Only pathologic complete response to neoadjuvant chemotherapy improves significantly the long term survival of patients with resectable esophageal squamous cell carcinoma: Final report of a randomized, controlled trial of preoperative chemotherapy versus surgery Alone

Cancer

Volumn 91, Issue 11, 2001, Pages 2165-2174

  Ancona, Ermanno ^a   Ruol, Alberto ^a,c   Santi, Stefano ^a   Merigliano, Stefano ^a   Sileni, Vanna Chiarion ^a   Koussis, Haralabos ^a   Zaninotto, Giovanni ^a   Bonavina, Luigi ^b   Peracchia, Alberto ^b  

^a UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

Author keywords

Esophagus; Neoadjuvant chemotherapy; Randomized controlled trial; Squamous cell carcinoma; Surgery

Indexed keywords

CISPLATIN; FLUOROURACIL;

ADULT; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER CHEMOTHERAPY; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ESOPHAGUS CARCINOMA; ESOPHAGUS RESECTION; FEMALE; HUMAN; LYMPHADENECTOMY; MAJOR CLINICAL STUDY; MALE; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SQUAMOUS CELL CARCINOMA; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, SQUAMOUS CELL; CISPLATIN; COMBINED MODALITY THERAPY; DISEASE PROGRESSION; ESOPHAGEAL NEOPLASMS; FEMALE; FLUOROURACIL; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 0035371059     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0142(20010601)91:11<2165::AID-CNCR1245>3.0.CO;2-H     Document Type: Article

References (41)

