Ultra-compact fiber-optic two-photon microscope for functional fluorescence imaging in vivo

Optics Express

Volumn 16, Issue 8, 2008, Pages 5556-5564

  Engelbrecht, Christoph J ^a   Johnston, Richard S ^b   Seibel, Eric J ^b   Heimchen, Fritjof ^a  

^a University of Zurich Brain Research Institute   (Switzerland)

^b University of Washington   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORESCENCE MICROSCOPY; IMAGING SYSTEMS; PHOTONIC CRYSTALS; TWO PHOTON PROCESSES;

FIBER-OPTIC TWO-PHOTON MICROSCOPE; FUNCTIONAL FLUORESCENCE IMAGING;

FIBER OPTICS;

ANIMAL; ARTICLE; CEREBELLUM; DENDRITE; ELECTRONICS; FIBER OPTICS; IMAGE ENHANCEMENT; INSTRUMENTATION; METHODOLOGY; MOUSE; MULTIPHOTON MICROSCOPY; RAT; ULTRASTRUCTURE;

ANIMALS; CEREBELLUM; DENDRITES; FIBER OPTICS; IMAGE ENHANCEMENT; MICE; MICROSCOPY, FLUORESCENCE, MULTIPHOTON; MINIATURIZATION; RATS;

EID: 42149143533     PISSN: None     EISSN: 10944087     Source Type: Journal    
DOI: 10.1364/OE.16.005556     Document Type: Article

References (39)

