-
2
-
-
0026150396
-
Selegiline: A review of its pharmacology, symptomatic benefits and protective potential in Parkinsons disease
-
Chrisp P, Mammen GJ, Sorkin EM. Selegiline: a review of its pharmacology, symptomatic benefits and protective potential in Parkinsons disease. Drugs Aging. 1991;1:228-48.
-
(1991)
Drugs Aging
, vol.1
, pp. 228-48
-
-
Chrisp, P.1
Mammen, G.J.2
Sorkin, E.M.3
-
3
-
-
12244296145
-
Rasagiline: Neurodegeneration neuroprotection, and mitochondrial permeability transition
-
DOI 10.1002/jnr.20350, Brain Energy Metabolism: Transporters, Mitochondria and Neurodegeneration
-
YoudimMB, Bar AO, Yogev-Falach Weinreb O,MaruyamaW, Naoi M, Amit T. Rasagiline: neurodegeneration, neuroprotection, and mitochondrial permeability transition. J Neurosci Res. 2005;79:172-9. (Pubitemid 40116432)
-
(2005)
Journal of Neuroscience Research
, vol.79
, Issue.1-2
, pp. 172-179
-
-
Youdim, M.B.H.1
Am, O.B.2
Yogev-Falach, M.3
Weinreb, O.4
Maruyama, W.5
Naoi, M.6
Amit, T.7
-
4
-
-
0033525427
-
Neuroprotection by pramipexole against dopamine- and levodopa-induced cytotoxicity
-
DOI 10.1016/S0024-3205(99)00062-4, PII S0024320599000624
-
Zou L, Jankovic J, Rowe DB,XieW, Appel S, LeW. Neuroprotection of pramipexole against dopamine and levodopa-induced cytotoxicity. Life Sci. 1999;64:1275-85. (Pubitemid 29156855)
-
(1999)
Life Sciences
, vol.64
, Issue.15
, pp. 1275-1285
-
-
Zou, L.1
Jankovic, J.2
Rowe, D.B.3
Xie, W.4
Appel, S.H.5
Le, W.6
-
5
-
-
0031594295
-
10 attenuates the 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice
-
DOI 10.1016/S0006-8993(97)01192-X, PII S000689939701192X
-
Beal MF, Matthews RT, Tieleman A, Shults CW. Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic neurons in aged mice. Brain Res. 1998;783:109-114. (Pubitemid 28131427)
-
(1998)
Brain Research
, vol.783
, Issue.1
, pp. 109-114
-
-
Beal, M.F.1
Matthews, R.T.2
Tieleman, A.3
Shults, C.W.4
-
6
-
-
0024456653
-
Effect of deprenyl on the progression of disability in early Parkinsons disease
-
The Parkinson Study Group Nov 16
-
The Parkinson Study Group. Effect of deprenyl on the progression of disability in early Parkinsons disease. N Engl J Med. 1989 Nov 16;321(20):1364-71.
-
(1989)
N Engl J Med
, vol.321
, Issue.20
, pp. 1364-71
-
-
-
7
-
-
0027530638
-
Effects of tocopherol and deprenyl on the progression of disability in early Parkinsons disease
-
The Parkinsons Study Group
-
The Parkinsons Study Group. Effects of tocopherol and deprenyl on the progression of disability in early Parkinsons disease. N Engl J Med. 1993:328;176-83.
-
(1993)
N Engl J Med
, vol.328
, pp. 176-83
-
-
-
8
-
-
0030042620
-
Impact of deprenyl and tocopherol treatment on Parkinsons disease in DATATOP subjects not requiring levodopa
-
The Parkinsons Study Group
-
The Parkinsons Study Group. Impact of deprenyl and tocopherol treatment on Parkinsons disease in DATATOP subjects not requiring levodopa. Ann Neurol. 1996;39:29-36.
-
(1996)
Ann Neurol
, vol.39
, pp. 29-36
-
-
-
9
-
-
9044226896
-
Impact of deprenyl and tocopherol treatment on Parkinsons disease in DATATOP subjects requiring levodopa
-
The Parkinsons Study Group
-
The Parkinsons Study Group. Impact of deprenyl and tocopherol treatment on Parkinsons disease in DATATOP subjects requiring levodopa. Ann Neurol. 1996:39:37-45.
