Compact and flexible raster scanning multiphoton endoscope capable of imaging unstained tissue

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 43, 2011, Pages 17598-17603

  Rivera, David R ^a   Brown, Christopher M ^a   Ouzounov, Dimitre G ^a   Pavlova, Ina ^a   Kobat, Demirhan ^a   Webb, Watt W ^a   Xu, Chris ^a  

^a School of Operations Research and Industrial Engineering   (United States)

Author keywords

Endogenous fluorescence; Microendoscopy; Nonlinear optical endoscopy; Real time optical diagnosis; Scanning fiber endoscopy

Indexed keywords

GLASS FIBER;

ANIMAL TISSUE; ARTICLE; ENDOSCOPE; EXCITATION; FLUORESCENCE; ILLUMINATION; LASER; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SCANNER; PRIORITY JOURNAL; RADIATION FIELD;

ANIMALS; DIAGNOSTIC TECHNIQUES AND PROCEDURES; ENDOSCOPES; ENDOSCOPY; FLUORESCENCE; LASERS; MICE; OPTICAL FIBERS;

EID: 80055068027     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1114746108     Document Type: Article

References (30)

1. Zipfel WR, et al. (2003) Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation. Proc Natl Acad Sci USA 100:7075-7080. (Pubitemid 36706395)
2. Mukherjee S, et al. (2009) Human bladder cancer diagnosis using Multiphoton microscopy. Proc Soc Photo Opt Instrum Eng 7161:716117-1-716117-10.
3. Pavlova I, et al. (2010) Multiphoton microscopy as a diagnostic imaging modality for lung cancer. Proc Soc Photo Opt Instrum Eng 7569:756918-1-756918-7.
4. Wang CC, et al. (2009) Differentiation of normal and cancerous lung tissues by multiphoton imaging. J Biomed Opt 14:044034-1-044034-4.
5. Wilder-Smith P, et al. (2004) In vivo multiphoton fluorescence imaging: A novel approach to oral malignancy. Lasers Surg Med 35:96-103. (Pubitemid 39150407)
6. Skala MC, et al. (2005) Multiphoton microscopy of endogenous fluorescence differentiates normal, precancerous, and cancerous squamous epithelial tissues. Cancer Res 65:1180-1186. (Pubitemid 40270142)
7. Lin SJ, et al. (2006) Discrimination of basal cell carcinoma from normal dermal stroma by quantitative multiphoton imaging. Opt Lett 31:2756-2758.
8. Gu M, Bao HC, Li JL (2010) Cancer-cell microsurgery using nonlinear optical endomicroscopy. J Biomed Opt 15:050502-1-050502-3.
9. Huang X, El-Sayed IH, Qian W, El-Sayed MA (2006) Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods. J Am Chem Soc 128:2115-2120. (Pubitemid 43277351)
10. Helmchen F, Fee MS, Tank DW, Denk W (2001) A miniature head-mounted neurotechnique two-photon microscope: High-resolution brain imaging in freely moving animals. Neuron 31:903-912. (Pubitemid 32925278)
11. Wu T, Ding Z, Wang K, Chen M, Wang C (2009) Two-dimensional scanning realized by an asymmetry fiber canilever driven by single piezo bender actuator for optical coherence tomography. Opt Express 17:13819-13829.
12. Seibel EJ, Smithwick QYJ (2002) Unique features of optical scanning, single fiber endoscopy. Lasers Surg Med 30:177-183. (Pubitemid 34275034)
13. Myaing MT, MacDonald DJ, Li X (2006) Fiber-optic scanning two-photon fluorescence endoscope. Opt Lett 31:1076-1078. (Pubitemid 43837457)
14. Engelbrecht CJ, Johnston RS, Seibel EJ, Helmchen F (2008) Ultra-compact fiber-optic two-photon microscope for functional fluorescence imaging in vivo. Opt Express 16:5556-5564. (Pubitemid 351544174)
15. Wu Y, Leng Y, Xi J, Li X (2009) Scanning all-fiber-optic endomicroscopy system for 3D nonlinear optical imaging of biological tissues. Opt Express 17:7907-7915.
16. Hendriks BHW, et al. (2011) High-resolution resonant and nonresonant fiber-scanning confocal microscope. J Biomed Opt 16:026007-1-026007-8.
17. Sawinski J, Denk W (2007) Miniature random-access fiber scanner for in vivo multiphoton imaging. J Appl Phys 102:034701-1-034701-8.
18. Goetz M, et al. (2007) In-vivo confocal real-time mini-microscopy in animal models of human inflammatory and neoplastic diseases. Endoscopy 39:350-356. (Pubitemid 46605935)
19. Le Harzic R, Weinigel M, Riemann I, Konig K, Messerschmidt B (2008) Nonlinear optical endoscope based on a compact two axes piezo scanner and a miniature objective lens. Opt Express 16:20588-20596.
20. Dickensheets D, Kino GS (1996) Micromachined scanning confocal optical microscope. Opt Lett 21:764-766. (Pubitemid 126574986)
21. Hofmann U, et al. (1999) Electrostatically driven micromirrors for a miniaturized confocal laser scanning microscope. Proc Soc Photo Opt Instrum Eng 3878:29-38. (Pubitemid 30554164)
22. Piyawattanametha W, et al. (2009) In vivo brain imaging using a portable 2.9 g two-photon microscope based on a microelectromechanical systems scanning mirror. Opt Lett 34:2309-2311.
23. Fu L, Jain A, Cranfield C, Xie H, Gu M (2007) Three-dimensional nonlinear optical endoscopy. J Biomed Opt 12:040501-1-040501-3.
24. Piyawattanametha W, et al. (2006) Fast-scanning two-photon fluorescence imaging based on a microelectromechanical systems two-dimensional scanning mirror. Opt Lett 31:2018-2020. (Pubitemid 44542760)
25. Tang S, et al. (2009) Design and implementation of fiber-based multiphoton endoscopy with microelectromechanical systems scanning. J Biomed Opt 14:034005-1-034005-7.
26. Kinsler LE, Frey AR, Coppens AB, Sanders JV (1982) Fundamentals of Acoustics (Wiley, New York), 3rd Ed.
27. Durst ME, Kobat D, Xu C (2009) Tunable dispersion compensation by a rotating cylindrical lens. Opt Lett 34:1195-1197.
28. Boyd RW (1992) Nonlinear Optics (Academic, San Diego), pp 274-280.
29. Dela Cruz JM, McMullen JD, Williams RM, Zipfel WR (2010) Feasibility of using multiphoton excited tissue autofluorescence for in vivo human histopathology. Biomed Opt Express 1:1320-1330.
30. Nguyen QT, Tsai PS, Kleinfeld D (2006) MPScope: A versatile software suite for multiphoton microscopy. J Neurosci Methods 156:351-9. (Pubitemid 44233677)