Site-specific recombinase strategy to create induced pluripotent stem cells efficiently with plasmid DNA

Stem Cells

Volumn 29, Issue 11, 2011, Pages 1696-1704

  Karow, Marisa ^a   Chavez, Christopher L ^a   Farruggio, Alfonso P ^a   Geisinger, Jonathan M ^a   Keravala, Annahita ^a   Jung, W Edward ^a   Lan, Feng ^a   Wu, Joseph C ^a   Yanru, Chen Tsai ^a   Calos, Michele P ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adipose derived mesenchymal stem cells; Induced pluripotent stem cells; Nonviral reprogramming strategy; Phage integrase

Indexed keywords

CELL DNA; CRE RECOMBINASE; GENOMIC DNA; INTEGRASE; KRUPPEL LIKE FACTOR 4; OCTAMER TRANSCRIPTION FACTOR 4; PLASMID DNA; REX PROTEIN; REX1 PROTEIN; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLASTOCYST; CELL DIFFERENTIATION; CHIMERA; CONTROLLED STUDY; DNA METHYLATION; EMBRYO; EMBRYO CELL; EMBRYO DEVELOPMENT; EMBRYOID BODY; FEMALE; FIBROBLAST; GENE CASSETTE; GENE DELETION; GENE SEQUENCE; GENETIC TRANSFECTION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL; PROMOTER REGION; TERATOMA;

ADIPOSE TISSUE; ANIMALS; BLOTTING, SOUTHERN; CELLS, CULTURED; DNA NUCLEOTIDYLTRANSFERASES; INDUCED PLURIPOTENT STEM CELLS; MESENCHYMAL STEM CELLS; MICE; NUCLEAR REPROGRAMMING; PLASMIDS; POLYMERASE CHAIN REACTION;

MURINAE;

EID: 80054942925     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.730     Document Type: Article

References (41)

