A point mutation in translation initiation factor eIF2B leads to function- and time-specific changes in brain gene expression

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Marom, Liraz ^a   Ulitsky, Igor ^a,b   Cabilly, Yuval ^a   Shamir, Ron ^a   Elroy Stein, Orna ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INITIATION FACTOR 2; INITIATION FACTOR 2BETA; MESSENGER RNA; MYELIN; TRANSCRIPTOME; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; GUANINE NUCLEOTIDE EXCHANGE FACTOR;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; BRAIN MATURATION; BRAIN TISSUE; CELL STRESS; CONTROLLED STUDY; COPING BEHAVIOR; DEVELOPMENTAL STAGE; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; GENOME ANALYSIS; HYPERSENSITIVITY; MALE; MOUSE; MOUSE MUTANT; NERVE CELL DIFFERENTIATION; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; OLIGODENDROGLIA; PERINATAL PERIOD; POINT MUTATION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; TRANSCRIPTOMICS; WHITE MATTER; WILD TYPE; ANIMAL; ASTROCYTE; BRAIN; C57BL MOUSE; CELL CULTURE; CELL CYCLE; CYTOLOGY; DISEASE MODEL; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENETICS; LEUKOENCEPHALOPATHY; METABOLISM; MYELIN SHEATH; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIME;

EUKARYOTA; MUS;

ANIMALS; ASTROCYTES; BIOLOGICAL MARKERS; BRAIN; CELL CYCLE; CELLS, CULTURED; DISEASE MODELS, ANIMAL; EUKARYOTIC INITIATION FACTOR-2B; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; LEUKOENCEPHALOPATHIES; MALE; MICE; MICE, INBRED C57BL; MYELIN SHEATH; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POINT MUTATION; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS;

EID: 80055101686     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026992     Document Type: Article

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