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Volumn 16, Issue 7, 2011, Pages 1081-1091

Serum interleukin-6 levels correlate with resistance to treatment of chronic hepatitis C infection with pegylated-interferon-α2b plus ribavirin

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; PEGINTERFERON ALPHA2B; RIBAVIRIN;

EID: 80055094219     PISSN: 13596535     EISSN: None     Source Type: Journal    
DOI: 10.3851/IMP1864     Document Type: Article
Times cited : (19)

References (47)
  • 1
    • 78650291999 scopus 로고    scopus 로고
    • Progression of initially mild hepatic fibrosis in patients with chronic hepatitis C infection
    • Williams MJ, Lang-Lenton M. Progression of initially mild hepatic fibrosis in patients with chronic hepatitis C infection. J Viral Hepat 2011; 18:17-22.
    • (2011) J Viral Hepat , vol.18 , pp. 17-22
    • Williams, M.J.1    Lang-Lenton, M.2
  • 2
    • 57349182990 scopus 로고    scopus 로고
    • Pathogenesis of HCV-associated HCC: Dualpass carcinogenesis through activation of oxidative stress and intracellular signaling
    • Koike K. Pathogenesis of HCV-associated HCC: Dualpass carcinogenesis through activation of oxidative stress and intracellular signaling. Hepatol Res 2007; 37 Suppl 2:S115-S120.
    • (2007) Hepatol Res , vol.37 , Issue.SUPPL. 2
    • Koike, K.1
  • 3
    • 0025166005 scopus 로고
    • Hepatitis C virus infection is associated with the development of hepatocellular carcinoma
    • Saito I, Miyamura T, Ohbayashi A, et al. Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc Natl Acad Sci U S A 1990; 87:6547-6549.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 6547-6549
    • Saito, I.1    Miyamura, T.2    Ohbayashi, A.3
  • 4
    • 0037179698 scopus 로고    scopus 로고
    • Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
    • Fried MW, Shiffman ML, Reddy KR, et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002; 347:975-982.
    • (2002) N Engl J Med , vol.347 , pp. 975-982
    • Fried, M.W.1    Shiffman, M.L.2    Reddy, K.R.3
  • 5
    • 0034619946 scopus 로고    scopus 로고
    • Peginterferon alfa-2a in patients with chronic hepatitis C
    • Zeuzem S, Feinman SV, Rasenack J, et al. Peginterferon alfa-2a in patients with chronic hepatitis C. N Engl J Med 2000; 343:1666-1672.
    • (2000) N Engl J Med , vol.343 , pp. 1666-1672
    • Zeuzem, S.1    Feinman, S.V.2    Rasenack, J.3
  • 6
    • 72249094116 scopus 로고    scopus 로고
    • Peginterferon alfa-2a plus ribavirin is more effective than peginterferon alfa-2b plus ribavirin for treating chronic hepatitis C virus infection
    • Ascione A, De Luca M, Tartaglione MT, et al. Peginterferon alfa-2a plus ribavirin is more effective than peginterferon alfa-2b plus ribavirin for treating chronic hepatitis C virus infection. Gastroenterology 2010; 138:116-122.
    • (2010) Gastroenterology , vol.138 , pp. 116-122
    • Ascione, A.1    De Luca, M.2    Tartaglione, M.T.3
  • 7
    • 75449106958 scopus 로고    scopus 로고
    • Efficacy and safety of peginterferon alfa-2a (40KD) plus ribavirin in hepatitis C patients with advanced fibrosis and cirrhosis
    • Bruno S, Shiffman ML, Roberts SK, et al. Efficacy and safety of peginterferon alfa-2a (40KD) plus ribavirin in hepatitis C patients with advanced fibrosis and cirrhosis. Hepatology 2010; 51:388-397.
    • (2010) Hepatology , vol.51 , pp. 388-397
    • Bruno, S.1    Shiffman, M.L.2    Roberts, S.K.3
  • 8
    • 70349292099 scopus 로고    scopus 로고
    • Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    • Ge D, Fellay J, Thompson AJ, et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 2009; 461:399-401.
    • (2009) Nature , vol.461 , pp. 399-401
    • Ge, D.1    Fellay, J.2    Thompson, A.J.3
  • 9
    • 70349533037 scopus 로고    scopus 로고
    • Genome-wide association of IL28B with response to pegylated interferonalpha and ribavirin therapy for chronic hepatitis C
    • Tanaka Y, Nishida N, Sugiyama M, et al. Genome-wide association of IL28B with response to pegylated interferonalpha and ribavirin therapy for chronic hepatitis C. Nat Genet 2009; 41:1105-1109.
