Mitochondrial targeting liposomes incorporating daunorubicin and quinacrine for treatment of relapsed breast cancer arising from cancer stem cells

Biomaterials

Volumn 33, Issue 2, 2012, Pages 565-582

  Zhang, Liang ^a   Yao, Hong Juan ^a   Yu, Yang ^a   Zhang, Yan ^a   Li, Ruo Jing ^a   Ju, Rui Jun ^a   Wang, Xiao Xing ^a   Sun, Meng Ge ^a   Shi, Ji Feng ^a   Lu, Wan Liang ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Apoptosis; Breast cancer stem cells; Mitochondrial signaling pathway; Mitochondrial targeting daunorubicin plus quinacrine liposomes; Relapse of breast cancer

Indexed keywords

BREAST CANCER; BREAST CANCER STEM CELLS; CANCER CELLS; CANCER STEM CELLS; CASPASES; CYTOCHROME C; DAUNORUBICIN; IN-VITRO; MAMMOSPHERES; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; MITOCHONDRIAL SIGNALING PATHWAY; MITOCHONDRIAL TARGETING DAUNORUBICIN PLUS QUINACRINE LIPOSOMES; NEW STRATEGY; RELAPSE OF BREAST CANCER;

CELL DEATH; CELL MEMBRANES; CHEMOTHERAPY; ENZYME INHIBITION; LIPOSOMES; MAMMALS; MITOCHONDRIA; PHOSPHOLIPIDS; STEM CELLS; TUMORS;

DISEASES;

CASPASE 3; CASPASE 9; CYTOCHROME C; DAUNORUBICIN; LIPOSOME; MEPACRINE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PROTEIN BAX;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER RELAPSE; CANCER STEM CELL; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME MECHANISM; FEMALE; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR XENOGRAFT;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BREAST NEOPLASMS; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CYTOCHROMES C; DAUNORUBICIN; FEMALE; HUMANS; LIPOSOMES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, SCID; MITOCHONDRIA; NEOPLASM RECURRENCE, LOCAL; NEOPLASTIC STEM CELLS; QUINACRINE;

MUS;

EID: 80055109899     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.09.055     Document Type: Article

References (43)

