Myalgia and fatigue: Translation from mouse sensory neurons to fibromyalgia and chronic fatigue syndromes

Translational Pain Research: From Mouse to Man

Volumn , Issue , 2009, Pages 251-282

  Light, Alan R ^a   Vierck, Charles J ^b   Light, Kathleen C ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 80054970112     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (101)

1. Adreani CM, Hill JM, Kaufman MP. 1997. Responses of group III and IV muscle afferents to dynamic exercise. J Appl Physiol. 82: 1811–1817.
2. Adreani CM, Kaufman MP. 1998. Effect of arterial occlusion on responses of group III and IV afferents to dynamic exercise. J Appl Physiol. 84: 1827–1833.
3. Alam M, Smirk FH. 1937. Observations in man upon a blood pressure raising reflex arising from the voluntary muscles. J Physiol. 89: 372–383.
4. Ambalavanar R, Moritani M, Moutanni A, Gangula P, Yallampalli C, Dessem D. 2006. Deep tissue inflammation upregulates neuropeptides and evokes nociceptive behaviors which are modulated by a neuropeptide antagonist. Pain. 120: 53–68.
5. Ambalavanar R, Yallampalli C, Yallampalli U, Dessem D. 2007. Injection of adjuvant but not acidic saline into craniofacial muscle evokes nociceptive behaviors and neuropeptide expression. Neuroscience. 149: 650–659.
6. Baekken PM, Skorpen F, Stordal E, Zwart JA, Hagen K. 2008. Depression and anxiety in relation to catechol-O-methyltransferase Val158Met genotype in the general population: the Nord-Trondelag Health Study (HUNT). BMC Psychiatry. 8: 48.
7. Bellinger AM, Mongillo M, Marks AR. 2008. Stressed out: the skeletal muscle ryanodine receptor as a target of stress. J Clin Invest. 118: 445–453.
8. Birder LA, Perl ER. 1999. Expression of alpha2-adrenergic receptors in rat primary afferent neurones after peripheral nerve injury or inflammation. J Physiol. 515 (Pt 2): 533–542.
9. Boyd RE. 2001. Alpha2-adrenergic receptor agonists as analgesics. Curr Top Med Chem. 1: 193–197.
10. Brooks JC, Zambreanu L, Godinez A, Craig AD, Tracey I. 2005. Somatotopic organisation of the human insula to painful heat studied with high resolution functional imaging. Neuroimage. 27: 201–209.
11. Brown DR, Hofer RE, Patterson DE, Fronapfel PJ, Maxson PM, Narr BJ, Eisenach JH, Blute ML, Schroeder DR, Warner DO. 2004. Intrathecal anesthesia and recovery from radical prostatectomy: a prospective, randomized, controlled trial. Anesthesiology. 100: 926–934.
12. Caseras X, Mataix-Cols D, Rimes KA, Giampietro V, Brammer M, Zelaya F, Chalder T, Godfrey E. 2008. The neural correlates of fatigue: an exploratory imaginal fatigue provocation study in chronic fatigue syndrome. Psychol Med. 38: 941–951.
13. Chacur M, Lambertz D, Hoheisel U, Mense S. 2008. Role of spinal microglia in myositisinduced central sensitisation: An immunohistochemical and behavioural study in rats. Eur J Pain.
14. Cheung K, Hume P, Maxwell L. 2003. Delayed onset muscle soreness: treatment strategies and performance factors. Sports Med. 33: 145–164.
15. Christianson JA, McIlwrath SL, Koerber HR, Davis BM. 2006. Transient receptor potential vanilloid 1-immunopositive neurons in the mouse are more prevalent within colon afferents compared to skin and muscle afferents. Neuroscience. 140: 247–257.
16. Connor M, Naves LA, McCleskey EW. 2005. Contrasting phenotypes of putative proprioceptive and nociceptive trigeminal neurons innervating jaw muscle in rat. Mol Pain. 1: 31.
17. Cook DB, Lange G, Ciccone DS, Liu WC, Steffener J, Natelson BH. 2004. Functional imaging of pain in patients with primary fibromyalgia. J Rheumatol. 31: 364–378.
18. Cook DB, O’Connor PJ, Lange G, Steffener J. 2007. Functional neuroimaging correlates of mental fatigue induced by cognition among chronic fatigue syndrome patients and controls. Neuroimage. 36: 108–122.
