Chronopharmacological assessment identified GLUT4 as a factor responsible for the circadian variation of the hypoglycemic effect of tolbutamide in rats

Drug Metabolism and Pharmacokinetics

Volumn 26, Issue 5, 2011, Pages 503-515

  Miyazaki, Makoto ^a   Fujii, Toshiki ^a   Takeda, Nobuhiro ^a   Magotani, Hiroaki ^a   Iwanaga, Kazunori ^a   Kakemi, Masawo ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Albumin; Circadian change; Circadian rhythm; Glucose transporter 4; Hypoglycemic effect; Insulin; Insulin resistance; Pharmacokinetic pharmacodynamic modeling; Protein binding; Tolbutamide

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; TOLBUTAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHRONOPHARMACOLOGY; CIRCADIAN RHYTHM; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG PROTEIN BINDING; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; MALE; NONHUMAN; PHARMACODYNAMICS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT;

EID: 80055079404     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.DMPK-11-RG-021     Document Type: Article

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