1. Morrison B.J., Schmidt C.W., Lakhani S.R., Reynolds B.A., Lopez J.A. Breast cancer stem cells: implications for therapy of breast cancer. Breast Cancer Res 2008, 10(4):1-14.
2. Chuthapisith S., Eremin J., El-Sheemey M., Eremin O. Breast cancer chemoresistance: emerging importance of cancer stem cells. Surg Oncol 2010, 19(1):27-32.
3. Nishizuka S. Profiling cancer stem cells using protein array technology. Eur J Cancer 2006, 42(9):1273-1282.
4. Green D.R., Reed J.C. Mitochondria and apoptosis. Science 1998, 281(5381):1309-1312.
5. Liang G.W., Lu W.L., Wu J.W., Zhao J.H., Hong H.Y., Long C., et al. Enhanced therapeutic effects on the multi-drug resistant human leukemia cells in vitro and xenograft in mice using the stealthy liposomal vincristine plus quinacrine. Fundam Clin Pharmacol 2008, 22(4):429-437.
6. Fasanmade A.A., Owuor E.D., Ee R.P., Qato D., Heller M., Kong A.N. Quinacrine induces cytochrome c-dependent apoptotic signaling in human cervical carcinoma cells. Arch Pharm Res 2001, 24(2):126-135.
7. Schneider Berlin K.R., Ammini C.V., Rowe T.C. Dequalinium induces a selective depletion of mitochondrial DNA from HeLa human cervical carcinoma cells. Exp Cell Res 1998, 245(1):137-145.
8. Zhang Y., Li R.J., Ying X., Tian W., Yao H.J., Men Y., et al. Targeting therapy with mitosomal daunorubicin plus amlodipine has the potential to circumvent intrinsic resistant breast cancer. Mol Pharmacol 2011, 8(1):162-175.
9. Wang X.X., Li Y.B., Yao H.J., Ju R.J., Zhang Y., Li R.J., et al. The use of mitochondrial targeting resveratrol liposomes modified with a dequalinium polyethylene glycol-distearoylphosphatidyl ethanolamine conjugate to induce apoptosis in resistant lung cancer cells. Biomaterials 2011, 32(24):5673-5687.
10. Lin Y.Y., Li J.J., Chang C.H., Lu Y.C., Hwang J.J., Tseng Y.L., et al. Evaluation of pharmacokinetics of 111 ln-labeled VNB-PEGylated liposomes after intraperitoneal and intravenous administration in a tumor/ascites mouse model. Cancer Biother Radiopharm 2009, 24(4):453-460.
11. Liu Y., Lu W.L., Guo J., Du J., Li T., Wu J.W., et al. A potential target associated with both cancer and cancer stem cells: a combination therapy for eradication of breast cancer using vinorelbine stealthy liposomes plus parthenolide stealthy liposomes. J Control Release 2008, 129(1):18-25.
12. Li R.J., Ying X., Zhang Y., Ju R.J., Wang X.X., Yao H.J., et al. All-trans retinoic acid stealth liposomes prevent the relapse of breast cancer arising from the cancer stem cells. J Control Release 2011, 149(3):281-291.
13. Engelmann K., Shen H., Finn O.J. MCF-7 side population cells with characteristics of cancer stem/progenitor cells express the tumor antigen MUC1. Cancer Res 2008, 68(7):2419-2426.
14. Winquist R.J., Boucher D.M., Wood M., Furey B.F. Targeting cancer stem cells for more effective therapies: taking out cancer's locomotive engine. Biochem Pharmacol 2009, 78(4):326-334.
15. Rappa G., Mercapide J., Anzanello F., Prasmickaite L., Xi Y., Ju J., et al. Growth of cancer cell lines under stem cell-like conditions has the potential to unveil therapeutic targets. Exp Cell Res 2008, 314(10):2110-2122.
16. Ying X., Wen H., Lu W.L., Du J., Guo J., Tian W., et al. Dual-targeting daunorubicin liposomes improve the therapeutic efficacy of brain glioma in animals. J Control Release 2010, 141(2):183-192.
17. Guo J., Zhou J., Ying X., Men Y., Li R.J., Zhang Y., et al. Effects of stealth liposomal daunorubicin plus tamoxifen on the breast cancer and cancer stem cells. J Pharm Pharm Sci 2010, 13(2):136-151.
18. Ponti D., Costa A., Zaffaroni N., Pratesi G., Petrangolini G., Coradini D., et al. Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res 2005, 65(13):5506-5511.
19. Hirsch H.A., Iliopoulos D., Tsichlis P.N., Struhl K. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res 2009, 69(19):7507-7511.
20. Du J., Lu W.L., Ying X., Liu Y., Du P., Tian W., et al. Dual-targeting topotecan liposomes modified with tamoxifen and wheat germ agglutinin significantly improve drug transport across the blood-brain barrier and survival of brain tumor-bearing animals. Mol Pharmacol 2009, 6(3):905-917.
21. Tian W., Ying X., Du J., Guo J., Men Y., Zhang Y., et al. Enhanced efficacy of functionalized epirubicin liposomes in treating brain glioma-bearing rats. Eur J Pharm Sci 2010, 41(2):232-243.
