Regulation of epithelial-mesenchymal transition by homeobox gene DLX4 in JEG-3 trophoblast cells: A role in preeclampsia

Reproductive Sciences

Volumn 18, Issue 11, 2011, Pages 1138-1145

  Sun, Yun Yan ^a   Lu, Meng ^a   Xi, Xiao Wei ^a   Qiao, Qin Qin ^a   Chen, Ling Ling ^a   Xu, Xian Ming ^a   Feng, You Ji ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

DLX4; E cadherin; epithelial mesenchymal transition; homeobox gene; preeclampsia; Snail

Indexed keywords

TRANSCRIPTION FACTOR SNAIL; UVOMORULIN;

ADULT; ARTICLE; CELL MOTILITY; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; DLX4 GENE; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE; GENE CONTROL; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; PLACENTA; PREECLAMPSIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; TROPHOBLAST; UPREGULATION;

CADHERINS; CELL LINE; DOWN-REGULATION; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; OXYGEN; PRE-ECLAMPSIA; PREGNANCY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS; TRANSFECTION; TROPHOBLASTS;

EID: 80054998788     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719111408112     Document Type: Article

References (42)

1. Sibai BM, Caritis S, Hauth J. What we have learned about preeclampsia?. Semin Perinatol. 2003 ; 27 (3). 239-246
2. Cao ZY Chinese Obstetrics and Gynecology. Beijing: People's Health Publishing House ; 2004: 398.
3. Roberts JM, Cooper DW. Pathogenesis and genetics of pre-eclampsia. Lancet. 2001 ; 357 (9249). 53-56 (Pubitemid 32056505)
4. Redman CW, Sargent lan L. Latest advances in understanding preeclampsia. Science. 2005 ; 308 (10). 1592-1594 (Pubitemid 40807500)
5. Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest. 2009 ; 119 (6). 1420-1428
6. Roussos ET, Keckesova Z, Haley JD, Epstein DM, Weinberg RA, Condeelis JS. AACR special conference on epithelial-mesenchymal transition and cancer progression and treatment. Cancer Res. 2010 ; 70 (19). 7360-7364
7. Kalluri R. EMT: when epithelial cells decide to become mesenchymal-like cells. J Clin Invest. 2009 ; 119 (6). 1417-1419
8. Weier JF, Weier HU, Jung CJ, et al. Human cytotrophoblasts acquire aneuploidies as they differentiate to an invasive phenotype. Dev Biol. 2005 ; 279 (2). 420-432 (Pubitemid 40298749)
9. Lala PK, Lee BP, Xu G, Chakraborty C. Human placental trophoblast as an in vitro model for tumor progression. Can J Physiol Pharmacol. 2002 ; 80 (2). 142-149 (Pubitemid 34258663)
10. Kokkinos MI, Murthi P, Wafai R, Thompson EW, Newgreen DF. Cadherins in the human placenta-epithelial-mesenchymal transition (EMT) and placental development. Placenta. 2010 ; 31 (9). 747-755
11. Vićovac L, Aplin JD. Epithelial-mesenchymal transition during trophoblast differentiation. Acta Anat (Basel). 1996 ; 156 (3). 202-216 (Pubitemid 27072576)
12. Abell AN, Granger DA, Johnson NL, Vincent-Jordan N, Dibble CF, Johnson GL. Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase. Mol Cell Biol. 2009 ; 29 (10). 2748-2761
13. Panganiban G, Rubenstein JL. Developmental functions of the Distal-less/Dlx homeobox genes. Development. 2002 ; 129 (19). 4371-4386 (Pubitemid 35203722)
14. Graham A. Jaw development: chinless wonders. Curr Biol. 2002 ; 12 (23). R810 - R812
15. Long JE, Garel S, Alvarez-Dolado M, et al. Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation. J Neurosci. 2007 ; 27 (12). 3230-3243 (Pubitemid 46474124)
16. Holleville N, Matéos S, Bontoux M. Dlx5 drives Runx2 expression and osteogenic differentiation in developing cranial suture mesenchyme. Dev Biol. 2007 ; 304 (2). 860-874 (Pubitemid 46527561)
17. Morasso MI, Radoja N. Dlx genes, p63, and ectodermal dysplasias. Birth Defects Res C: Embryo Today. 2005 ; 75 (3). 163-171 (Pubitemid 41456318)
18. Morasso MI, Grinberg A, Robinson G, Sargent TD, Mahon KA. Placental failure in mice lacking the homeobox gene Dlx3. Proc Natl Acad Sci USA. 1999 ; 96 (1). 162-167 (Pubitemid 29036070)
19. Holland MP, Bliss SP, Berghorn KA, Roberson MS. A role for CCAAT/enhancer-binding protein beta in the basal regulation of the distal-less 3 gene promoter in placental cells. Endocrinology. 2004 ; 145 (3). 1096-1105 (Pubitemid 38280988)