    • (2009) Nat Genet , vol.41 , pp. 1105-1109
    • Tanaka, Y.1    Nishida, N.2    Sugiyama, M.3
  • 10
    • 9144257569 scopus 로고    scopus 로고
    • Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection
    • Enomoto N, Sakuma I, Asahina Y, et al. Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection. N Engl J Med 1996; 334:77-82.
    • (1996) N Engl J Med , vol.334 , pp. 77-82
    • Enomoto, N.1    Sakuma, I.2    Asahina, Y.3
  • 12
    • 0025190892 scopus 로고
    • Interleukin-6 and the acute phase response
    • Heinrich PC, Castell JV, Andus T. Interleukin-6 and the acute phase response. Biochem J 1990; 265:621-636. (Pubitemid 20053863)
    • (1990) Biochemical Journal , vol.265 , Issue.3 , pp. 621-636
    • Heinrich, P.C.1    Castell, J.V.2    Andus, T.3
  • 13
    • 0025375152 scopus 로고
    • Interleukin-6: A regulator of plasma protein gene expression in hepatic and non-hepatic tissues
    • Sehgal PB. Interleukin-6: a regulator of plasma protein gene expression in hepatic and non-hepatic tissues. Mol Biol Med 1990; 7:117-130. (Pubitemid 20198143)
    • (1990) Molecular Biology and Medicine , vol.7 , Issue.2 , pp. 117-130
    • Sehgal, P.B.1
  • 15
    • 0031746396 scopus 로고    scopus 로고
    • Human interleukin 6 gene is activated by hepatitis B virus-X protein in human hepatoma cells
    • Lee Y, Park US, Choi I, et al. Human interleukin 6 gene is activated by hepatitis B virus-X protein in human hepatoma cells. Clin Cancer Res 1998; 4:1711-1717. (Pubitemid 28304733)
    • (1998) Clinical Cancer Research , vol.4 , Issue.7 , pp. 1711-1717
    • Lee, Y.1    Park, U.-S.2    Choi, I.3    Yoon, S.K.4    Park, Y.M.5    Lee, Y.I.6
  • 16
    • 0025845292 scopus 로고
    • Elevated plasma interleukin-6 and increased severity and mortality in alcoholic hepatitis
    • Sheron N, Bird G, Goka J, et al. Elevated plasma interleukin-6 and increased severity and mortality in alcoholic hepatitis. Clin Exp Immunol 1991; 84:449-453.
    • (1991) Clin Exp Immunol , vol.84 , pp. 449-453
    • Sheron, N.1    Bird, G.2    Goka, J.3
  • 17
    • 49649096375 scopus 로고    scopus 로고
    • Visceral fat: A key mediator of steatohepatitis in metabolic liver disease
    • van der Poorten D, Milner KL, Hui J, et al. Visceral fat: a key mediator of steatohepatitis in metabolic liver disease. Hepatology 2008; 48:449-457.
    • (2008) Hepatology , vol.48 , pp. 449-457
    • Van Der Poorten, D.1    Milner, K.L.2    Hui, J.3
  • 18
    • 0026026639 scopus 로고
    • Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients
    • Khoruts A, Stahnke L, McClain CJ, et al. Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients. Hepatology 1991; 13:267-276.
    • (1991) Hepatology , vol.13 , pp. 267-276
    • Khoruts, A.1    Stahnke, L.2    McClain, C.J.3
  • 19
    • 30344444475 scopus 로고    scopus 로고
    • Hepatitis C virus induces toll-like receptor 4 expression, leading to enhanced production of beta interferon and interleukin-6
    • DOI 10.1128/JVI.80.2.866-874.2006
    • Machida K, Cheng KT, Sung VM, et al. Hepatitis C virus induces toll-like receptor 4 expression, leading to enhanced production of beta interferon and interleukin-6. J Virol 2006; 80:866-874. (Pubitemid 43062898)
    • (2006) Journal of Virology , vol.80 , Issue.2 , pp. 866-874
    • Machida, K.1    Cheng, K.T.H.2    Sung, V.M.-H.3    Levine, A.M.4    Foung, S.5    Lai, M.M.C.6
  • 21
    • 34447327216 scopus 로고    scopus 로고
    • Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    • DOI 10.1126/science.1140485
    • Naugler WE, Sakurai T, Kim S, et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 2007; 317:121-124. (Pubitemid 47056470)
    • (2007) Science , vol.317 , Issue.5834 , pp. 121-124
    • Naugler, W.E.1    Sakurai, T.2    Kim, S.3    Maeda, S.4    Kim, K.5    Elsharkawy, A.M.6    Karin, M.7
  • 23
    • 77956114717 scopus 로고    scopus 로고
    • Anti-inflammatory effects of excessive weight loss: Potent suppression of adipose interleukin 6 and tumour necrosis factor alpha expression
    • Moschen AR, Molnar C, Geiger S, et al. Anti-inflammatory effects of excessive weight loss: potent suppression of adipose interleukin 6 and tumour necrosis factor alpha expression. Gut 2010; 59:1259-1264.
