Environmental and biological monitoring of benzene exposure in a cohort of Italian taxi drivers

Toxicology Letters

Volumn 167, Issue 2, 2006, Pages 142-151

  Manini, Paola ^a   De Palma, Giuseppe ^a   Andreoli, Roberta ^a   Poli, Diana ^a   Mozzoni, Paola ^a   Folesani, Giuseppina ^a   Mutti, Antonio ^a   Apostoli, Pietro ^b  

^a UNIVERSITY OF PARMA   (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

Author keywords

Benzene; GSTM1 polymorphism; S Phenylmercapturic acid; t,t Muconic acid; Taxi drivers; Urinary benzene

Indexed keywords

BENZENE; BENZENE DERIVATIVE; BIOLOGICAL MARKER; COTININE; CYTOCHROME P450 2E1; ENZYME; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE T1; MICROSOMAL EPOXIDE HYDROLASE; MUCONIC ACID; PHENYLMERCAPTURIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ADULT; AIR POLLUTION INDICATOR; AIR SAMPLING; ARTICLE; BIOLOGICAL MONITORING; COHORT ANALYSIS; CONTROLLED STUDY; DRIVER; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; FEMALE; GAS CHROMATOGRAPHY; GENETIC POLYMORPHISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; MASS SPECTROMETRY; MICROSOME MEMBRANE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SMOKING; SOLID PHASE MICROEXTRACTION; TANDEM MASS SPECTROMETRY; URINARY EXCRETION;

ACETYLCYSTEINE; ADULT; AIR POLLUTANTS, OCCUPATIONAL; BENZENE; BENZENE DERIVATIVES; COTININE; ENVIRONMENTAL MONITORING; EPOXIDE HYDROLASES; GLUTATHIONE TRANSFERASE; HUMANS; ITALY; MALE; MIDDLE AGED; MOTOR VEHICLES; NAD(P)H DEHYDROGENASE (QUINONE); OCCUPATIONAL EXPOSURE; POLYMORPHISM, GENETIC; SMOKING; SORBIC ACID;

EID: 33751018237     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2006.08.016     Document Type: Article

References (38)

