Ailanthoidol suppresses lipopolysaccharide-stimulated inflammatory reactions in RAW264.7 cells and endotoxin shock in mice

Journal of Cellular Biochemistry

Volumn 112, Issue 12, 2011, Pages 3816-3823

  Kim, Jin Kyung ^a   Jun, Jong Gab ^b  

^a Catholic University of Daegu   (South Korea)

^b Hallym University   (South Korea)

Author keywords

Ailanthoidol; Endotoxin shock; Inflammation; Macrophages

Indexed keywords

AILANTHOIDOL; ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NEOLIGNAN; NITRIC OXIDE; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; IN VITRO SELECTION; IN VIVO STUDY; INHIBITION KINETICS; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPTIC SHOCK; SURVIVAL;

ANIMALS; BENZOFURANS; CELL LINE; FLOW CYTOMETRY; INFLAMMATION; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED BALB C; MICROSCOPY, FLUORESCENCE; NF-KAPPA B; SHOCK, SEPTIC;

ANIMALIA; MUS; SALVIA MILTIORRHIZA; ZANTHOXYLUM AILANTHOIDES;

EID: 80054973147     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.23312     Document Type: Article

References (20)

1. Alvarez RG, Zamora ZB, Borrego A, Delgado R, Schulz S, Alonso Y,. 2009. Ozone oxidative preconditioning reduces nitrite levels in blood serum in LPS: Induced endotoxic shock in mice. Inflamm Res 58: 441-443.
2. Blackwell TS, Christman JW,. 1997. The role of nuclear factor-kappa B in cytokine gene regulation. Am J Respir Cell Mol Biol 7: 3-9. (Pubitemid 127500814)
3. Boudet AM,. 2007. Evolution and current status of research in phenolic compounds. Phytochemistry 68: 2722-2735.
4. Cauwels A, Brouckaert P,. 2011. Nitrite regulation of shock. Cardiovasc Res 89: 553-559.
5. Chen YC, Liao CH, Chen IS,. 2007. Lignans, an amide and anti-platelet activities from Piper philippinum. Phytochemistry 68: 2101-2111.
6. Hajishengallis G, Lambris JD,. 2011. Microbial manipulation of receptor crosstalk in innate immunity. Nat Rev Immunol 11: 187-200.
7. Hwang JW, Choi DH, Jeon JH, Kim JK, Jun JG,. 2010. Facile preparation of 2-arylbenzo[b]furan molecules and their anti-inflammatory effects. Bull Korean Chem Soc 31: 965-970.
8. Kaileh M, Sen R,. 2010. Role of NF-kappaB in the anti-inflammatory effects of tocotrienols. J Am Coll Nutr 29: 334S-339S.
9. Kao CL, Chern JW,. 2002. A novel strategy for the synthesis of benzofuran skeleton neolignans: Application to ailanthoidol, XH-14, and obovaten. J Org Chem 67: 6772-6787.
10. Lang RM, Hammer M, Mages J,. 2006. DUSP meet immunology: Dual specificity MAPK phosphatases in control of the inflammatory response. J Immunol 177: 7497-7504. (Pubitemid 44846262)
11. Lee YJ, Kao ES, Chu CY, Lin WL, Chiou YH, Tseng TH,. 2006. Inhibitory effect of ailanthoidol on 12-O-tetradecanoyl-phorbol-13-acetate-induced tumor promotion in mouse skin. Oncol Rep 16: 921-927.
12. Lin SY, Chen CL, Lee YJ,. 2003. Total synthesis of ailanthoidol and precursor XH14 by Stille coupling. J Org Chem 68: 2968-2971.
13. Medzhitov R,. 2008. Origin and physiological roles of inflammation. Nature 454: 428-435.
14. Mookherjee N, Hancock RE,. 2007. Cationic host defence peptides: Innate immune regulatory peptides as a novel approach for treating infections. Cell Mol Life Sci 64: 922-933. (Pubitemid 46597762)
15. O'Neill LA, Bowie AG,. 2007. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol 7: 353-364. (Pubitemid 46674493)
16. Reuter S, Prasad S, Phromnoi K, Ravindran J, Sung B, Yadav VR, Kannappan R, Chaturvedi MM, Aggarwal BB,. 2010. Thiocolchicoside exhibits anticancer effects through downregulation of NF-κB pathway and its regulated gene products linked to inflammation and cancer. Cancer Prev Res 3: 1462-1472.
17. Takeda K, Akira S,. 2004. TLR signaling pathways. Semin Immunol 16: 3-9. (Pubitemid 38147427)
18. Vaid M, Sharma SD, Katiyar SK,. 2010. Honokiol, a phytochemical from the Magnolia plant, inhibits photocarcinogenesis by targeting UVB-induced inflammatory mediators and cell cycle regulators: Development of topical formulation. Carcinogenesis 31: 2004-2011.
19. Yamamoto M, Takeda K, Akira S,. 2004. TIR domain-containing adaptors define the specificity of TLR signaling. Mol Immunol 40: 861-868. (Pubitemid 38032809)
20. Yang GY, Li YK, Wang RR, Li XN, Xiao WL, Yang LM, Pu JX, Zheng YT, Sun HD,. 2010. Dibenzocyclooctadiene lignans from Schisandra wilsoniana and their anti-HIV-1 activities. J Nat Prod 73: 915-919.