robinson, B.L., Peters, W.: The effect of combinations of qinghaosu (artemisisnin) with standard antimalarial drugs in the suppressive treatment of malaria in mice. Trans Royal Soc Trop Med Hyg., 81, 554-558, 1987.
24. Muregi, F.W., Chhabra, S.C., Njagi, E.N.M., Lang'at-Thoruwa, C.C., Njue, W.M., Orago, A.S.S., Omar, S.A., Ndiege, I.O.: In vitro antiplasmodial activity of some plants used in Kisii, Kenya against malaria and their chloroquine potentiation effects. J Ethnopharmacol., 84, 235-239, 2003.
25. Muregi, F.W., Chhabra, S.C., Njagi, E.N.M., Lang'at-Thoruwa, C.C., Njue, W.M., Orago, A.S.S., Omar, S.A., Ndiege, I.O.: Anti-plasmodial activity of some Kenyan medicinal plants extracts singly and in combination with chloroquine. Phytother Res., 18, 379-384, 2004.
26. Weenen, H., Nkunya, M.H.H., Bray, D.H., Mwasumbi, L.B., Kinabo, S., Kilimani, V.A.: Antimalarial Activity of Tanzanian Medicinal Plants. Planta Med., 56, 368-370, 1990.
27. Dahanukar, S.A., Kulkarni, F.A., Rege, N.N.: Pharmacology of medicinal plants and natural products. Indian J Pharmacol., 32, S81-S118, 2000.
28. Mueller, M.S., Karhagomba, I.B., Hirt, H.M., Wemakor, E.: The potential of Artemisia annua L. as a locally produced remedy for malaria in the tropics: agricultural, chemical and clinical aspects. J Ethnopharmacol., 73, 487-493, 2000.