20. Quinn LM, Johnson BV, Nicholl J, Sutherland GR, Kalionis B. Isolation and identification of homeobox genes from the human placenta including a novel member of the distal-less family, DLX4. Gene. 1997 ; 187 (1). 55-61 (Pubitemid 27110434)
21. Quinn LM, Latham SE, Kalionis B. A distal-less class homeobox gene, DLX4, is a candidate for regulating epithelial-mesenchymal cell interactions in the human placenta. Placenta. 1998 ; 19 (1). 87-93 (Pubitemid 28112066)
22. Sun Y, Lu X, Yin L, Zhao F, Feng Y. Inhibition of DLX4 promotes apoptosis in choriocarcinoma cell lines. Placenta. 2006 ; 27 (4-5). 375-383
23. Radisky DC. Defining a role for the homeoprotein Six1 in EMT and mammary tumorigenesis. J Clin Invest. 2009 ; 119 (9). 2528-2531
24. Yoshida H, Broaddus R, Cheng W, Xie S, Naora H. Deregulation of the HOXA10 homeobox gene in endometrial carcinoma: role in epithelial-mesenchymal transition. Cancer Res. 2006 ; 66 (2). 889-897 (Pubitemid 43165955)
25. Cunningham FG, Hauth JC, Leveno KJ, Gilstrap III L, Bloom SL, Wenstrom KD Williams Obstetrics. New York: McGraw-Hill Medical Publishing Division ; 2005: 761.
26. Janatpour MJ, McMaster MT, Genbacev O, et al. Id-2 regulates critical aspects of human cytotrophoblast differentiation invasion and migration. Development. 2000 ; 127 (3). 549-558 (Pubitemid 30093403)
27. Murthi P, Doherty V, Said J, Donath S, Brennecke SP, Kalionis B. Homeobox gene HLX1 expression is decreased in idopathic human fetal growth restriction. Am J Pathol. 2006 ; 168 (2). 511-518 (Pubitemid 43271149)
28. Murthi P, Said JM, Doherty VL, et al. Homeobox gene DLX4 expression is increased in idiopathic human fetal growth restriction. Mol Hum Reprod. 2006 ; 12 (12). 763-769 (Pubitemid 44811655)
29. Lyall F. Priming and remodeling of human placental bed spiral arteries during pregnancy-a review. Placenta. 2005 ; 26 (SUPPL. A). S31 - S36
30. Roberts JM, Gammill HS. Preeclampsia recent insights. Hypertension. 2005 ; 46 (6). 1243-1249
31. Floridon C, Nielsen O, Holund B, et al. Localization of E-cadherin in villous, extravillous and vascular trophoblasts during intrauterine, ectopic and molar pregnancy. Mol Hum Reprod. 2000 ; 6 (10). 943-950
32. Batistatou A, Makrydimas G, Zagorianakou N, et al. Expression of dysadherin and E-cadherin in trophoblastic tissue in normal and abnormal pregnancy. Placenta. 2007 ; 28 (5-6). 590-592 (Pubitemid 46593783)
33. Harris LK, Jones CJP, Aplin JD. Adherin molecules in human trophoblast-a review. II. Extravillous trophoblast. Placenta. 2009 ; 30 (4). 299-304
34. Brown LM, Lacey HA, Baker PN. E-cadherin in the assessment of aberrant placental cytotrophoblast turnover in pregnancies complicated by pre-eclampsia. Histochem Cell Biol. 2005 ; 124 (6). 499-506 (Pubitemid 41661365)
35. Zhou Y, Damsky CH, Fisher SJ. Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome?. J Clin Invest. 1997 ; 99 (9). 2152-2164 (Pubitemid 27203771)
36. Hotz B, Arndt M, Dullat S, Bhargava S, Buhr HJ, Hotz HG. Epithelial to mesenchymal transition: expression of the regulators Snail, Slug, and Twist in pancreatic cancer. Clin Cancer Res. 2007 ; 13 (16). 4769-4776 (Pubitemid 47294783)
37. Arimoto-Ishida E, Sakata M, Sawada K, et al. Up-regulation of alpha5-integrin by E-cadhrin loss in hypoxia and its key role in the migration of extravillous trophoblast cells during early implantation. Endocrinology. 2009 ; 150 (9). 4306-4315
38. Blechschmidt K, Mylonas I, Mayr D, et al. Expression of E-cadherin and its repressor Snail in placental tissue of normal, preeclamptic and HELLP pregnancies. Virchows Arch. 2007 ; 450 (2). 195-202 (Pubitemid 46295231)
39. Fu Y, Lian Y, Kim KS, et al. BP1 homeoprotein enhances metastatic potential in ER-negative breast cancer. J Cancer. 2010 ; 1: 54-62
40. Tomida S, Yanagisawa K, Koshikawa K, et al. Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach. Oncogene. 2007 ; 26 (31). 4600-4608 (Pubitemid 47037043)
41. Kay HH, Zhu S, Tsoi S. Hypoxia and lactate production in trophoblast cells. Placenta. 2007 ; 28 (8-9). 854-860 (Pubitemid 47074378)
42. Oh SY, Choi SJ, Kim KH, Cho EY, Kim JH, Roh CR. Autophagy-related proteins, LC3 and Beclin-1, in placentas from pregnancies complicated by preeclampsia. Reprod Sci. 2008 ; 15 (9). 912-920