19. Coryell MW, Ziemann AE, Westmoreland PJ, Haenfler JM, Kurjakovic Z, Zha XM, Price M, Schnizler MK, Wemmie JA. 2007. Targeting ASIC1a reduces innate fear and alters neuronal activity in the fear circuit. Biol Psychiatry. 62 (10): 1140–1148.
20. Craig AD. 2003. Pain mechanisms: labeled lines versus convergence in central processing. Annu Rev Neurosci. 26: 1–30.
21. Cristino L, Starowicz K, De Petrocellis L, Morishita J, Ueda N, Guglielmotti V, Di M, V. 2008. Immunohistochemical localization of anabolic and catabolic enzymes for anandamide and other putative endovanilloids in the hippocampus and cerebellar cortex of the mouse brain. Neuroscience. 151: 955–968.
22. Davis JM, Bailey SP. 1997. Possible mechanisms of central nervous system fatigue during exercise. Med Sci Sports Exerc. 29: 45–57.
23. Di M, V, Gobbi G, Szallasi A. 2008. Brain TRPV1: a depressing TR(i)P down memory lane? Trends Pharmacol Sci. 29: 594–600.
24. Diatchenko L, Anderson AD, Slade GD, Fillingim RB, Shabalina SA, Higgins TJ, Sama S, et al. 2006. Three major haplotypes of the beta 2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder. Am J Med Genet B Neuropsychiatr Genet. 141: 449–462.
25. Drust B, Rasmussen P, Mohr M, Nielsen B, Nybo L. 2005. Elevations in core and muscle temperature impairs repeated sprint performance. Acta Physiol Scand. 183: 181–190.
26. Falk K, Swedberg K, Gaston-Johansson F, Ekman I. 2006. Fatigue is a prevalent and severe symptom associated with uncertainty and sense of coherence in patients with chronic heart failure. Eur J Cardiovasc Nurs. 6 (2): 99–104.
27. Funke B, Malhotra AK, Finn CT, Plocik AM, Lake SL, Lencz T, DeRosse P, Kane JM, Kucherlapati R. 2005. COMT genetic variation confers risk for psychotic and affective disorders: a case control study. Behav Brain Funct. 1: 19.
28. Geisser ME, Strader DC, Petzke F, Gracely RH, Clauw DJ, Williams DA. 2008. Comorbid somatic symptoms and functional status in patients with fibromyalgia and chronic fatigue syndrome: sensory amplification as a common mechanism. Psychosomatics. 49: 235–242.
29. Gibson A, Baden D, Lambert MI, Lambert EV, Harley YXR, Hampson D, Russell VA, Noakes TD. 2003. The conscious perception of the sensation of fatigue. Sports Med. 33: 167–176.
30. Gibson W, Arendt-Nielsen L, Taguchi T, Mizumura K, Graven-Nielsen T. 2009. Increased pain from muscle fascia following eccentric exercise: animal and human findings. Exp Brain Res.
31. Goertzel BN, Pennachin C, de Souza CL, Gurbaxani B, Maloney EM, Jones JF. 2006. Combinations of single nucleotide polymorphisms in neuroendocrine effector and receptor genes predict chronic fatigue syndrome. Pharmacogenomics. 7: 475–483.
32. Gracely RH, Petzke F, Wolf JM, Clauw DJ. 2002. Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia. Arthritis Rheum. 46: 1333–1343.
33. Hayes SG, Kindig AE, Kaufman MP. 2006. Cyclooxygenase blockade attenuates responses of group III and IV muscle afferents to dynamic exercise in cats. Am J Physiol Heart Circ Physiol. 290: H2239–H2246.
34. Hildebrand MS, de Silva MG, Klockars T, Rose E, Price M, Smith RJ, McGuirt WT, Christopoulos H, Petit C, Dahl HH. 2004. Characterisation of DRASIC in the mouse inner ear. Hear Res. 190: 149–160.
35. Hoheisel U, Unger T, Mense S. 2005. Excitatory and modulatory effects of inflammatory cytokines and neurotrophins on mechanosensitive group IV muscle afferents in the rat. Pain. 114: 168–176.
36. Holmes GP, Kaplan JE, Gantz NM, Komaroff AL, Schonberger LB, Straus SE, Jones JF, Dubois RE, Cunningham-Rundles C, Pahwa S. 1988. Chronic fatigue syndrome: a working case definition. Ann Intern Med. 108: 387–389.
37. Immke DC, McCleskey EW. 2001a. ASIC3: a lactic acid sensor for cardiac pain. ScientificWorldJournal. 1: 510–512.
38. Immke DC, McCleskey EW. 2001b. Lactate enhances the acid-sensing Na+ channel on ischemia- sensing neurons. Nat Neurosci. 4: 869–870.
