Cinnamon, Glucose, and Insulin Sensitivity

Nutraceuticals, Glycemic Health and Type 2 Diabetes

Volumn , Issue , 2009, Pages 127-140

  Anderson, Richard A ^a   Roussel, Anne Marie ^b,c  

^a BELTSVILLE HUMAN NUTRITION RESEARCH CENTER   (United States)

^b INSERM   (France)

^c Domaine Universitaire   (France)

Author keywords

Cinnamaldehyde, reducing blood glucose; Cinnamon compounds, activating insulin receptors; Cinnamon compounds, inhibiting phophotyrosine phosphatase (PTP 1B); Compounds in cinnamon, having insulin potentiating properties; Ferric reducing antioxidant power (FRAP); Hyperglycemia, causing auto oxidation of glucose; Insulin dependent utilization; Oral glucose tolerance tests (OGTT); Polycystic ovary syndrome (PCOS); Wortmanin potent inhibitor of phosphoinositol 3 kinase (PI 3 kinase)

Indexed keywords

EID: 80054980282     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780813804149.ch8     Document Type: Chapter

References (35)

1. Adisakwattana S, Roengsamran S, Hsu WH, Yibchok-anun S. 2005. Mechanisms of antihyperglycemic effect of p-methoxycinnamic acidin normal andstreptozotocininduced diabetic rats. Life Sci 78:406-412.
2. Anderson RA, Brantner JH, Polansky MM. 1978. An improved assay for biologically active chromium. J Agric FoodChem 26:1219-1221.
3. Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, Schoene NW, Graves DJ. 2004. Isolation andcharacterization of polyphenol type- A polymers from cinnamon with insulin-like biological activity. J Agric FoodChem 52:65-70.
4. Balcerczyk A, Bartosz G. 2003. Thiols are main determinants of total antioxidant capacity of cellular homogenates. Free Radic Res 37:537-541.
5. Broadhurst CL, Polansky MM, Anderson RA. 2000. Insulin-like biological activity of culinary andmed icinal plant aqueous extracts in vitro. J Agric FoodChem 48:849-852.
6. Cao H, Polansky MM, Anderson RA. 2007. Cinnamon extract and polyphenols affect the expression of tristetraprolin, insulin receptor, andglucose transporter 4 in mouse 3T3-L1 adipocytes. Arch Biochem Biophys 459:214-222.
7. Chrysohoou C, Panagiotakos DB, Pitsavos C, Skoumas I, Papademetriou L, Economou M, Stefanadis C. 2006. The implication of obesity on total antioxidant capacity in apparently healthy men and women: The ATTICA study. Nutr Metab Cardiovasc Dis 17:590-597.
8. CouillardC, Ruel G, Archer WR, Pomerleau S, Bergeron J, Couture P, Lamarche B, Bergeron N. 2005. Circulating levels of oxidative stress markers and endothelial adhesion molecules in men with abdominal obesity. J Clin Endocrinol Metab 90:6454-6459.
9. Cusi K, Maezono K, Osman A, Pendergrass M, Patti ME, Pratipanawatr T, DeFronzo RA, Kahn CR, Mandarino LJ. 2000. Insulin resistance differentially affects the PI 3-kinase- andMAP kinase-mediatedsignaling in human muscle. J Clin Invest 105:311-320.
10. Davi G, Falco A. 2005. Oxidant stress, inflammation and atherogenesis. Lupus 14:760-764.
11. Dhuley JN. 1999. Anti-oxidant effects of cinnamon (Cinnamomum verum) bark and greater cardamom (Amomum subulatum) seeds in rats fed high fat diet. Indian J Exp Biol 37:238-242.
12. Duke JA. 1992. Handbook of Phytomedical Constituents of GRAS Herbs and Other Economic Plants. Boca Raton, FL: CRC Press.
13. Gowder SJ, Devaraj H. 2006. Effect of the food flavour cinnamaldehyde on the antioxidant status of rat kidney. Basic Clin Pharmacol Toxicol 99:379-382.
14. Hayden MR, Tyagi SC. 2004. Neural redox stress and remodeling in metabolic syndrome, type 2 diabetes mellitus, and diabetic neuropathy.MedSci Monit 10:RA291-RA307.
15. Imparl-Radosevich J, Deas S, Polansky MM, Baedke DA, Ingebritsen TS, Anderson RA, Graves DJ. 1998. Regulation of PTP-1 andinsulin receptor kinase by fractions from cinnamon: Implications for cinnamon regulation of insulin signalling. Horm Res 50:177-182.