1. Ruol A, Panel of Experts. Multimodality treatment for non-metastatic cancer of the thoracic esophagus. Results of a consensus conference held at the 6th World Congress of the International Society for Diseases of the Esophagus. Dis Esophagus 1996;9:39-55.
2. Lehnert T. Multimodal therapy for squamous carcinoma of the oesophagus. Br J Surg 1999;86:727-39.
3. Muller JM, Erasmi H, Stelzner M, Zieren U, Pichlmaier H. Surgical therapy of oesophageal carcinoma. Br J Surg 1990; 77:845-57.
4. Kok TC, von Lanschot J, Siersema PD, von Overhagen H, Talanus HV. Neoadjuvant chemotherapy in operable esophageal squamous cell cancer: final report of a Phase III multicenter randomized controlled trial. Proc Am Soc Clin Oncol 1997;16:277.
5. Hilgenberg D, Carey RW, Wilkins WW, Choi NC, Mathisen DJ, Grillo HC. Preoperative chemotherapy, surgical resection, and selective postoperative therapy for squamous cell carcinoma of the esophagus. Ann Thorac Surg 1988;45:357-63.
6. Sischy B, Ryan L, Haller D, Smith T, Dayal Y, Schutt A, et al. Interim report of EST 1282 Phase III protocol for the evaluation of combined modalities in the treatment of patients with carcinoma of the esophagus. Proc Am Soc Clin Oncol 1990;9:407.
7. Urba S, Orringer M, Turrisi A, Whyte R, Natale R, Iannettoni M, et al. A randomized trial comparing transhiatal esophagectomy to preoperative concurrent chemo-radiation followed by esophagectomy in locoregional esophageal carcinoma. Proc Am Soc Clin Oncol 1995;14:199.
8. Urba S, Orringer, Turrisi A, Whyte R, Iannettoni M, Forastiere A. A randomized trial comparing surgery to preoperative concomitant chemoradiation plus surgery in patients with resectable esophageal cancer. Proc Am Soc Clin Oncol 1997;16:983.
9. Walsh TN, Noonan N, Hollywood D, Kelly A, Keeling N, Hennessy TPJ. A comparison of multimodal therapy and surgery for esophageal adenocarcinoma. N Engl J Med 1996; 335;462-7.
10. Forastiere AA, Heitmiller RF, Kleinberg GL. Multimodality therapy for esophageal cancer. Chest 1997;112:195S-200S.
11. Roth JA, Pass HI, Flanagan MM, Graeber GM, Rosenberg JC, Steinberg S. Randomized clinical trial of preoperative and postoperative adjuvant chemotherapy with cisplatin, vindesine, and bleomycin for carcinoma of the esophagus. J Thorac Cardiovasc Surg 1988;96:242-8.
12. Al Sarraf M. The current status of combined modality treatment containing chemotherapy in patients with esophageal cancer. Int J Radiat Oncol Biol Phys 1990;19:813-5.
13. Kies MS, Rosen ST, Tsang TK, Shetty R, Schneider PA, Wallemark CB, et al. Cisplatin and 5-fluorouracil in the primary treatment of squamous esophageal cancer. Cancer 1987;60: 2156-60.
14. De Besi P, Chiarion Sileni V, Salvagno L, Tremolada C, Cartei G, Fosser V, et al. Phase II study of cisplatin, 5-FU, and allopurinol in advanced esophageal cancer. Cancer Treat Rep 1986;70:909-10.
15. Hermanek P, Sobin LH. Oesophagus. In: Hermanek P, Sobin LH, editors. TNM classification of malignant tumours. Berlin: Springer, 1987:40-2.
16. Meinert CL. Stratified and blocked allocation using the Moses-Oakford algorithm and a table of random numbers. In: Meinert CL, editor. Clinical trials. Design, conduct and analysis. Oxford: Oxford University Press, 1986:107-12.
17. World Health Organization. WHO handbook for reporting results of cancer treatment (publication no. 48). Geneva: WHO, 1979.
18. Kelsen DP, Ginsberg R, Pajak TF, Sheahan DG, Gunderson L, Mortimer J, et al. Chemotherapy followed by surgery compared with surgery alone for localized esophageal cancer. N Engl J Med 1998;339:1979-84.
19. Swisher SG, Deford L, Merriman KW, Walsh GL, Smythe R, Vaporicyan A, et al. Effect of operative volume on morbidity, mortality, and hospital use after esophagectomy for cancer. J Thorac Cardiovasc Surg 2000;119:1126-34.
20. Maipang T, Vasinanukorn P, Petpichetchian C, Chamroonkul S, Geater A, Chansawwaang S, et al. Induction chemotherapy in the treatment of patients with carcinoma of the esophagus. J Surg Oncol 1994;56:191-7.
21. Nygaard K, Hagen S, Hansen HS, Hatlevoll R, Hultborn R, Jakobsen A, et al. Pre-operative radiotherapy prolongs survival in operable esophageal carcinoma: a randomized, multicenter study of pre-operative radiotherapy and chemotherapy. The second Scandinavian trial in esophageal cancer. World J Surg 1992;16:1104-10.