39. Immke DC, McCleskey EW. 2003. Protons open acid-sensing ion channels by catalyzing relief of Ca2+ blockade. Neuron. 37: 75–84.
40. Jones RC, III, Xu L, Gebhart GF. 2005. The mechanosensitivity of mouse colon afferent fibers and their sensitization by inflammatory mediators require transient receptor potential vanilloid 1 and acid-sensing ion channel 3. J Neurosci. 25: 10981–10989.
41. Kaufman MP. 2003. Has the phoenix risen? J Physiol. 548: 666.
42. Kaufman MP, Hayes SG. 2002. The exercise pressor reflex. Clin Auton Res. 12: 429–439.
43. Khan MH, Sinoway LI. 2000. Muscle reflex control of sympathetic nerve activity in heart failure: the role of exercise conditioning. Heart Fail Rev. 5: 87–100.
44. Khasar SG, McCarter G, Levine JD. 1999. Epinephrine produces a beta-adrenergic receptor- mediated mechanical hyperalgesia and in vitro sensitization of rat nociceptors. J Neurophysiol. 81: 1104–1112.
45. Kniffki KD, Mense S, Schmidt RF. 1978. Responses of group IV afferent units from skeletal muscle to stretch, contraction and chemical stimulation. Exp Brain Res. 31: 511–522.
46. Kniffki KD, Mense S, Schmidt RF. 1981. Muscle receptors with fine afferent fibers which may evoke circulatory reflexes. Circ Res. 48: I25–I31.
47. Kruger K, Lechtermann A, Fobker M, Volker K, Mooren FC. 2008. Exercise-induced redistribution of T lymphocytes is regulated by adrenergic mechanisms. Brain Behav Immun. 22: 324–338.
48. Kruger L, Silverman JD, Mantyh PW, Sternini C, Brecha NC. 1989. Peripheral patterns of calcitonin- gene-related peptide general somatic sensory innervation: cutaneous and deep terminations. J Comp Neurol. 280: 291–302.
49. Lee DH, Liu X, Kim HT, Chung K, Chung JM. 1999. Receptor subtype mediating the adrenergic sensitivity of pain behavior and ectopic discharges in neuropathic Lewis rats. J Neurophysiol. 81: 2226–2233.
50. Leffler A, Monter B, Koltzenburg M. 2006. The role of the capsaicin receptor TRPV1 and acid-sensing ion channels (ASICS) in proton sensitivity of subpopulations of primary nociceptive neurons in rats and mice. Neuroscience. 139: 699–709.
51. Li Y, Ji A, Weihe E, Schafer MK. 2004. Cell-specific expression and lipopolysaccharideinduced regulation of tumor necrosis factor alpha (TNF alpha) and TNF receptors in rat dorsal root ganglion. J Neurosci. 24: 9623–9631.
52. Light AR, Hughen RW, Zhang J, Rainier J, Liu Z, Lee J. 2008. Dorsal root ganglion neurons innervating skeletal muscle respond to physiological combinations of protons, ATP, and lactate mediated by ASIC, P2X, and TRPV1. J Neurophysiol. 100: 1184–1201.
53. Light AR, White AT, Hughen RW, Light KC. Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients, but not in normal subjects. J Pain epub July 30.
54. Light KC, Bragdon EE, Grewen KM, Brownley KA. 2009b. Adrenergic dysregulation and pain with and without acute beta-blockade in women with fibromyalgia and temporomandibular disorder. J Pain. 10: 452–552.
55. Mamet J, Lazdunski M, Voilley N. 2003. How nerve growth factor drives physiological and inflammatory expressions of acid-sensing ion channel 3 in sensory neurons. J Biol Chem. 278: 48907–48913.
56. Mathew SJ, Mao X, Keegan KA, Levine SM, Smith EL, Heier LA, Otcheretko V, Coplan JD, Shungu DC. 2009. Ventricular cerebrospinal fluid lactate is increased in chronic fatigue syndrome compared with generalized anxiety disorder: an in vivo 3.0 T (1)H MRS imaging study. NMR Biomed. 22 (3): 251–258.
57. Mense S. 2009. Algesic agents exciting muscle nociceptors. Exp Brain Res. 196:89–100.
58. Mense S, Meyer H. 1985. Different types of slowly conducting afferent units in cat skeletal muscle and tendon. J Physiol (Lond). 363: 403–417.