16. Jarvill-Taylor KJ, Anderson RA, Graves DJ. 2001. A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. J Am Coll Nutr 20:327-336.
17. Khan A, Bryden NA, Polansky MM, Anderson RA. 1990. Insulin potentiating factor andchromium content of selectedfood s andspices. Biol Trace Elem Res 24:183-188.
18. Khan A, Safdar M, Ali Khan MM, Khattak KN, Anderson RA. 2003. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 26:3215-3218.
19. Kim SH, Hyun SH, Choung SY. 2006. Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice. J Ethnopharmacol 104:119-123.
20. Lee JS, Choi MS, Jeon SM, Jeong TS, Park YB, Lee MK, Bok SH. 2001. Lipidlowering and antioxidative activities of 3,4-di(OH)-cinnamate and 3,4-di(OH)- hydrocinnamate in cholesterol-fed rats. Clin Chim Acta 314:221-229.
21. Mang B, Wolters M, Schmitt B, Kelb K, Lichtinghagen R, Stichtenoth DO, Hahn A. 2006. Effects of a cinnamon extract on plasma glucose, HbA, andser um lipids in diabetes mellitus type 2. Eur J Clin Invest 36:340-344.
22. Martin JA, Brooks DA, Prieto L, Gonzalez R, Torrado A, Rojo I, Lopez de UB, Lamas C, Ferritto R, Dolores Martin-Ortega M, Agejas J, Parra F, Rizzo JR, Rhodes GA, Robey RL, Alt CA, Wendel SR, Zhang TY, Reifel-Miller A, Montrose-Rafizadeh C, Brozinick JT, Hawkins E, Misener EA, Briere DA, Ardecky R, Fraser JD, Warshawsky AM. 2005. 2-Alkoxydihydrocinnamates as PPARagonists. Activity modulation by the incorporation of phenoxy substituents. Bioorg MedChem Lett 15:51-55.
23. Osawa T, Kato Y. 2005. Protective role of antioxidative food factors in oxidative stress causedb y hyperglycemia. Ann N Y AcadSci 1043:440-451.
24. Preuss HG, EchardB , Polansky MM, Anderson R. 2006. Whole cinnamon andaqueous extracts ameliorate sucrose-inducedb loodpressure elevations in spontaneously hypertensive rats. J Am Coll Nutr 25:144-150.
25. Qin B, Nagasaki M, Ren M, Bajotto G, Oshida Y, Sato Y. 2003. Cinnamon extract (traditional herb) potentiates in vivo insulin-regulated glucose utilization via enhancing insulin signaling in rats. Diabetes Res Clin Pract 62:139-148.
26. Qin B, Nagasaki M, Ren M, Bajotto G, Oshida Y, Sato Y. 2004. Cinnamon extract prevents the insulin resistance induced by a high-fructose diet. Horm Metab Res 36:119-125.
27. Robertson RP. 2004. Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes. J Biol Chem 279:42351-42354.
28. Rodrigo R, Bosco C. 2006. Oxidative stress and protective effects of polyphenols: Comparative studies in human and rodent kidney. A review. Comp Biochem Physiol C Toxicol Pharmacol 142:317-327.
29. Roussel AM, Hininger, I, Benaraba R, Ziegenfuss TN, Anderson RA. 2008. Antioxidant effects of cinnamon extract in people with impaired fasting glucose that are overweight or obese. J Am Coll Nutr (update).
30. Subash BP, Prabuseenivasan S, Ignacimuthu S. 2007. Cinnamaldehyde-a potential antidiabetic agent. Phytomedicine 14:15-22.
31. Vanschoonbeek K, Thomassen BJ, Senden JM, Wodzig WK, van Loon LJ. 2006. Cinnamon supplementation does not improve glycemic control in postmenopausal type 2 diabetes patients. J Nutr 136:977-980.
32. Verspohl EJ, Bauer K, Neddermann E. 2005. Antidiabetic effect ofCinnamomumcassia andCinnamomum zeylanicum in vivo andin vitro. Phytother Res 19:203-206.
33. Wang JG, Anderson RA, Graham GM, III, Chu MC, Sauer MV, Guarnaccia MM, Lobo RA. 2007. The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: A pilot study. Fertil Steril 88:240-243.
34. Yu Y, Lyons TJ. 2005. A lethal tetrad in diabetes: hyperglycemia, dyslipidemia, oxidative stress, and endothelial dysfunction. Am J Med Sci 330:227-232.
35. Ziegenfuss TN, Hofheins JE, Mendel RW, Landis J, Anderson RA. 2006. Effects of a water-soluble cinnamon extract on body composition and features of the metabolic syndrome in pre-diabetic men and women. J Int Soc Sport Nutr 3:45-53.