Environmental and lifestyle factors affect benzene uptake biomonitoring of residents near a petrochemical plant

Environment International

Volumn 39, Issue 1, 2012, Pages 2-7

  Fustinoni, Silvia ^a   Campo, Laura ^a   Satta, Giannina ^b   Campagna, Marcello ^b   Ibba, Antonio ^b   Tocco, Maria Giuseppina ^b   Atzeri, Sergio ^b   Avataneo, Giuseppe ^b   Flore, Costantino ^b   Meloni, Michele ^b   Bertazzi, Pier Alberto ^a   Cocco, Pierluigi ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Benzene exposure; Biomonitoring; General population; Urinary benzene

Indexed keywords

LINEAR REGRESSION; PETROCHEMICAL PLANTS; PETROCHEMICALS;

AIR SAMPLING; BIOMONITORING; CLOSE PROXIMITY; ENVIRONMENTAL TOBACCO SMOKES; GENERAL POPULATION; LOW LEVEL; MULTIPLE LINEAR REGRESSION ANALYSIS; SMALL TOWNS; STUDY GROUPS; URBAN TRAFFIC; URINARY BENZENE;

BENZENE;

BENZENE; TOBACCO SMOKE;

BENZENE; BIOMONITORING; ENVIRONMENTAL FACTOR; EXCRETION; LIFESTYLE; MULTIPLE REGRESSION; SMOKING; TOBACCO; TRAFFIC EMISSION;

ADULT; AIR SAMPLING; ALCOHOL CONSUMPTION; ARTICLE; BIOLOGICAL MONITORING; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; FEMALE; FOOD INTAKE; HUMAN; ITALY; LIFESTYLE MODIFICATION; LIMIT OF QUANTITATION; MALE; MASS SPECTROMETRY; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HEALTH; OCCUPATIONAL SAFETY; PETROCHEMICAL INDUSTRY; PRIORITY JOURNAL; SHIFT WORKER;

NICOTIANA TABACUM;

EID: 80054967305     PISSN: 01604120     EISSN: 18736750     Source Type: Journal    
DOI: 10.1016/j.envint.2011.09.001     Document Type: Article

References (35)

