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Journal of the American Chemical Society

Volumn 133, Issue 42, 2011, Pages 16766-16769

Nucleoside optimization for RNAi: A high-throughput platform

(8) Butora, Gabor a Kenski, Denise M b Cooper, Abby J b Fu, Wenlang a Qi, Ning a Li, Jenny J b Flanagan, W Michael b Davies, Ian W a

a MERCK RESEARCH LABORATORIES (United States)

b Sirna Therapeutics Inc (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANONICAL BASIS; DIRECT CONTACT; ENDONUCLEASES; FUNCTIONALIZATIONS; HIGH-THROUGHPUT; INOSINE; LARGE GROUPS; MODIFIED NUCLEOSIDES; PHOSPHORAMIDITES; PLATFORM APPROACH; RATIONAL DESIGN; RNA-INDUCED SILENCING COMPLEXES; SYSTEMATIC EVALUATION; THERAPEUTIC APPLICATION;

RNA; SUGARS;

BIOMOLECULES;

ARGONAUTE PROTEIN; INOSINE; MESSENGER RNA; NUCLEOSIDE DERIVATIVE; NUCLEOTIDE; OLIGOMER; PHOSPHORAMIDOUS ACID; RNA INDUCED SILENCING COMPLEX;

ARTICLE; CHEMICAL MODIFICATION; HUMAN; PROCESS OPTIMIZATION; RNA INTERFERENCE; SYNTHESIS;

BASE SEQUENCE; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; NUCLEOSIDES; RNA INTERFERENCE;

EID: 80054995636 PISSN: 00027863 EISSN: 15205126 Source Type: Journal
DOI: 10.1021/ja2068774 Document Type: Article

Times cited : (14)

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