-
(1996)
Ann Neurol
, vol.39
, pp. 37-45
-
-
-
10
-
-
33646686620
-
Selegiline slows the progression of the symptoms of Parkinson disease
-
DOI 10.1212/01.wnl.0000204007.46190.54, PII 0000611420060425000016
-
Palhagen S, Heinonen E, Hägglund J, Kaugesaar T,Mäki-Ikola O, Palm R; Swedish Parkinson Study Group. Selegiline slows the progression of the symptoms Parkinsons disease. Neurology. 2006;66:1200-06. (Pubitemid 43739704)
-
(2006)
Neurology
, vol.66
, Issue.8
, pp. 1200-1206
-
-
Palhagen, S.1
Heinonen, E.2
Hagglund, J.3
Kaugesaar, T.4
Maki-Ikola, O.5
Palm, R.6
-
11
-
-
0030865454
-
Slowing the progression of Alzheimer disease: Methodologic issues
-
Leber P. Slowing the progression of Alzheimers disease: methodological issues. AlzheimerDis AssocDis. 1997;11 Suppl 5:S10-21. (Pubitemid 27472532)
-
(1997)
Alzheimer Disease and Associated Disorders
, vol.11
, Issue.SUPPL. 5
-
-
Leber, P.1
-
12
-
-
0024343466
-
The effect of deprenyl (selegiline) on the natural history of Parkinson's disease
-
Tetrud JW, Langston JW. The effect of deprenyl (selegiline) on the natural history of Parkinsons disease. Science. 1989;245:519-22. (Pubitemid 19204003)
-
(1989)
Science
, vol.245
, Issue.4917
, pp. 519-522
-
-
Tetrud, J.W.1
Langston, J.W.2
-
13
-
-
61949280270
-
Disease modification trials in Parkinsons disease: Target populations, endpoints and study design
-
Rascol O. Disease modification trials in Parkinsons disease: target populations, endpoints and study design. Neurology. 2009:72:S51-8.
-
(2009)
Neurology
, vol.72
-
-
Rascol, O.1
-
14
-
-
0036894795
-
A controlled trial of rasagiline in early Parkinson disease: The TEMPO study
-
The Parkinson Study Group
-
The Parkinson Study Group. A controlled trial of rasagiline in early Parkinson disease: The TEMPO study. Arch Neurol. 2002;59:1937-43.
-
(2002)
Arch Neurol
, vol.59
, pp. 1937-43
-
-
-
15
-
-
2342655732
-
A controlled, randomized, delayed start study of rasagiline in early Parkinson disease
-
The Parkinson Study Group
-
The Parkinson Study Group. A controlled, randomized, delayed start study of rasagiline in early Parkinson disease. Arch Neurol. 2004;61:561-6.
-
(2004)
Arch Neurol
, vol.61
, pp. 561-6
-
-
-
16
-
-
67651165337
-
Long-term outcome of early versus delayed rasagiline treatment in early Parkinsons disease
-
On behalf of the TEMPO Open-label Study Group
-
Hauser RA, LewMF, Hurtig HI, Ondo W,Wojcieszek J, Fitzer-Attas CJ, on behalf of the TEMPO Open-label Study Group. Long-term outcome of early versus delayed rasagiline treatment in early Parkinsons disease. Mov Disord. 2009;24:564-73.
-
(2009)
Mov Disord
, vol.24
, pp. 564-73
-
-
Hauser, R.A.1
Lew, M.F.2
Hurtig, H.I.3
Ondo, W.4
Wojcieszek, J.5
Fitzer-Attas, C.J.6
-
17
-
-
70349456475
-
A double-blind, delayed-start trial of rasagiline in Parkinsons disease
-
For the ADAGIO Study Investigators
-
Olanow CW, Rascol O, Hauser R, Feigin PD, Jankovic J, Lang A, Langston W, Melamed E, Poewe W, Stocchi F, Tolosa E, for the ADAGIO Study Investigators. A double-blind, delayed-start trial of rasagiline in Parkinsons disease. N Engl J Med. 2009;361:1268-78.
-
(2009)
N Engl J Med
, vol.361
, pp. 1268-78
-
-
Olanow, C.W.1
Rascol, O.2
Hauser, R.3
Feigin, P.D.4
Jankovic, J.5
Lang, A.6
Langston, W.7
Melamed, E.8
Poewe, W.9
Stocchi, F.10
Tolosa, E.11
-
18
-
-
77955831301
-
Rationale for delayed-start study of pramipexole in Parkinsons disease: The PROUD study
-
Aug 15
-
Schapira AH, Albrecht S, Barone P, Comella CL, McDermott MP, Mizuno Y, Poewe W, Rascol O, Marek K. Rationale for delayed-start study of pramipexole in Parkinsons disease: the PROUD study. Mov Disord. 2010 Aug 15;25(11):1627-32.
