In situ formation of N-trifluoroacetoxy succinimide (TFA-NHS): One-pot formation of succinimidyl esters, N-trifluoroacetyl amino acid succinimidyl esters, and N-maleoyl amino acid succinimidyl esters

Journal of Organic Chemistry

Volumn 76, Issue 21, 2011, Pages 9169-9174

  Leonard, Nicholas M ^a   Brunckova, Jarmila ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IN-SITU FORMATIONS; ONE POT; REACTION CONDITIONS; REACTION MECHANISM; SUCCINIMIDE; SUCCINIMIDYL ESTER;

AMINO ACIDS; ESTERIFICATION;

ESTERS;

AMINO ACID DERIVATIVE; CARBOXYLIC ACID; FUMARIC ACID; MALEIC ACID DERIVATIVE; N MALEOYL AMINO ACID SUCCINIMIDYL ESTER; N TRIFLUOROACETOXY SUCCINIMIDE; PYRIDINE; SUCCINIMIDE DERIVATIVE; SUCCINIMIDYL ESTER; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; AMINO ACID SUBSTITUTION; AMINO ACID SYNTHESIS; ARTICLE; CHEMICAL REACTION; ESTERIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOMERIZATION; ONE POT SYNTHESIS; STRUCTURE ANALYSIS;

AMINO ACIDS; ESTERS; MOLECULAR STRUCTURE; STEREOISOMERISM; SUCCINIMIDES;

EID: 80055070156     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo201686e     Document Type: Article

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