Investigating the neural mechanisms of aware and unaware fear memory with fMRI

Journal of Visualized Experiments

Volumn , Issue 56, 2011, Pages

  Knight, David C ^a   Wood, Kimberly H ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Conditioning; Contingency awareness; Fear; fMRI; Issue 56; Learning; Memory; Neuroscience; Skin conductance

Indexed keywords

EID: 80054956639     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/3083     Document Type: Article

References (23)

1. LaBar, K.S., Gatenby, J.C., Gore, J.C., LeDoux, J.E., & Phelps, E.A. Human amygdala activation during conditioned fear acquisition and extinction: a mixed-trial fMRI study. Neuron. 20, 937-945, doi: S0896-6273(00)80475-4 [pii] (1998).
2. Buchel, C., Morris, J., Dolan, R.J. & Friston, K.J. Brain systems mediating aversive conditioning: an event-related fMRI study. Neuron. 20, 947-957, doi:S0896-6273(00)80476-6 [pii] (1998).
3. Cheng, D.T., Knight, D.C., Smith, C.N., Stein, E.A. & Helmstetter, F.J. Functional MRI of human amygdala activity during Pavlovian fear conditioning: stimulus processing versus response expression. Behav. Neurosci. 117, 3-10 (2003).
4. Knight, D.C., Smith, C.N., Stein, E.A. & Helmstetter, F.J. Functional MRI of human Pavlovian fear conditioning: patterns of activation as a function of learning. Neuroreport. 10, 3665-3670 (1999).
5. Cheng, D.T., Knight, D.C., Smith, C.N. & Helmstetter, F.J. Human amygdala activity during the expression of fear responses. Behav. Neurosci. 120, 1187-1195, doi:2006-22387-001 [pii] 10.1037/0735-7044.120.5.1187 (2006).
6. Balderston, N.L. & Helmstetter, F.J. Conditioning with masked stimuli affects the timecourse of skin conductance responses. Behav. Neurosci. 124, 478-489, doi:2010-16138-005 [pii] 10.1037/a0019927 (2010).
7. Esteves, F., Parra, C., Dimberg, U. & Ohman, A. Nonconscious associative learning: Pavlovian conditioning of skin conductance responses to masked fear-relevant facial stimuli. Psychophysiology. 31, 375-385 (1994).
8. Cheng, D.T., Richards, J. & Helmstetter, F.J. Activity in the human amygdala corresponds to early, rather than late period autonomic responses to a signal for shock. Learn. Mem. 14, 485-490, doi:14/7/485 [pii] 10.1101/lm.632007 (2007).
9. Knight, D.C., Nguyen, H.T. & Bandettini, P.A. The role of the human amygdala in the production of conditioned fear responses. Neuroimage. 26, 1193-1200, doi:S1053-8119(05)00184-9 [pii] 10.1016/j.neuroimage.2005.03.020 (2005).
10. Knight, D.C., Nguyen, H.T. & Bandettini, P.A. The role of awareness in delay and trace fear conditioning in humans. Cogn. Affect. Behav. Neurosci. 6, 157-162 (2006).
11. Schultz, D.H. & Helmstetter, F.J. Classical conditioning of autonomic fear responses is independent of contingency awareness. J. Exp. Psychol. Anim. Behav. Process. 36, 495-500, doi:2010-21866-002 [pii] 10.1037/a0020263 (2010).
12. Dunsmoor, J.E., Bandettini, P.A. & Knight, D.C. Neural correlates of unconditioned response diminution during Pavlovian conditioning. Neuroimage. 40, 811-817, doi:S1053-8119(07)01090-7 [pii] 10.1016/j.neuroimage.2007.11.042 (2008).
13. Katkin, E.S., Wiens, S. & Ohman, A. Nonconscious fear conditioning, visceral perception, and the development of gut feelings. Psychol. Sci. 12, 366-370 (2001).
14. Knight, D.C., Waters, N.S., King, M.K. & Bandettini, P.A. Learning-related diminution of unconditioned SCR and fMRI signal responses. Neuroimage. 49, 843-848, doi:S1053-8119(09)00777-0 [pii] 10.1016/j.neuroimage.2009.07.012 (2010).
15. Knight, D.C., Waters, N.S. & Bandettini, P.A. Neural substrates of explicit and implicit fear memory. Neuroimage. 45, 208-214, doi:S1053-8119(08)01217-2 [pii] 10.1016/j.neuroimage.2008.11.015 (2009).
16. Lovibond, P.F. & Shanks, D.R. The role of awareness in Pavlovian conditioning: empirical evidence and theoretical implications. J. Exp. Psychol. Anim. Behav. Process. 28, 3-26 (2002).
17. LaBar, K.S. & Disterhoft, J.F. Conditioning, awareness, and the hippocampus. Hippocampus. 8, 620-626, doi:10.1002/(SICI)1098-1063(1998)8:6<620::AID-HIPO4>3.0.CO;2-6 (1998).
18. R.W. AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Comput. Biomed. Res. 29, 162-173, doi:S0010480996900142 [pii] (1996).
19. Knight, D.C., Nguyen, H.T. & Bandettini, P.A. Expression of conditional fear with and without awareness. Proc. Natl. Acad. Sci. U. S. A. 100, 15280-15283, doi:10.1073/pnas.2535780100 2535780100 [pii] (2003).
20. Bunce, S.C., Bernat, E., Wong, P.S. & Shevrin, H. Further evidence for unconscious learning: preliminary support for the conditioning of facial EMG to subliminal stimuli. J. Psychiatr. Res. 33, 341-347, doi:S0022-3956(99)00003-5 [pii] (1999).
21. Kotze, H.F. & Moller, A.T. Effect of auditory subliminal stimulation on GSR. Psychol. Rep. 67, 931-934 (1990).
22. Miller, J. Threshold variability in subliminal perception experiments: fixed threshold estimates reduce power to detect subliminal effects. J. Exp. Psychol. Hum. Percept. Perform. 17, 841-851 (1991).
23. Tabbert, K., Stark, R., Kirsch, P. & Vaitl, D. Dissociation of neural responses and skin conductance reactions during fear conditioning with and without awareness of stimulus contingencies. Neuroimage. 32, 761-770, doi:S1053-8119(06)00221-7 [pii] 10.1016/j.neuroimage.2006.03.038 (2006).