    • (2010) Gut , vol.59 , pp. 1259-1264
    • Moschen, A.R.1    Molnar, C.2    Geiger, S.3
  • 24
    • 23044468612 scopus 로고    scopus 로고
    • Interleukin-6 depletion selectively improves hepatic insulin action in obesity
    • DOI 10.1210/en.2004-1468
    • Klover PJ, Clementi AH, Mooney RA. Interleukin-6 depletion selectively improves hepatic insulin action in obesity. Endocrinology 2005; 146:3417-3427. (Pubitemid 41058114)
    • (2005) Endocrinology , vol.146 , Issue.8 , pp. 3417-3427
    • Klover, P.J.1    Clementi, A.H.2    Mooney, R.A.3
  • 27
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004; 4:499-511. (Pubitemid 38931765)
    • (2004) Nature Reviews Immunology , vol.4 , Issue.7 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 28
    • 40649109728 scopus 로고    scopus 로고
    • The wolf in sheep's clothing: The role of interleukin-6 in immunity, inflammation and cancer
    • Naugler WE, Karin M. The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer. Trends Mol Med 2008; 14:109-119.
    • (2008) Trends Mol Med , vol.14 , pp. 109-119
    • Naugler, W.E.1    Karin, M.2
  • 30
    • 33847016551 scopus 로고    scopus 로고
    • Defective Hepatic Response to Interferon and Activation of Suppressor of Cytokine Signaling 3 in Chronic Hepatitis C
    • DOI 10.1053/j.gastro.2006.11.045, PII S0016508506025261
    • Huang Y, Feld JJ, Sapp RK, et al. Defective hepatic response to interferon and activation of suppressor of cytokine signaling 3 in chronic hepatitis C. Gastroenterology 2007; 132:733-744. (Pubitemid 46274665)
    • (2007) Gastroenterology , vol.132 , Issue.2 , pp. 733-744
    • Huang, Y.1    Feld, J.J.2    Sapp, R.K.3    Nanda, S.4    Lin, J.-H.5    Blatt, L.M.6    Fried, M.W.7    Murthy, K.8    Liang, T.J.9
  • 31
    • 77956908091 scopus 로고    scopus 로고
    • IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones
    • Suda G, Sakamoto N, Itsui Y, et al. IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones. Virology 2010; 407:80-90.
    • (2010) Virology , vol.407 , pp. 80-90
    • Suda, G.1    Sakamoto, N.2    Itsui, Y.3
  • 32
    • 33747040825 scopus 로고    scopus 로고
    • Pattern recognition receptors: A contemporary view on liver diseases
    • DOI 10.1002/hep.21308
    • Szabo G, Dolganiuc A, Mandrekar P. Pattern recognition receptors: a contemporary view on liver diseases. Hepatology 2006; 44:287-298. (Pubitemid 44214866)
    • (2006) Hepatology , vol.44 , Issue.2 , pp. 287-298
    • Szabo, G.1    Dolganiuc, A.2    Mandrekar, P.3
  • 33
    • 23944485662 scopus 로고    scopus 로고
    • Evasion of intracellular host defence by hepatitis C virus
    • DOI 10.1038/nature04078
    • Gale M, Jr., Foy EM. Evasion of intracellular host defence by hepatitis C virus. Nature 2005; 436:939-945. (Pubitemid 41191669)
    • (2005) Nature , vol.436 , Issue.7053 , pp. 939-945
    • Gale Jr., M.1    Foy, E.M.2
  • 34
    • 70349238777 scopus 로고    scopus 로고
    • Adipokines in liver diseases
    • Marra F, Bertolani C. Adipokines in liver diseases. Hepatology 2009; 50:957-969.
    • (2009) Hepatology , vol.50 , pp. 957-969
    • Marra, F.1    Bertolani, C.2
  • 35
    • 0028929156 scopus 로고
    • Interleukin-6 stimulates hepatic triglyceride secretion in rats
    • Nonogaki K, Fuller GM, Fuentes NL, et al. Interleukin-6 stimulates hepatic triglyceride secretion in rats. Endocrinology 1995; 136:2143-2149.
