Transformation of structurally diverse steroidal analogues by the fungus Corynespora cassiicola CBS 161.60 results in generation of 8β- monohydroxylated metabolites with evidence in favour of 8β-hydroxylation through inverted binding in the 9α-hydroxylase

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1811, Issue 12, 2011, Pages 1054-1061

  Hunter, A Christy ^a   Rymer, Sarah Jane ^a   Dedi, Cinzia ^a   Dodd, Howard T ^a   Nwozor, Queen C ^a   Moghimi, S Moein ^b  

^a UNIVERSITY OF BRIGHTON   (United Kingdom)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

8 Hydroxylation; Androgen; Biocatalyst; Corynespora cassiicola; Dual binding region; Progestogen

Indexed keywords

16ALPHA 17ALPHA EPOXY PREGN 4 ENE 3,20 DIONE; 8BETA 17ALPHA DIHYDROXY PREGN 4 EN 3,20 DIONE; 8BETA MONOHYDROXYLATED METABOLITE; 9ALPHA 15BETA DIHYDROXY PREGN 4 EN 3,20 DIONE; 9ALPHA HYDROXYLASE; ANDROSTENEDIONE; CORTICOSTEROID DERIVATIVE; CORTODOXONE; DRUG METABOLITE; FUNGAL ENZYME; GESTONORONE; HYDROXYPROGESTERONE ACETATE; OXYGENASE; PROGESTERONE; TESTOSTERONE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BIOCATALYST; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; CORYNESPORA CASSIICOLA; CRYSTALLOGRAPHY; ENZYME ANALYSIS; EXTRACTION; FUNGUS; FUNGUS SPORE; HYDROXYLATION; INCUBATION TIME; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

ANDROGENS; ASCOMYCOTA; BINDING SITES; BIOTRANSFORMATION; CELL CULTURE TECHNIQUES; CRYSTALLOGRAPHY, X-RAY; HYDROXYLATION; INDUSTRIAL MICROBIOLOGY; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; PROGESTINS; PROTEIN BINDING; STEROID HYDROXYLASES; STEROIDS;

CORYNESPORA CASSIICOLA; FUNGI;

EID: 80155182004     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2011.09.016     Document Type: Article

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