59. Micevych PE, Kruger L. 1992. The status of calcitonin gene-related peptide as an effector peptide. Ann N Y Acad Sci. 657: 379–396.
60. Molliver DC, Immke DC, Fierro L, Pare M, Rice FL, McCleskey EW. 2005. ASIC3, an acidsensing ion channel, is expressed in metaboreceptive sensory neurons. Mol Pain. 1: 35.
61. Mosso A. (1904) Fatigue.
62. Muller J. (1840) Handbuch der Physiologie des Menschen. Koblenz, Germany: J. Holscher
63. Naves LA, McCleskey EW. 2005. An acid-sensing ion channel that detects ischemic pain. Braz J Med Biol Res. 38: 1561–1569.
64. NINDS. 2001. Restless Legs Syndrome Fact Sheet. NIH Publication No 01-4847. www.ninds.nih.gov/disorders/restless_legs/detail_restless_legs.htm
65. Noakes TD. 2007. The central governor model of exercise regulation applied to the marathon. Sports Med. 37: 374–377.
66. Noakes TD, St Clair GA, Lambert EV. 2005. From catastrophe to complexity: a novel model of integrative central neural regulation of effort and fatigue during exercise in humans: summary and conclusions. Br J Sports Med. 39: 120–124.
67. O’Halloran KD, Perl ER. 1997. Effects of partial nerve injury on the responses of C-fiber polymodal nociceptors to adrenergic agonists. Brain Res. 759: 233–240.
68. Ohara K, Nagai M, Suzuki Y, Ohara K. 1998. Low activity allele of catechol-o-methyltransferase gene and Japanese unipolar depression. Neuroreport. 9: 1305–1308.
69. Page AJ, Brierley SM, Martin CM, Price MP, Symonds E, Butler R, Wemmie JA, Blackshaw LA. 2005. Different contributions of ASIC channels 1a, 2, and 3 in gastrointestinal mechanosensory function. Gut. 54: 1408–1415.
70. Pall ML, Anderson JH. 2004. The vanilloid receptor as a putative target of diverse chemicals in multiple chemical sensitivity. Arch Environ Health. 59: 363–375.
71. Papka RE, McNeill DL. 1993. Light- and electron-microscopic study of synaptic connections in the paracervical ganglion of the female rat: special reference to calcitonin gene-related peptide-, galanin- and tachykinin (substance P and neurokinin A)-immunoreactive nerve fibers and terminals. Cell Tissue Res. 271: 417–428.
72. Peng BG, Ahmad S, Chen S, Chen P, Price MP, Lin X. 2004. Acid-sensing ion channel 2 contributes a major component to acid-evoked excitatory responses in spiral ganglion neurons and plays a role in noise susceptibility of mice. J Neurosci. 24: 10167–10175.
73. Perl ER. 1971. Is pain a specific sensation. J Psychiatr Res. 8: 273–287.
74. Perl ER. 1998. Getting a line on pain: is it mediated by dedicated pathways? Nat Neurosci. 1: 177–178.
75. Perl ER. 2007. Ideas about pain, a historical view. Nat Rev Neurosci. 8: 71–80.
76. Reeves WC, Jones JF, Maloney E, Heim C, Hoaglin DC, Boneva RS, Morrissey M, Devlin R. 2007. Prevalence of chronic fatigue syndrome in metropolitan, urban, and rural Georgia. Popul Health Metr. 5: 5.
77. Reinohl J, Hoheisel U, Unger T, Mense S. 2003. Adenosine triphosphate as a stimulant for nociceptive and non-nociceptive muscle group IV receptors in the rat. Neurosci Lett. 338: 25–28.
78. Rybicki KJ, Waldrop TG, Kaufman MP. 1985. Increasing gracilis muscle interstitial potassium concentrations stimulate group III and IV afferents. J Appl Physiol. 58: 936–941.
79. Sato J, Perl ER. 1991. Adrenergic excitation of cutaneous pain receptors induced by peripheral nerve injury. Science. 251: 1608–1610.
80. Schmaling KB, Lewis DH, Fiedelak JI, Mahurin R, Buchwald DS. 2003. Single-photon emission computerized tomography and neurocognitive function in patients with chronic fatigue syndrome. Psychosom Med. 65: 129–136.
81. Silverman JD, Kruger L. 1989. Calcitonin-gene-related-peptide-immunoreactive innervation of the rat head with emphasis on specialized sensory structures. J Comp Neurol. 280: 303–330.
