Tspan-1 interacts with the thiamine transporter-1 in human intestinal epithelial cells and modulates its stability

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 301, Issue 5, 2011, Pages

  Nabokina, Svetlana M ^a,b   Senthilkumar, Sundar Rajan ^a,b   Said, Hamid M ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA LONG BEACH HEALTHCARE SYSTEM   (United States)

Author keywords

Bacterial two hybrid analysis; Protein stability; Protein protein interactions; Thiamine transport

Indexed keywords

CARRIER PROTEIN; COMPLEMENTARY DNA; GLUTATHIONE TRANSFERASE; PROTEIN TSPAN; TETRASPANIN; THIAMINE; THIAMINE TRANSPORTER 1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL FUNCTION; CELL STRAIN CACO 2; CELL TYPE; CONTROLLED STUDY; CYTOLOGY; DNA LIBRARY; GENETIC CODE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; INTESTINE EPITHELIUM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; REGULATORY MECHANISM; SEQUENCE ANALYSIS; TWO HYBRID SYSTEM;

CELL LINE; EPITHELIAL CELLS; HUMANS; INTESTINAL MUCOSA; INTESTINES; MEMBRANE TRANSPORT PROTEINS; TETRASPANINS;

EID: 80055027660     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00269.2011     Document Type: Article

References (37)