-
(2010)
Mov Disord.
, vol.25
, Issue.11
, pp. 1627-32
-
-
Schapira, A.H.1
Albrecht, S.2
Barone, P.3
Comella, C.L.4
McDermott, M.P.5
Mizuno, Y.6
Poewe, W.7
Rascol, O.8
Marek, K.9
-
19
-
-
85055805094
-
Immediate vs. delayed start pramipexole in early Parkinsons disease: The PROUD Study (poster 1.278)
-
on behalf of the PROUDStudy Group Dec 13-16; Miami, FL
-
Schapira AH, Albrecht S, Barone P, Comella CL, McDermott MP, Mizuno Y, Poewe W, Rascol O,Marek K, on behalf of the PROUDStudy Group. Immediate vs. delayed start pramipexole in early Parkinsons disease: the PROUD Study (poster 1.278). Poster session presented at: WFN XVIII World Congress on Parkinsons Disease and Related Disorders; 2009 Dec 1316; Miami, FL.
-
(2009)
WFN XVIII World Congress on Parkinsons Disease and Related Disorders
-
-
Schapira, A.H.1
Albrecht, S.2
Barone, P.3
Comella, C.L.4
McDermott, M.P.5
Mizuno, Y.6
Poewe, W.7
Rascol, O.8
Marek, K.9
-
20
-
-
19744378296
-
Levodopa and the progression of Parkinsons disease
-
The Parkinson Study Group
-
The Parkinson Study Group. Levodopa and the progression of Parkinsons disease. N Engl J Med. 2004;351:2498-508.
-
(2004)
N Engl J Med
, vol.351
, pp. 2498-508
-
-
-
21
-
-
26444597591
-
Does levodopa slow or hasten the rate of progression of Parkinsons disease?
-
The Parkinson Study Group
-
Fahn S; The Parkinson Study Group. Does levodopa slow or hasten the rate of progression of Parkinsons disease? J Neurol. 2005;252 Suppl 4: IV/37-42.
-
(2005)
J Neurol
, vol.252
, Issue.SUPPL. 4
-
-
Fahn, S.1
-
22
-
-
0024848034
-
Abnormalities of the electron transport chain in idiopathic Parkinson's disease
-
DOI 10.1002/ana.410260606
-
Parker WJ Jr, Boyson SJ, Parks JK. Abnormalities of the electron transport chain in idiopathic Parkinsons disease. Ann Neurol. 1989;26:719-23. (Pubitemid 20011004)
-
(1989)
Annals of Neurology
, vol.26
, Issue.6
, pp. 719-723
-
-
Parker Jr., W.D.1
Boyson, S.J.2
Parks, J.K.3
-
23
-
-
0026484964
-
Platelet mitochondrial function in Parkinsons disease
-
Kridge D, Carroll MT, Cooper JM, Marsden CD, Schapira AHV. Platelet mitochondrial function in Parkinsons disease. Ann Neurol. 1992;32:782-8.
-
(1992)
Ann Neurol
, vol.32
, pp. 782-8
-
-
Kridge, D.1
Carroll, M.T.2
Cooper, J.M.3
Marsden, C.D.4
Schapira, A.H.V.5
-
24
-
-
0030612117
-
10 levels correlate with the activities of complexes I and II/III in mitochondria from Parkinsonian and nonparkinsonian subjects
-
DOI 10.1002/ana.410420221
-
Shults CW, Haas RH, Passov D, Beal MF. Coenzyme Q10 levels correlate with activities of complexes I and II/III in mitochondria from parkinsonian and non-parkinsonian subjects. Ann Neurol. 1997;42:261-4. (Pubitemid 27340475)
-
(1997)
Annals of Neurology
, vol.42
, Issue.2
, pp. 261-264
-
-
Shults, C.W.1
Haas, R.H.2
Passov, D.3
Beal, M.F.4
-
25
-
-
0036771852
-
The Parkinson Study Group. Effects of Coenzyme Q10 in early Parkinsons disease: Evidence of slowing the functional decline
-
Schults C, Oakes D, Kieburtz K, Beal MF, Haas R, Plumb S, Juncos JL, Nutt J, Shoulson I, Carter J, Kompoliti K, Perlmutter JS, Reich S, Stern M, Watts RL, Kurlan R, Molho E, Harrison M, Lew M; The Parkinson Study Group. Effects of Coenzyme Q10 in early Parkinsons disease: evidence of slowing the functional decline. Arch Neurol. 2002;59:1541-50.
