Enhancing neuroplasticity in the basal ganglia: The role of exercise in Parkinson's disease

Movement Disorders

Volumn 25, Issue SUPPL. 1, 2010, Pages

  Petzinger, Giselle M ^a,b   Fisher, Beth E ^b   Van Leeuwen, Jon Eric ^a   Vukovic, Marta ^a   Akopian, Garnik ^c   Meshul, Charlie K ^d   Holschneider, Daniel P ^a   Nacca, Angelo ^a   Walsh, John P ^c   Jakowec, Michael W ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Animal models; Dopamine; Electrophysiology; Glutamate; MPTP; PET imaging; Treadmill

Indexed keywords

ARTICLE; BASAL GANGLION; BRAIN ELECTROPHYSIOLOGY; CLINICAL TRIAL; DOPAMINERGIC TRANSMISSION; EXERCISE; HUMAN; NERVE CELL PLASTICITY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; METABOLISM; PATHOLOGY; PHYSIOLOGY; SENSITIVITY AND SPECIFICITY;

DOPAMINE;

BASAL GANGLIA; DOPAMINE; EXERCISE; HUMANS; NEURONAL PLASTICITY; PARKINSON DISEASE; SENSITIVITY AND SPECIFICITY;

EID: 77953404135     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.22782     Document Type: Article

References (46)

