Vitamin B1 (thiamine) uptake by human retinal pigment epithelial (ARPE-19) cells: Mechanism and regulation

Journal of Physiology

Volumn 582, Issue 1, 2007, Pages 73-85

  Subramanian, Veedamali S ^a   Mohammed, Zainab M ^a   Molina, Andres ^a   Marchant, Jonathan S ^b   Vaziri, Nosratola D ^a   Said, Hamid M ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c VA LONG BEACH HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE; CELL PROTEIN; HUMAN THIAMINE TRANSPORTER 1; HUMAN THIAMINE TRANSPORTER 2; MELARSOPROL; PROTEIN KINASE (CALCIUM,CALMODULIN); SODIUM; THIAMINE; THIOL DERIVATIVE; UNCLASSIFIED DRUG; CALCIUM ION; SODIUM ION; THIOL GROUP;

ARTICLE; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENERGY; EXTRACELLULAR SPACE; HUMAN; HUMAN CELL; HUMAN TISSUE; MEGALOBLASTIC ANEMIA; PH; PHENOTYPE; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TEMPERATURE DEPENDENCE; CELL FUNCTION; CELL SURFACE; DRUG TRANSPORT; EPITHELIUM CELL; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; HTHTR 1 GENE; HTHTR 2 GENE; REGULATORY MECHANISM; REPORTER GENE; RETINAL TISSUE; SIGNAL TRANSDUCTION;

4-CHLOROMERCURIBENZENESULFONATE; AMILORIDE; ANEMIA, MEGALOBLASTIC; BIOLOGICAL TRANSPORT, ACTIVE; CALCIUM; CALMODULIN; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; MEMBRANE TRANSPORT PROTEINS; MUTATION; PIGMENT EPITHELIUM OF EYE; PROTEIN TRANSPORT; RNA, MESSENGER; SIGNAL TRANSDUCTION; SODIUM; SULFHYDRYL REAGENTS; TEMPERATURE; THIAMINE; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 34347236918     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2007.128843     Document Type: Article

References (48)

