Transformation of some 3α-substituted steroids by Aspergillus tamarii KITA reveals stereochemical restriction of steroid binding orientation in the minor hydroxylation pathway

Journal of Steroid Biochemistry and Molecular Biology

Volumn 118, Issue 3, 2010, Pages 171-176

  Christy Hunter, A ^a   Khuenl Brady, Hedda ^a   Barrett, Patrice ^a   Dodd, Howard T ^a   Dedi, Cinzia ^a  

^a UNIVERSITY OF BRIGHTON   (United Kingdom)

Author keywords

3 Steroid transformation; Aspergillus tamarii; Baeyer Villiger oxidation; Biocatalyst; Enzyme induction; Hindered hydroxylase binding

Indexed keywords

17 KETONE; 3 ALPHA ACETIC ACID; 3 ALPHA ACETOXY 5 ALPHA ANDROSTAN 17 ONE; 3 ALPHA ALCOHOL; ACETIC ACID; ANDROSTERONE; OXYGENASE; STEROID; STEROID 11BETA MONOOXYGENASE; TESTOSTERONE DERIVATIVE; UNCLASSIFIED DRUG; ANDROSTANE DERIVATIVE; STEROID MONOOXYGENASE;

ARTICLE; ASPERGILLUS; ASPERGILLUS TAMARII; BINDING SITE; BIOTRANSFORMATION; CHEMICAL STRUCTURE; CONTROLLED STUDY; FUNGAL METABOLISM; HYDROXYLATION; LACTONIZATION; NONHUMAN; OXIDATION; OXIDATION REDUCTION REACTION; STEREOCHEMISTRY; STEROID BINDING; STEROID METABOLISM; STRUCTURE ACTIVITY RELATION; TIME; BIOCATALYSIS; ENZYME SPECIFICITY; ENZYMOLOGY; INFRARED SPECTROPHOTOMETRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSIOLOGY; STEREOISOMERISM;

ASPERGILLUS TAMARII;

ANDROSTANOLS; ASPERGILLUS; BIOCATALYSIS; BIOTRANSFORMATION; HYDROXYLATION; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; SPECTROPHOTOMETRY, INFRARED; STEREOISOMERISM; STEROID 11-BETA-HYDROXYLASE; STEROID HYDROXYLASES; SUBSTRATE SPECIFICITY;

EID: 74449086578     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2009.12.003     Document Type: Article

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