    • (1995) Endocrinology , vol.136 , pp. 2143-2149
    • Nonogaki, K.1    Fuller, G.M.2    Fuentes, N.L.3
  • 36
    • 33645114359 scopus 로고    scopus 로고
    • Nonresponse to antiviral therapy is associated with obesity and increased hepatic expression of suppressor of cytokine signalling 3 (SOCS-3) in patients with chronic hepatitis C, viral genotype 1
    • Walsh MJ, Jonsson JR, Richardson MM, et al. Nonresponse to antiviral therapy is associated with obesity and increased hepatic expression of suppressor of cytokine signalling 3 (SOCS-3) in patients with chronic hepatitis C, viral genotype 1. Gut 2006; 55:529-535.
    • (2006) Gut , vol.55 , pp. 529-535
    • Walsh, M.J.1    Jonsson, J.R.2    Richardson, M.M.3
  • 37
    • 79959351119 scopus 로고    scopus 로고
    • Circulating interleukin-1beta and interleukin-6 concentrations are closely associated with gamma-glutamyltranspeptidase activity in middle-aged Japanese men without obvious cardiovascular diseases
    • Mochizuki K, Misaki Y, Miyauchi R, et al. Circulating interleukin-1beta and interleukin-6 concentrations are closely associated with gamma-glutamyltranspeptidase activity in middle-aged Japanese men without obvious cardiovascular diseases. Metabolism 2011; 60:914-922.
    • (2011) Metabolism , vol.60 , pp. 914-922
    • Mochizuki, K.1    Misaki, Y.2    Miyauchi, R.3
  • 39
    • 23844498434 scopus 로고    scopus 로고
    • Gamma-glutamyl transferase (GGT) as an independent predictive factor of sustained virologic response in patients with hepatitis C treated with interferon-alpha and ribavirin
    • DOI 10.1097/01.mcg.0000174025.19214.32
    • Villela-Nogueira CA, Perez RM, de Segadas Soares JA, Coelho HS. Gamma-glutamyl transferase (GGT) as an independent predictive factor of sustained virologic response in patients with hepatitis C treated with interferon-alpha and ribavirin. J Clin Gastroenterol 2005; 39:728-730. (Pubitemid 41177095)
    • (2005) Journal of Clinical Gastroenterology , vol.39 , Issue.8 , pp. 728-730
    • Villela-Nogueira, C.A.1    Perez, R.M.2    De Segadas, S.J.A.3    Moraes, C.H.S.4
  • 41
    • 0032189103 scopus 로고    scopus 로고
    • The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic- onset juvenile chronic arthritis
    • Fishman D, Faulds G, Jeffery R, et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 1998; 102:1369-1376. (Pubitemid 28467565)
    • (1998) Journal of Clinical Investigation , vol.102 , Issue.7 , pp. 1369-1376
    • Fishman, D.1    Faulds, G.2    Jeffey, R.3    Mohamed-Ali, V.4    Yudkin, J.S.5    Humphries, S.6    Woo, P.7
  • 43
    • 0042856824 scopus 로고    scopus 로고
    • Polymorphisms in tumour necrosis factor-alpha, transforming growth factor-beta, interleukin-10, interleukin-6, interferon-gamma, and outcome of hepatitis C virus infection
    • DOI 10.1002/jmv.10472
    • Barrett S, Collins M, Kenny C, et al. Polymorphisms in tumour necrosis factor-alpha, transforming growth factorbeta, interleukin-10, interleukin-6, interferon-gamma, and outcome of hepatitis C virus infection. J Med Virol 2003; 71:212-218. (Pubitemid 37048464)
    • (2003) Journal of Medical Virology , vol.71 , Issue.2 , pp. 212-218
    • Barrett, S.1    Collins, M.2    Kenny, C.3    Ryan, E.4    Keane, C.O.5    Crowe, J.6
  • 46
    • 33646458250 scopus 로고    scopus 로고
    • Interleukin-6 and its soluble receptor in patients with liver cirrhosis and hepatocellular carcinoma
    • Soresi M, Giannitrapani L, D'Antona F, et al. Interleukin-6 and its soluble receptor in patients with liver cirrhosis and hepatocellular carcinoma. World J Gastroenterol 2006; 12:2563-2568.
    • (2006) World J Gastroenterol , vol.12 , pp. 2563-2568
    • Soresi, M.1    Giannitrapani, L.2    D'Antona, F.3
  • 47
    • 70349849505 scopus 로고    scopus 로고
    • Serum IL-6 levels and the risk for hepatocarcinogenesis in chronic hepatitis C patients: An analysis based on gender differences
    • Nakagawa H, Maeda S, Yoshida H, et al. Serum IL-6 levels and the risk for hepatocarcinogenesis in chronic hepatitis C patients: an analysis based on gender differences. Int J Cancer 2009; 125:2264-2269.
    • (2009) Int J Cancer , vol.125 , pp. 2264-2269
    • Nakagawa, H.1    Maeda, S.2    Yoshida, H.3


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