1. Andreoli R., Manini P., Bergamaschi E., Brustolin A., and Mutti A. Solid-phase microextraction and gas chromatography-mass spectrometry for the determination of monoaromatic hydrocarbons in blood and urine: application to people exposed to air pollutants. Chromatographia 50 (1999) 167-172
2. Arand M., Muhlbauer R., Hengstler J., Jager E., Fuchs J., Winkler R., and Oesch F. A multiplex polymerase chain reaction protocol for the simultaneous analysis of glutathione S-transferase GSTM1 and GSTT1 polymorphisms. Anal. Biochem. 236 (1996) 184-186
3. ARPA (Agenzia Regionale Protezione Ambiente, Emilia Romagna), 2004. Available at: http://www.arpa.emr.it/.
4. BIOLIND.NET, 2005. Available at: http://www.biolind.net.
5. Bono R., Traversi D., Maestri L., Schilirò T., Ghittori S., Baiocchi C., and Gilli G. Urban air and tobacco smoke in benzene exposure in a cohort of traffic policemen. Chem. Biol. Interact. (2005) 153-154, 239-242
6. Boogard P.J., and van Sittert N.J. Biological monitoring of exposure to benzene: a comparison between S-phenylmercapturic acid, trans,trans-muconic acid, and phenol. Occup. Environ. Med. 52 (1995) 611-620
7. Brugnone F., Perbellini L., Maranelli G., Romeo L., and Lombardini F. Reference values for blood benzene in occupationally unexposed general population. Int. Arch. Occup. Environ. Health 61 (1992) 513-518
8. Coles B.F., Morel F., Rauch C., Huber W.W., Yang M., Teitel C.H., Green B., Lang N.P., and Kadlubar F.F. Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2. Pharmacogenetics 11 (2001) 663-669
9. Crebelli R., Tomei F., Zijno A., Ghittori S., Imbriani M., Gamberale D., Martini A., and Carere A. Exposure to benzene in urban workers: environmental and biological monitoring of traffic police in Rome. Occup. Environ. Med. 58 (2001) 165-171
10. Darrall K.G., Figgins J.A., Brown R.D., and Phillips G.F. Determination of benzene and associated volatile compounds in mainstream cigarette smoke. Analyst 123 (1998) 1095-1101
11. De Palma G., Manini P., Mozzoni P., Andreoli R., Bergamaschi E., Cavazzini S., Franchini I., and Mutti A. Polymorphism of xenobiotic-metabolizing enzymes and excretion of styrene-specific maercapturic acids. Chem. Res. Toxicol. 14 (2001) 1393-1400
12. Farmer P.B., Kaur B., Roach J., Levy L., Consonni D., Bertazzi P.A., Pesatori A., Fustinoni S., Buratti M., Bonzini M., Colombi A., Popov T., Cavallo D., Desideri A., Valerio F., Pala M., Bolognesi C., and Merlo F. The use of S-phenylmercapturic acid as biomarker in molecular epidemiology studies of benzene. Chem. Biol. Interact. (2005) 153-154, 97-102
13. Fustinoni S., Consonni D., Campo L., Buratti M., Colombi A., Pesatori A.C., Bonzini M., Bertazzi P.A., Foà V., Garte S., Farmer P.B., Levy L.S., Pala M., Valerio F., Fontana V., Desideri A., and Merlo D. Monitoring low benzene exposure: comparative evaluation of urinary biomarkers, influence of cigarette smoking, and genetic polymorphisms. Cancer Epidemiol. Biomarkers Prev. 14 (2005) 2237-2244
14. Garte S., Gaspari L., Alexandrie A.K., Ambrosone C., Autrup H., Autrup J.L., Baranova H., Bathum L., Benhamou S., Moffetta P., Bouchardy C., Breskvar K., Brockmoller J., Cascorbi I., Clipper M.L., Coutelle C., Daly A., Dell'Omo M., Dolzan V., Dresler C.M., Fryer A., Haugen A., Hein D.W., Hildesheim A., Hirvonen A., Hsieh L.L., Ingelman-Sundberg M., Kalina I., Kang D., Kihara M., Kiyohara C., Kremers P., Lazarus P., Le Marchand L., Lechner M.C., van Lieshout E.M., London S., Manni J.J., Maugard C.M., Morita S., Nazar-Stewart V., Noda K., Oda Y., Parl F.F., Pastorelli R., Persson I., Peters W.H., Rannug A., Rebbeck T., Risch A., Roelandt L., Romkes M., Ryberg D., Salagovic J., Schoket B., Seidegard J., Shields P.G., Sim E., Sinnet D., Strange R.C., Stucker I., Sugimura H., To-Figueras J., Vineis P., Yu M.C., and Taioli E. Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiol. Biomarkers Prev. 10 (2001) 1239-1248
15. Ghittori S., Imbriani M., Maestri L., Capodaglio E., and Cavalleri A. Determination of S-phenylmercapturic acid in urine as an indicator of exposure to benzene. Toxicol. Lett. 108 (1999) 329-334
16. Haufroid V., Buchet J.P., Gardinal G., Ghittori S., Imbriani M., and Lison D. Importance of genetic polymorphisms for enzymes involved in the biotransformation of styrene in humans and interest for interpretation of biomarkers of exposure. Biomarkers 6 (2001) 236-249
17. Henry R.J. Clinical Chemistry Principle and Techniques. 2nd ed. (1974), Harper & Row, New York
18. IARC, 1982. Benzene. In: Some Industrial Chemicals and Dyestuffs IARC Monographs on the Evaluation of Carcinogenic Risk to Humans, vol. 29, 93-148.