1. Agenzia Regionale per l'Ambiente Lombardia Historical series of air benzene in the provinces of Lombardy Available on line at:, (last accessed 21 April 2011). http://ita.arpalombardia.it/ita/qaria/doc_EvoluzioneAnni.asp.
2. American Conference of Governmental Industrial Hygienists (ACGIH) TLVs and BEIs based on the documentation of the threshold limit values for chemical substances and physical agents and biological indices 2010, ACGIH, Cincinnati, OH.
3. Barbieri A., Violante F.S., Sabatini L., Graziosi F., Mattioli S. Urinary biomarkers and low-level environmental benzene concentration: assessing occupational and general population. Chemosphere 2008, 74:64-69.
4. Campo L., Cattaneo A., Consonni D., Scibetta L., Costamagna P., Cavallo D.M., et al. Urinary methyl tert-butyl ether and benzene as biomarkers of exposure to urban traffic. Environ Int 2011, 37:404-411.
5. Carrieri M., Tranfo G., Pigini D., Salamon F., Scappellato M.L., Fracasso M.E., et al. Correlation between environmental and biological monitoring of exposure to benzene in petrochemical industry operators. Toxicol Lett 2010, 192:17-21.
6. Cogliano V.J., Baan R., Straif K. Updating IARC's carcinogenicity assessment of benzene. Am J Ind Med 2011, 54:165-167.
7. Crebelli R., Tomei F., Zijno A., Ghittori S., Imbriani M., Gamberale D., et al. Exposure to benzene in urban workers: environmental and biological monitoring of traffic police in Rome. Occup Environ Med 2001, 58:165-171.
8. Delgado-Saborit J.M., Aquilina N.J., Meddings C., Baker S., Harrison R.M. Model development and validation of personal exposure to volatile organic compound concentrations. Environ Health Perspect 2009, 117:1571-1579.
9. Duarte-Davidson R., Courage C., Rushton L., Levy L. Benzene in the environment: an assessment of the potential risks to the health population. Occup Environ Med 2001, 58:2-13.
10. European Commission Directive 98/70/EC of the European Parliament and of the Council of 13 October 1998 relating to the quality of petrol and diesel fuels and amending Directive 93/12/EEC 1998, European Commission, Brussels, Belgium.
11. European Commission Council Directive 97/42/EC of 27 June 1997 amending for the first time Directive 90/394/EEC on protecting workers from risks related to exposure to carcinogens at work [Sixth Individual Directive according to Art. 16(1) of Directive 89/391/EEC]. Official Journal of the European Communities No. L179, 08.07.1997 1997, European Commission, Brussels, Belgium.
12. European Commission Directive 2000/69/EC (2000) of the European Parliament and of the Council of 16 November relating to limit values for benzene and carbon monoxide in ambient air 2000, European Commission, Brussels, Belgium.
13. European Commission Benzene. Summary risk assessment report 2007, European Commission, Joint Research Centre, Institute for Health and consumer Protection, Available on line at:. http://ecb.jrc.ec.europa.eu/documents/Existing-Chemicals/RISK_ASSESSMENT/SUMMARY/benzenesum063.pdf.
14. Fustinoni S., Buratti M., Giampiccolo R., Colombi A. Biological and environmental monitoring of exposure to airborne benzene and other aromatic hydrocarbons in Milan traffic wardens. Toxicol Lett 1995, 77:387-392.
15. Fustinoni S., Consonni D., Campo L., Buratti M., Colombi A., Pesatori A.C., et al. Monitoring low benzene exposure: comparative evaluation of urinary biomarkers, influence of cigarette smoking, and genetic polymorphisms. Cancer Epidemiol Biomarkers Prev 2005, 14:2237-2244.
16. Fustinoni S., Rossella F., Campo L., Mercadante R., Bertazzi P.A. Urinary BTEX, MTBE and naphthalene as biomarkers to gain environmental exposure profiles of the general population. Sci Total Environ 2010, 408:2840-2849.
17. Fustinoni S., Campo L., Mercadante R., Manini P. Methodological issues in biological monitoring of low exposures: the case of urinary benzene and S-phenylmercapturc acid. J Chromatogr B 2010, 878:2534-2540.
18. Fustinoni S., Campo L., Mercadante R., Consonni D., Mielizynska D., Bertazzi P.A. A quantitative approach to evaluate urinary benzene and S-phenylmercapturic acid as biomarkers of low benzene exposure. Biomarkers 2011, 16:334-345.
19. Haufroid V., Lison D. Urinary cotinine as a tobacco-smoke exposure index: a minireview. Int Arch Occup Environ Health 1998, 71:162-168.
20. Hoet P., De Smedt E., Ferrari M., Imbriani M., Maestri L., Negri S., et al. Evaluation of urinary biomarkers of exposure to benzene: correlation with blood benzene and influence of confounding factors. Int Arch Occup Environ Health 2009, 82:985-995.
21. International Agency for Research on Cancer (IARC) Monographs on the evaluation of the carcinogenic risk of chemicals to humans. Overall evaluation of carcinogenicity; an updating of IARC monograph 1987, volumes 1 to 42. Suppl. 7. World Health Organization, Lyon, France.
22. Istituto Superiore per la Protezione e la Ricerca Ambientale, ISPRA (last accessed 21 April 2011). http://www.areeurbane.apat.it.
23. Italian Legislation n.3, Art. 51, 16 January 2003 (Tutela della salute dei non fumatori) Gazzetta Ufficiale n.15, 20 January 2003, Supplemento ordinario n°5, enforced from 10 January 2005. Available on line at: (last accessed 21 April 2011). http://www.governo.it/GovernoInforma/Dossier/tabagismo/legge_3_2003.pdf.
24. Kroll M.H., Chesler R., Hagengruber C., Blank D.W., Kestner J., Rawe M. Automated determination of urinary creatinine without sample dilution: theory and practice. Clin Chem 1986, 32:446-452.
25. Lovreglio P., Barbieri A., Carrieri M., Sabatini L., Fracasso M.E., Doria D., et al. Validity of new biomarkers of internal dose for use in the biological monitoring of occupational and environmental exposure to low concentrations of benzene and toluene. Int Arch Occup Environ Health 2010, 83:341-356.
26. Manini P., De Palma G., Andreoli R., Poli D., Mozzoni P., Folesani G., et al. Environmental and biological monitoring of benzene in a cohort of Italian taxi drivers. Toxicol Lett 2006, 67:142-151.
27. Manini P., De Palma G., Andreoli R., Poli D., Petyx M., Corradi M., et al. Biological monitoring of low benzene exposure in Italian traffic policemen. Toxicol Lett 2008, 181:25-30.
28. Mansi A., Bruni R., Capone P., Paci E., Pigini D., Simeoni C., et al. Low occupational exposure to benzene in a petrochemical plant: modulationg effect of genetic polymorphism and smoking habit on the urinary t,t-MA/SPMA ratio. Toxicol Lett 2011, [Epub ahead of print].
29. National Industrial Chemical Notification Assessment Scheme (NICNAS) Benzene. Priority existing chemical assessment no. 21. Sydney, Australia 2001.
30. Regione Sardegna Realizzazione dell'inventario regionale delle sorgenti di emissione, del documento sulla valutazione della qualità dell'aria ambiente in Sardegna e dell'individuazione delle possibili misure da attuare per il raggiungimento degli obiettivi di cui al Decreto Legislativo n. 351 del 1999 Available on line, (last accessed 15 April 2011). http://www.apat.gov.it/site/it-IT/Servizi_per_l%27Ambiente/Inventario_delle_Emissioniin_Atmosfera_%28CORINAIR-IPCC%29/.
31. Scarselli A., Binazzi A., Di Marzio D. Occupational exposure levels to benzene in Italy: findings from a national database. Int Arch Occup Environ Health 2011, 84:617-625.
32. Sigma-Aldrich Application note Radiello available on line at:, (Last accessed 31-12-2010). http://www.sigmaaldrich.com/etc/medialib/docs/Supelco/Application_Notes/radiello_d1_d6.Par.0001.File.tmp/radiello_d1_d6.pdf.
33. Smith M.T. Advances in understanding benzene health effects and susceptibility. Annu Rev Public Health 2010, 31:133-148.
34. Wallace L., Pellizzari E., Hartwell T., Perritt R., Ziegenfus R. Exposure to benzene and other volatile compounds from active and passive smoking. Arch Environ Health 1987, 42:272-277.
35. Wallace L. Environmental exposure to benzene: an update. Environ Health Perspect 1996, 104:1129-1136.