1. Miyai I, Fujimoto Y, Yamamoto H, et al. Long-term effect of body weight-supported treadmill training in Parkinson's disease: a randomized controlled trial. Arch Phys Med Rehabil 2002; 83: 1370-1373.
2. Schenkman M, Cutson TM, Kuchibhatla M, et al. Exercise to improve spinal flexibility and function for people with Parkinson's disease: a randomized, controlled trial. J Am Geriatr Soc 1998; 46: 1207-1216.
3. Comella CL, Stebbins GT, Brown-Toms N, Goetz CG. Physical therapy and Parkinson's disease: a controlled clinical trial. Neurology 1994; 44: 376-378.
4. Toole T, Maitland CG, Warren E, Hubmann MF, Panton L. The effects of loading and unloading treadmill walking on balance, gait, fall risk, and daily function in Parkinsonism. NeuroRehabilitation 2005; 20: 307-322.
5. Adkins DL, Boychuk J, Remple MS, Kleim JA. Motor training induces experience-specific patterns of plasticity across motor cortex and spinal cord. J Appl Physiol 2006; 101: 1776-1782.
6. Will B, Galani R, Kelche C, Rosenzweig MR. Recovery from brain injury in animals: relative efficacy of environmental enrichment, physical exercise or formal training (1990-2002). Prog Neurobiol 2004; 72: 167-182.
7. Fisher B, Sullivan KJ. Activity-dependent factors affecting post-stroke functional outcomes. Top Stroke Rehabil 2001; 8: 31-44.
8. Winstein CJ, Grafton ST, Pohl PS. Motor task difficulty and brain activity: investigation of goal-directed reciprocal aiming using positron emission tomography. J Neurophysiol 1997; 77: 1581-1594.
9. Johansen-Berg H, Dawes H, Guy C, Smith SM, Wade DT, Matthews PM. Correlation between motor improvements and altered fMRI activity after rehabilitative therapy. Brain 2002; 125: 2731-2742.
10. Wittenberg GF, Chen R, Ishii K, et al. Constraint-induced therapy in stroke: magnetic-stimulation motor maps and cerebral activation. Neurorehabil Neural Repair 2003; 17: 48-57.
11. Dobkin BH, Firestine A, West M, Saremi K, Woods R. Ankle dorsiflexion as an fMRI paradigm to assay motor control for walking during rehabilitation. Neuroimage 2004; 23: 370-381.
12. Forrester LW, Hanley DF, Macko RF. Effects of treadmill exercise on transcranial magnetic stimulation-induced excitability to quadriceps after stroke. Arch Phys Med Rehabil 2006; 87: 229-234.
13. Liepert J. Motor cortex excitability in stroke before and after constraint-induced movement therapy. Cogn Behav Neurol 2006; 19: 41-47.
14. Liepert J, Bauder H, Wolfgang HR, Miltner WH, Taub E, Weiller C. Treatment-induced cortical reorganization after stroke in humans. Stroke 2000; 31: 1210-1216.
15. Jones TA, Chu CJ, Grande LA, Gregory AD. Motor skills training enhances lesion-induced structural plasticity in the motor cortex of adult rats. J Neurosci 1999; 19: 10153-10163.
16. Friel KM, Nudo RJ. Recovery of motor function after focal cortical injury in primates: compensatory movement patterns used during rehabilitative training. Somatosens Mot Res 1998; 15: 173-189.
17. Tillakaratne NJ, de Leon RD, Hoang TX, Roy RR, Edgerton VR, Tobin AJ. Use-dependent modulation of inhibitory capacity in the feline lumbar spinal cord. J Neurosci 2002; 22: 3130-3143.
18. de Leon RD, London NJ, Roy RR, Edgerton VR. Failure analysis of stepping in adult spinal cats. Prog Brain Res 1999; 123: 341-348.
19. Fisher BE, Petzinger GM, Nixon K, et al. Exercise-induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-lesioned mouse basal ganglia. J Neurosci Res 2004; 77: 378-390.
20. Petzinger GM, Walsh JP, Akopian G, et al. Effects of treadmill exercise on dopaminergic transmission in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-lesioned mouse model of basal ganglia injury. J Neurosci 2007; 27: 5291-5300.
21. Tillerson JL, Cohen AD, Philhower J, Miller GW, Zigmond MJ, Schallert T. Forced limb-use effects on the behavioral and neurochemical effects of 6-hydroxydopamine. J Neurosci 2001; 21: 4427-4435.
22. Bouyer JJ, Park DH, Joh TH, Pickel VM. Chemical and structural analysis of the relation between cortical inputs and tyrosine hydroxylase-containing terminals in rat neostriatum. Brain Res 1984; 302: 267-275.
23. Freund TF, Powell JF, Smith AD. Tyrosine hydroxylase-immunoreactive boutons in synaptic contact with identified striatonigral neurons, with particular reference to dendritic spines. Neuroscience 1984; 13: 1189-1215.
24. Neely MD, Schmidt DE, Deutch AY. Cortical regulation of dopamine depletion-induced dendritic spine loss in striatal medium spiny neurons. Neuroscience 2007; 149: 457-464.
25. Cepeda C, Hurst RS, Altemuis KL, et al. Facilitated glutamatergic transmission in the striatum of D2 dopamine receptor-deficient mice. J Neurophysiol 2001; 85: 659-670.
26. Schwarting RK, Huston JP. The unilateral 6-hydroxydopamine lesion model in behavioral brain research. Analysis of functional deficits, recovery and treatments. Prog Neurobiol 1996; 20: 275-331.
27. Meshul CK, Emre N, Nakamura CM, Allen C, Donohue MK, Buckman JF. Time-dependent changes in striatal glutamate synapses following a 6-hydroxydopamine lesion. Neuroscience 1999; 88: 1-16.
28. Mortensen OV, Amara SG. Dynamic regulation of the dopamine transporter. Eur J Pharmacol 2003; 479: 159-170.
29. Gerfen CR, Keefe KA, Gauda EB. D1 and D2 dopamine receptor function in the striatum: coactivation of D1- and D2-dopamine receptors on separate populations of neurons results in potentiated immediate early gene responses in D1-containing neurons. J Neurosci 1995; 15: 8167-8176.
30. LaHoste GJ, Yu J, Marshall JF. Striatal Fos expression is indicative of dopamine D1/D2 synergism and receptor supersensitivity. Proc Natl Acad Sci USA 1993; 90: 7451-7455.
31. Van Leeuwen JE, Petzinger GM, Walsh JP, et al. Altered AMPA receptor expression with treadmill exercise in the 1-methyl-4-phenyl-1, 2, 3, 4-tetrahydropyridine-lesioned mouse model of basal ganglia injury. J Neurosci Res (in press).
32. Isaac JT, Ashby M, McBain CJ. The role of the gluR2 subunit in AMPA receptor function and synaptic plasticity. Neuron 2007; 54: 859-871.
33. Esteban JA. Intracellular machinery for the transport of AMPA receptors. Br J Pharmacol 2007; 153 ( Suppl): S35-S43.
34. Hollmann M, Hartley M, Heinemann S. Ca2+ permeability of KA-AMPA-gated glutamate receptor channels depends on subunit composition. Science 1991; 252: 851-853.
35. Bernard V, Somogyi P, Bolam JP. Cellular, subcellular, and subsynaptic distribution of AMPA-type glutamate receptor subunits in the neostriatum of the rat. J Neurosci 1997; 17: 819-833.
36. Liu SJ, Cull-Candy SG. Activity-dependent change in AMPA receptor properties in cerebellar stellate cells. J Neurosci 2002; 22: 3881-3889.
37. Gardner SM, Takamiya K, Xia J, et al. Calcium-permeable AMPA receptor plasticity is mediated by subunit-specific interactions with PICK1 and NSF. Neuron 2005; 45: 903-915.
38. Seidenman KJ, Steinberg JP, Huganir R, Malinow R. Glutamate receptor subunit 2 Serine 880 phosphorylation modulates synaptic transmission and mediates plasticity in CA1 pyramidal cells. J Neurosci 2003; 23: 9220-9228.
39. Geiger JR, Melcher T, Koh DS, et al. Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS. Neuron 1995; 15: 193-204.
40. Jiang J, Suppiramaniam V, Wooten MW. Posttranslational modifications and receptor-associated proteins in AMPA receptor trafficking and synaptic plasticity. Neurosignals 2007; 15: 266-282.
41. Yang J, Sadler TR, Givrad TK, Maarek JM, Holschneider DP. Changes in brain functional activation during resting and locomotor states after unilateral nigrostriatal damage in rats. Neuroimage 2007; 36: 755-773.
42. Cantello R, Gianelli M, Bettucci D, Civardi C, De Angelis MS, Mutani R. Parkinson's disease rigidity: magnetic motor evoked potentials in a small hand muscle. Neurology 1991; 41: 1449-1456.
43. Valls-Sole J, Pascual-Leone A, Brasil-Neto JP, Cammarota A, McShane L, Hallett M. Abnormal facilitation of the response to transcranial magnetic stimulation in patients with Parkinson's disease. Neurology 1994; 44: 735-741.
44. Cantello R, Gianelli M, Civardi C, Mutani R. Magnetic brain stimulation: the silent period after the motor evoked potential. Neurology 1992; 42: 1951-1959.
45. Strafella AP, Valzania F, Nassetti SA, et al. Effects of chronic levodopa and pergolide treatment on cortical excitability in patients with Parkinson's disease: a transcranial magnetic stimulation study. Clin Neurophysiol 2000; 111: 1198-1202.
46. Young MS, Triggs WJ, Bowers D, Greer M, Friedman WA. Stereotactic pallidotomy lengthens the transcranial magnetic cortical stimulation silent period in Parkinson's disease. Neurology 1997; 49: 1278-1283.