Neoadjuvant chemoradiotherapy for resectable oesophageal and gastro-oesophageal junction cancer-do we need another randomised trial?

Clinical Oncology

Volumn 23, Issue 10, 2011, Pages 696-705

  Hingorani, M ^a   Crosby, T ^b   Maraveyas, A ^a   Dixit, S ^a   Bateman, A ^c   Roy, R ^a  

^a CASTLE HILL HOSPITAL   (United Kingdom)

^b VELINDRE CANCER CENTRE   (United Kingdom)

^c UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Chemoradiotherapy; Neoadjuvant chemotherapy; Oesophageal cancer

Indexed keywords

ADJUVANT CHEMOTHERAPY; ADJUVANT THERAPY; ARTICLE; CANCER SURVIVAL; CHEMORADIOTHERAPY; ESOPHAGUS CANCER; HUMAN; MEDLINE; META ANALYSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); STOMACH ADENOCARCINOMA; STOMACH CANCER; SURGICAL MORTALITY;

CHEMORADIOTHERAPY, ADJUVANT; ESOPHAGEAL NEOPLASMS; ESOPHAGOGASTRIC JUNCTION; HUMANS; NEOADJUVANT THERAPY; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 80055102981     PISSN: 09366555     EISSN: 14332981     Source Type: Journal    
DOI: 10.1016/j.clon.2011.05.005     Document Type: Article

References (51)

