Genetic associations in the vitamin D receptor and colorectal cancer in African Americans and caucasians

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Kupfer, Sonia S ^a   Anderson, Jeffrey R ^a   Ludvik, Anton E ^a   Hooker, Stanley ^a   Skol, Andrew ^a   Kittles, Rick A ^b   Keku, Temitope O ^c   Sandler, Robert S ^c   Ruiz Ponte, Clara ^d   Castellvi Bel, Sergi ^e   Castells, Antoni ^e   Carracedo, Angel ^d   Ellis, Nathan A ^b  

^a UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^e UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

VITAMIN D; VITAMIN D RECEPTOR; CALCITRIOL RECEPTOR;

ADULT; AFRICAN AMERICAN; AGED; ARTICLE; CAUCASIAN; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; GENDER; GENE; GENETIC ASSOCIATION; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; SINGLE NUCLEOTIDE POLYMORPHISM; SPAIN; TUMOR LOCALIZATION; UNITED STATES; VDR GENE; VITAMIN INTAKE; BLOOD; COLORECTAL TUMOR; ETHNOLOGY; GENETICS;

AFRICAN AMERICANS; CHICAGO; COLORECTAL NEOPLASMS; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENE-ENVIRONMENT INTERACTION; HUMANS; INTRONS; NORTH CAROLINA; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, CALCITRIOL; SPAIN; VITAMIN D;

EID: 80055064637     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026123     Document Type: Article

References (59)

