Nanopore-based single-molecule mass spectrometry on a lipid membrane microarray

ACS Nano

Volumn 5, Issue 10, 2011, Pages 8080-8088

  Baaken, Gerhard ^a   Ankri, Norbert ^b   Schuler, Anne Katrin ^a   Rühe, Jürgen ^a   Behrends, Jan C ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b AIX MARSEILLE UNIVERSITY   (France)

Author keywords

alpha hemolysin; array; lipid bilayer; mass spectrometry; microsystem; nanopore; poly(ethylene glycol); polymer

Indexed keywords

ALPHA-HEMOLYSIN; ARRAY; HIGH RESOLUTION; HIGH THROUGHPUT; HIGH-DENSITY ARRAYS; LIPID MEMBRANES; SINGLE MOLECULE; SINGLE-MOLECULE ANALYSIS;

BLOOD; ETHYLENE; GLYCOLS; MASS SPECTROMETRY; MICROELECTRODES; MOLECULES; NANOPORES; POLYETHYLENE GLYCOLS;

LIPID BILAYERS;

HEMOLYSIN; MACROGOL DERIVATIVE;

ARTICLE; CELL MEMBRANE; CHEMISTRY; ELECTRIC CONDUCTIVITY; INSTRUMENTATION; LIPID BILAYER; MASS SPECTROMETRY; MICROARRAY ANALYSIS; MICROELECTRODE; NANOPORE;

CELL MEMBRANE; ELECTRIC CONDUCTIVITY; HEMOLYSIN PROTEINS; LIPID BILAYERS; MASS SPECTROMETRY; MICROARRAY ANALYSIS; MICROELECTRODES; NANOPORES; POLYETHYLENE GLYCOLS;

EID: 80055022387     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn202670z     Document Type: Article

References (34)

