Coll2-1, Coll2-1NO 2 and myeloperoxidase concentrations in the synovial fluid of equine tarsocrural joints affected with osteochondrosis

Veterinary Research Communications

Volumn 35, Issue 7, 2011, Pages 401-408

  Verwilghen, Denis R ^a,e   Martens, Ann ^b   Busschers, Evita ^c   Franck, Thierry ^a   Deberg, Michelle ^a   Henrotin, Yves ^a   Vanderheyden, Laurent ^d   Serteyn, Didier ^a,d  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c Veterinair Centrum Someren   (Netherlands)

^d European Centre of the Horse of Mont le Soie   (Belgium)

^e SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

Biomarkers; Coll2 1; Collagen degradation; Horse; MPO; Osteochondrosis

Indexed keywords

BIOLOGICAL MARKER; CARBOXY TERMINAL TELOPEPTIDE; CARBOXY TERMINAL TELOPEPTIDE TYPE 2 COLLAGEN; COLLAGEN TYPE 2; MYELOPEROXIDASE; NITRATED COLLAGEN TYPE 2; UNCLASSIFIED DRUG;

ARTICLE; CARTILAGE DEGENERATION; COLLAGEN DEGRADATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; HORSE DISEASE; JOINT; NONHUMAN; OSTEOCHONDROSIS; SYNOVIAL FLUID LEVEL; TARSOCRURAL JOINT;

ANIMALS; BIOLOGICAL MARKERS; COLLAGEN TYPE II; HINDLIMB; HORSE DISEASES; HORSES; JOINT DISEASES; OSTEOCHONDROSIS; PEPTIDE FRAGMENTS; PEROXIDASE; SYNOVIAL FLUID; TARSAL JOINTS;

EQUIDAE;

EID: 80054944851     PISSN: 01657380     EISSN: 15737446     Source Type: Journal    
DOI: 10.1007/s11259-011-9487-5     Document Type: Article

References (43)

