Antiplasmodial activity of Ajuga bracteosa against Plasmodium berghei infected BALB/c mice

Indian Journal of Medical Research

Volumn 131, Issue 3, 2010, Pages 440-444

  Chandel, S ^a   Bagai, U ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

ELEAB; In vivo; Medicinal plant; Plasmodium berghei

Indexed keywords

AJUGA BRACTEOSA EXTRACT; ALCOHOL; ANTIPROTOZOAL AGENT; CHLOROQUINE; PLANT EXTRACT; PYRIMETHAMINE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; AJUGA BRACTEOSA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; DRUG SCREENING; FEMALE; LD 50; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; PHYTOCHEMISTRY; PLANT LEAF; PLASMODIUM BERGHEI INFECTION; RODENT; SURVIVAL; TOXICITY TESTING;

ADMINISTRATION, ORAL; AJUGA; ANIMALS; ANTIMALARIALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; FEMALE; MALARIA; MICE; MICE, INBRED BALB C; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; PLASMODIUM BERGHEI; TIME FACTORS;

EID: 77949688527     PISSN: 09715916     EISSN: 09715916     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Guadalupe E, Garcia L, Rodriguez JB. Current status and progress made in malaria chemotherapy. Curr Med Chem 2007; 14: 289-14.
2. Sahu NK, Sahu S, Kohli DV. Novel molecular target for antimalarial drug development. Chem Bio Drug Design 2008; 71: 287-97.
3. Basco LK, Mitaku S, Skaltsounis AL, Ravelomantosa N, Tillequin F, Koch M, et al. In vitro activities of furoquinoline and acridone alkaloids against P. falciparum. Antimicrob Agents Chemother 1994; 38: 1169-71.
4. Ibezim EC, Odo U. Current trends in malaria chemotherapy. Afr J Biotechnol 2008: 7: 349-56.
5. Ridley RG. Medical need, scientific opportunity and drive for antimalarial drug. Nature 2002; 415: 686-93.
6. Jones FA. Herbs - Useful plants. Their role in history and today. Eur J Gastroenterol Hepatol 1996; 8: 1227-31.
7. Phillipson JD, Wright CW. Can ethnopharmacology contribute to the development of antimalarial agents? J Ethnopharmacol 1991; 32: 155-65.
8. Phillipson JD. Natural products as drugs. Trans R soc trop Med Hyg 1994; 88: S17-9.
9. Klayman DL, Lin AJ, Acton N, Scovill JP, Hoch JM, Milous WK, et al. Isolation of artemisinin (quinghaosu) from Artemisia annua growing in the United States. J Nat Prod 1984; 47: 715-7.
10. Klayman DL. Quinghaosu (artemisinin): an antimalarial drug from China. Science 1985; 228: 1049-55.
11. Trigg PI. Quinghaosu (artemisinin) as an antimalarial drug. Economic and Medicinal Plant Research. London: Academic Press. 1985. p.1-56.
12. Kirtikar KR, Basu BD. Indian medicinal plants, 1st ed. Allahabad: Indian Press; 1918. p.1048.
13. Harbone JB. Phytochemical methods, In: Marquis JK, editor. A guide to modern techniques of plants analysis. London: Chapman and Hall; 1983.
14. Trease GE, Evans WC. In: Tindall B, editor. Trease and Evans Pharmacognosy. 13th ed. London: Philadelphia; 1989.
15. Lorke D. A new approach to practical acute toxicity. Toxicology 1983; 54: 275-87.
16. Knight DJ, Peters W. The antimalarial action of N-benzylox- ydihydrotriazines. The action of Cycolguanil (BRL50216) against rodent malaria and studies on its mode of action. Ann trop Med Parasitol 1980; 74: 393-404.
17. Su RB, Wei XL, Liu V, Li J. Antimalarial effect of agmantine on Plasmodium berghei L173 strain. Acta Pharmacol sin 2003: 24: 918-22.
18. Peters W. Drug resistance in Plasmodium berghei. Exp Parasitol 1965; 17: 80-9.
19. Ryley, JF, Peters W. The antimalarial activity of some quinolone esters. Am trop Med Parasitol 1970; 84: 209-22.
20. Tshibangu JN, Chifundera K, Kaminsky R, Wright AD, Konig GM. Screening of African medicinal plants for antimalarial inhibitory activity. J Ethnopharmacol 2002; 80: 25-35.
21. Philipson JD, Wright CW. Antiprotozoal compound from plant source. Planta Med 1990; 57: 553-9.
22. Kuria KA, Chepkwony H, Govaerts C, Roets E, Busson R, De Witte P, et al. The antiplasmodial activity of isolates from Ajuga remota. J Nat Prod 2002: 65: 789-93.
23. Cantrell CL, Rajab MS, Franzblau SG, Fronczek FR, Fisher NH. Antimicrobacterial ergosterol-5, 8- endoperoxide from Ajuga remota. Planta Med 1999: 68: 732-4.
24. Linares GE, Ravaschino EL, Rodriguez JB. Progresses in the field of drug design to combat tropical protozoan parasitic diseases. Curr Med Chem 2006: 13: 335-60.
25. Foley M, Tilley L. Quinoline antimalarials mechanisms of action & prospects for new agents. Pharmacol ther 1998; 79: 55-87.
26. Melendez E, Krettli AU. Effects of Levamisole on experimental infections by Plasmodium berghei in mice. Rev soc Med trop 1987; 20: 193-8.
27. Nzilla A. The past, present and future of antifolates in the treatment of Plasmodium falciparum infection. J Antimicrob Chemother 2006; 57: 1043-54.