1. Slominski A, Wortsman J, (2000) Neuroendocrinology of the skin. Endocr Rev 21: 457-487.
2. Holick MF, (2000) Calcium and vitamin D. Diagnostics and therapeutics. Clin Lab Med 2000 20: 569-590.
3. Garland CF, Garland FC, (1980) Do sunlight and vitamin D reduce the likelihood of colon cancer? Int J Epidemiol 9: 227-231.
4. Yin L, Grandi N, Raum E, Haug U, Arndt V, et al. (2009) Meta-analysis: longitudinal studies of serum vitamin D and colorectal cancer risk. Aliment Pharmacol Ther 30: 113-125.
5. Gorham ED, Garland CF, Garland FC, Grant WB, Mohr SB, et al. (2007) Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. Am J Prev Med 32: 210-216.
6. Wei MY, Garland CF, Gorham ED, Mohr SB, Giovannucci E, (2008) Vitamin D and prevention of colorectal adenoma: a meta-analysis. Cancer Epidemiol Biomarkers Prev 17: 2958-2969.
7. Garland CF, Comstock GW, Garland FC, Helsing KJ, Shaw EK, et al. (1989) Serum 25-hydroxyvitamin D and colon cancer: eight-year prospective study. Lancet 334: 1176-1178.
8. Tangrea J, Helzlsouer K, Pietinen P, Taylor P, Hollis P, et al. (1997) Serum levels of vitamin D metabolites and the subsequent risk of colon and rectal cancer in Finnish men. Cancer Causes Control 8: 615-625.
9. Levine AJ, Harper JM, Ervin CM, Chen YH, Harmon E, et al. (2001) Serum 25-hydroxyvitamin D, dietary calcium intake, and distal colorectal adenoma risk. Nutr Cancer 39: 35-41.
10. Feskanich D, Ma J, Fuchs CS, Kirkner GJ, Hankinson SE, et al. (2004) Plasma vitamin D metabolites and risk of colorectal cancer in women. Cancer Epidemiol Biomarkers Prev 13: 1502-1508.
11. Wu K, Feskanich D, Fuchs CS, Willett WC, Hollis BW, et al. (2007) A nested case control study of plasma 25-hydroxyvitamin D concentrations and risk of colorectal cancer. J Natl Cancer Inst 99: 1120-1129.
12. Platz EA, Hankinson SE, Hollis BW, Colditz GA, Hunter DJ, et al. (2000) Plasma 1,25-dihydroxy- and 25-hydroxyvitamin D and adenomatous polyps of the distal colorectum. Cancer Epidemiol Biomarkers Prev 9: 1059-1065.
13. Garland C, Shekelle RB, Barrett-Connor E, Criqui MH, Rossof AH, et al. (1985) Dietary vitamin D and calcium and risk of colorectal cancer: a 19-year prospective study in men. Lancet 325: 307-309.
14. Matsuoka LY, Wortsman J, Haddad JG, Kolm P, Hollis BW, (1991) Racial pigmentation and the cutaneous synthesis of vitamin D. Arch Dermatol 127: 536-538.
15. Martins D, Wolf M, Pan D, Zadshir A, Tareen N, et al. (2007) Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey. Arch Intern Med 167: 1159-1165.
16. Fiscella K, Winters P, Tancredi D, Hendren S, Franks P, (2011) Racial disparity in death from colorectal cancer: does vitamin D deficiency contribute? Cancer 117: 1061-1069.
17. Kostner K, Denzer N, Muller CS, Klein R, Tilgen W, et al. (2009) The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature. Anticancer Res 29: 3511-3536.
18. Raimondi S, Johansson H, Maisonneuve P, Gandini S, (2009) Review and meta-analysis on vitamin D receptor polymorphisms and cancer risk. Carcinogenesis 30: 1170-1180.
19. Flugge J, Laschinski G, Roots I, Krusekopf S, (2009) Vitamin D receptor poly(A) microsatellite and colorectal cancer risk in Caucasians. Int J Colorectal Dis 24: 171-175.
20. Gong YL, Xie DW, Deng ZL, Bostick RM, Miao XJ, et al. (2005) Vitamin D receptor gene Tru9I polymorphism and risk for incidental sporadic colorectal adenomas. World J Gastroenterol 11: 4794-4799.
21. Hughes DJ, Hlavata I, Soucek P, Pardini B, Naccarati A, et al. (2011) Variation in the Vitamin D Receptor Gene is not Associated with Risk of Colorectal Cancer in the Czech Republic. J Gastrointest Cancer 42: 149-154.
22. Ingles SA, Wang J, Coetzee GA, Lee ER, Frankl HD, et al. (2001) Vitamin D receptor polymorphisms and risk of colorectal adenomas (United States). Cancer Causes Control 12: 607-614.
23. Jenab M, McKay J, Bueno-de-Mesquita HB, van Duijnhoven FJ, Ferrari P, et al. (2009) Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations. Cancer Epidemiol Biomarkers Prev 18: 2485-2491.
24. Kim HS, Newcomb PA, Ulrich CM, Kenner CL, Bigler J, et al. (2001) Vitamin D receptor polymorphism and the risk of colorectal adenomas: evidence of interaction with dietary vitamin D and calcium. Cancer Epidemiol Biomarkers Prev 10: 869-874.
25. Li C, Li Y, Gao LB, Wang YY, Zhou B, et al. (2009) Vitamin D receptor gene polymorphisms and the risk of colorectal cancer in a Chinese population. Dig Dis Sci 54: 634-639.
26. Mahmoudi T, Mohebbi SR, Pourhoseingholi MA, Fatemi SR, Zali MR, (2010) Vitamin D receptor gene ApaI polymorphism is associated with susceptibility to colorectal cancer. Dig Dis Sci 55: 2008-2013.
27. Murtaugh MA, Sweeney C, Ma KN, Potter JD, Caan BJ, et al. (2006) Vitamin D receptor gene polymorphisms, dietary promotion of insulin resistance, and colon and rectal cancer. Nutr Cancer 55: 35-43.
28. Ochs-Balcom HM, Cicek MS, Thompson CL, Tucker CL, Elston RC, et al. (2008) Association of vitamin D receptor gene variants, adiposity and colon cancer. Carcinogenesis 29: 1788-1793.
29. Peters U, Hayes RB, Chatterjee N, Shao W, Schoen RE, et al. (2004) Circulating vitamin D metabolites, polymorphism in vitamin D receptor, and colorectal adenoma risk. Cancer Epidemiol Biomarkers Prev 13: 546-552.
30. Slattery ML, Yakumo K, Hoffman M, Neuhausen S, (2001) Variants of the VDR gene and risk of colon cancer (United States). Cancer Causes Control 12: 359-364.