1. Daly J.M., Karnell L.H., Menck H.R. National cancer database report on oesophageal carcinoma. Cancer 1996, 78:1820.
2. Kelsen D.P., Ginsberg R., Pajak T.F., et al. Chemotherapy followed by surgery compared with surgery alone for localized oesophageal cancer. N Engl J Med 1998, 339:1979.
3. Hulscher J.B., van Sandick J.W., de Boer A.G., et al. Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the oesophagus. N Engl J Med 2002, 347:1662.
4. Altorki N., Kent M., Ferrara C., Port J. Three-field lymph node dissection for squamous cell and adenocarcinoma of the oesophagus. Ann Surg 2002, 236:177.
5. Orringer M.B., Marshall B., Iannettoni M.D. Transhiatal esophagectomy: clinical experience and refinements. Ann Surg 1999, 230:392.
6. Berger B., Belka C. Evidence-based radiation oncology: oesophagus. Radiother Oncol 2009, 92:276-290.
7. Apinop C., Puttisak P., Preecha N. A prospective study of combined therapy in esophageal cancer. Hepatogastroenterology 1994, 41:391-393.
8. Walsh T.N., Noonan N., Hollywood D., Kelly A., Keeling N., Hennessy T.P. A comparison of multimodal therapy and surgery for oesophageal adenocarcinoma. N Engl J Med 1996, 335:462-467.
9. DeMeester S.R. Adenocarcinoma of the oesophagus and cardia: a review of the disease and its treatment. Ann Surg Oncol 2006, 13:12-30.
10. Funk E.M., Witte J. Multimodal therapy for oesophageal adenocarcinoma. N Engl J Med 1997, 336:375.
11. Bosset J.F., Gignoux M., Triboulet J.P., et al. Chemoradiotherapy followed by surgery compared with surgery alone in squamous-cell cancer of the oesophagus. N Engl J Med 1997, 337:161-167.
12. Urba S.G., Orringer M.B., Turrisi A., et al. Randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional oesophageal carcinoma. J Clin Oncol 2001, 19:305.
13. Kleinberg L., Forastiere A. Chemoradiation in the management of oesophageal cancer. J Clin Oncol 2007, 25:4110-4117.
14. Lee J.L., Park S.I., Kim S.B., et al. A single institutional phase III trial of preoperative chemotherapy with hyperfractionation radiotherapy plus surgery versus surgery alone for resectable esophageal squamous cell carcinoma. Ann Oncol 2004, 15:947-954.
15. Burmeister B.H., Smithers B.M., Gebski V., et al. Trans-Tasman Radiation Oncology Group; Australasian Gastro-Intestinal Trials Group. Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: a randomised controlled phase III trial. Lancet Oncol 2005, 6:659-668.
16. Carstens H., Albertsson M., Friesland S., et al. A randomized trial of chemoradiotherapy versus surgery alone in patients with resectable oesophageal cancer (abstract). J Clin Oncol 2007, 25:205.
17. Tepper J., Krasna M.J., Niedzwiecki D., et al. Phase III trial of trimodality therapy with cisplatin, fluorouracil, radiotherapy, and surgery compared with surgery alone for esophageal cancer: CALGB 9781. J Clin Oncol 2008, 26(7):1086-1092.
18. Kaklamanos I.G., Walker G.R., Ferry K., Franceschi D., Livingstone A.S. Neoadjuvant treatment for resectable cancer of the esophagus and the gastroesophageal junction: a meta-analysis of randomized clinical trials. Ann Surg Oncol 2003, 10:754-761.
19. Fiorica F., Di Bona D., Schepis F., et al. Preoperative chemoradiotherapy for oesophageal cancer: a systematic review and meta-analysis. Gut 2004, 53:925-930.
20. Urschel J.D., Vasan H. A meta-analysis of randomized controlled trials that compared neoadjuvant chemoradiation and surgery to surgery alone for resectable oesophageal cancer. Am J Surg 2003, 185:538.
21. Malthaner R.A., Wong R.K., Rumble R.B., Zuraw L. Members of the Gastrointestinal Cancer Disease Site Group of Cancer Care Ontario's Program in Evidence-based Care. Neo-adjuvant or adjuvant therapy for resectable oesophageal cancer: a systematic review and meta-analysis. BMC Med 2004, 2:35.
22. Jin Hai-Lin, Zhu Hong, Ling Ting-Sheng, Zhang Hong-Jie, Shi Rui-Hua Neo-adjuvant chemoradiotherapy for resectable oesophageal carcinoma: a meta-analysis. World J Gastroenterol 2009, 15(47):5983-5991.
23. Courrech Staal E.F., Aleman B.M., Boot H., van Velthuysen M.L., van Tinteren H., van Sandick J.W. Systematic review of the benefits and risks of neoadjuvant chemoradiation for oesophageal cancer. Br J Surg 2010, 97(10):1482-1496.
24. van Heijl M., van Lanschot J.J., Koppert L.B., et al. Neo-adjuvant chemoradiation followed by surgery versus surgery alone for patients with adenocarcinoma or squamous cell carcinoma of the oesophagus (CROSS). BMC Surg 2008, 8:21.
25. Gaast A.V., van hagen P., Hulshof M., et al. Effect of preoperative concurrent chemoradiotherapy on survival of patients with resectable esophageal or esophagogastric junction cancer: results from a multicenter randomized phase III study. J Clin Oncol 2010, 28. 15s;abstract 4004.
26. Maipang T., Vasinanukorn P., Petpichetchian C., et al. Induction chemotherapy in the treatment of patients with carcinoma of the esophagus. J Surg Oncol 1994, 56:191-197.
27. Law S., Fok M., Chow S., Chu K.M., Wong J. Preoperative chemotherapy versus surgical therapy alone for squamous cell carcinoma of the esophagus: a prospective randomized trial. J Thorac Cardiovasc Surg 1997, 114:210-217.