1. E. Selbel, T. Soper, R. Johnston, and R. Glenny, "Ultrathin laser scanning bronchoscope and guidance system for the peripheral lung," Lung Cancer 49, S162-S162 (2005).
2. E. J. Seibel, R. S. Johnston, C. M. Brown, J. A. Dominitz, and M. B. Kimmey, "Novel ultrathin scanning fiber endoscope for cholangioscopy and pancreatoscopy," Gastrointest. Endosc. 65, AM25-AM25 (2007).
3. A. F. Low, G. J. Tearney, B. E. Bouma, and I. K. Jang, "Technology insight: optical coherence tomography - current status and future development," Nature Clinical Practice Cardiovascular Medicine 3, 154-162 (2006).
4. Z. Yaqoob, J. G. Wu, E. J. McDowell, X. Heng, and C. H. Yang, "Methods and application areas of endoscopic optical coherence tomography," J. Biomed. Opt. 11, 063001 (2006).
5. F. Heimchen, "Miniaturization of fluorescence microscopes using fibre optics," Exp. Physiol. 87, 737-745 (2002).
6. A. D. Mehta, J. C. Jung, B. A. Flusberg, and M. J. Schnitzer, "Fiber optic in vivo imaging in the mammalian nervous system," Curr. Opin. Neurobiol. 14, 617-628 (2004).
7. B. A. Flusberg, E. D. Cocker, W. Piyawattanainetha, J. C. Jung, E. L. M. Cheung, and M. J. Schnitzer, "Fiber-optic fluorescence imaging," Nature Methods 2, 941-950 (2005).
8. L. Fu and M. Gu, "Fibre-optic nonlinear optical microscopy and endoscopy," J. Microsc. 226, 195-206 (2007).
9. J. C. Jung, A. D. Mehta, E. Aksay, R. Stepnoski, and M. J. Schnitzer, "In vivo mammalian brain Imaging using one- and two-photon fluorescence microendoscopy," J. Neurophysiol. 92, 3121-3133 (2004).
10. M. J. Levene, D. A. Dombeck, K. A. Kasischke, R. P. Molloy, and W. W. Webb, "In vivo multiphoton microscopy of deep brain tissue," J. Neurophysiol. 91, 1908-1912 (2004).
11. F. Heimchen, M. S. Fee, D. W. Tank, and W. Denk, "A miniature head-mounted two-photon microscope: High-resolution brain imaging in freely moving animals," Neuron 31, 903-912 (2001).
12. H. Adelsberger, O. Garaschuk, and A. Konnerth, "Cortical calcium waves in resting newborn mice," Nat. Neurosci. 8, 988-990 (2005).
13. M. Murayama, E. Perez-Garci, H. R. Luscher, and M. E. Larkum, "Fiberoptic system for recording dendritic calcium signals in layer 5 neocortical pyramidal cells in freely moving rats," J. Neurophysiol. 98, 1791-1805 (2007).
14. W. Denk, J. H. Strickler, and W. W. Webb, "Two-Photon Laser Scanning Fluorescence Microscopy," Science 248, 73-76 (1990).
15. W. Denk and K. Svoboda, "Photon upmanship: why multiphoton imaging is more than a gimmick," Neuron 18, 351-357 (1997).
16. F. Helmchen, and W. Denk, "Deep tissue two-photon microscopy," Nature Methods 2, 932-940 (2005).
17. J. Knittel, L. Schnieder, G. Buess, B. Messerschmidt, and T. Possner, "Endoscope-compatible confocal microscope using a gradient index-lens system," Opt. Commun. 188, 267-273 (2001).
18. J. C. Jung and M. J. Schnitzer, "Multiphoton endoscopy," Opt. Lett. 28, 902-904 (2003).
19. W. Göbel, J. N. D. Kerr, A. Nimmerjahn, and F. Helmchen, "Miniaturized two-photon microscope based on a flexible coherent fiber bundle and a gradient-index lens objective," Opt. Lett. 29, 2521-2523 (2004).
20. D. G. Ouzounov, K. D. Moll, M. A. Foster, W. R. Zipfel, W. W. Webb, and A. L. Gaeta, "Delivery of nanojoule femtosecond pulses through large-core microstructured fibers," Opt. Lett. 27, 1513-1515 (2002).
21. F. Helmchen, D. W. Tank, and W. Denk, "Enhanced two-photon excitation through optical fiber by single-mode propagation in a large core," Appl. Opt. 41, 2930-2934 (2002).
22. W. Göbel, A. Nimmerjahn, and F. Helmchen, "Distortion-free delivery of nanojoule femtosecond pulses from a Ti : sapphire laser through a hollow-core photonic crystal fiber," Opt. Lett. 29, 1285-1287 (2004).
23. B. A. Flusberg, J. C. Lung, E. D. Cocker, E. P. Anderson, and M. J. Schnitzer, "In vivo brain imaging using a portable 3.9 gram two-photon fluorescence microendoscope," Opt. Lett. 30, 2272-2274 (2005).
24. M. T. Myaing, D. J. MacDonald, and X. D. Li, "Fiber-optic scanning two-photon fluorescence endoscope," Opt. Lett. 31, 1076-1078 (2006).
25. L. Fu, X. Gan, and M. Gu, "Nonlinear optical microscopy based on double-clad photonic crystal fibers," Opt. Express 13, 5528-5534 (2005).
26. J. Sawinski and W. Denk, "Miniature random-access fiber scanner for in. vivo multiphoton imaging," J. Appl. Phys. 102, (2007).
27. W. Piyawattanametha, R. P. J. Barretto, T. H. Ko, B. A. Flusberg, E. D. Cocker, H. J. Ra, D. S. Lee, O. Solgaard, and M. J. Schnitzer, "Fast-scanning two-photon fluorescence imaging based on a microelectromechanical systems two-dimensional scanning mirror," Opt. Lett., 31, 2018-2020 (2006).
28. L. Fu, A. Jain, H. Xie, C. Cranfield, and M. Gu, "Nonlinear optical endoscopy based on a double-clad photonic crystal fiber and a MEMS mirror," Opt. Express 14, 1027-1032 (2006).
29. A. Monfared, N. H. Blevins, E. L. M. Cheung, J. C. Jung, G. Popelka, and M. J. Schnitzer, "In vivo Imaging of mammalian cochlear blood flow using fluorescence microendoscopy," Otology & Neurotology 27, 144-152 (2006).
30. P. Vincent, U. Maskos, I. Charvet, L. Bourgeais, L. Stoppini, N. Leresche, J. P. Changeux, R. Lambert, P. Meda, and D. Paupardin-Tritsch, "Live imaging of neural structure and function by fibred fluorescence microscopy," EMBO Rep7, 1154-1161 (2006).
31. E. J. Seibel and Q. Y. J. Smithwick, "Unique features of optical scanning, single fiber endoscopy," Lasers Surg. Med. 30, 177-183 (2002).
32. E. J. Seibel, R. S. Johnston, and C. D. Melville, "A full-color scanning fiber endoscope," Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications VI. Proceedings of the SPIE. 6083, 9-16 (2006).
33. S. W. Grill and E. H. K. Stelzer, "Method to calculate lateral and axial gain factors of optical setups with a large solid angle," J. Opt. Soc. Am. A 16, 2658-2665 (1999).
34. C. J. Engelbrecht and E. H. K. Stelzer, "Resolution enhancement in a light-sheet-based microscope (SPIM)," Opt. Lett. 31, 1477-1479 (2006).
35. M. R. Sullivan, A. Nimmerjahn, D. V. Sarkisov, F. Heimchen, and S. S. Wang, "In vivo calcium imaging of circuit activity in cerebellar cortex," J. Neurophysiol. 94, 1636-1644 (2005).
36. C. Stosiek, O. Garaschuk, K. Holthoff, and A. Konnerth, "In vivo two-photon calcium imaging of neuronal networks," Proc. Natl. Acad. Sci. USA 100, 7319-7324 (2003).
37. W. Göbel and F. Heimchen, "New angles on neuronal dendrites in vivo," J. Neurophysiol. 98, 3770-3779 (2007).
38. J.-F. Cardoso, "BLIND SOURCE SEPARATION and INDEPENDENT COMPONENT ANALYSIS," http://www.tsi.enst.fr/~cardoso/guidesepsou.html.
39. D. A. Dombeck, A. N. Khabbaz, F. Collman, T. L. Adelman, and D. W. Tank, "Imaging large-scale neural activity with cellular resolution in awake, mobile mice," Neuron 56, 43-57 (2007).