Polymeric nanoparticle-aptamer bioconjugates can diminish the toxicity of mercury in vivo

Toxicology Letters

Volumn 208, Issue 1, 2012, Pages 69-74

  Hu, Xiangang ^a,b   Tulsieram, Kurt Lomas ^b   Zhou, Qixing ^a,c   Mu, Li ^d   Wen, Jianping ^d  

^a NANKAI UNIVERSITY   (China)

^b UNIVERSITY OF WATERLOO   (Canada)

^c INSTITUTE OF APPLIED ECOLOGY   (China)

^d TIANJIN UNIVERSITY   (China)

Author keywords

Aptamer; In vivo; Mercury; Nanoparticle; Pharmacology; Toxicity

Indexed keywords

ANTIDOTE; CREATININE; MERCURY; POLYMERIC NANOPARTICLE APTAMER BIOCONJUGATE; UNCLASSIFIED DRUG; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIODEGRADATION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG SYNTHESIS; ENZYME ACTIVITY; IN VIVO STUDY; LEARNING; LIPID PEROXIDATION; MALE; MAZE TEST; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; TASK PERFORMANCE; UREA BLOOD LEVEL; URINARY EXCRETION;

ANIMALS; ANTIDOTES; APTAMERS, NUCLEOTIDE; BRAIN; BRAIN CHEMISTRY; KIDNEY; LEARNING; MALE; MEMORY; MERCURY; METABOLIC CLEARANCE RATE; METABOLIC DETOXICATION, DRUG; NANOCONJUGATES; RANDOM ALLOCATION; RATS; RATS, WISTAR;

RATTUS;

EID: 80155187596     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.10.006     Document Type: Article

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