Enhanced IL-10 production by CD4 + T cells primed in IL-15Rα-deficient mice

European Journal of Immunology

Volumn 41, Issue 11, 2011, Pages 3146-3156

  Chow, Kai Ping N ^a,b   Lee, Jan Mou ^c   Qiu, Jian Tai ^d   Liao, Shuen Kuei ^e   Lin, Shih Chieh ^b   Hsu, Shuo Lun ^b   Wu, Ning Ning ^b   Lin, Yen Fu ^b   Wu, Tzong Shoon ^b,f  

^a Department of Microbiology and Immunology ^*  (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c INSTITUTE OF MOLECULAR BIOLOGY   (Taiwan)

^d CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^e TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

CD4 + T cell differentiation; DCs; IL 10; IL 15 transpresentation

Indexed keywords

ANTIGEN; B7 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 15 RECEPTOR ALPHA; INTERLEUKIN 2; KEYHOLE LIMPET HEMACYANIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; OVA PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; CD4+ T LYMPHOCYTE; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DRAINING LYMPH NODE; IMMUNIZATION; IMMUNOLOGICAL PROCEDURES; KNOCKOUT MOUSE; LYMPH NODE; MICROENVIRONMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE PRIMING; WILD TYPE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL SEPARATION; FLOW CYTOMETRY; INTERLEUKIN-10; INTERLEUKIN-15 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT;

EID: 80054927732     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201141746     Document Type: Article

References (44)