1. Ashokkumar B, Vaziri ND, Said HM. Thiamin uptake by the human-derived renal epithelial (HEK-293) cells: cellular and molecular mechanisms. Am J Physiol Renal Physiol 291: F796-F805, 2006.
2. Ashokkumar B, Nabokina SM, Ma TY, Said HM. Identification of dynein light chain road block-1 as a novel interaction partner with the human reduced folate carrier. Am J Physiol Gastrointest Liver Physiol 297: G480-G487, 2009.
3. Berdanier CD. Advanced Nutrition Micronutrients. Boca Raton, FL: CRC, 1998, p. 80-88.
4. Boucheix C, Rubinstein E. Tetraspanins. Cell Mol Life Sci 58: 1189- 1205, 2001.
5. Boulware MJ, Subramanian VS, Said HM, Marchant JS. Polarized expression of members of the solute carrier SLC19A gene family of water-soluble multivitamin transporters: implications for physiological function. Biochem J 376: 43-48, 2003.
6. Claas C, Stipp CS, Hemler ME. Evaluation of prototype transmembrane 4 superfamily protein complexes and their relation to lipid rafts. J Biol Chem 276: 7974-7984, 2001.
7. Diaz GA, Banikazemi M, Oishi K, Desnick RJ, Gelb BD. Mutations in a new gene encoding a thiamine transporter cause thiamine responsive megaloblastic anemia syndrome. Nat Genet 22: 309-312, 1999.
8. Duffield A, Kamsteeg EJ, Brown AN, Pagel P, Caplan MJ. The tetraspanin CD63 enhances the internalization of the H,K-ATPase beta-subunit. Proc Natl Acad Sci USA 100: 15560-15565, 2003.
9. Dutta B, Huang W, Molero M, Kekuda R, Leibach FH, Devoe LD, Ganapathy V, Prasad PD. Cloning of the human thiamine transporter, a member of the folate transporter family. J Biol Chem 274: 31925-31929, 1999.
10. Eudy JD, Spiegelstein O, Barber RC, Wlodarczyk BJ, Talbot J, Finnell RH. Identification and characterization of human and mouse SLC19A3 gene: a novel member of the reduced folate family of micro-nutrient transporter genes. Mol Genet Metab 71: 581-590, 2000.
11. Fleming JC, Tartaglini E, Steinkamp M, Schorderit DF, Cohen N, Neufeld EJ. The gene mutated in thiamine-responsive anemia with diabetes and deafness (TRMA) encodes a functional thiamine transporter. Nat Genet 22: 305-308, 1999.
12. Hemler ME. Specific tetraspanin functions. J Cell Biol 155: 1103-1107, 2001.
13. Hemler ME. Tetraspanin functions and associated microdomains. Nat Rev Mol Cell Biol 6: 801-811, 2005.
14. Leevy CM, Baker H. Vitamins and alcoholism. Am J Clin Nutr 21: 1325-1328, 1968.
15. Mee L, Nabokina SM, Sekar VT, Subramanian VS, Maedler K, Said HM. Pancreatic beta cells and islets take up thiamin by a regulated carrier-mediated process: studies using mice and human pancreatic preparations. Am J Physiol Gastrointest Liver Physiol 297: G197-G206, 2009.
16. Munehira Y, Ohnishi T, Kawamoto S, Furuya A, Shitara K, Imamura M, Yokota T, Takeda S, Amachi T, Matsuo M, Kioka N, Ueda K. Alpha1-syntrophin modulates turnover of ABCA1. J Biol Chem 279: 15091-15095, 2004.
17. Nabokina SM, Said HM. Characterization of the 5 - regulatory region of the human thiamin transporter SLC19A3: in vitro and in vivo studies. Am J Physiol Gastrointest Liver Physiol 287: G822-G829, 2004.
18. Nabokina SM, Reidling JC, Said HM. Differentiation-dependent up-regulation of intestinal thiamin uptake: cellular and molecular mechanisms. J Biol Chem 280: 32676-32682, 2005.
19. Nabokina SM, Subramanian VS, Said HM. Association of PDZ-con-taining protein PDZD11 with the human sodium-dependent multivitamin transporter. Am J Physiol Gastrointest Liver Physiol 300: G561-G567, 2011.
20. Reidling JC, Said HM. In vitro and in vivo characterization of the minimal promoter region of the human thiamin transporter SLC19A2. Am J Physiol Cell Physiol 285: C633-C641, 2003.
21. Reidling JC, Said HM. Adaptive regulation of intestinal thiamin uptake: molecular mechanism using wild-type and transgenic mice carrying hTHTR-1 and -2 promoters. Am J Physiol Gastrointest Liver Physiol 288: G1127-G1134, 2005.
22. Reidling JC, Nabokina SM, Balamurugan K, Said HM. Developmental maturation of intestinal and renal thiamin uptake: studies in wild-type and transgenic mice carrying human THTR-1 and 2 promoters. J Cell Physiol 206: 371-377, 2006.
23. Said HM, Ortiz A, Kumar CK, Chatterjee N, Dudeja PK, Rubin S. Transport of thiamine in human intestine: mechanism and regulation in intestinal epithelial cell model Caco-2. Am J Physiol Cell Physiol 277: C645-C651, 1999.
24. Said HM, Balamurugan K, Subramanian VS, Marchant JS. Expression and functional contribution of hTHTR-2 in thiamin absorption in human intestine. Am J Physiol Gastrointest Liver Physiol 286: G491-G498, 2004.
25. Said H. Intestinal absorption of water-soluble vitamins in health and disease. Biochem J 437: 357-372, 2011.
26. Saito N, Kimura M, Kuchiba A, Itokawa Y. Blood thiamine levels in outpatients with diabetes mellitus. J Nutr Sci Vitaminol (Tokyo) 33: 421-430, 1987.
27. Stipp CS, Kolesnikova TV, Hemler ME. Functional domains in tetras-panin proteins. Trends Biochem Sci 28: 106-112, 2003.
28. Subramanian VS, Marchant JS, Parker I, Said HM. Cell biology of the human thiamine transporter-1 (hTHTR1). Intracellular trafficking and membrane targeting mechanisms. J Biol Chem 278: 3976-3984, 2003.
29. Subramanian VS, Marchant JS, Said HM. Targeting and trafficking of the human thiamine transporter-2 in epithelial cells. J Biol Chem 281: 5233-5245, 2006.
30. Subramanian VS, Mohammed ZM, Molina A, Marchant JS, Vaziri ND, Said HM. Vitamin B1 (thiamine) uptake by human retinal pigment epithelial (ARPE-19) cells: mechanism and regulation. J Physiol 582: 73-85, 2007.
31. Sun AQ, Balasubramaniyan N, Liu CJ, Shahid M, Suchy FJ. Association of the 16-kDa subunit c of vacuolar proton pump with the ileal Na+-dependent bile acid transporter: protein-protein interaction and intracellular trafficking. J Biol Chem 279: 16295-16300, 2004.
32. Tallaksen CM, Bell H, Bohmer T. Thiamine and thiamine phosphate ester deficiency assessed by high performance liquid chromatography in four clinical cases of Wernicke encephalopathy. Alcohol Clin Exp Res 17: 712-716, 1993.
33. Tanphaichirt V. Modern Nutrition in Health and Disease. New York: Lea and Febiger, 1994, p. 359-375.
34. Thomson AD. The absorption of sulfur-labeled thiamin hydrochloride in control subjects and in patients with intestinal malabsorption. Clin Sci (Lond) 31: 167-179, 1966.
35. Tomasulo PA, Kater RM, Iber FL. Impairment of thiamine absorption in alcoholism. Am J Clin Nutr 21: 1341-1344, 1968.
36. Victor M, Adams RD, Collins GH. The Wernicke-Korsakoff Syndrome and Related Neurological Disorders Due to Alcoholism and Malnutrition. Philadelphia, PA: Davis, 1989.
37. Wilson MC, Meredith D, Fox JE, Manoharan C, Davies AJ, Halestrap AP. Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). J Biol Chem 280: 27213-27221, 2004.