22. Schlag P. Randomized trial of preoperative chemotherapy for squamous cell cancer of the esophagus. Arch Surg 1992; 127:1446-50.
23. Law S, Fok M, Chow S, Chu KM, Wong J. Preoperative chemotherapy versus surgical therapy alone for squamous cell carcinoma of the esophagus: a prospective randomized trial. J Thorac Cardiovasc Surg 1997;114:210-7.
24. Ancona E, Ruol A, Castoro C, Chiarion V, Merigliano S, Santi S, et al. First-line chemotherapy improves the resection rate and long-term survival of locally advanced (T4, any N, M0) squamous cell carcinoma of the thoracic esophagus. Final report on 163 consecutive patients with 5-year follow-up. Ann Surg 1997;226:714-24.
25. Peracchia A, Desai PB, Ruol A, Biondetti P, Battaglia G, Coggi G. Esophageal cancer. In: Badellino F, Gipponi M, editors. Flow charts for diagnosis and staging of cancer in developed and developing countries. Geneva: International Union Against Cancer, 1998:27-43.
26. Bumm R, Panel of Experts. Staging and risk-analysis in esophageal carcinoma. Results of a consensus conference held at the 6th World Congress of the International Society for Diseases of the Esophagus. Dis Esophagus 1996;9:20-9.
27. Kelsen DP, Ginsberg R, Qian C, Gunderson L, Mortimer J, Estes N, et al. Chemotherapy followed by operation versus operation alone in the treatment of patients with localized esophageal cancer: a preliminary report on Intergroup Study 113 (RTOG 89-11). Proc Am Soc Clin Oncol 1997;17: 982.
28. Nooter K, Kok T, Bosman FT, van Wingerden KE, Storer G. Expression of the multidrug resistance protein (MRP) in squamous cell carcinoma of the oesophagus and response to pre-operative chemotherapy. Eur J Cancer 1998;34:81-6.
29. Andersen AP, Berdal P, Edsmyr F, Hagen S, Hatlevoll R, Nygaard K, et al. Irradiation, chemotherapy and surgery in esophageal cancer: a randomized clinical study. The first Scandinavian trial in esophageal cancer. Radiother Oncol 1984;2:179-88.
30. Apinop C, Puttisak P, Preecha N. A prospective study of combined therapy in esophageal cancer. Hepatogastroenterology 1994;41:391-3.
31. Bosset JF, Gignoux M, Triboulet JP, Tiret E, Mantion G, Elias D, et al. Chemoradiotherapy followed by surgery compared with surgery alone in squamous cell cancer of the esophagus. N Engl J Med 1997;337:161-7.
32. Le Prise E, Etienne PL, Meunier B, Maddern G, Benhassel M, Gedouin D, et al. A randomized study of chemotherapy, radiation therapy, and surgery versus surgery for localized squamous cell carcinoma of the esophagus. Cancer 1994;73: 1779-84.
33. Mathew G, Jamieson GG. Neoadjuvant therapy for oesophageal cancer. Br J Surg 1997;84:1185-7.
34. Wang M, Gu XZ, Yin WB, Huang GJ, Wang LJ, Zhang DW. Randomized clinical trial on the combination of preoperative irradiation and surgery in the treatment of esophageal carcinoma: report on 206 patients. Int J Radiat Oncol Biol Phys 1989;16:325-7.
35. Vogel SB, Mendenhall WM, Sombeck MD, Marsh R, Woodward ER. Downstaging of esophageal cancer after preoperative radiation and chemotherapy. Ann Surg 1995;221:685-95.
36. Forastiere AA, Orriger MB, Perez-Tamayo C, Urba SG, Zahura KM. Preoperative chemoradiation followed by transhiatal esophagectomy for carcinoma of the esophagus: final report. J Clin Oncol 1993;11:1118-23.
37. Bates B, Detterbeck F, Bernard S, Qaqish BF, Tepper JE. Concurrent radiation therapy and chemotherapy followed by esophagectomy for localized esophageal carcinoma. J Clin Oncol 1996;14:156-63.
38. Triboulet JP, Amrouni H, Guillem P, Vandenhaute B, Lecomte-houcke M, Adenis A. Devenir des cancers epidermoides de l'oesophage en response complete apres chimioradiotherapie pre-operatoire. Ann Chir 1998;52:503-8.
39. Kitamura K, Kuwano H, Arari K, Egashira A, Kawaguchi H, Saeki H, et al. Clinicopathologic features of patients with oesophageal cancer obtaining a histological complete response for preoperative hyperthermo-chemoradiotherapy. Int J Hyperthermia 1998;14:233-43.
40. Lackey L, Reagan T, Smith A, Anderson WJ. Neoadjuvant therapy in squamous cell carcinoma of the esophagus: role of resection and benefits in partial responders. Ann Thorac Surg 1989;48:218-21.
41. Bedenne L, Seitz JF, Milan C, Fraisse J, Conroy T, Lacourt J, et al. Preoperative radiotherapy and chemotherapy in epidermoid esophageal cancers: results of a Phase II multicentric trial by the French Foundation for Carcinology of the Digestive Tract (FFCD), Proc Am Soc Clin Oncol 1993;12:199.