1. LG Ameye M Deberg M Oliveira A Labasse JM Aeschlimann Y Henrotin 2007 The chemical biomarkers C2C, Coll2-1, and Coll2-1NO2 provide complementary information on type II collagen catabolism in healthy and osteoarthritic mice Arthritis Rheum 56 10 3336 3346 17907187 10.1002/art.22875 1:CAS:528: DC%2BD2sXht12rtLbO (Pubitemid 47585428)
2. T Art T Franck M Gangl D Votion S Kohnen G Deby-Dupont D Serteyn 2006 Plasma concentrations of myeloperoxidase in endurance and 3-day event horses after a competition Equine Vet J Suppl 36 298 302 17402436 10.1111/j.2042-3306. 2006.tb05557.x
3. Auer JA (2006) The Tarsus. In: Auer JA, Stick JA (eds) Equine surgery, 3rd edn. Elsevier Saunders, St. Louis, pp 1288-1306
4. S Baldus JP Eiserich ML Brennan RM Jackson CB Alexander BA Freeman 2002 Spatial mapping of pulmonary and vascular nitrotyrosine reveals the pivotal role of myeloperoxidase as a catalyst for tyrosine nitration in inflammatory diseases Free Radic Biol Med 33 7 1010 1019 12361810 10.1016/S0891-5849(02) 00993-0 1:CAS:528:DC%2BD38XnsVaht7s%3D (Pubitemid 35284038)
5. DC Bauer DJ Hunter SB Abramson M Attur M Corr D Felson D Heinegard JM Jordan TB Kepler NE Lane T Saxne B Tyree VB Kraus 2006 Classification of osteoarthritis biomarkers: a proposed approach Osteoarthr Cartil 14 8 723 727 16733093 10.1016/j.joca.2006.04.001 1:STN:280:DC%2BD28vgvVyiuw%3D%3D (Pubitemid 43986366)
6. JS Beckman WH Koppenol 1996 Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and the ugly Am J Physiol Cell Physiol 40 5 C1424 C1437
7. RC Billinghurst PA Brama PR van Weeren MS Knowlton CW McIlwraith 2004 Evaluation of serum concentrations of biomarkers of skeletal metabolism and results of radiography as indicators of severity of osteochondrosis in foals Am J Vet Res 65 2 143 150 14974569 10.2460/ajvr.2004.65.143 1:CAS:528: DC%2BD2cXhs1Gmur8%3D (Pubitemid 38312746)
8. ML Brennan WJ Wu XM Fu ZZ Shen W Song H Frost C Vadseth L Narine E Lenkiewicz MT Borchers AJ Lusis JJ Lee NA Lee HM Abu-Soud H Ischiropoulos SL Hazen 2002 A tale of two controversies - defining both the role of peroxidases in nitrotyrosine formation in vivo using eosinophil peroxidase and myeloperoxidase-deficient mice, and the nature of peroxidase-generated reactive nitrogen species J Biol Chem 277 20 17415 17427 11877405 10.1074/jbc.M112400200 1:CAS:528:DC%2BD38XktVCgtr0%3D (Pubitemid 34967541)
9. U Burner PG Furtmuller AJ Kettle WH Koppenol C Obinger 2000 Mechanism of reaction of myeloperoxidase with nitrite J Biol Chem 275 27 20597 20601 10777476 10.1074/jbc.M000181200 1:CAS:528:DC%2BD3cXkvVyhsLY%3D (Pubitemid 30457644)
10. JC de Grauw PA Brama P Wiemer H Brommer CH van de Lest PR van Weeren 2006 Cartilage-derived biomarkers and lipid mediators of inflammation in horses with osteochondritis dissecans of the distal intermediate ridge of the tibia Am J Vet Res 67 7 1156 1162 16817736 10.2460/ajvr.67.7.1156 (Pubitemid 44262956)
11. M Deberg A Labasse S Christgau P Cloos DB Henriksen JP Chapelle B Zegels JY Reginster Y Henrotin 2005 New serum biochemical markers (Coll 2-1 and Coll 2-1 NO2) for studying oxidative-related type II collagen network degradation in patients with osteoarthritis and rheumatoid arthritis Osteoarthr Cartil 13 3 258 265 15727893 10.1016/j.joca.2004.12.002 (Pubitemid 40277284)
12. MA Deberg AH Labasse J Collette L Seidel JY Reginster YE Henrotin 2005 One-year increase of Coll 2-1, a new marker of type II collagen degradation, in urine is highly predictive of radiological OA progression Osteoarthr Cartil 13 12 1059 1065 16154771 10.1016/j.joca.2005.06.014 1:STN:280: DC%2BD2MnjtVOrsw%3D%3D (Pubitemid 41672503)
13. M Deberg JE Dubuc A Labasse C Sanchez E Quettier A Bosseloir JM Crielaard Y Henrotin 2008 One year follow-up of Coll2-1, Coll2-1NO2 and myeloperoxydase serum levels in oa patients after hip or knee replacement Ann Rheum Dis 67 168 174 17644542 10.1136/ard.2007.073452 1:CAS:528:DC%2BD1cXisFCqsbc%3D (Pubitemid 351183304)