1. Ashokkumar B, Vaziri ND & Said HM (2006). Thiamin uptake by the human-derived renal epithelial (HEK 293) cells: Cellular and molecular mechanisms. Am J Physiol Renal Physiol 291, F796-F805.
2. Aukunuru JV, Sunkara G, Bandi N, Threson WB & Kompella UB (2001). Expression of multi-drug resistance-associated protein (MRP) in human retinal pigment epithelial cells and its interaction with BAPSG, a noval aldose reductase inhibitor. Pharm Res 18, 565-572.
3. Berdanier CD (1998). Advanced Nutrition-Micronutrients. CRC Press, New York.
4. Busik JV, Olson LK, Grant MB & Henry DN (2002). Glucose-induced activation of glucose uptake in cells from the inner and outer blood-retinal barrier. Invest Ophthalmol Vis Sci 43, 2356-2363.
5. Calingasan NY, Gandy SE, Baker H, Sheu KF, Smith JD, Lamb BT, Gearhart JD, Buxbaum JD, Harper C, Selkoe DJ, Price DL, Sisodia SS & Gibson GE (1996). Noval neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency. Am J Pathol 149, 1063-1071.
6. Calingasan NY, Gandy SE & Gibson GE (1997). Thiamine deficiency alters APP but not presenilin-1 immunoreactivity in vulnerable brain regions. Neuroreport 8, 2631-2634.
7. Diaz GA, Banikazemi M, Oishi K, Desnick RJ & Gelb BD (1999). Mutations in a new gene encoding a thiamine transporter cause thiamine-responsive megaloblastic anaemia syndrome. Nat Genet 22, 309-312.
8. Dunn KC, Aotaki-Keen AE, Putkey FR & Hjelmeland LM (1996). ARPE-19, a human retinal pigment epithelial cell line with differentiated properties. Exp Eye Res 62, 155-169.
9. Dutta B, Huang W, Molero M, Kekuda R, Leibach FH, Devoe LD, Ganapathy V & Prasad PD (1999). Cloning of the human thiamine transporter, a member of the folate transporter family. J Biol Chem 274, 31925-31929.
10. Eudy JD, Spiegel O, Barber RC, Wlodarczyk BJ, Talbot J & Finnell RH (2000). Identification and characterization of the human and mouse SLC19A3 gene: A novel member of the reduced folate family of micronutrient transporter genes. Mol Genet Metab 71, 581-590.
11. Fleming JC, Tartaglini E, Steinkamp M, Schorderit DF, Cohen N & Neufeld EJ (1999). The gene mutated in thiamine responsive anaemia with diabetes and deafness (TRMA) encodes a functional thiamine transporter. Nat Genet 22, 305-308.
12. Frederikse PH, Farnsworth P & Zigler JS Jr (1999). Thiamine deficiency in vivo produces fiber cell degeneration in mouse lenses. Biochem Biopys Res Commun 258, 703-707.
13. Hammes HP, Du X, Edelstein D, Taguchi T, Matsumura T, Ju Q, Lin J, Bierhaus A, Nawroth P, Hannak D, Neumaier M, Bergfeld R, Giardino I & Brownlee M (2003). Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nat Med 9, 294-299.
14. Labay V, Raz T, Baron D, Mandel H, Williams H, Barrett T, Szargel R, McDonald L, Shalata A, Nosaka K, Gregory S & Cohen N (1999). Mutations in SLC19A2 cause thiamine-responsive megaloblastic anaemia associated with diabetes mellitus and deafness. Nat Genet 22, 300-304.
15. Lagarde WH, Underwood LE, Moats-Staats BM & Calikoglu AS (2004). Novel mutation in the SLC19A2 gene in an African-American female with thiamine-responsive megaloblastic anemia syndrome. Am J Med Genet A 123, 299-305.
16. Leevy CM & Baker H (1968). Vitamins and alcoholism. Am J Clin Nutr 21, 325-328.
17. Livak KJ & Schmittgen TD (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C (T)) method. Methods 25, 402-408.
18. Martin MG, Lostao MP, Turk E, Lam J, Wright EM & Kreman M (1997). Compound missense mutations in the sodium/d-glucose cotransporter result in trafficking defects. Gastroenterology 112, 1206-1212.
19. Meire FM, Van Genderen MM, Lemmens K & Ens-Dokkum MH (2000). Thiamine-responsive megaloblastic anemia syndrome (TRMA) with cone-rod dystrophy. Ophthalmic Genet 21, 243-250.
20. Nabokina SM & Said HM (2004). Characterization of the 5′-regulatory region of the human thiamin transporter SLC19A3: In vitro and in vivo studies. J Cell Physiol 287, G822-G829.
21. Philp NJ, Wang D, Yoon H & Hjelmeland LM (2003). Polarized expression of monocarboxlate transporters in human retinal pigment epithelium and ARPE-19 cells. Invest Ophthalmol Vis Sci 44, 1716-1721.
22. Pow DV (2001). Amino acids and their transporters in the retina. Neurochem Int 38, 463-484.
23. Rajgopal A, Edmondson A, Goldman D & Zhao R (2001). SLC19A3 encodes a second thiamine transporter ThTr2. Biochim Biopys Acta 1537, 175-178.
24. Raz T, Labay V, Baron D, Szargel R, Anbinder Y, Barrett T, Rabl W, Viana MB, Mandel H, Baruchel A, Cayuela JM & Cohen N (2000). The spectrum of mutations, including four novel ones, in the thiamine-responsive megaloblastic anaemia gene SLC19A2 of eight families. Hum Mutat 13, 37-42.