1. Inaba, K., Metlay, J. P., Crowley, M. T. and Steinman, R. M., Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ. J. Exp. Med. 1990. 172: 631-640.
2. + T lymphocytes to peptide antigen in vivo. J. Immunol. 1993. 151: 6742-6750.
3. Kalinski, P., Hilkens, C. M., Wierenga, E. A. and Kapsenberg, M. L., T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal. Immunol. Today 1999. 20: 561-567.
4. Grabstein, K. H., Eisenman, J., Shanebeck, K., Rauch, C., Srinivasan, S., Fung, V., Beers, C. et al., Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science 1994. 264: 965-968.
5. Mortier, E., Woo, T., Advincula, R., Gozalo, S. and Ma, A., IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation. J. Exp. Med. 2008. 205: 1213-1225.
6. Dubois, S., Mariner, J., Waldmann, T. A. and Tagaya, Y., IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells. Immunity 2002. 17: 537-547.
7. Sandau, M. M., Schluns, K. S., Lefrancois, L. and Jameson, S. C., Cutting edge: transpresentation of IL-15 by bone marrow-derived cells necessitates expression of IL-15 and IL-15R alpha by the same cells. J. Immunol. 2004. 173: 6537-6541.
8. Mattei, F., Schiavoni, G., Belardelli, F. and Tough, D. F., IL-15 is expressed by dendritic cells in response to type I IFN, double-stranded RNA, or lipopolysaccharide and promotes dendritic cell activation. J. Immunol. 2001. 167: 1179-1187.
9. + T cell response against an intracellular parasite. Proc. Natl. Acad. Sci. USA 2006. 103: 6635-6640.
10. Baccala, R., Kono, D. H. and Theofilopoulos, A. N., Interferons as pathogenic effectors in autoimmunity. Immunol. Rev. 2005. 204: 9-26.
11. Moore, K. W., de Waal Malefyt, R., Coffman, R. L. and O'Garra, A., Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 2001. 19: 683-765.
12. O'Garra, A., Barrat, F. J., Castro, A. G., Vicari, A. and Hawrylowicz, C., Strategies for use of IL-10 or its antagonists in human disease. Immunol. Rev. 2008. 223: 114-131.
13. Ohteki, T., Suzue, K., Maki, C., Ota, T. and Koyasu, S., Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune response. Nat. Immunol. 2001. 2: 1138-1143.
14. Ruckert, R., Brandt, K., Bulanova, E., Mirghomizadeh, F., Paus, R. and Bulfone-Paus, S., Dendritic cell-derived IL-15 controls the induction of CD8 T cell immune responses. Eur. J. Immunol. 2003. 33: 3493-3503.
15. Jonuleit, H., Schmitt, E., Schuler, G., Knop, J. and Enk, A. H., Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J. Exp. Med. 2000. 192: 1213-1222.
16. Dhodapkar, M. V., Steinman, R. M., Krasovsky, J., Munz, C. and Bhardwaj, N., Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J. Exp. Med. 2001. 193: 233-238.
17. Legge, K. L., Gregg, R. K., Maldonado-Lopez, R., Li, L., Caprio, J. C., Moser, M. and Zaghouani, H., On the role of dendritic cells in peripheral T cell tolerance and modulation of autoimmunity. J. Exp. Med. 2002. 196: 217-227.
18. + Tr cells. Blood 2005. 105: 1162-1169.
19. Curotto de Lafaille, M. A. and Lafaille, J. J., Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? Immunity 2009. 30: 626-635.
20. Koka, R., Burkett, P., Chien, M., Chai, S., Boone, D. L. and Ma, A., Cutting edge: murine dendritic cells require IL-15R alpha to prime NK cells. J. Immunol. 2004. 173: 3594-3598.
21. Kuchroo, V. K., Das, M. P., Brown, J. A., Ranger, A. M., Zamvil, S. S., Sobel, R. A., Weiner, H. L. et al., B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 1995. 80: 707-718.
22. Schulz, O., Edwards, A. D., Schito, M., Aliberti, J., Manickasingham, S., Sher, A. and Reis e Sousa, C., CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal. Immunity 2000. 13: 453-462.
23. MacDonald, A. S., Straw, A. D., Dalton, N. M. and Pearce, E. J., Cutting edge: Th2 response induction by dendritic cells: a role for CD40. J. Immunol. 2002. 168: 537-540.
24. Dubois, S. P., Waldmann, T. A. and Muller, J. R., Survival adjustment of mature dendritic cells by IL-15. Proc. Natl. Acad. Sci. USA 2005. 102: 8662-8667.
25. Ohteki, T., Tada, H., Ishida, K., Sato, T., Maki, C., Yamada, T., Hamuro, J. and Koyasu, S., Essential roles of DC-derived IL-15 as a mediator of inflammatory responses in vivo. J. Exp. Med. 2006. 203: 2329-2338.
26. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997. 389: 737-742.
27. + T cells. J. Immunol. 2004. 173: 3155-3164.
28. Gonzalo, J. A., Delaney, T., Corcoran, J., Goodearl, A., Gutierrez-Ramos, J. C. and Coyle, A. J., Cutting edge: the related molecules CD28 and inducible costimulator deliver both unique and complementary signals required for optimal T cell activation. J. Immunol. 2001. 166: 1-5.
29. Kapsenberg, M. L., Dendritic-cell control of pathogen-driven T-cell polarization. Nat. Rev. Immunol. 2003. 3: 984-993.
30. Levings, M. K., Sangregorio, R., Galbiati, F., Squadrone, S., de Waal Malefyt, R. and Roncarolo, M. G., IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells. J. Immunol. 2001. 166: 5530-5539.
31. Cornish, G. H., Sinclair, L. V. and Cantrell, D. A., Differential regulation of T-cell growth by IL-2 and IL-15. Blood 2006. 108: 600-608.
32. Rubinstein, M. P., Kovar, M., Purton, J. F., Cho, J. H., Boyman, O., Surh, C. D. and Sprent, J., Converting IL-15 to a superagonist by binding to soluble IL-15Ralpha. Proc. Natl. Acad. Sci. USA 2006. 103: 9166-9171.
33. Sato, N., Patel, H. J., Waldmann, T. A. and Tagaya, Y., The IL-15/IL-15Ralpha on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells. Proc. Natl. Acad. Sci. USA 2007. 104: 588-593.
34. Kamanaka, M., Kim, S. T., Wan, Y. Y., Sutterwala, F. S., Lara-Tejero, M., Galan, J. E., Harhaj, E. and Flavell, R. A., Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse. Immunity 2006. 25: 941-952.
35. Braunstein, J., Qiao, L., Autschbach, F., Schurmann, G. and Meuer, S., T cells of the human intestinal lamina propria are high producers of interleukin-10. Gut 1997. 41: 215-220.
36. + T cells deficient in the IL-15 receptor alpha-chain. J. Immunol. 2002. 168: 705-712.
37. Lodolce, J. P., Boone, D. L., Chai, S., Swain, R. E., Dassopoulos, T., Trettin, S. and Ma, A., IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 1998. 9: 669-676.
38. Coombes, J. L. and Powrie, F., Dendritic cells in intestinal immune regulation. Nat. Rev. Immunol. 2008. 8: 435-446.
39. Iwasaki, A., Mucosal dendritic cells. Annu. Rev. Immunol. 2007. 25: 381-418.
40. McInnes, I. B. and Gracie, J. A., Interleukin-15: a new cytokine target for the treatment of inflammatory diseases. Curr. Opin. Pharmacol. 2004. 4: 392-397.
41. Pestka, S., Krause, C. D., Sarkar, D., Walter, M. R., Shi, Y. and Fisher, P. B., Interleukin-10 and related cytokines and receptors. Annu. Rev. Immunol. 2004. 22: 929-979.
42. Asselin-Paturel, C., Boonstra, A., Dalod, M., Durand, I., Yessaad, N., Dezutter-Dambuyant, C., Vicari, A. et al., Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology. Nat. Immunol. 2001. 2: 1144-1150.
43. O'Keeffe, M., Hochrein, H., Vremec, D., Caminschi, I., Miller, J. L., Anders, E. M., Wu, L. et al., Mouse plasmacytoid cells: long-lived cells, heterogeneous in surface phenotype and function, that differentiate into CD8(+) dendritic cells only after microbial stimulus. J. Exp. Med. 2002. 196: 1307-1319.
44. Chen, L., Calomeni, E., Wen, J., Ozato, K., Shen, R. and Gao, J. X., Natural killer dendritic cells are an intermediate of developing dendritic cells. J. Leukoc. Biol. 2007. 81: 1422-1433.