-
(2002)
Arch Neurol
, vol.59
, pp. 1541-50
-
-
Schults, C.1
Oakes, D.2
Kieburtz, K.3
Beal, M.F.4
Haas, R.5
Plumb, S.6
Juncos, J.L.7
Nutt, J.8
Shoulson, I.9
Carter, J.10
Kompoliti, K.11
Perlmutter, J.S.12
Reich, S.13
Stern, M.14
Watts, R.L.15
Kurlan, R.16
Molho, E.17
Harrison, M.18
Lew, M.19
-
28
-
-
33645894705
-
A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease
-
NINDS NET-PD Investigators Mar 14
-
NINDS NET-PD Investigators. A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease. Neurology. 2006 Mar 14;66(5):664-71.
-
(2006)
Neurology
, vol.66
, Issue.5
, pp. 664-71
-
-
-
29
-
-
33846115045
-
A randomized clinical trial of Coenzyme Q10 and GPI-1485 in early Parkinson disease
-
NINDS NET-PD Investigators Jan 2
-
NINDS NET-PD Investigators. A randomized clinical trial of Coenzyme Q10 and GPI-1485 in early Parkinson disease. Neurology. 2007 Jan 2;68(1):20-28.
-
(2007)
Neurology
, vol.68
, Issue.1
, pp. 20-28
-
-
-
30
-
-
84864604061
-
-
NINDS NET-PD Investigators Bethesda (MD): National Institutes of Health (NIH) Neurological Institute. 2011 Sept 22
-
NINDS NET-PD Investigators. NET-PD LS-1 creatine in Parkinsons disease Internet.. Bethesda (MD): National Institutes of Health (NIH) Neurological Institute. 2011 Sept 22.. Available from: http://www.ninds.nih.gov/disorders/ clinical trials/NCT00449865.htm.
-
NET-PD LS-1 Creatine in Parkinsons Disease Internet
-
-
-
31
-
-
3242795769
-
Exercise-induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse basal ganglia
-
DOI 10.1002/jnr.20162
-
Fisher BE, Petzinger GM, Nixon K, Hogg E, Bremmer S, Meshul C, Jakowec MW. Exercise-induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-lesioned mouse basal ganglia. J Neurosci Res. 2004;77:378-90. (Pubitemid 38970982)
-
(2004)
Journal of Neuroscience Research
, vol.77
, Issue.3
, pp. 378-390
-
-
Fisher, B.E.1
Petzinger, G.M.2
Nixon, K.3
Hogg, E.4
Bremmer, S.5
Meshul, C.K.6
Jakowec, M.W.7
-
32
-
-
45849121443
-
The effect of exercise training in improving motor performance and corticomotor excitability in people with early parkinson's disease
-
DOI 10.1016/j.apmr.2008.01.013, PII S0003999308002359
-
Fisher BE,Wu AD, Salem GJ, Song J, Lin J, Yip J, Cen S, Gordon J, Jakowec M, Petzinger G. The effect of exercise training in improving motor performance and corticomotor excitability in people with early Parkinsons disease. Arch Phys Med Rehabil. 2008 Jul;89(7):1221-29. (Pubitemid 351884995)
-
(2008)
Archives of Physical Medicine and Rehabilitation
, vol.89
, Issue.7
, pp. 1221-1229
-
-
Fisher, B.E.1
Wu, A.D.2
Salem, G.J.3
Song, J.4
Lin, C.-H.J.5
Yip, J.6
Cen, S.7
Gordon, J.8
Jakowec, M.9
Petzinger, G.10
-
33
-
-
77953404135
-
Enhancing neuroplasticity in the basal ganglia: The role of exercise in Parkinsons disease
-
Petzinger GM, Fisher BE, Van Leeuwen JE, Vukovic M, Akopian G, Meshul CK, Holschneider DP, Nacca A, Walsh J, Jakowec MJ. Enhancing neuroplasticity in the basal ganglia: the role of exercise in Parkinsons disease. Mov Disord. 2010;25 Suppl 1:S141-5.