25. Reidling JC, Nabokina SM, Balamurugan K & Said HM (2006). Developmental maturation of intestinal and renal thiamin uptake: Studies in wild-type and transgenic mice carrying human THTR-1 and -2 promoters. J Cell Physiol 206, 371-377.
26. Reidling JC & Said HM (2003). In vitro and in vivo characterization of the minimal promoter region of the human thiamin transporter SLC19A2. Am J Physiol Cell Physiol 285, C633-C641.
27. Reidling JC & Said HM (2005). Adaptive regulation of intestinal thiamin uptake: Molecular mechanism using wild-type and transgenic mice carrying hTHTR-1 and -2 promoters. Am J Physiol Gastrointest Liver Physiol 288, G1127-G1134.
28. Reidling JC, Subramanian VS, Dudeja PK & Said HM (2002). Expression and promoter analysis of SLC19A2 in the human intestine. Biochim Biophys Acta 1561, 180-187.
29. Ricketts CJ, Minton JA, Ariyawansa I, Wales JK, Lo IF & Barrett TG (2006). Thiamine-responsive megaloblastic anaemia syndrome: Long-term follow-up and mutation analysis of seven families. Acta Paediatr 95, 99-104.
30. Rindi G & Laforenza U (2000). Thiamine intestinal transport and related issues: Recent aspects. Proc Soc Exp Biol Med 224, 246-255.
31. Said HM, Balamurugan K, Subramanian VS & Marchant JS (2004). Expression and functional contribution of the human thiamin transporter-2 (hTHTR-2) in thiamin absorption in the human intestine. Am J Physiol Gastrointest Liver Physiol 286, G491-G498.
32. Said HM, Ortiz A, Kumar C, Chatterjee N, Dudeja P & Rubin S (1999). Transport of thiamine in human intestine: Mechanism and regulation in intestinal epithelial cell model Caco-2. Am J Physiol Cell Physiol 277, C645-C651.
33. Said HM, Ortiz A, Subramanian VS, Neufeld EJ, Moyer MP & Dudeja P (2001). Mechanism of thiamine uptake by human colonocytes: Studies with cultured colonic epithelial cell line NCM 460. Am J Physiol Cell Physiol 277, C645-C651.
34. 2+-calmodulin-mediated pathway. J Physiol 566, 369-377.
35. Saito N, Kimura M, Kuchiba A & Itokawa Y (1987). Blood thiamine levels in outpatients with diabetes mellitus. J Nutr Sci Vitaminol (Tokyo) 33, 421-430.
36. Scharfe C, Hauschild M, Klopstock T, Janssen AJM, Heidemann PH, Meitinger T & Jaksch M (2000). A noval mutation in the thiamine responsive megaloblastic anaemia gene SLC19A2 in a patient with deficiency of respiratory chain complex I. J Med Genet 37, 669-673.
37. Schweingruber ME (2004). The melaminophenyl arsenicals melarsoprol and melarsenoxide interfere with thiamin metabolism in the fission yeast Schizosaccharomyces pombe. Antimicrob Agents Chemother 48, 3268-3271.
38. Stagg AR, Fleming JC, Baker MA, Sakamoto M, Cohen N & Neufeld EJ (1999). Defective high-affinity thiamine transporter leads to cell death in thiamine-responsive megaloblastic anemia syndrome fibroblasts. J Clin Invest 103, 723-729.
39. Stein M-P, Wandinger-Ness A & Roitbak T (2002). Altered trafficking and epithelial cell polarity in disease. Trends Cell Biol 12, 374-381.
40. Subramanian VS, Chatterjee N & Said HM (2003 a). Folate uptake in the human intestine: Promoter activity and effect of folate deficiency. J Cell Physiol 196, 403-408.
41. Subramanian VS, Marchant JS, Parker I & Said HM (2003 b). Cell biology of the human thiamine transporter-1 (hTHTR1): Intracellular trafficking and membrane targeting mechanisms. J Biol Chem 278, 3976-3984.
42. Szyniarowski P, Bettendorff L & Schweingruber ME (2006). The antitrypanosomal drug melarsoprol competitively inhibits thiamin uptake in mouse neuroblastoma cells. Cell Biol Toxicol 22, 183-187.
43. Tallaksen CME, Bohmer T & Bell H (1992). Blood and serum thiamin and thiamin phosphate esters concentrations in patients with alcohol dependence syndrome before and after thiamin treatment. Alcohol Clin Exp Res 16, 320-325.
44. Tanphaichirt V (1994). Thiamin. In Modern Nutrition in Health and Disease, ed. Shils ME, Olsen JA & Shike M, pp 359-375. Lea & Febiger, New York.
45. Tomasulo PA, Kater RMH & Iber FL (1968). Impairment of thiamine absorption in alcoholism in alcoholism. Am J Clin Nutr 21, 1341-1344.
46. Traebert M, Hattenhauer O, Murer H, Kaissling B & Biber J (1999). Expression of type II Na-P(i) cotransporter in alveolar type II cells. Am J Physiol Lung Cell Mol Physiol 277, L868-L873.
47. Victor M, Adams RD & Collins GH (1989). The Wernicke-Korsakoff Syndrome and Related Neurological Disorders due to Alcoholism and Malnutrition. Davis, Philadelphia, PA.
48. Wilkinson GN (1961). Statistical estimation in enzyme kinetics. Biochem J 80, 324-332.