22. Li L., Geisler I., Chmielewski J., Cheng J.X. Cationic amphiphilic polyproline helix P11LRR targets intracellular mitochondria. J Control Release 2010, 142(2):259-266.
23. Chen T.G., Chen T.L., Chang H.C., Tai Y.T., Cherng Y.G., Chang Y.T., et al. Oxidized low-density lipoprotein induces apoptotic insults to mouse cerebral endothelial cells via a Bax-mitochondria-caspase protease pathway. Toxicol Appl Pharmacol 2007, 219(1):42-53.
24. Petronilli V., Miotto G., Canton M., Brini M., Colonna R., Bernardi P., et al. Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescence. Biophys J 1999, 76(2):725-734.
25. Wang M., Ruan Y., Chen Q., Li S., Wang Q., Cai J. Curcumin induced HepG2 cell apoptosis-associated mitochondrial membrane potential and intracellular free Ca2+ concentration. Eur J Pharmacol 2011, 650(1):41-47.
26. Griffioen K.J., Ghribi O., Fox N., Savory J., DeWitt D.A. Aluminum maltolate-induced toxicity in NT2 cells occurs through apoptosis and includes cytochrome c release. Neurotoxicology 2004, 25(5):859-867.
27. Gao L.W., Zhang J., Yang W.H., Wang B., Wang J.W. Glaucocalyxin A induces apoptosis in human leukemia HL-60 cells through mitochondria-mediated death pathway. Toxicol In Vitro 2011, 25(1):51-63.
28. Troiano L., Ferraresi R., Lugli E., Nemes E., Roat E., Nasi M., et al. Multiparametric analysis of cells with different mitochondrial membrane potential during apoptosis by polychromatic flow cytometry. Nat Protoc 2007, 2(11):2719-2727.
29. Yao H.J., Ju R.J., Wang X.X., Zhang Y., Li R.J., Yu Y., et al. The antitumor efficacy of functional paclitaxel nanomicelles in treating resistant breast cancers by oral delivery. Biomaterials 2011, 32(12):3285-3302.
30. Cho S.J., Kang N.S., Park S.Y., Kim B.O., Rhee D.K., Pyo S. Induction of apoptosis and expression of apoptosis related genes in human epithelial carcinoma cells by helicobacter pylori VacA toxin. Toxicon 2003, 42(6):601-611.
31. Li M., Jung A., Ganswindt U., Marini P., Friedl A., Daniel P.T., et al. Aurora kinase inhibitor ZM447439 induces apoptosis via mitochondrial pathways. Biochem Pharmacol 2010, 79(2):122-129.
32. Christgen M., Ballmaier M., Bruchhardt H., von Wasielewski R., Kreipe H., Lehmann U. Identification of a distinct side population of cancer cells in the Cal-51 human breast carcinoma cell line. Mol Cell Biochem 2007, 306(1-2):201-212.
33. Ruiz i Altaba A., Sánchez P., Dahmane N. Gli and hedgehog in cancer: tumours, embryos and stem cells. Nat Rev Cancer 2002, 2(5):361-372.
34. Dontu G., Abdallah W.M., Foley J.M., Jackson K.W., Clarke M.F., Kawamura M.J., et al. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 2003, 17(10):1253-1270.
35. McBride H.M., Neuspiel M., Wasiak S. Mitochondria: more than just a powerhouse. Curr Biol 2006, 16(14):R551-R560.
36. Li X., Ruan G.R., Lu W.L., Hong H.Y., Liang G.W., Zhang Y.T., et al. A novel stealth liposomal topotecan with amlodipine: apoptotic effect is associated with deletion of intracellular Ca2+ by amlodipine thus leading to an enhanced antitumor activity in leukemia. J Control Release 2006, 112(2):186-198.
37. Grimshaw M.J., Cooper L., Papazisis K., Coleman J.A., Bohnenkamp H.R., Chiapero-Stanke L., et al. Mammosphere culture of metastatic breast cancer cells enriches for tumorigenic breast cancer cells. Breast Cancer Res 2008, 10(3):R52.
38. Ngen E.J., Rajaputra P., You Y. Evaluation of delocalized lipophilic cationic dyes as delivery vehicles for photosensitizers to mitochondria. Bioorg Med Chem 2009, 17(18):6631-6640.
39. Liou S.F., Lin H.H., Liang J.C., Chen I.J., Yeh J.L. Inhibition of human prostate cancer cells proliferation by a selective alpha1-adrenoceptor antagonist labedipinedilol-A involves cell cycle arrest and apoptosis. Toxicology 2009, 256(1-2):13-24.
40. Shimizu S., Narita M., Tsujimoto Y. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 1999, 399(6735):483-487.
41. Enomoto R., Komai T., Yoshida Y., Sugahara C., Kawaguchi E., Okazaki K., et al. Terfenadine induces thymocyte apoptosis via mitochondrial pathway. Eur J Pharmacol 2004, 496(1-3):11-21.
42. Balachandran R., Ter Haar E., Yalowich J.C., Welsh M.J., Grant S.G., Day B.W. Induction of human breast cancer cell apoptosis from G2/M preceded by stimulation into the cell cycle by Z-1, 1-dichloro-2, 3-diphenylcyclopropane. Biochem Pharmacol 1999, 57(1):97-110.
43. Dean M., Fojo T., Bates S. Tumour stem cells and drug resistance. Nat Rev Cancer 2005, 5(4):275-284.