1. Groth AC, Olivares EC, Thyagarajan B et al. A phage integrase directs efficient site-specific integration in human cells. Proc Natl Acad Sci U S A 2000;97:5995-6000. (Pubitemid 30367512)
2. Thyagarajan B, Olivares EC, Hollis RP et al. Site-specific genomic integration in mammalian cells mediated by phage φ/C31 integrase. Mol Cell Biol 2001;21:3926-3934. (Pubitemid 32476454)
3. Olivares EC, Hollis RP, Chalberg TW et al. Site-specific genomic integration produces therapeutic factor IX levels in mice. Nat Biotechnol 2002;20:1124-1128. (Pubitemid 35285441)
4. Keravala A, Chavez CL, Hu G et al. Long-term phenotypic correction in factor IX knockout mice by using phiC31 integrase-mediated gene therapy. Gene Ther 2011;18:842-848.
5. Takahashi K, Yamanaka S.Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-676. (Pubitemid 44233629)
6. Sommer CA, Mostoslavsky G.Experimental approaches for the generation of induced pluripotent stem cells. Stem Cell Res Ther 2010;1:26.
7. Sidhu KS.New approaches for the generation of induced pluripotent stem cells. Expert Opin Biol Ther 2011;11:569-579.
8. Sommer CA, Stadtfeld M, Murphy GJ et al. Induced pluripotent stem cell generation using a single lentiviral stem cell cassette. Stem Cells 2009;27:543-549.
9. Okita K, Hong H, Takahashi K et al. Generation of mouse-induced pluripotent stem cells with plasmid vectors. Nat Protoc 2010;5:418-428.
10. Montserrat N, Garreta Bahima E, Gonzalez F et al. Simple generation of human induced pluripotent stem cells using poly({beta}-amino esters) as non-viral gene delivery system. J Biol Chem 2011;286:12417-12428.
11. Jia F, Wilson KD, Sun N et al. A nonviral minicircle vector for deriving human iPS cells. Nat Methods 2010;7:197-199.
12. Woltjen K, Michael IP, Mohseni P et al. piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature 2009;458:766-770.
13. Yusa K, Rad R, Takeda J et al. Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon. Nat Methods 2009;6:363-369.
14. Kim D, Kim CH, Moon JI et al. Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell 2009;4:472-476.
15. Warren L, Manos PD, Ahfeldt T et al. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 2010;7:618-636.
16. Anokye-Danso F, Trivedi CM, Juhr D et al. Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell 2011;8:376-388.
17. Miyoshi N, Ishii H, Nagano H et al. Reprogramming of mouse and human cells to pluripotency using mature microRNAs. Cell Stem Cell 2011;8:633-638.
18. Sun N, Panetta N, Gupta D et al. Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells. Proc Natl Acad Sci U S A 2009;106:15720-15725.
19. Sugii S, Kida Y, Kawamura T et al. Human and mouse adipose-derived cells support feeder-independent induction of pluripotent stem cells. Proc Natl Acad Sci U S A 2010;107:3558-3563.
20. Narsinh KH, Jia F, Robbins RC et al. Generation of adult human induced pluripotent stem cells using nonviral minicircle DNA vectors. Nat Protoc 2011;6:78-88.
21. Conley BJ, Denham M, Gulluyan L et al. Mouse embryonic stem cell derivation, and mouse and human embryonic stem cell culture and differentiation as embryoid bodies. Curr Protoc Cell Biol 2005; Chapter 23:Unit 23.2.
22. Chalberg TC, Portlock JL, Olivares EC et al. Integration specificity of phage phiC31 integrase in the human genome. J Mol Biol 2006;357:28-48. (Pubitemid 43339312)
23. Papapetrou EP, Lee G, Malani N et al. Genomic safe harbors permit high beta-globin transgene expression in thalassemia induced pluripotent stem cells. Nat Biotechnol 2011;29:73-78.
24. Nakagawa M, Takizawa N, Narita M et al. Promotion of direct reprogramming by transformation-deficient Myc. Proc Natl Acad Sci U S A 2010;107:14152-14157.
25. Yamashita T, Kawai H, Tian F et al. Tumorigenic development of induced pluripotent stem cells in ischemic mouse brain. Cell Transplant 2010;20:883-891.
26. Kaji K, Norrby K, Paca A et al. Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature 2009;458:771-775.
27. Sommer CA, Sommer AG, Longmire TA et al. Excision of reprogramming transgenes improves the differentiation potential of iPS cells generated with a single excisable vector. Stem Cells 2010;28:64-74.
28. Chang CW, Lai YS, Pawlik KM et al. Polycistronic lentiviral vector for "hit and run" reprogramming of adult skin fibroblasts to induced pluripotent stem cells. Stem Cells 2009;27:1042-1049.
29. Yu J, Hu K, Smuga-Otto K et al. Human induced pluripotent stem cells free of vector and transgene sequences. Science 2009;324:797-801.
30. Okita K, Yamanaka S.Induction of pluripotency by defined factors. Exp Cell Res 2010;316:2565-2570.
31. Gonzalez F, Barragan Monasterio M, Tiscornia G et al. Generation of mouse-induced pluripotent stem cells by transient expression of a single nonviral polycistronic vector. Proc Natl Acad Sci U S A 2009;106:8918-8922.
32. Ye L, Chang JC, Lin C et al. Generation of induced pluripotent stem cells using site-specific integration with phage integrase. Proc Natl Acad Sci U S A 2010;107:19467-19472.
33. Nishiumi F, Sone T, Kishine H et al. Simultaneous single cell stable expression of 2-4 cDNAs in HeLaS3 using psiC31 integrase system. Cell Struct Funct 2009;34:47-59.
34. Ye J, McGinnis S, Madden TL.BLAST: Improvements for better sequence analysis. Nucleic Acids Res 2006;34:W6-W9. (Pubitemid 44529725)
35. Soldner F, Hockemeyer D, Beard C et al. Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell 2009;136:964-977.
36. Okita K, Ichisaka T, Yamanaka S.Generation of germline-competent induced pluripotent stem cells. Nature 2007;448:313-317.
37. Somers A, Jean JC, Sommer CA et al. Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette. Stem Cells 2010;28:1728-1740.
38. Olivares EC, Hollis RP, Calos MP.Phage R4 integrase mediates efficient integration in mammalian cells. Gene 2001;278:167-176. (Pubitemid 33055791)
39. Ellis J, Baum C, Benvenisty N et al. Benefits of utilizing gene-modified iPSCs for clinical applications. Cell Stem Cell 2010;7:429-430.
40. Liu Y, Lakshmipathy U, Ozgenc A et al. hESC engineering by integrase-mediated chromosomal targeting. Methods Mol Biol 2010;584:229-268.
41. Keravala A, Groth AC, Jarrahian S et al. A diversity of serine phage integrases mediate site-specific recombination in mammalian cells. Mol Genet Genomics 2006;276:135-146. (Pubitemid 44079953)