19. Imbriani M., and Ghittori S. Gases and organic solvents in urine as biomarkers of occupational exposure: a review. Int. Arch. Occup. Environ. Health 78 (2005) 1-19
20. Jo W.-K., and Yu C.-H. Public bus and taxicab drivers' exposure to aromatic work-time volatile organic compounds. Environ. Res. 86 (2001) 66-72
21. Maffei F., Hrelia P., Angelini S., Carbone F., Forti G.C., Barbieri A., Sanguinetti G., Mattioli S., and Violante F.S. Effects of environmental benzene: micronucleus frequencies and hematological values in traffic police working in an urban area. Mutat. Res. 583 (2005) 1-11
22. Melikian A.A., O'Connor R., Prahalad A.K., Hu P., Li H., Kagan M., and Thompson S. Determination of the urinary benzene metabolites S-phenylmercapturic acid and trans,trans-muconic acid by liquid chromatography-tandem mass spectrometry. Carcinogenesis 20 (1999) 719-726
23. Melikian A.A., Qu Q., Shore R., Li G., Li H., Jin X., Cohen B., Chen L., Li Y., Yin S., Mu R., Zhang X., and Wang Y. Personal exposure to different levels of benzene and its relationships to the urinary metabolites S-phenylmercapturic acid and trans,trans-muconic acid. J. Chromatogr. A 778 (2002) 211-221
24. Negri S., Bono R., Maestri L., Ghittori S., and Imbriani M. High pressure liquid chromatographic-mass spectrometric determination of sorbic acid in urine: verification of formation of trans,trans-muconic acid. Chem. Biol. Interact. (2005) 153-154, 243-246
25. Qu Q., Shore R., Li G., Jin X., Chen L.C., Cohen B., Melikian A.A., Eastmond D., Rappaport S., Rupa D., Waidyanatha S., Yin S., Yan H., Meng M., Winnik W., Kwok E.S., Li Y., Mu R., Xu B., Zhang X., and Li K. Validation and evaluation of biomarkers in workers exposed to benzene in China. Res. Resp. Heath Eff. Inst. 115 (2003) 1-87
26. Qu Q., Shore R., Li G., Su L., Jin X., Melikian A.A., Roy N., Chen L.C., Wirgin I., Cohen B., Yin S., Li Y., and Mu R. Biomarkers of benzene: urinary metabolites in relation to individual genotype and personal exposure. Chem. Biol. Interact. (2005) 153-154, 85-95
27. Rossi A.M., Guarnieri C., Rovesti S., Gobba F., Ghittori S., Vivoli G., and Barale R. Genetic polymorphisms influence variability in benzene metabolism in humans. Pharmacogenetics 9 (1999) 445-451
28. Sarmanova J., Tynkova L., Susova S., Gut I., and Soucek P. Genetic polymorphisms of biotransformation enzymes: allele frequencies in the population of the Czech Republic. Pharmacogenetics 10 (2000) 781-788
29. Schulz W.A., Krummeck A., Rosinger I., Eickelmann P., Neuhaus C., Ebert T., Schmitz-Drager B.J., and Sies H. Increased frequency of a null-allele for NAD(P)H:quinone oxidoreductase in patients with urological malignancies. Pharmacogenetics 7 (1997) 235-239
30. Schupp T., Bolt H.M., Jaeckh R., and Hengstler J.G. Benzene and its methyl-derivatives: derivation of maximum exposure levels in automobiles. Toxicol. Lett. 160 (2006) 93-104
31. Smith C.A.D., and Harrison D. Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema. Lancet 350 (1997) 630-633
32. Sørensen M., Skov H., Autrup H., Hertel O., and Loft S. Urban benzene exposure and oxidative DNA damage: influence of genetic polymorphisms in metabolism genes. Sci. Total Environ. 309 (2003) 69-80
33. Sørensen M., Poole J., Autrup H., Muzyka V., Jensen A., Loft S., and Knudsen L.E. Benzene exposure assessed by metabolite excretion in Estonian oil shale mineworkers: influence of glutathione S-transferase polymorphisms. Cancer Epidemiol. Biomarkers Prev. 13 (2004) 1729-1735
34. Tomei F., Ghittori S., Imbriani M., Pavanello S., Carere A., Marcon F., Martini A., Baccolo T.P., Tomao E., Zijno A., and Crebelli R. Environmental and biological monitoring of traffic warderns from the city of Rome. Occup. Med. 51 (2001) 198-203
35. Verdina A., Galati R., Falasca G., Ghittori S., Imbriani M., Tomei F., Marcellini L., Zijno A., and Vecchio V.D. Metabolic polymorphisms and urinary biomarkers in subjects with low benzene exposure. J. Toxicol. Environ. Health A 64 (2001) 607-618
36. Waidyanatha S., Rothman N., Fustinoni S., Smith M.T., Hayes R.B., Bechtold W., Dosemeci M., Guilan L., Yin S., and Rappaport S.M. Urinary benzene as a biomarker of exposure among occupationally exposed and unexposed subjects. Carcinogenesis 22 (2001) 279-286
37. WHO, 1993. WHO Environmental Health Criteria 155. Biomarkers and risk assessment, concepts and principles. ICPS, Geneva.
38. WHO Working Group, 1996. Updating and Revision of the Air Quality Guidelines for Europe; Report on the WHO Working Group on Volatile Organic Compounds. EUR/ICP/EHAZ 94 05/MT12.