1. Murphy, R. J.; Muthukumar, M. Threading Synthetic Polyelectrolytes through Protein Pores J. Chem. Phys. 2007, 126, 051101-1-4
2. Kasianowicz, J. J.; Robertson, J. W. F.; Chan, E. R.; Reiner, J. E.; Stanford, V. M. Nanoscopic Porous Sensors Annu. Rev. Anal. Chem. 2008, 1, 737-766
3. Majd, S.; Yusko, E. C.; Billeh, Y. N.; Macrae, M. X.; Yang, J.; Mayer, M. Applications of Biological Pores in Nanomedicine, Sensing, and Nanoelectronics Curr. Opin. Biotechnol. 2010, 21, 439-476
4. Krasilnikov, O. V.; Rodrigues, C. G.; Bezrukov, S. M. Single Polymer Molecules in a Protein Nanopore in the Limit of a Strong Polymer-Pore Attraction Phys. Rev. Lett. 2006, 97, 018301
5. Bayley, H.; Martin, C. R. Resistive-Pulse Sensing-from Microbes to Molecules Chem. Rev. 2000, 100, 2575-2594
6. Maglia, G.; Heron, A. J.; Stoddart, D.; Japrung, D.; Bayley, H. Analysis of Single Nucleic Acid Molecules with Protein Nanopores Methods Enzymol. 2010, 475, 591-623
7. Hanke, W.; Schlue, W. R. Planar Lipid Bilayers: Methods and Applications; Academic Press: London, 1993.
8. Akeson, M.; Branton, D.; Kasianowicz, J. J.; Brandin, E.; Deamer, D. W. Microsecond Time-Scale Discrimination among Polycytidylic Acid, Polyadenylic Acid, and Polyuridylic Acid as Homopolymers or as Segments within Single RNA Molecules Biophys. J. 1999, 77, 3227-3233
9. Mayer, M.; Kriebel, J. K.; Tosteson, M. T.; Whitesides, G. M. Microfabricated Teflon Membranes for Low-Noise Recordings of Ion Channels in Planar Lipid Bilayers Biophys. J. 2003, 85, 2684-2695 (Pubitemid 37210814)
10. Sondermann, M.; George, M.; Fertig, N.; Behrends, J. C. High-Resolution Electrophysiology on a Chip: Transient Dynamics of Alamethicin Channel Formation Biochim. Biophys. Acta: Biomembranes 2006, 1758, 545-551 (Pubitemid 43767732)
11. Fertig, N.; Blick, R. H.; Behrends, J. C. Whole Cell Patch Clamp Recording Performed on a Planar Glass Chip Biophys. J. 2002, 82, 3056-3062 (Pubitemid 34547648)
12. Fertig, N.; Klau, M.; George, M.; Blick, R. H.; Behrends, J. C. Activity of Single Ion Channel Proteins Detected with a Planar Microstructure Appl. Phys. Lett. 2002, 81, 4865-4867
13. Dunlop, J.; Bowlby, M.; Peri, R.; Vasilyev, D.; Arias, R. High-Throughput Electrophysiology: An Emerging Paradigm for Ion-Channel Screening and Physiology Nat. Rev. Drug Discovery 2008, 7, 358-368
14. Sigworth, F. J.; Klemic, K. G. Microchip Technology in Ion-Channel Research IEEE Trans. NanoBiosci. 2005, 4, 121-127 (Pubitemid 40384653)
15. Peterman, M. C.; Ziebarth, J. M.; Braha, O.; Bayley, H.; Fishman, H. A.; Bloom, D. M. Ion Channels and Lipid Bilayer Membranes under High Potentials Using Microfabricated Apertures Biomed. Microdevices 2002, 4, 231-236 (Pubitemid 34823415)
16. Sandison, M. E.; Morgan, H. Rapid Fabrication of Polymer Microfluidic Systems for the Production of Artificial Lipid Bilayers J. Micromech. Microeng. 2005, 15, S139-S144
17. Suzuki, H.; Tabata, K. V.; Noji, H.; Takeuchi, S. Highly Reproducible Method of Planar Lipid Bilayer Reconstitution in Polymethyl Methacrylate Microfluidic Chip Langmuir 2006, 22, 1937-1942
18. Sandison, M. E.; Zagnoni, M.; Abu-Hantash, M.; Morgan, H. Micromachined Glass Apertures for Artificial Lipid Bilayer Formation in a Microfluidic System J. Micromech. Microeng. 2007, 17, S189-S196
19. Le Pioufle, B.; Suzuki, H.; Tabata, K. V.; Noji, H.; Takeuchi, S. Lipid Bilayer Microarray for Parallel Recording of Transmembrane Ion Currents Anal. Chem. 2008, 80, 328-332 (Pubitemid 351448439)
20. Hromada, L. P.; Nablo, B. J.; Kasianowicz, J. J.; Gaitan, M. A.; DeVoe, D. L. Single Molecule Measurements within Individual Membrane-Bound Ion Channels Using a Polymer-Based Bilayer Lipid Membrane Chip Lab Chip 2008, 8, 602-608 (Pubitemid 351442767)
21. Zagnoni, M.; Sandison, M. E.; Morgan, H. Microfluidic Array Platform for Simultaneous Lipid Bilayer Membrane Formation Biosens. Bioelectron. 2009, 24, 1235-1240
22. Poulos, J. L.; Jeon, T. J.; Damoiseaux, R.; Gillespie, E. J.; Bradley, K. A.; Schmidt, J. J. Ion Channel and Toxin Measurement Using a High Throughput Lipid Membrane Platform Biosens. Bioelectron. 2009, 24, 1806-1810
23. Thei, F.; Rossi, M.; Bennati, M.; Crescentini, M.; Lodesani, F.; Morgan, H.; Tartagni, M. Parallel Recording of Single Ion Channels: A Heterogeneous System Approach IEEE Trans. Nanotechnol. 2010, 9, 295-312
24. Maurer, J. A.; White, V. E.; Dougherty, D. A.; Nadeau, J. L. Reconstitution of Ion Channels in Agarose-Supported Silicon Orifices Biosens. Bioelectron. 2007, 22, 2577-2584 (Pubitemid 46484248)
25. Suzuki, H.; Tabata, K.; Kato-Yamada, Y.; Noji, H.; Takeuchi, S. Planar Lipid Bilayer Reconstitution with a Micro-Fluidic System Lab Chip 2004, 4, 502-505 (Pubitemid 39468924)
26. Osaki, T.; Suzuki, H.; Le Pioufle, B.; Takeuchi, S. Multichannel Simultaneous Measurements of Single-Molecule Translocation in Alpha-Hemolysin Nanopore Array Anal. Chem. 2009, 81, 9866-9870
27. Baaken, G.; Sondermann, M.; Schlemmer, C.; Ruhe, J.; Behrends, J. C. Planar Microelectrode-Cavity Array for High-Resolution and Parallel Electrical Recording of Membrane Ionic Currents Lab Chip 2008, 8, 938-944 (Pubitemid 351752866)
28. Robertson, J. W. F.; Rodrigues, C. G.; Stanford, V. M.; Rubinson, K. A.; Krasilnikov, O. V.; Kasianowicz, J. J. Single-Molecule Mass Spectrometry in Solution Using a Solitary Nanopore Proc. Natl. Acad. Sci. U. S. A. 2007, 104, 8207-8211 (Pubitemid 47175466)
29. Chang, Y. J.; Mohseni, K.; Bright, V. M. Fabrication of Tapered Su-8 Structure and Effect of Sidewall Angle for a Variable Focus Microlens Using EWOD Sens. Actuators, A 2007, 136, 546-553 (Pubitemid 46678745)
30. Robertson, J. W. F.; Kasianowicz, J. J.; Reiner, J. E. Changes in Ion Channel Geometry Resolved to Sub-Angstrom Precision Via Single Molecule Mass Spectrometry J. Phys.: Condens. Matter 2010, 22, 454108
31. Rodrigues, C. G.; Machado, D. C.; Chevtchenko, S. F.; Krasilnikov, O. V. Mechanism of KCl Enhancement in Detection of Nonionic Polymers by Nanopore Sensors Biophys. J. 2008, 95, 5186-5192
32. Reiner, J. E.; Kasianowicz, J. J.; Nablo, B. J.; Robertson, J. W. F. Theory for Polymer Analysis Using Nanopore-Based Single-Molecule Mass Spectrometry Proc. Natl. Acad. Sci. U. S. A. 2010, 107, 12080-12085
33. Renner, S.; Bessonov, A.; Simmel, F. C. Voltage-Controlled Insertion of Single A-Hemolysin and Mycobacterium Smegmatis Nanopores into Lipid Bilayer Membranes Appl. Phys. Lett. 2011, 98, 083701
34. Lemay, S. G. Nanopore-Based Biosensors: The Interface between Ionics and Electronics ACS Nano 2009, 3, 775-779