LC8 dynein light chain (DYNLL1) binds to the C-terminal domain of ATM-interacting protein (ATMIN/ASCIZ) and regulates its subcellular localization

Biochemical and Biophysical Research Communications

Volumn 414, Issue 3, 2011, Pages 493-498

  Rapali, Péter ^b   García Mayoral, María Flor ^d   Martínez Moreno, Mónica ^a   Tárnok, Krisztián ^b   Schlett, Katalin ^b   Albar, Juan Pablo ^c   Bruix, Marta ^d   Nyitray, László ^b   Rodriguez Crespo, Ignacio ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^c CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^d INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

Author keywords

ATMIN; Dynein; Intracellular transport; Microtubules

Indexed keywords

ATM PROTEIN; DYNEIN ADENOSINE TRIPHOSPHATASE; GREEN FLUORESCENT PROTEIN; LC8 DYNEIN LIGHT CHAIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; DNA BINDING MOTIF; DNA DAMAGE; HUMAN; IN VITRO STUDY; ISOTHERMAL TITRATION CALORIMETRY; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PURIFICATION; YEAST;

AMINO ACID SEQUENCE; BINDING SITES; CARRIER PROTEINS; CYTOPLASMIC DYNEINS; HUMANS; INTRACELLULAR SPACE; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; NUCLEAR PROTEINS; PROTEIN STRUCTURE, TERTIARY; TWO-HYBRID SYSTEM TECHNIQUES;

MAMMALIA;

EID: 80054955365     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.09.093     Document Type: Article

References (31)