28. Ancona E., Ruol A., Santi S., et al. Only pathologic complete response to neoadjuvant chemotherapy improves significantly the long term survival of patients with resectable esophageal squamous cell carcinoma: final report of a randomized, controlled trial of preoperative chemotherapy versus surgery alone. Cancer 2001, 91:2165-2174.
29. Medical Research Council Oesophageal Cancer Working Group. Surgical resection with or without preoperative chemotherapy in oesophageal cancer: a randomised controlled trial. Lancet 2002, 359:1727.
30. Allum W.H., Stenning S.P., Bancewicz J., et al. Long-term results of a randomized trial of surgery with or without preoperative chemotherapy in oesophageal cancer. J Clin Oncol 2009, 27:5062.
31. Cunningham D., Allum W.H., Stenning S.P., et al. MAGIC Trial Participants. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med 2006, 355:11-20.
32. Boige V., Pignon J., Saint-Aubert B., et al. Final results of a randomized trial comparing preoperative 5-fluorouracil/cisplatin to surgery alone in adenocarcinoma of stomach and lower oesophagus (ASLE): FNLCC ACCORD07-FFCD 9703 trial (abstract). J Clin Oncol 2007, 25:200.
33. Schuhmacher C., Schlag P., Lordick F., et al. Neo-adjuvant chemotherapy versus surgery alone for locally advanced adenocarcinoma of the stomach and cardia: randomized EORTC phase III trial #40954. (Abstract #4510). J Clin Oncol 2009, 27:204.
34. Urschel J.D., Vasan H., Blewett C.J. A meta-analysis of randomized controlled trials that compared neo-adjuvant chemotherapy and surgery to surgery alone for resectable oesophageal cancer. Am J Surg 2002, 183:274-279.
35. Graham A.J., Shrive F.M., Ghali W.A., et al. Defining the optimal treatment of locally advanced esophageal cancer: a systematic review and decision analysis. Ann Thorac Surg 2007, 83:1257-1264.
36. Gebski V., Burmeister B., Smithers B.M., Foo K., Zalcberg J., Simes J. Survival benefits from neo-adjuvant chemoradiotherapy or chemotherapy in esophageal cancer - a meta-analysis. Lancet Oncol 2007, 8:226-234. Australasian Gastro-Intestinal Trials Group.
37. Stahl M., Walz M.K., Stuschke M., et al. Phase III comparison of preoperative chemotherapy compared with chemoradiotherapy in patients with locally advanced adenocarcinoma of the esophagogastric junction. J Clin Oncol 2009, 27:851.
38. Luu T.D., Gaur P., Force S.D., et al. Neo-adjuvant chemoradiation versus chemotherapy for patients undergoing esophagectomy for oesophageal cancer. Ann Thorac Surg 2008, 85(4):1217-1223. discussion 1223-1224.
39. Crosby T.D., Evans M. The management of locally advanced carcinoma of the oesophagus - SCOPE for improvement?. Clin Oncol (R Coll Radiol) 2009, 21(4):281-284.
40. Malthaner R., Wong R.K., Spithoff K. Gastrointestinal Cancer Disease Site Group of Cancer Care Ontario's Program in Evidence-based Care. Preoperative or postoperative therapy for resectable oesophageal cancer: an updated practice guideline. Clin Oncol (R Coll Radiol) 2010, 22(4):250-256.
41. Berger A.C., Farma J., Scott W.J., et al. Complete response to neo-adjuvant chemoradiotherapy for resectable oesophageal carcinoma: a meta-analysis. J Clin Oncol 2005, 23:4330-4337.
42. Rizk N.P., Venkatraman E., Bains M.S., et al. American Joint Committee on Cancer staging system does not accurately predict survival in patients receiving multimodality therapy for oesophageal adenocarcinoma. J Clin Oncol 2007, 25:507.
43. Oesophageal Cancer 2010, NCCN Clinical Practice Guidelines in Oncology, Available at, V1. http://www.nccn.org/professionals/physician_gls/PDF/esophageal.pdf.
44. Kelsen D.P., Winter K.A., Gunderson L.L., et al. Long-term results of RTOG trial 8911 (USA Intergroup 113): a random assignment trial comparison of chemotherapy followed by surgery compared with surgery alone for oesophageal cancer. J Clin Oncol 2007, 25:3719.
45. van de Schoot L., Romme E.A., van der Sangen M.J., et al. A highly active and tolerable neoadjuvant regimen combining paclitaxel, carboplatin, 5-FU, and radiation therapy in patients with stage II and III oesophageal cancer. Ann Surg Oncol 2008, 15:88.
46. Spigel D.R., Greco F.A., Meluch A.A., et al. Phase I/II trial of preoperative oxaliplatin, docetaxel, and capecitabine with concurrent radiation therapy in localized carcinoma of the oesophagus or gastroesophageal junction. J Clin Oncol 2010, 28(13):2213-2219.
47. Siewert J.R., Ott K. Are squamous and adenocarcinomas of the oesophagus the same disease?. Semin Radiat Oncol 2007, 17:38.
48. Bedenne L., Michel P., Bouché O., et al. Chemoradiation followed by surgery compared with chemoradiation alone in squamous cancer of the esophagus: FFCD 9102. J Clin Oncol 2007, 25(10):1160-1168.
49. Stahl M., Stuschke M., Lehmann N., et al. Chemoradiation with and without surgery in patients with locally advanced squamous cell carcinoma of the oesophagus. J Clin Oncol 2005, 23:2310.
50. Hyngstrom J.R., Posner M.C. Neo-adjuvant strategies for the treatment of locally advanced oesophageal cancer. J Surg Oncol 2010, 101(4):299-304.
51. Barnett S.A., Rizk N.P. Randomized clinical trials in oesophageal carcinoma. Surg Oncol Clin North Am 2010, 19(1):59-80.