Siderite (FeCO 3) and magnetite (Fe 3O 4) overload-dependent pulmonary toxicity is determined by the poorly soluble particle not the iron content

Inhalation Toxicology

Volumn 23, Issue 13, 2011, Pages 763-783

  Pauluhn, Jürgen ^a   Wiemann, Martin ^b  

^a BAYER PHARMA AG   (Germany)

^b IBE R and D gGmbH   (Germany)

Author keywords

Disposition; Insoluble particles; Iron; Lung overload; Magnetite; Oxidative stress; Particle clearance; Pulmonary and extrapulmonary toxicity; Repeated inhalation exposure; Siderite

Indexed keywords

8 HYDROXYGUANINE; CARBONIC ACID DERIVATIVE; FERRIC CARBONATE; IRON; IRON OXIDE; MAGNETITE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BREATHING PATTERN; BREATHING RATE; BRONCHIOLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOCYTOSIS; EXPOSURE; LIPID PEROXIDATION; LUNG ALVEOLUS EPITHELIUM; LUNG ALVEOLUS MACROPHAGE; LUNG LAVAGE; LUNG TOXICITY; LUNG WEIGHT; LYMPH NODE; MALE; MODEL; MOLECULAR WEIGHT; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PARTICLE SIZE; PLETHYSMOGRAPHY; PNEUMONIA; PRIORITY JOURNAL; RAT; SOLUBILITY; TIDAL VOLUME;

ANIMALS; BRONCHOALVEOLAR LAVAGE; CARBONATES; EPITHELIAL CELLS; FERRIC COMPOUNDS; FERRITINS; FERUMOXYTOL; GUANINE; HEME OXYGENASE-1; IRON; LIPID PEROXIDATION; LYMPH NODES; MALE; NEUTROPHILS; PNEUMONIA; RATS; RATS, WISTAR; SOLUBILITY; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

RATTUS;

EID: 80155174961     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958378.2011.606431     Document Type: Article

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