31. Slattery ML, Herrick J, Wolff RK, Caan BJ, Potter JD, et al. (2007) CDX2 VDR polymorphism and colorectal cancer. Cancer Epidemiol Biomarkers Prev 16: 2752-2755.
32. Slattery ML, Murtaugh M, Caan B, Ma KN, Wolff R, et al. (2004) Associations between BMI, energy intake, energy expenditure, VDR genotype and colon and rectal cancers (United States). Cancer Causes Control 15: 863-872.
33. Slattery ML, Neuhausen SL, Hoffman M, Caan B, Curtin K, et al. (2004) Dietary calcium, vitamin D, VDR genotypes and colorectal cancer. Int J Cancer 111: 750-756.
34. Parisi E, Rene JM, Cardus A, Valcheva P, Pinol-Felis C, et al. (2008) Vitamin D receptor levels in colorectal cancer. Possible role of BsmI polymorphism. J Steroid Biochem Mol Biol 111: 87-90.
35. Park K, Woo M, Nam J, Kim JC, (2006) Start codon polymorphisms in the vitamin D receptor and colorectal cancer risk. Cancer Lett 237: 199-206.
36. Slattery ML, Sweeney C, Murtaugh M, Ma KN, Caan BJ, et al. (2006) Associations between vitamin D, vitamin D receptor gene and the androgen receptor gene with colon and rectal cancer. Int J Cancer 118: 3140-3146.
37. Slattery ML, Wolff RK, Herrick JS, Caan BJ, Samowitz W, (2010) Calcium, vitamin D, VDR genotypes, and epigenetic and genetic changes in rectal tumors. Nutr Cancer 62: 436-442.
38. Sweeney C, Curtin K, Murtaugh MA, Caan BJ, Potter JD, et al. (2006) Haplotype analysis of common vitamin D receptor variants and colon and rectal cancers. Cancer Epidemiol Biomarkers Prev 15: 744-749.
39. Theodoratou E, Farrington SM, Tenesa A, McNeill G, Cetnarskyj R, et al. (2008) Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding. Int J Cancer 123: 2170-2179.
40. Wong HL, Seow A, Arakawa K, Lee HP, Yu MC, et al. (2003) Vitamin D receptor start codon polymorphism and colorectal cancer risk: effect modification by dietary calcium and fat in Singapore Chinese. Carcinogenesis 24: 1091-1095.
41. Yaylim-Eraltan I, Arzu Ergen H, Arikan S, Okay E, Ozturk O, et al. (2007) Investigation of the VDR gene polymorphisms association with susceptibility to colorectal cancer. Cell Biochem Funct 25: 731-737.
42. Poynter JN, Jacobs ET, Figueiredo JC, Lee WH, Conti DV, et al. (2010) Genetic variation in the vitamin D receptor (VDR) and the vitamin D-binding protein (GC) and risk for colorectal cancer: results from the Colon Cancer Family Registry. Cancer Epidemiol Biomarkers Prev 19: 525-536.
43. Egan JB, Thompson PA, Ashbeck EL, Conti DV, Duggan D, et al. (2010) Genetic polymorphisms in vitamin D receptor VDR/RXRA influence the likelihood of colon adenoma recurrence. Cancer Res 70: 1496-1504.
44. Kupfer SS, Anderson JR, Hooker S, Skol A, Kittles RA, et al. (2010) Genetic heterogeneity in colorectal cancer associations between African and European Americans. Gastroenterology 139: 1677-1685.
45. Weinberg CR, Sandler DP, (1991) Randomized recruitment in case-control studies. Am J Epidemiol 134: 421-432.
46. Block G, Hartman AM, Dresser CM, Carroll MD, Gannon J, et al. (1986) A data-based approach to diet questionnaire design and testing. Am J Epidemiol 124: 453-469.
47. Sansbury LB, Millikan RC, Schroeder JC, North KE, Moorman PG, et al. (2006) COX-2 polymorphism, use of nonsteroidal anti-inflammatory drugs, and risk of colon cancer in African Americans (United States). Cancer Causes Control 17: 257-266.
48. Pinol V, Castells A, Andreu M, Castellvi-Bel S, Alenda C, et al. (2005) Accuracy of revised Bethesda guidelines, microsatellite instability, and immunohistochemistry for the identification of patients with hereditary nonpolyposis colorectal cancer. JAMA 293: 1986-94.
49. Fernández-Rozadilla C, Tarrio R, Clofent J, de Castro L, Brea-Fernandez A, et al. (2010) Colorectal cancer susceptibility quantitative trait loci in mice as a novel approach to detect low-penetrance variants in humans: a two-stage case-control study. Cancer Epidemiol Biomarkers Prev 19: 619-623.
50. Barrett JC, Fry B, Maller J, Daly MJ, (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21: 263-265.
51. Kupfer SS, Torres JB, Hooker S, Anderson JR, Skol A, et al. (2009) Novel single nucleotide polymorphism associations with colorectal cancer on chromosome 8q24 in African and European Americans. Carcinogenesis 30: 1353-1357.
52. Robbins C, Torres JB, Hooker S, Bonilla C, Hernandez W, et al. (2007) Confirmation study of prostate cancer risk variants at 8q24 in African Americans identifies a novel risk locus. Genome Res 17: 1717-1722.
53. Falush D, Stephens M, Pritchard JK, (2003) Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. Genetics 164: 1567-1587.
54. Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, et al. (2008) Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 40: 638-645.
55. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, et al. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81: 559-575.
56. Li Y, Willer CJ, Ding J, Scheet P, Abecasis GR, (2010) MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol 34: 816-834.
57. Li Y, Willer C, Sanna S, Abecasis G, (2009) Genotype imputation. Annu Rev Genomics Hum Genet 10: 387-406.
58. Ahn J, Yu K, Stolzenberg-Solomon R, Simon KC, McCullough ML, et al. (2010) Genome-wide association study of circulating vitamin D levels. Hum Mol Genet 19: 2739-2745.
59. Ramagopalan SV, Heger A, Berlanga AJ, Maugeri NJ, Lincoln MR, et al. (2010) A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution. Genome Res 20: 1352-1360.