82. Sites BD, Beach M, Biggs R, Rohan C, Wiley C, Rassias A, Gregory J, Fanciullo G. 2003. Intrathecal clonidine added to a bupivacaine-morphine spinal anesthetic improves postoperative analgesia for total knee arthroplasty. Anesth Analg. 96: 1083–8, table.
83. St Clair GA, Noakes TD. 2004. Evidence for complex system integration and dynamic neural regulation of skeletal muscle recruitment during exercise in humans. Br J Sports Med. 38: 797–806.
84. Staud R, Cannon RC, Mauderli AP, Robinson ME, Price DD, Vierck CJ, Jr. 2003. Temporal summation of pain from mechanical stimulation of muscle tissue in normal controls and subjects with fibromyalgia syndrome. Pain. 102: 87–95.
85. Sugiura T, Bielefeldt K, Gebhart GF. 2007. Mouse colon sensory neurons detect extracellular acidosis via TRPV1. Am J Physiol Cell Physiol. 292: C1768–C1774.
86. Sugiura T, Kasai M, Katsuya H, Mizumura K. 2003. Thermal properties of acid-induced depolarization in cultured rat small primary afferent neurons. Neurosci Lett. 350: 109–112.
87. Takahashi K, Taguchi T, Itoh K, Okada K, Kawakita K, Mizumura K. 2005. Influence of surface anesthesia on the pressure pain threshold measured with different-sized probes. Somatosens Mot Res. 22: 299–305.
88. Toth A, Boczan J, Kedei N, Lizanecz E, Bagi Z, Papp Z, Edes I, Csiba L, Blumberg PM. 2005. Expression and distribution of vanilloid receptor 1 (TRPV1) in the adult rat brain. Brain Res Mol Brain Res. 135: 162–168.
89. Tsai SJ, Gau YT, Hong CJ, Liou YJ, Yu YW, Chen TJ. 2009. Sexually dimorphic effect of catechol-O-methyltransferase val158met polymorphism on clinical response to fluoxetine in major depressive patients. J Affect Disord. 113: 183–187.
90. Vierck CJ, Jr. 2006. Mechanisms underlying development of spatially distributed chronic pain (fibromyalgia). Pain. 124: 242–263.
91. Voilley N, de Weille J, Mamet J, Lazdunski M. 2001. Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors. J Neurosci. 21: 8026–8033.
92. Waldmann R, Bassilana F, de Weille J, Champigny G, Heurteaux C, Lazdunski M. 1997a. Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons. J Biol Chem. 272: 20975–20978.
93. Waldmann R, Champigny G, Bassilana F, Heurteaux C, Lazdunski M. 1997b. A proton-gated cation channel involved in acid-sensing. Nature. 386: 173–177.
94. Wemmie JA, Askwith CC, Lamani E, Cassell MD, Freeman JH, Jr., Welsh MJ. 2003. Acidsensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning. J Neurosci. 23: 5496–5502.
95. Wemmie JA, Coryell MW, Askwith CC, Lamani E, Leonard AS, Sigmund CD, Welsh MJ. 2004. Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior. Proc Natl Acad Sci U S A. 101: 3621–3626.
96. Williamson JW, Nobrega AC, McColl R, Mathews D, Winchester P, Friberg L, Mitchell JH. 1997. Activation of the insular cortex during dynamic exercise in humans. J Physiol. 503 (Pt 2): 277–283.
97. Wilson LB, Andrew D, Craig AD. 2002. Activation of spinobulbar lamina I neurons by static muscle contraction. J Neurophysiol. 87: 1641–1645.
98. Wright-Browne V, Schnee AM, Jenkins MA, Thall PF, Aggarwal BB, Talpaz M, Estrov Z. 1998. Serum cytokine levels in infectious mononucleosis at diagnosis and convalescence. Leuk Lymphoma. 30: 583–589.
99. Wyller VB, Thaulow E, Amlie JP. 2007. Treatment of chronic fatigue and orthostatic intolerance with propranolol. J Pediatr. 150: 654–655.
100. Yagi J, Wenk HN, Naves LA, McCleskey EW. 2006. Sustained currents through ASIC3 ion channels at the modest pH changes that occur during myocardial ischemia. Circ Res. 99: 501–509.
101. Yoshiuchi K, Farkas J, Natelson BH. 2006. Patients with chronic fatigue syndrome have reduced absolute cortical blood flow. Clin Physiol Funct Imaging. 26: 83–86.