Nanopore-based biosensors: The interface between ionics and electronics

ACS Nano

Volumn 3, Issue 4, 2009, Pages 775-779

  Lemay, Serge G ^a  

^a DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

APPLIED SCIENCE; DNA POLYMERASE; ELECTRICAL SIGNAL; EXTERNAL CONTROL; IONIC CURRENT; NANOFLUIDIC SYSTEMS; NANOSCALE SENSORS; SINGLE DNA MOLECULES; SINGLE MOLECULE;

BINDING ENERGY; BIOSENSORS; DNA; GENES; NANOFLUIDICS; NANOPORES; NUCLEIC ACIDS;

BINDING SITES;

ION; NANOMATERIAL;

ELECTRONICS; GENETIC PROCEDURES; INSTRUMENTATION; NANOTECHNOLOGY; NOTE;

BIOSENSING TECHNIQUES; ELECTRONICS; IONS; NANOSTRUCTURES; NANOTECHNOLOGY;

EID: 66949179078     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn900336j     Document Type: Article

References (23)

1. Walter, N. G.; Huang, C.-Y.; Manzo, A. J.; Sobhy, M. A. Do-It-Yourself Guide: How to Use the Modern Single-Molecule Toolkit. Nat. Methods 2008, 5, 475-489.
2. Minsoung, R.; Burns, M. A. Nanopore Sequencing Technology: Research Trends and Applications. Trends Biotechnol. 2006, 24, 580-586.
3. Kasianowicz, J. J.; Robertson, J. W. F.; Chan, E. R.; Reiner, J. E.; Stanford, V. M. Nanoscopic Porous Sensors. Annu. Rev. Anal. Chem. 2008, 1, 737-766.
4. Dekker, C. Solid-State Nanopores. Nat. Nanotechnol. 2007, 2, 209-215.
5. Kasianowicz, J. J.; Brandin, E.; Branton, D.; Deamer, D. W. Characterization of Individual Polynucleotide Molecules Using a Membrane Channel. Proc. Natl. Acad. Sci. USA. 1996, 93, 13770-13773.
6. Clarke, J.; Wu, H.-C.; Jayasinghe, L; Patel, A.; Reid, S.; Bayley, H. Continuous Base Identification for Single-Molecule Nanopores DNA Sequencing. Nat. Nanotechnol. 2009, doi: 10.1038/nnano. 2009.12.
7. Wilson, N. A.; Abu-Shumays, R.; Gyarfas, B.; Wang, H.; Lieberman, K. R.; Akeson, M.; Dunbar, W. B. Electronic Control of DNA Polymerase Binding and Unbinding to Single DNA Molecules. ACS Nano 2009, 4, 995-1003.
8. Movileanu, L; Howorka, S.; Braha, O.; Bayley, H. Detecting Protein Analytes that Modulate Transmembrane Movement of a Polymer Chain within a Single Protein Pore. Nat. Biotechnol. 2000, 18, 1091-1095.
9. Benner, S.; Chen, R. J. A.; Wilson, N. A.; Abu-Shumays, R.; Hurt, N.; Lieberman, K. R.; Deamer, D. W.; Dunbar, W. B.; Akeson, M. Sequence-Specific Detection of Individual DNA Polymerase Complexes in Real Time Using a Nanopore. Nat. Nanotechnol. 2007, 2, 718-724.
10. Hornblower, B.; Coombs, A.; Whitaker, R. D.; Kolomeisky, A.; Picone, S. J.; Meller, A.; Akeson, M. Single-Molecule Analysis of DNA-Protein Complexes Using Nanopores. Nat. Methods 2007, 4, 315-317.
11. Cockroft, S. L; Chu, J.; Amorin, M.; Bayley, H.; Ghadiri, M. R. A Single-Molecule Nanopore Device Detects DNA Polymerase Activity with Single-Nucleotide Resolution. J. Am. Chem. Soc. 2008, 130, 818-820.
12. Tabard-Cossa, V.; Trivedi, D.; Wiggin, M.; Jetha, N. N.; Marziali, A. Noise Analysis and Reduction in Solid-State Nanopores. Nanotechnoloav 2007, 18, 1-6.
13. Smeets, R. M. M.; Keyser, U. F.; Dekker, N. H.; Dekker, C. Noise in Solid-State Nanopores. Proc. Natl. Acad. Sci. USA. 2008, 105, 417-421.
14. Reimhult, E.; Kumar, K. Membrane Biosensor Platforms Using Nano-and Microporous Supports. Trends Biotechnol. 2008, 26, 82-89.
15. Gerhard, B.; Sondermann, M.; Schlemmer, C.; Ruhe, J.; Behrends, J. C. Planar Microelectrode-Cavity Array for High-Resolution and Parallel Electrical Recording of Membrane Ionic Currents. Lab Chip 2008, 8, 938-944.
16. Zagnoni, M.; Sandison, M. E.; Morgan, H. Microfluidic Array Platform for Simultaneous Lipid Bilayer Membrane Formation. Biosens. Bioelectron. 2009, 5, 1235-1240.
17. Martinez, J. A.; Misra, N.; Wang, Y.; Stroeve, P.; Grigoropoulos, P. G.; Noy, A. Highly Efficient Biocompatible Single Silicon Nanowire Electrodes with Functional Biological Pore Channels. Nano Lett. 2009, 9, 1121-1126.
18. Holden, M. A.; Bayley, H. Direct Introduction of Single Protein Channels and Pores into Lipid Bilayers. J. Am. Chem. Soc. 2005, 127, 6502-6503.
19. Zagnoni, M.; Sandison, M. E.; Marius, P.; Lee, A. G.; Morgan, H. Controlled Delivery of Proteins into Bilayer Lipid Membranes on Chip. Lab Chip 2007, 7, 1176-1183.
20. Ervin, E. N.; Kawano, R.; White, R. J.; White, H. S. Simultaneous Alternating and Direct Current Readout of Protein Ion Channel Blocking Events Using Glass Nanopore Membranes. Anal. Chem. 2008, 80, 2069-2076.
21. Potentially even more problematic, it can also lead to formation of gas bubbles in the microcavity.
22. s at very high frequencies. The interface of the electrode/electrolyte may also limit the current, but this becomes increasingly irrelevant with increasing frequency.
23. Branton, D.; Deamer, D. W.; Marziali, A.; Bayley, H.; Benner, S. A.; Butler, T.; Di Ventra, M.; Garaj, S.; Hibbs, A.; Huang, X.; et al. The Potential and Challenges of Nanopore Sequencing. Nat. Biotechnol. 2008, 26, 1146-1153.