1. Benashski S.E., Harrison A., Patel-King R.S., King S.M. Dimerization of the highly conserved light chain shared by dynein and myosin V. J. Biol. Chem. 1997, 272:20929-20935.
2. Espindola F.S., Suter D.M., Partata L.B., Cao T., Wolenski J.S., Cheney R.E., King S.M., Mooseker M.S. The light chain composition of chicken brain myosin-Va: calmodulin, myosin-II essential light chains, and 8-kDa dynein light chain/PIN. Cell. Motil. Cytoskelet. 2000, 47:269-281.
3. Merino-Gracia J., Garcia-Mayoral M.F., Rodriguez-Crespo I. The association of viral proteins with host cell dynein components during virus infection. FEBS J. 2011, 278:2997-3011.
4. King S.M., Barbarese E., Dillman J.F., Patel-King R.S., Carson J.H., Pfister K.K. Brain cytoplasmic and flagellar outer arm dyneins share a highly conserved Mr 8000 light chain. J. Biol. Chem. 1996, 271:19358-19366.
5. Barbar E. Dynein light chain LC8 is a dimerization hub essential in diverse protein networks. Biochemistry 2008, 47:503-508.
6. Z.R. Hodi, P. Radnai, L. Molnar, T. Szenes, A. Kardos, J. Buday, L. Stafford, W.F., L. Nyitray, The LC8 family of dynein light chains: multifunctional chaperon-like proteins, FEBS J. 274 (2007) 106 (Suppl. 1 Meeting Abstract: B1-372007).
7. Rapali P., Radnai L., Suveges D., Harmat V., Tolgyesi F., Wahlgren W.Y., Katona G., Nyitray L., Pal G. Directed evolution reveals the binding motif preference of the LC8/DYNLL hub protein and predicts large numbers of novel binders in the human proteome. PLoS One 2011, 6:e18818.
8. Rapali P., Szenes A., Radnai L., Bakos A., Pal G., Nyitray L. DYNLL/LC8: a light chain subunit of the dynein motor complex and beyond. FEBS J. 2011, 278:2980-2996.
9. Benison G., Karplus P.A., Barbar E. Structure and dynamics of LC8 complexes with KXTQT-motif peptides: swallow and dynein intermediate chain compete for a common site. J. Mol. Biol. 2007, 371:457-468.
10. Martinez-Moreno M., Navarro-Lerida I., Roncal F., Albar J.P., Alonso C., Gavilanes F., Rodriguez-Crespo I. Recognition of novel viral sequences that associate with the dynein light chain LC8 identified through a pepscan technique. FEBS Lett. 2003, 544:262-267.
11. Fan J., Zhang Q., Tochio H., Li M., Zhang M. Structural basis of diverse sequence-dependent target recognition by the 8 kDa dynein light chain. J. Mol. Biol. 2001, 306:97-108.
12. Rodriguez-Crespo I., Yelamos B., Roncal F., Albar J.P., Ortiz de Montellano P.R., Gavilanes F. Identification of novel cellular proteins that bind to the LC8 dynein light chain using a pepscan technique. FEBS Lett. 2001, 503:135-141.
13. Lo K.W., Naisbitt S., Fan J.S., Sheng M., Zhang M. The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif. J. Biol. Chem. 2001, 276:14059-14066.
14. Garcia-Mayoral M.F., Rodriguez-Crespo I., Bruix M. Structural models of DYNLL1 with interacting partners: African swine fever virus protein p54 and postsynaptic scaffolding protein gephyrin. FEBS Lett. 2011, 585:53-57.
15. Radnai L., Rapali P., Hodi Z., Suveges D., Molnar T., Kiss B., Becsi B., Erdodi F., Buday L., Kardos J., Kovacs M., Nyitray L. Affinity, avidity and kinetics of target sequence binding to LC8 dynein light chain isoforms. J. Biol. Chem. 2010, 285:38649-38657.
16. Williams J.C., Roulhac P.L., Roy A.G., Vallee R.B., Fitzgerald M.C., Hendrickson W.A. Structural and thermodynamic characterization of a cytoplasmic dynein light chain-intermediate chain complex. Proc. Natl. Acad. Sci. USA 2007, 104:10028-10033.
17. Kanu N., Behrens A. ATMIN defines an NBS1-independent pathway of ATM signalling. EMBO J. 2007, 26:2933-2941.
18. Rodriguez-Crespo I., Straub W., Gavilanes F., Ortiz de Montellano P.R. Binding of dynein light chain (PIN) to neuronal nitric oxide synthase in the absence of inhibition. Arch. Biochem. Biophys. 1998, 359:297-304.
19. Garcia-Mayoral M.F., Martinez-Moreno M., Albar J.P., Rodriguez-Crespo I., Bruix M. Structural basis for the interaction between dynein light chain 1 and the glutamate channel homolog GRINL1A. FEBS J. 2010, 277:2340-2350.
20. Navarro-Lerida I., Martinez-Moreno M., Ventoso I., Alvarez-Barrientos A., Rodriguez-Crespo I. Binding of CAP70 to inducible nitric oxide synthase and implications for the vectorial release of nitric oxide in polarized cells. Mol. Biol. Cell 2007, 18:2768-2777.
21. Romero P., Obradovic Z., Li X., Garner E.C., Brown C.J., Dunker A.K. Sequence complexity of disordered protein. Proteins 2001, 42:38-48.
22. Hall J., Hall A., Pursifull N., Barbar E. Differences in dynamic structure of LC8 monomer, dimer, and dimer-peptide complexes. Biochemistry 2008, 47:11940-11952.
23. Wang W., Lo K.W., Kan H.M., Fan J.S., Zhang M. Structure of the monomeric 8-kDa dynein light chain and mechanism of the domain-swapped dimer assembly. J. Biol. Chem. 2003, 278:41491-41499.
24. McNees C.J., Conlan L.A., Tenis N., Heierhorst J. ASCIZ regulates lesion-specific Rad51 focus formation and apoptosis after methylating DNA damage. EMBO J. 2005, 24:2447-2457.
25. Hiom K. DNA repair: how to PIKK a partner. Curr. Biol. 2005, 15:R473-R475.
26. Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R., Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 2007, 316:1160-1166.
27. Heierhorst J. Mdt1/ASCIZ: a new DNA damage response protein family. Cell Cycle 2008, 7:2654-2660.
28. Traven A., Heierhorst J. SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA-damage-response proteins. Bioessays 2005, 27:397-407.
29. Stelter P., Kunze R., Flemming D., Hopfner D., Diepholz M., Philippsen P., Bottcher B., Hurt E. Molecular basis for the functional interaction of dynein light chain with the nuclear-pore complex. Nat. Cell Biol. 2007, 9:788-796.
30. Naisbitt S., Valtschanoff J., Allison D.W., Sala C., Kim E., Craig A.M., Weinberg R.J., Sheng M. Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein. J. Neurosci. 2000, 20:4524-4534.
31. Lo K.W., Kan H.M., Chan L.N., Xu W.G., Wang K.P., Wu Z., Sheng M., Zhang M. The 8-kDa dynein light chain binds to p53-binding protein 1 and mediates DNA damage-induced p53 nuclear accumulation. J. Biol. Chem. 2005, 280:8172-8179.