Interaction of zwitterionic penicillins with the OmpF channel facilitates their translocation

Biophysical Journal

Volumn 90, Issue 5, 2006, Pages 1617-1627

  Danelon, Christophe ^a,e   Nestorovich, Ekaterina M ^b   Winterhalter, Mathias ^a,c   Ceccarelli, Matteo ^d   Bezrukov, Sergey M ^b  

^a INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c JACOBS UNIVERSITY BREMEN   (Germany)

^d UNIVERSITY OF CAGLIARI   (Italy)

^e EPFL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; AMPHOLYTE; AMPICILLIN; AZLOCILLIN; BETA LACTAM ANTIBIOTIC; CARBENICILLIN; OUTER MEMBRANE PROTEIN F; PENICILLIN DERIVATIVE; PIPERACILLIN; ANTIINFECTIVE AGENT; BETA LACTAM; PORIN;

ARTICLE; BINDING AFFINITY; CELL MEMBRANE TRANSPORT; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG TRANSPORT; ENTROPY; HYDROPHOBICITY; ION CURRENT; LIPID BILAYER; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOLECULAR SIZE; MOLECULAR WEIGHT; POROSITY; STRUCTURE ACTIVITY RELATION; BIOLOGICAL MODEL; CHANNEL GATING; CHEMICAL MODEL; CHEMISTRY; COMPARATIVE STUDY; COMPUTER SIMULATION; ELECTRICITY; ESCHERICHIA COLI; MEMBRANE FLUIDITY;

BACTERIA (MICROORGANISMS);

ANTI-BACTERIAL AGENTS; BETA-LACTAMS; COMPUTER SIMULATION; ELECTROSTATICS; ESCHERICHIA COLI; ION CHANNEL GATING; LIPID BILAYERS; MEMBRANE FLUIDITY; MODELS, BIOLOGICAL; MODELS, CHEMICAL; PENICILLINS; PORINS; POROSITY;

EID: 33646138013     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1529/biophysj.105.075192     Document Type: Article

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