14. Enzerink E, Dik KJ, Knaap JH, Van Weeren PR (2000) Radiographic development of osteochondral lesions in the hock and stifle in a group of Dutch Warmblood horses from 1-24 months of age. Paper presented at the 39th annual congres BEVA, Birmingham, England, 13-16 September 2000
15. S Fietz A Bondzio A Moschos B Hertsch R Einspanier 2008 Measurement of equine myeloperoxidase (MPO) activity in synovial fluid by a modified MPO assay and evaluation of joint diseases - an initial case study Res Vet Sci 84 3 347 353 17675122 10.1016/j.rvsc.2007.06.006 1:CAS:528:DC%2BD1cXks1aqt78%3D (Pubitemid 351486848)
16. Franck T, Grulke S, Deby-Dupont G, Deby C, Duvivier H, Peters F, Serteyn D, (2005) Development of an enzyme-linked immunosorbent assay for specific equine neutrophil myeloperoxidase measurement in blood. Journal of Veterinary Diagnostic Investigation 17:412-419 (Pubitemid 41414957)
17. M Gangl D Serteyn JP Lejeun N Schneider S Grulke F Peters T Vila G Deby-Dupont M Deberg Y Henrotin 2007 A type II-collagen derived peptide and its nitrated form as new markers of inflammation and cartilage degradation in equine osteochondral lesions Res Vet Sci 82 1 68 75 16780906 10.1016/j.rvsc.2006.03. 008 1:CAS:528:DC%2BD28Xht12ktrbN (Pubitemid 44882881)
18. ER Garvican A Vaughan-Thomas JF Innes PD Clegg 2010 Biomarkers of cartilage turnover. Part 1: markers of collagen degradation and synthesis Vet J 185 1 36 42 20488735 10.1016/j.tvjl.2010.04.011 1:CAS:528:DC%2BC3cXnsVaqsL8%3D
19. JP Gaut J Byun HD Tran WM Lauber JA Carroll RS Hotchkiss A Belaaouaj JW Heinecke 2002 Myeloperoxidase produces nitrating oxidants in vivo J Clin Invest 109 10 1311 1319 12021246 1:CAS:528:DC%2BD38XjvFClsrY%3D (Pubitemid 34546895)
20. SP Green MS Baker DA Lowther 1990 Depolymerization of synovial fluid hyaluronic acid (HA) by the complete myeloperoxidase (MPO) system may involve the formation of a HA-MPO ionic complex J Rheumatol 17 12 1670 1675 1964699 1:STN:280:DyaK3M7psVSjuw%3D%3D
21. S Grulke H Benbarek I Caudron G Deby-Dupont M Mathy-Hartert F Farnir C Deby M Lamy D Serteyn 1999 Plasma myeloperoxidase level and polymorphonuclear leukocyte activation in horses suffering from large intestinal obstruction requiring surgery: preliminary results Can J Vet Res 63 2 142 147 10369573 1:STN:280:DyaK1M3ps1altg%3D%3D (Pubitemid 129675175)
22. Y Henrotin G Debydupont C Deby M Debruyn M Lamy P Franchimont 1993 Production of active oxygen species by isolated human chondrocytes Br J Rheumatol 32 7 562 567 8393361 10.1093/rheumatology/32.7.562 1:STN:280:DyaK3szjvVGjsQ%3D%3D (Pubitemid 23224931)
23. YE Henrotin SX Zheng GP Deby AH Labasse JMR Crielaard JYL Reginster 1998 Nitric oxide downregulates interleukin 1 beta (IL-1 beta) stimulated IL-6, IL-8, and prostaglandin E-2 production by human chondrocytes J Rheumatol 25 8 1595 1601 9712106 1:CAS:528:DyaK1cXlsF2gsb4%3D (Pubitemid 28364768)
24. Y Henrotin M Deberg JE Dubuc E Quettier S Christgau JY Reginster 2004 Type II collagen peptides for measuring cartilage degradation Biorheology 41 3-4 543 547 15299285 1:CAS:528:DC%2BD2cXlvF2hsLc%3D (Pubitemid 39277110)
25. Y Henrotin S Addison V Kraus M Deberg 2007 Type II collagen markers in osteoarthritis: what do they indicate? Curr Opin Rheumatol 19 5 444 450 17762609 10.1097/BOR.0b013e32829fb3b5 1:CAS:528:DC%2BD2sXpvVensbg%3D (Pubitemid 47344236)
26. Y Henrotin M Deberg M Mathy-Hartert G Deby-Dupont 2009 Biochemical biomarkers of oxidative collagen damage Adv Clin Chem 49 31 55 19947354 10.1016/S0065-2423(09)49002-4 1:CAS:528:DC%2BC3cXmt1Omtg%3D%3D
27. JL Huebner JM Williams M Deberg Y Henrotin VB Kraus 2010 Collagen fibril disruption occurs early in primary guinea pig knee osteoarthritis Osteoarthr Cartil 18 3 397 405 19825496 10.1016/j.joca.2009.09.011 1:STN:280: DC%2BC3c7kvFOltg%3D%3D
28. F Jenner MW Ross BB Martin DW Richardson 2008 Scapulohumeral osteochondrosis. A retrospective study of 32 horses Vet Comp Orthop Traumatol 21 5 406 412 19011703 1:STN:280:DC%2BD1cjksVWqsw%3D%3D