-
(2010)
Mov Disord
, vol.25
, Issue.SUPPL. 1
-
-
Petzinger, G.M.1
Fisher, B.E.2
Van Leeuwen, J.E.3
Vukovic, M.4
Akopian, G.5
Meshul, C.K.6
Holschneider, D.P.7
Nacca, A.8
Walsh, J.9
Jakowec, M.J.10
-
34
-
-
34347359673
-
'Rejuvenation' protects neurons in mouse models of Parkinson's disease
-
DOI 10.1038/nature05865, PII NATURE05865
-
Chan CS, Guzman JN, Ilijic E, Mercer JN, Rick C, Tkatch T, Meredith GE, Surmeier DJ. Rejuvenation protects neurons in mouse models of Parkinsons disease. Nature. 2007;447:1081-6. (Pubitemid 47014425)
-
(2007)
Nature
, vol.447
, Issue.7148
, pp. 1081-1086
-
-
Chan, C.S.1
Guzman, J.N.2
Ilijic, E.3
Mercer, J.N.4
Rick, C.5
Tkatch, T.6
Meredith, G.E.7
Surmeier, D.J.8
-
35
-
-
77953447144
-
A molecular basis for the increased vulnerability of substantia nigra dopamine neurons in aging and Parkinsons disease
-
Chan CS, Gertler TS, Surmeier DJ. A molecular basis for the increased vulnerability of substantia nigra dopamine neurons in aging and Parkinsons disease. Mov Disord. 2010;25 Suppl 1:S63-70.
-
(2010)
Mov Disord
, vol.25
, Issue.SUPPL. 1
-
-
Chan, C.S.1
Gertler, T.S.2
Surmeier, D.J.3
-
36
-
-
84864596348
-
-
The Parkinson Study Group Fox Foundation for Parkinsons Research and Northwestern University; Simuni T. Safety, tolerability and efficacy assessment of Dynacirc CR in Parkinsons disease (STEADYPD) Internet.. Bethesda (MD): National Institutes of Health (NIH) 2009-2011 Sept 22
-
The Parkinson Study Group; Michael J; Fox Foundation for Parkinsons Research and Northwestern University; Simuni T. Safety, tolerability and efficacy assessment of Dynacirc CR in Parkinsons disease (STEADYPD) Internet.. Bethesda (MD): National Institutes of Health (NIH).2009-2011 Sept 22.. Available from: http://clinicaltrials.gov/ct2/show?term=isradipine&rank=2.
-
-
-
Michael, J.1
-
37
-
-
84864590458
-
-
Fox Foundation for Parkinsons Research Bethesda (MD): National Institutes of Health (NIH) 2009 -2011 Sept 22
-
Schwarzschild M, Michael J; Fox Foundation for Parkinsons Research. Safety of urate elevation in Parkinsons disease (SURE-PD) Internet.. Bethesda (MD): National Institutes of Health (NIH).2009 -2011 Sept 22.. Available from: http://www.pdtrials.org/en/browse/all/view/259.
-
Safety of Urate Elevation in Parkinsons Disease (SURE-PD) Internet
-
-
Schwarzschild, M.1
Michael, J.2
-
38
-
-
4344648152
-
Biomarkers of antioxidant capacity in the hydrophilic and lipophilic compartments of human plasma
-
DOI 10.1016/j.abb.2004.03.006, PII S000398610400147X
-
Yeum KJ, Russell RM, Krinsky NI, Aldini G. Biomarkers of antioxidant capacity in the hydrophilic and lipophilic compartments of human plasma. Arch Biochem Biophys. 2004;430:97-103. (Pubitemid 39119784)
-
(2004)
Archives of Biochemistry and Biophysics
, vol.430
, Issue.1
, pp. 97-103
-
-
Yeum, K.-J.1
Russell, R.M.2
Krinsky, N.I.3
Aldini, G.4
-
39
-
-
80155124532
-
Urate attenuates MPTPinduced dopaminergic neurotoxicity in mice [abstract no.797.8]
-
Nov 3-7; San Diego, CA
-
Luo W, Schwarzschild MA, Xu K. Urate attenuates MPTPinduced dopaminergic neurotoxicity in mice [abstract no.797.8]. Paper presented at: Annual Meeting of the Society for Neuroscience; 2007 Nov 3-7; San Diego, CA.
-
(2007)
Annual Meeting of the Society for Neuroscience
-
-
Luo, W.1
Schwarzschild, M.A.2
Xu, K.3
-
40
-
-
34548021226
-
Plasma urate and risk of Parkinson's disease
-
DOI 10.1093/aje/kwm127
-
Weisskopf MG, OReilly E, Chen H, Schwarzschild MA, Ascherio A. Plasma urate and risk of Parkinsons disease. Am J Epidemiol. 2007;166:561-7. (Pubitemid 47283643)
-
(2007)
American Journal of Epidemiology
, vol.166
, Issue.5
, pp. 561-567
-
-
Weisskopf, M.G.1
O'Reilly, E.2
Chen, H.3
Schwarzschild, M.A.4
Ascherio, A.5
|