29. H Kaur B Halliwell 1994 Evidence for nitric oxide-mediated oxidative damage in chronic inflammation - nitrotyrosine in serum and synovial-fluid from rheumatoid patients FEBS Lett 350 1 9 12 8062931 10.1016/0014-5793(94)00722-5 1:CAS:528:DyaK2cXlslKrsr0%3D (Pubitemid 24261386)
30. K Kuwabara H Jyoyama JH Fleisch Y Hori 2002 Inhibition of antigen-induced arthritis in guinea pigs by a selective LTB4 receptor antagonist LY293111Na Inflamm Res 51 11 541 550 12540018 10.1007/PL00012425 1:CAS:528: DC%2BD38Xps1egtL4%3D (Pubitemid 36009180)
31. S Laverty M Ionescu M Marcoux L Boure B Doize AR Poole 2000 Alterations in cartilage type-II procollagen and aggrecan contents in synovial fluid in equine osteochondrosis J Orthop Res 18 3 399 405 10937626 10.1002/jor.1100180311 1:CAS:528:DC%2BD3cXmtVOqt7k%3D (Pubitemid 30599615)
32. S Laverty S Okouneff M Ionescu A Reiner I Pidoux C Webber Y Rossier RC Billinghurst AR Poole 2002 Excessive degradation of type II collagen in articular cartilage in equine osteochondrosis J Orthop Res 20 6 1282 1289 12472241 10.1016/S0736-0266(02)00053-0 1:CAS:528:DC%2BD38XotVWhsL4%3D (Pubitemid 35363986)
33. EG Laws DW Richardson MW Ross W Moyer 1993 Racing performance of standardbreds after conservative and surgical treatment for tarsocrural osteochondrosis Equine Vet J 25 3 199 202 8508747 10.1111/j.2042-3306.1993. tb02943.x 1:STN:280:DyaK3s3osFSkug%3D%3D
34. JP Lejeune D Serteyn M Gangl N Schneider G Deby-Dupont M Deberg Y Henrotin 2007 Plasma concentrations of a type II collagen-derived peptide and its nitrated form in growing ardenner sound horses and in horses suffering from juvenile digital degenerative osteoarthropathy Vet Res Commun 31 5 591 601 17252318 10.1007/s11259-007-3518-2 (Pubitemid 46371901)
35. SL Myers KD Brandt O Eilam 1995 Even low-grade synovitis significantly accelerates the clearance of protein from the canine knee. Implications for measurement of synovial fluid "markers" of osteoarthritis Arthritis Rheum 38 8 1085 1091 7639804 10.1002/art.1780380810 1:CAS:528:DyaK2MXns1WisLo%3D
36. JJ Runge DN Biery DF Lawler TP Gregor RH Evans RD Kealy SD Szabo GK Smith 2008 The effects of lifetime food restriction on the development of osteoarthritis in the canine shoulder Vet Surg 37 1 102 107 18199063 10.1111/j.1532-950X.2007.00354.x
37. J Schiller J Arnhold K Sonntag K Arnold 1996 NMR studies on human, pathologically changed synovial fluids: role of hypochlorous acid Magn Reson Med 35 6 848 853 8744012 10.1002/mrm.1910350610 1:STN:280:DyaK28zjvVOiug%3D%3D (Pubitemid 26172620)
38. N Schneider AL Mouithys-Mickalad JP Lejeune GP Deby-Dupont M Hoebeke DA Serteyn 2005 Synoviocytes, not chondrocytes, release free radicals after cycles of anoxia/re-oxygenation Biochem Biophys Res Commun 334 2 669 673 16036131 10.1016/j.bbrc.2005.06.147 1:CAS:528:DC%2BD2MXmsVOgu7c%3D (Pubitemid 40982418)
39. D Serteyn S Grulke T Franck A Mouithys-Mickalad G Deby-Dupont 2003 Neutrophile myeloperoxidase, protective enzyme with strong oxidative activities Ann Med Vet 147 2 79 93 (Pubitemid 37356847)
40. Spellmeyer K (2003) Myeloperoxidase-Aktivität im Serum und in der Synovia bei Hunden mit Osteoarthritis Eine prospektive Studie. Doctoral Thesis, Freie Universität Berlin, Berlin
41. MJ Steinbeck LJ Nesti PF Sharkey J Parvizi 2007 Myeloperoxidase and chlorinated peptides in osteoarthritis: potential biomarkers of the disease J Orthop Res 25 9 1128 1135 17474133 10.1002/jor.20400 1:CAS:528: DC%2BD2sXhtVCqsLrF (Pubitemid 47365287)
42. Van Weeren PR (2006) Osteochondrosis. In: Auer JA, Stick JA (eds) Equine surgery, 3rd edn. Elsevier Saunders, St. Louis, pp 1166-1178
43. D Verwilghen V Busoni M Gangl T Franck JP Lejeune L Vanderheyden J Detilleux S Grulke M Deberg Y Henrotin D Serteyn 2009 Relationship between biochemical markers and radiographic scores in the evaluation of the osteoarticular status of Warmblood stallions Res Vet Sci 87 2 319 328 19298987 10.1016/j.rvsc.2009.02.002 1:CAS:528:DC%2BD1MXos12ktbo%3D